{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:27:22Z","timestamp":1791350842185,"version":"4.3.1"},"reference-count":168,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.569914","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T08:16:32Z","timestamp":1601367392000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["L-Arginine-Nitric Oxide-Asymmetric Dimethylarginine Pathway and the Coronary Circulation: Translation of Basic Science Results to Clinical Practice"],"prefix":"10.3389","volume":"11","author":[{"given":"Attila","family":"Czir\u00e1ki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Lenkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Sulyok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Szokodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1161\/01.ATV.0000081742.92006.59","article-title":"Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase","volume":"23","author":"Achan","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"H1574","DOI":"10.1152\/ajpheart.1999.276.5.H1574","article-title":"L-arginine limits myocardial cell death secondary to hypoxia-reoxygenation by a cGMP-dependent mechanism","volume":"276","author":"Agullo","year":"1999","journal-title":"Am. J. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3892\/ijmm_00000176","article-title":"Stent placement in patients with coronary heart disease decreases plasma levels of the endogenous nitric oxide synthase inhibitor ADMA","volume":"23","author":"Ajtay","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3892\/ijmm_00000384","article-title":"Effects of stent implementation on plasma levels of asymmetric dimethylarginine in patients with or without ST-segment elevation acute myocardial infarction","volume":"25","author":"Ajtay","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cca.2006.07.001","article-title":"Oxidative injury and antioxidants in coronary artery bypass graft surgery: off-pump CABG significantly reduces oxidative stress","volume":"375","author":"Akila","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"B6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1023\/a:1022155206928","article-title":"The nitric oxide-endothelin-1 connection","volume":"8","author":"Alonso","year":"2003","journal-title":"Heart Fail Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/s0735-1097(98)00668-8","article-title":"Combined effects of nitric oxide and oxygen during acute pulmonary vasodilator testing","volume":"33","author":"Atz","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.yjmcc.2004.05.004","article-title":"Arginase pathway in human endothelial cells in pathophysiological conditions","volume":"37","author":"Bachetti","year":"2004","journal-title":"J. Mol. Cell Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.amjcard.2004.11.023","article-title":"Plasma asymmetric dimethylarginine concentrations in newly diagnosed patients with acute myocardial infarction or unstable angina pectoris during two weeks of medical treatment","volume":"95","author":"Bae","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"B10","first-page":"52","article-title":"Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus","author":"Bagi","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/ncpneph0344","article-title":"Mechanisms of disease: in utero programming in the pathogenesis of hypertension","volume":"2","author":"Barker","year":"2006","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1161\/01.CIR.0000092948.04444.C7","article-title":"Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels","volume":"108","author":"Berkowitz","year":"2003","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1161\/01.res.79.4.840","article-title":"Function and production of nitric oxide in the coronary circulation of the conscious dog during exercise","volume":"79","author":"Bernstein","year":"1996","journal-title":"Circ. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1161\/01.cir.101.18.2160","article-title":"Oral L-arginine in patients with coronary artery disease on medical management","volume":"101","author":"Blum","year":"2000","journal-title":"Circulation"},{"key":"B15","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1042\/cs0870303","article-title":"L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects","volume":"87","author":"Bode-Boger","year":"1994","journal-title":"Clin. Sci. (Lond.)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.pharmthera.2007.03.002","article-title":"The L-arginine paradox: Importance of the L-arginine\/asymmetrical dimethylarginine ratio","volume":"114","author":"Bode-Boger","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1161\/01.cir.96.4.1282","article-title":"Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin","volume":"96","author":"Boger","year":"1997","journal-title":"Circulation"},{"key":"B18","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.phrs.2009.07.001","article-title":"Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality\u2013an update on patient populations with a wide range of cardiovascular risk","volume":"60","author":"Boger","year":"2009","journal-title":"Pharmacol. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2842S","DOI":"10.1093\/jn\/134.10.2842S","article-title":"Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the \u201cL-arginine paradox\u201d and acts as a novel cardiovascular risk factor","volume":"134","author":"Boger","year":"2004","journal-title":"J. Nutr."},{"key":"B20","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1177\/1358836X0501000104","article-title":"Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials","author":"Boger","year":"2005","journal-title":"Vasc. Med."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/201742","article-title":"Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease","volume":"2012","author":"Borgeraas","year":"2012","journal-title":"Cardiol. Res. Pract."},{"key":"B22","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1161\/01.atv.19.3.767","article-title":"Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation","volume":"19","author":"Bosmans","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1007\/s00125-010-1910-x","article-title":"Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus","volume":"53","author":"Broekhuizen","year":"2010","journal-title":"Diabetologia"},{"key":"B24","first-page":"BR248","article-title":"Asymmetric dimethylarginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects","volume":"15","author":"Cable","year":"2009","journal-title":"Med. Sci. Monit."},{"key":"B25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/s0002-9149(97)00354-8","article-title":"Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris","volume":"80","author":"Ceremuzynski","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1073\/pnas.79.6.2106","article-title":"Role of endothelial cells in relaxation of isolated arteries by bradykinin","volume":"79","author":"Cherry","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B27","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0167-5273(90)90118-o","article-title":"The role of nitric oxide in mediating endothelium dependent relaxations in the human epicardial coronary artery","volume":"29","author":"Chester","year":"1990","journal-title":"Int. J. Cardiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.amjcard.2008.09.085","article-title":"Association of leukocyte and neutrophil counts with infarct size, left ventricular function and outcomes after percutaneous coronary intervention for ST-elevation myocardial infarction","volume":"103","author":"Chia","year":"2009","journal-title":"Am. J. Cardiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1172\/JCI118632","article-title":"Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults","volume":"97","author":"Clarkson","year":"1996","journal-title":"J. Clin. Invest."},{"key":"B30","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/jcp.1041230304","article-title":"Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture","volume":"123","author":"Cocks","year":"1985","journal-title":"J. Cell Physiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1172\/JCI115937","article-title":"Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit","volume":"90","author":"Cooke","year":"1992","journal-title":"J. Clin. Invest."},{"key":"B32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/MCA.0b013e3283441d5c","article-title":"Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine","volume":"22","author":"Cziraki","year":"2011","journal-title":"Coron. Artery Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-12-385061-4.00007-6","article-title":"Organic nitrates and nitrate tolerance\u2013state of the art and future developments","volume":"60","author":"Daiber","year":"2010","journal-title":"Adv. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2337\/diacare.14.3.173","article-title":"Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease","volume":"14","author":"DeFronzo","year":"1991","journal-title":"Diabetes Care"},{"key":"B35","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/anae.14577","article-title":"Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass","volume":"74","author":"Dekker","year":"2019","journal-title":"Anaesthesia"},{"key":"B36","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1067\/mva.2000.103788","article-title":"Vascular smooth muscle cell effect on endothelial cell endothelin-1 production","volume":"31","author":"Di Luozzo","year":"2000","journal-title":"J. Vasc. Surg."},{"key":"B37","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.ahj.2011.09.012","article-title":"Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials","volume":"162","author":"Dong","year":"2011","journal-title":"Am. Heart J."