{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:07:22Z","timestamp":1793725642644,"version":"4.6.1"},"reference-count":267,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Sirtuins are NAD\n                    <jats:sup>+<\/jats:sup>\n                    dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins. Modulation of sirtuins can thus be utilized as a therapeutic target for metabolic disorders. Neurological diseases have distinct clinical manifestations but are mainly age-associated and due to loss of protein homeostasis. Sirtuins mediate several life extension pathways and brain functions that may allow therapeutic intervention for age-related diseases. There is compelling evidence to support the fact that SIRT1 and SIRT2 are shuttled between the nucleus and cytoplasm and perform context-dependent functions in neurodegenerative diseases including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and Huntington\u2019s disease (HD). In this review, we highlight the regulation of SIRT1 and SIRT2 in various neurological diseases. This study explores the various modulators that regulate the activity of SIRT1 and SIRT2, which may further assist in the treatment of neurodegenerative disease. Moreover, we analyze the structure and function of various small molecules that have potential significance in modulating sirtuins, as well as the technologies that advance the targeted therapy of neurodegenerative disease.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2020.585821","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T23:01:39Z","timestamp":1610492499000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":167,"title":["SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases"],"prefix":"10.3389","volume":"11","author":[{"given":"Ramu","family":"Manjula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumari","family":"Anuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Alcain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1111\/j.1471-4159.2009.06228.x","article-title":"The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide","volume":"110","author":"Albani","year":"2009","journal-title":"J. Neurochem."},{"key":"B2","first-page":"241","volume-title":"\u201cCoenzyme Q and age\u2010related neurodegenerative disorders: Parkinson and Alzheimer diseases BT,\u201d in Coenzyme Q in aging.","author":"Alca\u00edn","year":"2020"},{"key":"B3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1471-4159.2005.03492.x","article-title":"Neuronal protection by sirtuins in alzheimer\u2019s disease","volume":"96","author":"Anekonda","year":"2006","journal-title":"J. Neurochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/JGP.0b013e31819431ea","article-title":"A combination therapy of donepezil and cilostazol for patients with moderate alzheimer disease: pilot follow-up study","volume":"17","author":"Arai","year":"2009","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s12640-014-9492-x","article-title":"3,4-dihydroxyphenylethanol attenuates spatio-cognitive deficits in an alzheimer\u2019s disease mouse model: modulation of the molecular signals in neuronal survival-apoptotic programs","volume":"27","author":"Arunsundar","year":"2014","journal-title":"Neurotox. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.molcel.2005.02.022","article-title":"Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme","volume":"17","author":"Avalos","year":"2005","journal-title":"Mol. Cell."},{"key":"B7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.abb.2018.05.012","article-title":"Mounting evidence validates ursolic acid directly activates SIRT1: a powerful STAC which mimic endogenous activator of SIRT1","volume":"650","author":"Bakhtiari","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"B8","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05354","article-title":"Resveratrol improves health and survival of mice on a high-calorie diet","volume":"444","author":"Baur","year":"2006","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/j.1747-0285.2009.00901.x","article-title":"Resveratrol is not a direct activator of sirt1 enzyme activity","volume":"74","author":"Beher","year":"2009","journal-title":"Chem. Biol. Drug Des."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3233\/JAD-151135","article-title":"Sirtuin 2 inhibition improves cognitive performance and acts on amyloid-\u03b2 protein precursor processing in two Alzheimer's disease mouse models","volume":"53","author":"Biella","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.bbrc.2018.03.209","article-title":"Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2","volume":"499","author":"Bilousova","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nrg2188","article-title":"Genetic links between diet and lifespan: shared mechanisms from yeast to humans","volume":"8","author":"Bishop","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.molcel.2008.09.018","article-title":"The SIRT2 deacetylase regulates autoacetylation of p300","volume":"32","author":"Black","year":"2008","journal-title":"Mol. Cell."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e34805","DOI":"10.1371\/journal.pone.0034805","article-title":"SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo","volume":"7","author":"Bobrowska","year":"2012","journal-title":"PLoS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S1474-4422(11)70013-8","article-title":"The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations","volume":"10","author":"Bonda","year":"2011","journal-title":"Lancet Neurol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"17187","DOI":"10.1074\/jbc.M501250200","article-title":"Mechanism of human SIRT1 activation by resveratrol","volume":"280","author":"Borra","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1038\/nm1067","article-title":"Molecular pathways to neurodegeneration","volume":"10","author":"Bossy-Wetze","year":"2004","journal-title":"Nat. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.3390\/ijms20051249","article-title":"Sirtuins in alzheimer\u2019s disease: SIRT2-related genophenotypes and implications for pharmacoepigenetics","volume":"20","author":"Cacabelos","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.expneurol.2013.11.013","article-title":"Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner","volume":"251","author":"Calliari","year":"2014","journal-title":"Exp. Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"17574","DOI":"10.1038\/s41598-018-35687-8","article-title":"A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer\u2019s disease mouse model","volume":"8","author":"Campagna","year":"2018","journal-title":"Sci. Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.mam.2013.01.004","article-title":"Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes","volume":"34","author":"Cant\u00f3","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1101\/gad.265462.115","article-title":"Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol","volume":"29","author":"Cao","year":"2015","journal-title":"Genes Dev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1136\/jclinpath-2018-205320","article-title":"Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with alzheimer\u2019s disease","volume":"71","author":"Cao","year":"2018","journal-title":"J. Clin. Pathol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13148-016-0224-3","article-title":"Sirtuin functions and modulation: from chemistry to the clinic","volume":"8","author":"Carafa","year":"2016","journal-title":"Clin. Epigenet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1093\/hmg\/ddp243","article-title":"Impaired PGC-1alpha function in muscle in huntington\u2019s disease","volume":"18","author":"Chaturvedi","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"B26","doi-asserted-by":"publisher","first-page":"40364","DOI":"10.1074\/jbc.M509329200","article-title":"SIRT1 protects against microglia-dependent amyloid-\u03b2 toxicity through inhibiting NF-\u03baB signaling","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0116919","DOI":"10.1371\/journal.pone.0116919","article-title":"The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.celrep.2012.11.001","article-title":"The sirtuin 2 inhibitor AK-7 is neuroprotective in huntington\u2019s disease mouse models","volume":"2","author":"Chopra","year":"2012","journal-title":"Cell Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12017-009-8104-z","article-title":"An overview of APP processing enzymes and products","volume":"12","author":"Chow","year":"2010","journal-title":"Neuromolecular Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/molecules25030455","article-title":"Discovery of selective SIRT2 inhibitors as therapeutic agents in B-cell lymphoma and other malignancies","volume":"25","author":"Chowdhury","year":"2020","journal-title":"Molecules"},{"key":"B31","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"key":"B32","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.tins.2005.05.003","article-title":"Notch to remember","volume":"28","author":"Costa","year":"2005","journal-title":"Trends Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"8340","DOI":"10.1021\/jm500777s","article-title":"Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach","volume":"57","author":"Cui","year":"2014","journal-title":"J. Med. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3389\/fendo.2018.00657","article-title":"Metformin is a direct SIRT1-activating compound: computational modeling and experimental validation","volume":"9","author":"Cuy\u00e0s","year":"2018","journal-title":"Front. Endocrinol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"7645","DOI":"10.1038\/ncomms8645","article-title":"Crystallographic structure of a small molecule SIRT1 activator-enzyme complex","volume":"6","author":"Dai","year":"2015","journal-title":"Nat. Commun."},{"key":"B36","doi-asserted-by":"publisher","first-page":"32695","DOI":"10.1074\/jbc.M110.133892","article-title":"SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator","volume":"285","author":"Dai","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.nbd.2011.09.002","article-title":"Activation of glycogen synthase kinase-3 beta mediates \u03b2-amyloid induced neuritic damage in alzheimer\u2019s disease","volume":"45","author":"DaRocha-Souto","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature07861","article-title":"CBP\/p300-mediated acetylation of histone H3 on lysine 56","volume":"459","author":"Das","year":"2009","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7217","DOI":"10.1073\/pnas.0610068104","article-title":"Resveratrol stimulates AMP kinase activity in neurons","volume":"104","author":"Dasgupta","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B40","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jmb.2013.10.009","article-title":"Structural and functional analysis of human SIRT1","volume":"426","author":"Davenport","year":"2014","journal-title":"J. Mol. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3233\/jad-2004-6304","article-title":"Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling","volume":"6","author":"De La Monte","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e2000374","DOI":"10.1371\/journal.pbio.2000374","article-title":"The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease","volume":"15","author":"de Oliveira","year":"2017","journal-title":"PLoS Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/cmdc.201402431","article-title":"The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro parkinson\u2019s disease model","volume":"10","author":"Di Fruscia","year":"2015","journal-title":"ChemMedChem"},{"key":"B44","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41386-019-0503-8","article-title":"Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model","volume":"45","author":"Diaz-Perdigon","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"26675","DOI":"10.18632\/oncotarget.5596","article-title":"Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration","volume":"6","author":"Diaz-Ruiz","year":"2015","journal-title":"Oncotarget"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1021\/jm400204k","article-title":"Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3","volume":"56","author":"Disch","year":"2013","journal-title":"J. Med. Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.bbrc.2016.01.013","article-title":"The epigenetic regulation of HIF-1\u03b1 by SIRT1 in MPP(+) treated SH-SY5Y cells","volume":"470","author":"Dong","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10571-015-0222-6","article-title":"A\u03b225-35 suppresses mitochondrial biogenesis in primary hippocampal neurons","volume":"36","author":"Dong","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1128\/mcb.23.9.3173-3185.2003","article-title":"Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle","volume":"23","author":"Dryden","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.exger.2018.09.019","article-title":"Resveratrol and alzheimer\u2019s disease. From molecular pathophysiology to clinical trials","volume":"113","author":"Drygalski","year":"2018","journal-title":"Exp. Gerontol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e16172","DOI":"10.1371\/journal.pone.0016172","article-title":"Efficacy of fumaric acid esters in the R6\/2 and YAC128 models of huntington\u2019s disease","volume":"6","author":"Ellrichmann","year":"2011","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jmgm.2019.02.014","article-title":"Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors","volume":"89","author":"Eren","year":"2019","journal-title":"J. Mol. Graph. Model."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1021\/acs.biochem.5b00150","article-title":"Kinetic and structural basis for acyl-group selectivity and NAD(+) dependence in sirtuin-catalyzed deacylation","volume":"54","author":"Feldman","year":"2015","journal-title":"Biochemistry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.bbadis.2014.02.010","article-title":"Effect of resveratrol on mitochondrial function: implications in parkin-associated familiar parkinson\u2019s disease","volume":"1842","author":"Ferretta","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B55","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/89668","article-title":"Structure of the histone deacetylase SIRT2","volume":"8","author":"Finnin","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"7104","DOI":"10.1021\/jm3005288","article-title":"Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors","volume":"55","author":"Frid\u00e9n-Saxin","year":"2012","journal-title":"J. Med. Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"14138","DOI":"10.1073\/pnas.94.25.14138","article-title":"Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor","volume":"94","author":"Gehm","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B58","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/s41416-018-0278-4","article-title":"Phase 1 study of ARQ 761, a \u03b2-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis","volume":"119","author":"Gerber","year":"2018","journal-title":"Br. J. Cancer"},{"key":"B59","doi-asserted-by":"publisher","first-page":"E2772","DOI":"10.1073\/pnas.1303628110","article-title":"Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism","volume":"110","author":"Gertz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1093\/hmg\/ddh214","article-title":"Comparison of pathways controlling toxicity in the eye and brain in drosophila models of human neurodegenerative diseases","volume":"13","author":"Ghosh","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"B61","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3233\/jad-2006-9s338","article-title":"Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial alzheimer\u2019s disease","volume":"9","author":"Goate","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2005.10.022","article-title":"One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development","volume":"188","author":"Gonz\u00e1lez-Santiago","year":"2006","journal-title":"Atherosclerosis"},{"key":"B63","doi-asserted-by":"publisher","first-page":"11500","DOI":"10.1523\/JNEUROSCI.3203-08.2008","article-title":"Nicotinamide restores cognition in alzheimer\u2019s disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau","volume":"28","author":"Green","year":"2008","journal-title":"J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"38837","DOI":"10.1074\/jbc.M106779200","article-title":"Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening","volume":"276","author":"Grozinger","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.exger.2016.05.011","article-title":"Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7","volume":"82","author":"Guan","year":"2016","journal-title":"Exp. Gerontol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1056\/nejmra1100831","article-title":"Sirtuins, aging, and medicine","volume":"364","author":"Guarente","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.3892\/mmr.2016.4957","article-title":"Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells","volume":"13","author":"Guo","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B68","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1139\/h11-070","article-title":"Deacetylation of PGC-1\u03b1 by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis","volume":"36","author":"Gurd","year":"2011","journal-title":"Appl. Physiol. Nutr. Metabol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"319","DOI":"10.18632\/aging.100299","article-title":"The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae","volume":"3","author":"Ha","year":"2011","journal-title":"Aging (Albany NY)"},{"key":"B70","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"B72","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neulet.2017.12.037","article-title":"Pathological histone acetylation in Parkinson's disease: neuroprotection and inhibition of microglial activation through SIRT 2 inhibition","volume":"666","author":"Harrison","year":"2018","journal-title":"Neurosci. Lett."},{"key":"B73","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ejcb.2009.11.006","article-title":"SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology","volume":"89","author":"Harting","year":"2010","journal-title":"Eur. J. Cell Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.nbd.2010.08.017","article-title":"Nicotinamide improves motor deficits and upregulates PGC-1\u03b1 and BDNF gene expression in a mouse model of huntington\u2019s disease","volume":"41","author":"Hathorn","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.bbrc.2003.08.029","article-title":"Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene","volume":"309","author":"Hiratsuka","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B76","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.expneurol.2010.05.006","article-title":"Resveratrol protects against peripheral deficits in a mouse model of huntington\u2019s disease","volume":"225","author":"Ho","year":"2010","journal-title":"Exp. Neurol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/j.1365-2125.2012.04340.x","article-title":"Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man","volume":"75","author":"Hoffmann","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1021\/acschembio.9b00384","article-title":"A glycoconjugated SIRT2 inhibitor with aqueous solubility allows structure-based design of SIRT2 inhibitors","volume":"14","author":"Hong","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"38186","DOI":"10.1038\/srep38186","article-title":"Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation","volume":"6","author":"Hou","year":"2016","journal-title":"Sci. Rep."