{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:06:45Z","timestamp":1793239605092,"version":"4.5.0"},"reference-count":208,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) plays a key role in the regulation of physiological processes in mammals. The decline in H\n                    <jats:sub>2<\/jats:sub>\n                    S level has been reported in numerous renal disorders. In animal models of renal disorders, treatment with H\n                    <jats:sub>2<\/jats:sub>\n                    S donors could restore H\n                    <jats:sub>2<\/jats:sub>\n                    S levels and improve renal functions. H\n                    <jats:sub>2<\/jats:sub>\n                    S donors suppress renal dysfunction by regulating autophagy, apoptosis, oxidative stress, and inflammation through multiple signaling pathways, such as TRL4\/NLRP3, AMP-activated protein kinase\/mammalian target of rapamycin, transforming growth factor-\u03b21\/Smad3, extracellular signal-regulated protein kinases 1\/2, mitogen-activated protein kinase, and nuclear factor kappa B. In this review, we summarize recent developments in the effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S donors on the treatment of common renal diseases, including acute\/chronic kidney disease, renal fibrosis, unilateral ureteral obstruction, glomerulosclerosis, diabetic nephropathy, hyperhomocysteinemia, drug-induced nephrotoxicity, metal-induced nephrotoxicity, and urolithiasis. Novel H\n                    <jats:sub>2<\/jats:sub>\n                    S donors can be designed and applied in the treatment of common renal diseases.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2020.564281","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T01:20:04Z","timestamp":1605748804000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Roles of Hydrogen Sulfide Donors in Common Kidney Diseases"],"prefix":"10.3389","volume":"11","author":[{"given":"Ebenezeri Erasto","family":"Ngowi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sarfraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attia","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazeer Hussain","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadullah","family":"Khattak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Feng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ying","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"B1","first-page":"121","article-title":"Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat","volume":"5","author":"Ahangarpour","year":"2014","journal-title":"Vet. 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