},{"key":"B38","first-page":"127","article-title":"Regular exercise enhances blood pressure lowering effect of acetylcholine by increased contribution of nitric oxide","volume":"87","author":"Dornyei","year":"2000","journal-title":"Acta Physiol. Hung"},{"key":"B39","doi-asserted-by":"publisher","first-page":"C846","DOI":"10.1152\/ajpcell.00288.2015","article-title":"Mechanotransduction of the endothelial glycocalyx mediates nitric oxide production through activation of TRP channels","volume":"311","author":"Dragovich","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/0002-9149(92)90760-v","article-title":"Effects of infusion of L-arginine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries","volume":"70","author":"Dubois-Rande","year":"1992","journal-title":"Am. J. Cardiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1161\/01.cir.100.19.1951","article-title":"Contribution of vasodilator prostanoids and nitric oxide to resting flow, metabolic vasodilation, and flow-mediated dilation in human coronary circulation","volume":"100","author":"Duffy","year":"1999","journal-title":"Circulation"},{"key":"B42","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/j.1440-1681.2007.04638.x","article-title":"Arginase: a critical regulator of nitric oxide synthesis and vascular function","volume":"34","author":"Durante","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1161\/01.cir.94.2.130","article-title":"Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms","volume":"94","author":"Egashira","year":"1996","journal-title":"Circulation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1161\/01.res.79.2.331","article-title":"Role of endothelium-derived nitric oxide in coronary vasodilatation induced by pacing tachycardia in humans","volume":"79","author":"Egashira","year":"1996","journal-title":"Circ. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/cbf.1766","article-title":"The effect of L-arginine or L-citrulline supplementation on biochemical parameters and the vascular aortic wall in high-fat and high-cholesterol-fed rats","volume":"29","author":"El-Kirsh","year":"2011","journal-title":"Cell Biochem. Funct."},{"key":"B46","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/s0008-6363(97)00242-3","article-title":"Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure","volume":"37","author":"Feng","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/S0011-393X(00)80048-X","article-title":"Effect of L-arginine on endothelium-dependent coronary vasodilatory reserve in spontaneously hypertensive rats","volume":"61","author":"Fujita","year":"2000","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"B48","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/0006-291x(90)92343-x","article-title":"NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation","volume":"168","author":"Fukuto","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"H2242","DOI":"10.1152\/ajpheart.00587.2008","article-title":"Role of TNF-alpha-induced reactive oxygen species in endothelial dysfunction during reperfusion injury","volume":"295","author":"Gao","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"H1813","DOI":"10.1152\/ajpheart.1990.259.6.H1813","article-title":"L-arginine-dependent vascular smooth muscle relaxation and cGMP formation","volume":"259","author":"Gold","year":"1990","journal-title":"Am. J. Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/BF03256591","article-title":"Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate","volume":"9","author":"Gori","year":"2009","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"B53","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1161\/01.cir.83.3.739","article-title":"Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators","volume":"83","author":"Habib","year":"1991","journal-title":"Circulation"},{"key":"B54","first-page":"183","article-title":"Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome","volume":"1","author":"Hadi","year":"2005","journal-title":"Vasc. Health Risk Manag."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1096\/fj.03-0115fje","article-title":"Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase","volume":"17","author":"Hein","year":"2003","journal-title":"FASEB J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1210\/jcem.80.7.7608279","article-title":"Intravenous administration of L-arginine inhibits angiotensin-converting enzyme in humans","volume":"80","author":"Higashi","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B57","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1536\/ihj.33.41","article-title":"Effect of systemic L-arginine administration on hemodynamics and nitric oxide release in man","volume":"33","author":"Hishikawa","year":"1992","journal-title":"Jpn. Heart J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"H429","DOI":"10.1152\/ajpheart.00501.2001","article-title":"Neuronal NOS-dependent dilation to flow in coronary arteries of male eNOS-KO mice","volume":"282","author":"Huang","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/hh0102.102330","article-title":"Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview","volume":"90","author":"Ignarro","year":"2002","journal-title":"Circ. Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1056\/NEJM199311253292204","article-title":"The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction","volume":"329","author":"Investigators","year":"1993","journal-title":"N Engl. J. Med."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3634948","article-title":"Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders","volume":"2016","author":"Janus","year":"2016","journal-title":"Mediators Inflammation"},{"key":"B62","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0305-0491(95)02138-8","article-title":"Comparative properties of arginases","volume":"114","author":"Jenkinson","year":"1996","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1021\/jm801220a","article-title":"Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping","volume":"52","author":"Ji","year":"2009","journal-title":"J. Med. Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"H987","DOI":"10.1152\/ajpheart.1992.262.4.H987","article-title":"Regulation of arteriolar tone and responses via L-arginine pathway in skeletal muscle","volume":"262","author":"Kaley","year":"1992","journal-title":"Am. J. Physiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.forsciint.2012.10.036","article-title":"Comprehensive evaluation of pericardial biochemical markers in death investigation","volume":"224","author":"Kawamoto","year":"2013","journal-title":"Forensic Sci. Int."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071679","article-title":"The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure","volume":"11","author":"Khalaf","year":"2019","journal-title":"Nutrients"},{"key":"B67","doi-asserted-by":"publisher","first-page":"H578","DOI":"10.1152\/ajpheart.00745.2016","article-title":"The human coronary vasodilatory response to acute mental stress is mediated by neuronal nitric oxide synthase","volume":"313","author":"Khan","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s11357-020-00180-6","article-title":"Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood","volume":"42","author":"Kiss","year":"2020","journal-title":"Geroscience"},{"key":"B69","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/MCA.0b013e328311d32b","article-title":"Asymmetric dimethylarginine and coronary collateral vessel development","volume":"19","author":"Kocaman","year":"2008","journal-title":"Coron. Artery Dis."},{"key":"B70","doi-asserted-by":"publisher","first-page":"H1485","DOI":"10.1152\/ajpheart.1989.257.5.H1485","article-title":"Effects of endothelial impairment on arteriolar dilator responses in vivo","volume":"257","author":"Koller","year":"1989","journal-title":"Am. J. Physiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"H1194","DOI":"10.1152\/ajpheart.1993.264.4.H1194","article-title":"L-arginine analogues blunt prostaglandin-related dilation of arterioles","volume":"264","author":"Koller","year":"1993","journal-title":"Am. J. Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"H326","DOI":"10.1152\/ajpheart.1994.267.1.H326","article-title":"Corelease of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioles","volume":"267","author":"Koller","year":"1994","journal-title":"Am. J. Physiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1161\/01.res.76.4.544","article-title":"Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles. Role of endothelial nitric oxide and prostaglandins","volume":"76","author":"Koller","year":"1995","journal-title":"Circ. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e103260","DOI":"10.1371\/journal.pone.0103260","article-title":"Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus","volume":"9","author":"Kovamees","year":"2014","journal-title":"PloS One"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-145","article-title":"Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study","volume":"12","author":"Kruszelnicka","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1126\/science.7123259","article-title":"Coronary vascular reactivity after acute myocardial ischemia","volume":"218","author":"Ku","year":"1982","journal-title":"Science"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00237","article-title":"Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase","volume":"4","author":"Kuo","year":"2013","journal-title":"Front. Immunol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s00424-013-1356-3","article-title":"The role of ENaC in vascular endothelium","volume":"466","author":"Kusche-Vihrog","year":"2014","journal-title":"Pflugers Arch."},{"key":"B79","doi-asserted-by":"publisher","first-page":"H10","DOI":"10.1152\/ajpheart.00574.2011","article-title":"The coronary circulation in exercise training","volume":"302","author":"Laughlin","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1161\/01.cir.88.1.43","article-title":"Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans","volume":"88","author":"Lefroy","year":"1993","journal-title":"Circulation"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1161\/01.cir.97.21.2123","article-title":"Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans","volume":"97","author":"Lerman","year":"1998","journal-title":"Circulation"},{"key":"B82","doi-asserted-by":"publisher","first-page":"E75","DOI":"10.1152\/ajpendo.2001.280.1.E75","article-title":"Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells","volume":"280","author":"Li","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B83","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1161\/CIRCRESAHA.113.301577","article-title":"The identification of nitric oxide as endothelium-derived relaxing factor","volume":"113","author":"Loscalzo","year":"2013","journal-title":"Circ. Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/clc.4960261006","article-title":"Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease","volume":"26","author":"Lu","year":"2003","journal-title":"Clin. Cardiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.ehj.2003.08.013","article-title":"Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention","volume":"24","author":"Lu","year":"2003","journal-title":"Eur. Heart J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrd2466","article-title":"The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics","volume":"7","author":"Lundberg","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"B87","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.pharmthera.2006.05.003","article-title":"The role of nitric oxide in the post-ischemic revascularization process","volume":"112","author":"Luque Contreras","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1161\/01.res.66.4.1088","article-title":"Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins","volume":"66","author":"Luscher","year":"1990","journal-title":"Circ. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.ijcard.2016.06.254","article-title":"Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis","volume":"220","author":"Mangiacapra","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1373\/clinchem.2006.076711","article-title":"Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study)","volume":"53","author":"Meinitzer","year":"2007","journal-title":"Clin. Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine-nitric oxide pathway","volume":"329","author":"Moncada","year":"1993","journal-title":"N Engl. J. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"S193","DOI":"10.1038\/sj.bjp.0706458","article-title":"The discovery of nitric oxide and its role in vascular biology","author":"Moncada","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbrc.2014.10.029","article-title":"Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability","volume":"454","author":"Morita","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B94","doi-asserted-by":"publisher","first-page":"H1672","DOI":"10.1152\/ajpheart.00832.2003","article-title":"Inflammation- and ischemia-induced shedding of venular glycocalyx","volume":"286","author":"Mulivor","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11154-012-9229-1","article-title":"Role of insulin resistance in endothelial dysfunction","volume":"14","author":"Muniyappa","year":"2013","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"B96","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1210\/er.2007-0006","article-title":"Cardiovascular actions of insulin","volume":"28","author":"Muniyappa","year":"2007","journal-title":"Endocr. Rev."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1172\/JCI1560","article-title":"Nitric oxide synthase modulates angiogenesis in response to tissue ischemia","volume":"101","author":"Murohara","year":"1998","journal-title":"J. Clin. Invest."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e0135498","DOI":"10.1371\/journal.pone.0135498","article-title":"Elevated Levels of Asymmetric Dimethylarginine (ADMA) in the Pericardial Fluid of Cardiac Patients Correlate with Cardiac Hypertrophy","volume":"10","author":"Nemeth","year":"2015","journal-title":"PloS One"},{"key":"B99","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1139\/cjpp-2015-0030","article-title":"Pericardial fluid of cardiac patients elicits arterial constriction: role of endothelin-1","volume":"93","author":"Nemeth","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.3109\/14767051003677962","article-title":"L-arginine supplementation in women with chronic hypertension: impact on blood pressure and maternal and neonatal complications","volume":"23","author":"Neri","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1054\/clnu.2002.0612","article-title":"The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA)","volume":"22","author":"Nijveldt","year":"2003","journal-title":"Clin. Nutr."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1093\/ndt\/gfg452","article-title":"Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia","volume":"18","author":"Nijveldt","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"B103","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0735-1097(96)00429-9","article-title":"Importance of nitric oxide in the coronary artery at rest and during pacing in humans","volume":"29","author":"Nishikawa","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"B104","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1016\/S0021-9258(18)81786-0","article-title":"Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney","volume":"264","author":"Ogawa","year":"1989","journal-title":"J. Biol. Chem."