},{"key":"B80","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"4572893","DOI":"10.1155\/2018\/4572893","article-title":"Procyanidins extracted from Lotus seedpod ameliorate amyloid-","volume":"2018","author":"Huang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B82","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.4161\/cc.25268","article-title":"Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation- independent mechanism","volume":"12","author":"Hubbard","year":"","journal-title":"Cell Cycle"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1126\/science.1231097","article-title":"Evidence for a common mechanism of SIRT1 regulation by allosteric activators","volume":"339","author":"Hubbard","year":"","journal-title":"Science"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1021\/jm901055u","article-title":"Novel 3-arylideneindolin-2-ones as inhibitors of NAD+-dependent histone deacetylases (sirtuins)","volume":"53","author":"Huber","year":"2010","journal-title":"J. Med. Chem."},{"key":"B85","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature"},{"key":"B86","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/sj.onc.1209857","article-title":"SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress","volume":"26","author":"Inoue","year":"2007","journal-title":"Oncogene"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.4161\/cc.8.8.8245","article-title":"SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest","volume":"8","author":"Inoue","year":"2009","journal-title":"Cell Cycle"},{"key":"B88","doi-asserted-by":"publisher","first-page":"50985","DOI":"10.1074\/jbc.M306552200","article-title":"Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone\/protein deacetylases","volume":"278","author":"Jackson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nm.2559","article-title":"Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway","volume":"18","author":"Jeong","year":"2012","journal-title":"Nat. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1007\/s11064-016-2110-y","article-title":"Sirtuins and their roles in brain aging and neurodegenerative disorders","volume":"42","author":"J\u0119\u015bko","year":"2017","journal-title":"Neurochem. Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective role of Sirt1 in mammalian models of huntington\u2019s disease through activation of multiple Sirt1 targets","volume":"18","author":"Jiang","year":"2012","journal-title":"Nat. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/acn3.135","article-title":"Sirtuin 1 activator SRT2104 protects huntington\u2019s disease mice","volume":"1","author":"Jiang","year":"2014","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.bbrc.2008.01.114","article-title":"Sirt2 interacts with 14-3-3 \u03b2\/\u03b3 and down-regulates the activity of p53","volume":"368","author":"Jin","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B94","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s12640-017-9766-1","article-title":"Huntington\u2019s disease and mitochondria","volume":"32","author":"Jodeiri Farshbaf","year":"2017","journal-title":"Neurotox. Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2013.04.016","article-title":"PGC-1\u03b1, mitochondrial dysfunction, and Huntington\u2019s disease","volume":"62","author":"Johri","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/NEN.0b013e3181922348","article-title":"Sirtuin 1 reduction parallels the accumulation of tau in alzheimer disease","volume":"68","author":"Julien","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"17038","DOI":"10.1074\/jbc.M500655200","article-title":"Substrate-specific activation of sirtuins by resveratrol","volume":"280","author":"Kaeberlein","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"B99","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.molcel.2011.07.038","article-title":"Peptide switch is essential for sirt1 deacetylase activity","volume":"44","author":"Kang","year":"2011","journal-title":"Mol. Cell."},{"key":"B100","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.3390\/molecules25143287","article-title":"Natural products as modulators of sirtuins","volume":"25","author":"Karaman Mayack","year":"2020","journal-title":"Molecules"},{"key":"B101","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/ni0302-221","article-title":"NF-\u03baB at the crossroads of life and death","volume":"3","author":"Karin","year":"2002","journal-title":"Nat. Immunol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.ejmech.2014.02.003","article-title":"Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors","volume":"76","author":"Khanfar","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"B103","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","article-title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer\u2019s disease and amyotrophic lateral sclerosis","volume":"26","author":"Kim","year":"","journal-title":"EMBO J."