},{"key":"B105","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1681\/ASN.2014050430","article-title":"Role of the vascular wall in sodium homeostasis and salt sensitivity","volume":"26","author":"Olde Engberink","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1093\/cvr\/cvaa003","article-title":"ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on \u2018coronary microvascular dysfunction in cardiovascular disease\u2019","volume":"116","author":"Padro","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"H3227","DOI":"10.1152\/ajpheart.00998.2007","article-title":"Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems","volume":"293","author":"Palm","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/333664a0","article-title":"Vascular endothelial cells synthesize nitric oxide from L-arginine","volume":"333","author":"Palmer","year":"1988","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/s0006-291x(88)81362-7","article-title":"L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation","volume":"153","author":"Palmer","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.amjcard.2017.06.036","article-title":"Impact of Asymmetric Dimethylarginine on Coronary Physiology Early After Heart Transplantation","volume":"120","author":"Parikh","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"35338","DOI":"10.1074\/jbc.M109.037036","article-title":"Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production","volume":"284","author":"Pope","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B112","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1161\/01.cir.92.3.320","article-title":"Contribution of nitric oxide to metabolic coronary vasodilation in the human heart","volume":"92","author":"Quyyumi","year":"1995","journal-title":"Circulation"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1172\/JCI117852","article-title":"Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis","volume":"95","author":"Quyyumi","year":"1995","journal-title":"J. Clin. Invest."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/s0735-1097(97)00279-9","article-title":"Effect of L-arginine on human coronary endothelium-dependent and physiologic vasodilation","volume":"30","author":"Quyyumi","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1161\/01.cir.95.1.104","article-title":"Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia. Comparison of acetylcholine and substance P","volume":"95","author":"Quyyumi","year":"1997","journal-title":"Circulation"},{"key":"B116","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/s0735-1097(98)00323-4","article-title":"Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and L-arginine","volume":"32","author":"Quyyumi","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1161\/01.hyp.28.3.367","article-title":"Nitric oxide and the regulation of blood pressure in the hypertension-prone and hypertension-resistant Sabra rat","volume":"28","author":"Rees","year":"1996","journal-title":"Hypertension"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1161\/CIRCULATIONAHA.106.684852","article-title":"Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia","volume":"116","author":"Rehm","year":"2007","journal-title":"Circulation"},{"key":"B119","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00424-007-0212-8","article-title":"The endothelial glycocalyx: composition, functions, and visualization","volume":"454","author":"Reitsma","year":"2007","journal-title":"Pflugers Arch."},{"key":"B120","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.pharmthera.2013.07.004","article-title":"Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets","volume":"140","author":"Rochette","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"B121","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1093\/cvr\/cvp277","article-title":"Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia","volume":"85","author":"Sankaralingam","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.bbrc.2006.05.015","article-title":"Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging","volume":"345","author":"Scalera","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1007\/s00726-015-2031-0","article-title":"Effects of chronic oral L-arginine administration on the L-arginine\/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir","volume":"47","author":"Schneider","year":"2015","journal-title":"Amino Acids"},{"key":"B124","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/j.1476-5381.2009.00303.x","article-title":"A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena","volume":"158","author":"Schuhmacher","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"493 e491","DOI":"10.1016\/j.ahj.2006.06.005","article-title":"Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study","volume":"152","author":"Schulze","year":"2006","journal-title":"Am. Heart J."},{"key":"B126","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1527-5299.2002.00715.x","article-title":"The nitric oxide pathway and oxidative stress in heart failure","volume":"8","author":"Searles","year":"2002","journal-title":"Congest. Heart Fail"},{"key":"B127","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1161\/CIRCULATIONAHA.108.822205","article-title":"Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo","volume":"119","author":"Seddon","year":"2009","journal-title":"Circulation"},{"key":"B128","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.cardfail.2010.09.003","article-title":"\u201cThe L-arginine-asymmetric dimethylarginine ratio is strongly related to the severity of chronic heart failure. No effects of exercise