},{"key":"B104","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1196\/annals.1397.051","article-title":"Protective effects of piceatannol against beta-amyloid-induced neuronal cell death","volume":"1095","author":"Kim","year":"","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.jnutbio.2007.06.001","article-title":"Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK","volume":"19","author":"Kim","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/cns.12404","article-title":"DPP-4 inhibitor linagliptin attenuates a\u03b2-induced cytotoxicity through activation of AMPK in neuronal cells","volume":"21","author":"Kornelius","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"B107","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3934\/NEUROSCIENCE.2019.4.333","article-title":"Identification of biomarkers associated with parkinson\u2019s disease by gene expression profiling studies and bioinformatics analysis","volume":"6","author":"Krokidis","year":"2019","journal-title":"AIMS Neurosci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/j.1742-7843.2010.00537.x","article-title":"Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats","volume":"107","author":"Kumar","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/00008877-200609000-00014","article-title":"Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms","volume":"17","author":"Kumar","year":"2006","journal-title":"Behav. Pharmacol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"e61560","DOI":"10.1371\/journal.pone.0061560","article-title":"Sirtuin1: a promising serum protein marker for early detection of alzheimer\u2019s disease","volume":"8","author":"Kumar","year":"2013","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nm.2624","article-title":"Finding a sirtuin truth in huntington\u2019s disease","volume":"18","author":"La Spada","year":"2012","journal-title":"Nat. Med."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1\u03b1","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"B113","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.ccr.2008.03.004","article-title":"Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator","volume":"13","author":"Lain","year":"2008","journal-title":"Cancer Cell"},{"key":"B114","doi-asserted-by":"publisher","first-page":"e2428","DOI":"10.1371\/journal.pntd.0002428","article-title":"Schistosoma mansoni sirtuins: characterization and potential as chemotherapeutic targets","volume":"7","author":"Lancelot","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"B115","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12974-015-0355-z","article-title":"\u03b2-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia","volume":"12","author":"Lee","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1002\/jnr.23421","article-title":"Cilostazol suppresses \u03b2-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-\u03b2","volume":"92","author":"Lee","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"B117","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.exger.2016.10.004","article-title":"Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: a double-blinded placebo controlled pilot study","volume":"87","author":"Lee","year":"2017","journal-title":"Exp. Gerontol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s13311-018-00708-x","article-title":"Efficacy of cilostazol administration in alzheimer\u2019s disease patients with white matter lesions: a positron-emission tomography study","volume":"16","author":"Lee","year":"2019","journal-title":"Neurotherapeutics"},{"key":"B119","doi-asserted-by":"publisher","first-page":"e0195968","DOI":"10.1371\/journal.pone.0195968","article-title":"Amelioration of huntington\u2019s disease phenotypes by beta-lapachone is associated with increases in sirt1 expression, creb phosphorylation and pgc-1\u03b1 deacetylation","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS One"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e0139095","DOI":"10.1371\/journal.pone.0139095","article-title":"Insight into the mechanism of intramolecular inhibition of the catalytic activity of sirtuin 2 (SIRT2)","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"B121","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ejmech.2013.10.068","article-title":"Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer\u2019s disease","volume":"71","author":"Li","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"B122","doi-asserted-by":"publisher","first-page":"e51395","DOI":"10.1371\/journal.pone.0051395","article-title":"A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers","volume":"7","author":"Libri","year":"2012","journal-title":"PLoS One"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.neurobiolaging.2012.11.020","article-title":"Nicotinamide forestalls pathology and cognitive decline in alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession","volume":"34","author":"Liu","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B124","doi-asserted-by":"publisher","first-page":"10804","DOI":"10.1073\/pnas.0400348101","article-title":"O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in alzheimer\u2019s disease","volume":"101","author":"Liu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B125","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1039\/c9cp04931b","article-title":"Multiscale landscape of molecular mechanism of SIRT1 activation by STACs","volume":"22","author":"Liu","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"B126","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3389\/fnagi.2019.00372","article-title":"Emerging role of sirtuin 2 in parkinson\u2019s disease","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3389\/fnins.2019.01444","article-title":"Interplay between mitochondrial oxidative disorders and proteostasis in alzheimer\u2019s disease","volume":"13","author":"Llanos-Gonz\u00e1lez","year":"2020","journal-title":"Front. Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"107755","DOI":"10.1016\/j.neuropharm.2019.107755","article-title":"Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1\u03b1 activity in neurons","volume":"160","author":"Lu","year":"2019","journal-title":"Neuropharmacology"},{"key":"B129","doi-asserted-by":"publisher","first-page":"7042","DOI":"10.18632\/aging.103062","article-title":"SIRT1 regulates O-GlcNAcylation of tau through OGT","volume":"12","author":"Lu","year":"2020","journal-title":"Aging (Albany. NY)"},{"key":"B130","doi-asserted-by":"publisher","first-page":"7927","DOI":"10.1073\/pnas.1002924107","article-title":"SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis","volume":"107","author":"Luthi-Carter","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B131","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s12017-014-8288-8","article-title":"Distinct patterns of sirtuin expression during progression of alzheimer\u2019s disease","volume":"16","author":"Lutz","year":"2014","journal-title":"NeuroMolecular Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3389\/fnins.2019.01400","article-title":"Neuroprotective effect of resveratrol via activation of Sirt1 signaling in a rat model of combined diabetes and alzheimer\u2019s disease","volume":"13","author":"Ma","year":"2019","journal-title":"Front. Neurosci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2174\/138945012799201711","article-title":"NAD+ metabolism and NAD(+)-dependent enzymes: promising therapeutic targets for neurological diseases","volume":"13","author":"Ma","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"B134","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1021\/jm4018064","article-title":"Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors","volume":"57","author":"Mahajan","year":"2014","journal-title":"J. Med. Chem."},{"key":"B135","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s11033-018-4172-1","article-title":"Expressions of some antioxidant genes in SH-SY5Y cells treated with \u03b2-lapachone, morphine and electromagnetic field","volume":"45","author":"Mahmoudinasab","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"B136","doi-asserted-by":"publisher","first-page":"103281","DOI":"10.1016\/j.bioorg.2019.103281","article-title":"Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2","volume":"92","author":"Manjula","year":"2019","journal-title":"Bioorg. Chem."},{"key":"B137","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/s00894-018-3877-3","article-title":"Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine","volume":"24","author":"Manna","year":"2018","journal-title":"J. Mol. Model."},{"key":"B276","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/s1568-1637(03)00013-8","article-title":"Methylation and acetylation in nervous system development and neurodegenerative disorders","volume":"2","author":"Mattson","year":"2003","journal-title":"Ageing Res. Rev."},{"key":"B138","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1021\/jm8014298","article-title":"Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity","volume":"52","author":"Medda","year":"2009","journal-title":"J. Med. Chem."},{"key":"B139","doi-asserted-by":"publisher","first-page":"5844","DOI":"10.1021\/acs.jmedchem.9b00255","article-title":"Identification of diketopiperazine-containing 2-anilinobenzamides as potent sirtuin 2 (SIRT2)-Selective inhibitors targeting the \u201cselectivity pocket\u201d, substrate-binding site, and NAD+-Binding site","volume":"62","author":"Mellini","year":"2019","journal-title":"J. Med. Chem."},{"key":"B140","doi-asserted-by":"publisher","first-page":"6400","DOI":"10.1039\/c7sc02738a","article-title":"Potent mechanism-based sirtuin-2-selective inhibition by an: in situ -generated occupant of the substrate-binding site, \u201cselectivity pocket\u201d and NAD+-binding site","volume":"8","author":"Mellini","year":"2017","journal-title":"Chem. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"E187","DOI":"10.1073\/pnas.1105304109","article-title":"The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop","volume":"109","author":"Menssen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20070140","article-title":"Sirtuins in mammals: insights into their biological function","volume":"404","author":"Michan","year":"2007","journal-title":"Biochem. J."},{"key":"B143","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1091\/mbc.E05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"Michishita","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"B144","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"B145","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1523\/JNEUROSCI.2369-17.2018","article-title":"SIRT1 deacetylates tau and reduces pathogenic tau spread in a mouse model of tauopathy","volume":"38","author":"Min","year":"2018","journal-title":"J. Neurosci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fphar.2012.00016","article-title":"Structures, substrates, and regulators of mammalian Sirtuins - opportunities and challenges for drug development","volume":"3","author":"Moniot","year":"2012","journal-title":"Front. Pharmacol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jsb.2013.02.012","article-title":"Crystal structure analysis of human Sirt2 and its ADP-ribose complex","volume":"182","author":"Moniot","year":"2013","journal-title":"J. Struct. Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/s0092-8674(04)00126-6","article-title":"Mammalian SIRT1 represses forkhead transcription factors","volume":"116","author":"Motta","year":"2004","journal-title":"Cell"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-016-0317-1","article-title":"Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders","volume":"55","author":"Motyl","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro-inflammation and induces adaptive immunity in alzheimer\u2019s disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"B151","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/j.bbadis.2015.07.003","article-title":"Sirtuins: double players in huntington\u2019s disease","volume":"852","author":"Naia","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B152","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1007\/s12035-016-0048-3","article-title":"Comparative mitochondrial-based protective effects of resveratrol and nicotinamide in huntington\u2019s disease models","volume":"54","author":"Naia","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/ja.2017.145","article-title":"Correction to: halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus halichondria","volume":"71","author":"Nakamura","year":"2018","journal-title":"J. Antibiot."},{"key":"B154","doi-asserted-by":"publisher","first-page":"8045","DOI":"10.1021\/jm050522v","article-title":"Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1","volume":"48","author":"Napper","year":"2005","journal-title":"J. Med. Chem."},{"key":"B155","doi-asserted-by":"publisher","first-page":"16456","DOI":"10.1074\/jbc.M501485200","article-title":"SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}","volume":"280","author":"Nemoto","year":"","journal-title":"J. Biol. Chem."},{"key":"B156","doi-asserted-by":"publisher","first-page":"16456","DOI":"10.1074\/jbc.M501485200","article-title":"SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1\u03b1","volume":"280","author":"Nemoto","year":"","journal-title":"J. Biol. Chem."