training","volume":"17","author":"Seljeflot","year":"2011","journal-title":"J. Card. Fail"},{"key":"B129","doi-asserted-by":"publisher","first-page":"H1277","DOI":"10.1152\/ajpheart.00927.2012","article-title":"Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload","volume":"304","author":"Shabeeh","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1161\/CIRCULATIONAHA.112.140335","article-title":"Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus","volume":"126","author":"Shemyakin","year":"2012","journal-title":"Circulation"},{"key":"B131","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s0735-1097(97)00439-7","article-title":"Prospective, multicenter study of the safety and feasibility of primary stenting in acute myocardial infarction: in-hospital and 30-day results of the PAMI stent pilot trial. Primary Angioplasty in Myocardial Infarction Stent Pilot Trial Investigators","volume":"31","author":"Stone","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1161\/01.ATV.0000136656.26019.6e","article-title":"Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress","volume":"24","author":"Suda","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"H1211","DOI":"10.1152\/ajpheart.1992.262.4.H1211","article-title":"Endothelium-dependent dilation to L-arginine in isolated rat skeletal muscle arterioles","volume":"262","author":"Sun","year":"1992","journal-title":"Am. J. Physiol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/s0002-9149(01)02252-4","article-title":"Effect of local delivery of L-arginine on in-stent restenosis in humans","volume":"89","author":"Suzuki","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1161\/01.RES.0000241051.83067.62","article-title":"Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus","volume":"99","author":"Szerafin","year":"2006","journal-title":"Circ. Res."},{"key":"B136","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/s0008-6363(98)00018-2","article-title":"Intrapericardial infusion of endothelin-1 induces ventricular arrhythmias in dogs","volume":"38","author":"Szokodi","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1177\/1358836X9900400105","article-title":"L-arginine and nitric oxide-related compounds in plasma: comparison of normal and arginine-free diets in a 24-h crossover study","volume":"4","author":"Tangphao","year":"1999","journal-title":"Vasc. Med."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.jacc.2005.04.066","article-title":"Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine","volume":"46","author":"Thum","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1124\/pr.55.2.3","article-title":"The pharmacology of nitric oxide in the peripheral nervous system of blood vessels","volume":"55","author":"Toda","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"B140","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejphar.2011.06.028","article-title":"Coronary hemodynamic regulation by nitric oxide in experimental animals: recent advances","volume":"667","author":"Toda","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1161\/01.HYP.0000256764.86208.3d","article-title":"Asymmetrical dimethylarginine inhibits shear stress-induced nitric oxide release and dilation and elicits superoxide-mediated increase in arteriolar tone","volume":"49","author":"Toth","year":"2007","journal-title":"Hypertension"},{"key":"B142","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/s0735-1097(97)00046-6","article-title":"Basal and flow-mediated nitric oxide production by atheromatous coronary arteries","volume":"29","author":"Tousoulis","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1136\/hrt.81.5.505","article-title":"Effects of L- and D-arginine on the basal tone of human diseased coronary arteries and their responses to substance P","volume":"81","author":"Tousoulis","year":"1999","journal-title":"Heart"},{"key":"B144","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1191\/1358863x02vm434ra","article-title":"L-arginine in cardiovascular disease: dream or reality","volume":"7","author":"Tousoulis","year":"2002","journal-title":"Vasc. Med."},{"key":"B145","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/ncpcardio0878","article-title":"Mechanisms of disease: L-arginine in coronary atherosclerosis\u2013a clinical perspective","volume":"4","author":"Tousoulis","year":"2007","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.2174\/0929867322666150625095046","article-title":"Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches","volume":"22","author":"Tousoulis","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"B147","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.cardiores.2003.08.003","article-title":"Preservation of NO production by statins in the treatment of heart failure","volume":"60","author":"Trochu","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"B148","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s0049-3848(97)00106-0","article-title":"Effect of L-arginine on in vitro plasmin-generation and fibrinogenolysis","volume":"87","author":"Udvardy","year":"1997","journal-title":"Thromb. Res."},{"key":"B149","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1161\/01.res.0000052990.68216.ef","article-title":"Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase","volume":"92","author":"Ueda","year":"2003","journal-title":"Circ. Res."