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.chembiol.2013.09.019","article-title":"Crystal structures of Sirt3 complexes with 4\u2032-bromo-resveratrol reveal binding sites and inhibition mechanism","volume":"20","author":"Nguyen","year":"","journal-title":"Chem. Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1107\/S0907444913015448","article-title":"Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism","volume":"69","author":"Nguyen","year":"","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"B159","first-page":"65","article-title":"Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells","volume":"3","author":"Nie","year":"2011","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1097\/WNR.0000000000000192","article-title":"SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells","volume":"25","author":"Nie","year":"2014","journal-title":"Neuroreport"},{"key":"B161","article-title":"Selective inhibitors of SIRT2 regulate perinuclear \u03b1-tubulin acetylation, migration, and invasion of breast cancer cells","author":"Nielsen","year":"2020","journal-title":"bioRxiv 2020.03.20.000380"},{"key":"B162","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/s1097-2765(03)00038-8","article-title":"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase","volume":"11","author":"North","year":"2003","journal-title":"Mol. Cell."},{"key":"B163","doi-asserted-by":"publisher","first-page":"e784","DOI":"10.1371\/journal.pone.0000784","article-title":"Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis","volume":"2","author":"North","year":"2007","journal-title":"PLoS One"},{"key":"B164","doi-asserted-by":"publisher","first-page":"11174","DOI":"10.1523\/JNEUROSCI.3004-06.2006","article-title":"Mitochondrial-dependent Ca2+ handling in Huntington\u2019s disease striatal cells: effect of histone deacetylase inhibitors","volume":"26","author":"Oliveira","year":"2006","journal-title":"J. Neurosci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mcn.2019.03.001","article-title":"Small molecules as therapeutic drugs for alzheimer\u2019s disease","volume":"96","author":"Oliver","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1126\/science.1143780","article-title":"Sirtuin 2 inhibitors rescue \u03b1-synuclein-mediated toxicity in models of parkinson\u2019s disease","volume":"317","author":"Outeiro","year":"2007","journal-title":"Science"},{"key":"B167","doi-asserted-by":"publisher","first-page":"8340","DOI":"10.1074\/jbc.M109.088682","article-title":"SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1","volume":"285","author":"Pacholec","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B168","doi-asserted-by":"publisher","first-page":"347","DOI":"10.2174\/1573406412666160107111612","article-title":"Identification of new inhibitors for human SIRT1: an in-silico approach","volume":"12","author":"Padmanabhan","year":"2016","journal-title":"Med. Chem."},{"key":"B169","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1038\/emboj.2013.200","article-title":"The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation","volume":"32","author":"Pais","year":"2013","journal-title":"EMBO J."},{"key":"B170","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1093\/hmg\/ddn273","article-title":"Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington\u2019s disease","volume":"17","author":"Pallos","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B171","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.bmcl.2015.05.015","article-title":"New indole-isoxazolone derivatives: synthesis, characterisation and in vitro SIRT1 inhibition studies","volume":"25","author":"Panathur","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B172","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1083\/jcb.200707126","article-title":"The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility","volume":"180","author":"Pandithage","year":"2008","journal-title":"J. Cell Biol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2011.04.068","article-title":"Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid \u03b2-induced cognitive deficits associated with decreased amyloid \u03b2 accumulation","volume":"408","author":"Park","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B174","doi-asserted-by":"publisher","first-page":"e0160620","DOI":"10.1371\/journal.pone.0160620","article-title":"Cilostazol modulates autophagic degradation of \u03b2-Amyloid peptide via SIRT1- Coupled LKB1\/AMPK\u03b1 signaling in neuronal cells","volume":"11","author":"Park","year":"2016","journal-title":"PLoS One"},{"key":"B175","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1097\/00019052-200210000-00015","article-title":"Recent advances in drug-induced neuropathies","volume":"15","author":"Peltier","year":"2002","journal-title":"Curr. Opin. Neurol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3233\/JAD-140444","article-title":"Neuroprotective role of trans-resveratrol in a murine model of familial alzheimer\u2019s disease","volume":"42","author":"Porquet","year":"2014","journal-title":"J. Alzheim. Dis."},{"key":"B177","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jmgm.2014.06.005","article-title":"Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders","volume":"52","author":"Pulla","year":"2014","journal-title":"J. Mol. Graph. Model."},{"key":"B178","doi-asserted-by":"publisher","first-page":"21745","DOI":"10.1074\/jbc.M602909200","article-title":"Neuronal SIRT1 activation as a novel mechanism underlying the prevention of alzheimer disease amyloid neuropathology by calorie restriction","volume":"281","author":"Qin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B179","doi-asserted-by":"publisher","first-page":"8152373","DOI":"10.1155\/2018\/8152373","article-title":"Neuroprotective mechanisms of resveratrol in Alzheimer\u2019s disease: role of SIRT1","volume":"2018","author":"Quadros Gomes","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B180","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.chembiol.2016.05.015","article-title":"SIRT2- and NRF2-targeting thiazole-containing compound with therapeutic activity in huntington\u2019s disease models","volume":"23","author":"Quinti","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.bbadis.2011.10.016","article-title":"Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington\u2019s disease","volume":"1822","author":"Reddy","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B182","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.npep.2018.07.001","article-title":"Sirtuin 1 and alzheimer\u2019s disease: an up-to-date review","volume":"71","author":"Rizzi","year":"2018","journal-title":"Neuropeptides"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/tcr.201800044","article-title":"Opening the selectivity pocket in the human lysine deacetylase Sirtuin2\u2013new opportunities, new questions","volume":"18","author":"Robaa","year":"2018","journal-title":"Chem. Rec."