},{"key":"B150","doi-asserted-by":"publisher","first-page":"H606","DOI":"10.1152\/ajpheart.2001.281.2.H606","article-title":"Role of endothelial [Ca2+]i in activation of eNOS in pressurized arterioles by agonists and wall shear stress","volume":"281","author":"Ungvari","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0002-9440(10)64166-1","article-title":"Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation","volume":"161","author":"Ungvari","year":"2002","journal-title":"Am. J. Pathol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.jacc.2019.11.061","article-title":"Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar","volume":"75","author":"Ungvari","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nrcardio.2013.93","article-title":"Presentation, management, and outcomes of ischaemic heart disease in women","volume":"10","author":"Vaccarino","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1161\/01.ATV.0000128897.54893.26","article-title":"Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway","volume":"24","author":"Vallance","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-z","article-title":"Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure","volume":"339","author":"Vallance","year":"1992","journal-title":"Lancet"},{"key":"B156","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1161\/01.RES.0000065917.53950.75","article-title":"The endothelial glycocalyx protects against myocardial edema","volume":"92","author":"van den Berg","year":"2003","journal-title":"Circ. Res."},{"key":"B157","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev.ph.48.030186.001515","article-title":"Modulation of vascular smooth muscle contraction by the endothelium","volume":"48","author":"Vanhoutte","year":"1986","journal-title":"Annu. Rev. Physiol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1161\/CIRCRESAHA.116.306531","article-title":"Thirty Years of Saying NO: Sources, Fate, Actions, and Misfortunes of the Endothelium-Derived Vasodilator Mediator","volume":"119","author":"Vanhoutte","year":"2016","journal-title":"Circ. Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1161\/HYPERTENSIONAHA.108.116731","article-title":"ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway","volume":"52","author":"Veresh","year":"2008","journal-title":"Hypertension"},{"key":"B160","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1159\/000337485","article-title":"Asymmetric dimethylarginine reduces nitric oxide donor-mediated dilation of arterioles by activating the vascular renin-angiotensin system and reactive oxygen species","volume":"49","author":"Veresh","year":"2012","journal-title":"J. Vasc. Res."},{"key":"B161","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1651-2227.2008.01115.x","article-title":"Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases","volume":"98","author":"Vida","year":"2009","journal-title":"Acta Paediatr."},{"key":"B162","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/s0735-1097(01)01380-8","article-title":"Endothelium-dependent vasodilation is independent of the plasma L-arginine\/ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance","volume":"38","author":"Walker","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1006\/bbrc.2000.2344","article-title":"Pharmacological concentrations of arginine influence human whole blood viscosity independent of nitric oxide synthase activity in vitro","volume":"269","author":"Walter","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.jtcvs.2006.08.001","article-title":"Expression of neuronal nitric oxide synthase in the internal thoracic artery and saphenous vein","volume":"132","author":"Webb","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B165","doi-asserted-by":"publisher","first-page":"e001833","DOI":"10.1161\/JAHA.115.001833","article-title":"Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studies","volume":"4","author":"Willeit","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"B166","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1177\/2047487315586094","article-title":"Levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and risk of coronary artery disease: A meta-analysis based on 4713 participants","volume":"23","author":"Xuan","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1161\/CIRCULATIONAHA.115.018741","article-title":"Invasive Assessment of Coronary Physiology Predicts Late Mortality After Heart Transplantation","volume":"133","author":"Yang","year":"2016","journal-title":"Circulation"},{"key":"B168","doi-asserted-by":"publisher","first-page":"43944","DOI":"10.18632\/oncotarget.16543","article-title":"Circulating asymmetric dimethylarginine and the risk of preeclampsia: a meta-analysis based on 1338 participants","volume":"8","author":"Yuan","year":"2017","journal-title":"Oncotarget"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.569914\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T18:42:17Z","timestamp":1617561737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.569914\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":168,"alternative-id":["10.3389\/fphar.2020.569914"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.569914","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"article-number":"569914"}}