},{"key":"B184","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1755-5949.2008.00045.x","article-title":"Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases","volume":"14","author":"Rocha-Gonz\u00e1lez","year":"2008","journal-title":"CNS Neurosci. Ther."},{"key":"B185","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.febslet.2007.11.034","article-title":"Metabolic adaptations through the PGC-1\u03b1 and SIRT1 pathways","volume":"582","author":"Rodgers","year":"2008","journal-title":"FEBS Lett."},{"key":"B186","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41419-018-0553-6","article-title":"SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons","volume":"9","author":"Romeo-Guitart","year":"2018","journal-title":"Cell Death Dis."},{"key":"B187","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1002\/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L","article-title":"Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAF biosynthesis","volume":"32","author":"Rongvaux","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1028415x.2019.1596613","article-title":"Sesamin and sesamol attenuate H 2 O 2\u2013induced oxidative stress on human neuronal cells via the SIRT1\u2013SIRT3\u2013FOXO3a signaling pathway","author":"Ruankham","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"B189","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1107\/S2053230X15019986","article-title":"Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking","volume":"71","author":"Rumpf","year":"","journal-title":"Acta Crystallogr. Sect. Struct. Biol. Commun."},{"key":"B190","doi-asserted-by":"publisher","first-page":"6263","DOI":"10.1038\/ncomms7263","article-title":"Selective Sirt2 inhibition by ligand-induced rearrangement of the active site","volume":"6","author":"Rumpf","year":"","journal-title":"Nat. Commun."},{"key":"B191","doi-asserted-by":"publisher","first-page":"e51429","DOI":"10.1371\/journal.pone.0051429","article-title":"Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations","volume":"8","author":"Sakkiah","year":"2013","journal-title":"PLoS One"},{"key":"B192","doi-asserted-by":"publisher","first-page":"15456","DOI":"10.1021\/bi011858j","article-title":"Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions","volume":"40","author":"Sauve","year":"2001","journal-title":"Biochemistry"},{"key":"B193","doi-asserted-by":"publisher","first-page":"9249","DOI":"10.1021\/bi034959l","article-title":"Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry","volume":"42","author":"Sauve","year":"2003","journal-title":"Biochemistry"},{"key":"B194","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1021\/acs.jmedchem.6b01872","article-title":"Chemically induced degradation of sirtuin 2 (Sirt2) by a Proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)","volume":"61","author":"Schiedel","year":"2018","journal-title":"J. Med. Chem."},{"key":"B195","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1021\/acs.jmedchem.5b01517","article-title":"Aminothiazoles as potent and selective Sirt2 inhibitors: a structure-activity relationship study","volume":"59","author":"Schiedel","year":"2016","journal-title":"J. Med. Chem."},{"key":"B196","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nbt.3130","article-title":"Acetylation site specificities of lysine deacetylase inhibitors in human cells","volume":"33","author":"Sch\u00f6lz","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.str.2007.02.002","article-title":"Structural basis of inhibition of the human NAD+-Dependent deacetylase SIRT5 by suramin","volume":"15","author":"Schuetz","year":"2007","journal-title":"Structure"},{"key":"B198","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3389\/fphar.2014.00089","article-title":"Sirtuin modulators control reactive gliosis in an in vitro model of alzheimer\u2019s disease","volume":"5","author":"Scuderi","year":"2014","journal-title":"Front. Pharmacol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"a006189","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B200","doi-asserted-by":"publisher","first-page":"9188","DOI":"10.1007\/s12035-018-1058-0","article-title":"SIRT2 inhibition confers neuroprotection by downregulation of FOXO3a and MAPK signaling pathways in ischemic stroke","volume":"55","author":"She","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial alzheimer\u2019s disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"B202","doi-asserted-by":"publisher","first-page":"e64953","DOI":"10.1371\/journal.pone.0064953","article-title":"Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy","volume":"8","author":"Shin","year":"2013","journal-title":"PLoS One"},{"key":"B203","doi-asserted-by":"publisher","first-page":"e0190717","DOI":"10.1371\/journal.pone.0190717","article-title":"Redox modulation of NQO1","volume":"13","author":"Siegel","year":"2018","journal-title":"PLoS One"},{"key":"B204","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1007\/s12035-016-9951-x","article-title":"Mitochondrial metabolism power SIRT2-dependent deficient traffic causing alzheimer\u2019s-disease related pathology","volume":"54","author":"Silva","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.drudis.2010.07.001","article-title":"Role of Sirtuin 1 in metabolic regulation","volume":"15","author":"Silva","year":"2010","journal-title":"Drug Discov. Today"},{"key":"B206","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0092-8674(00)80493-6","article-title":"Extrachromosomal rDNA circles\u2013a cause of aging in yeast","volume":"91","author":"Sinclair","year":"1997","journal-title":"Cell"},{"key":"B207","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.bpj.2019.11.1239","article-title":"Molecular dynamics simulation reveals new pocket for the design of novel amino acid coupled Sirt1 selective inhibitor","volume":"118","author":"Singh","year":"2020","journal-title":"Biophys. J."},{"key":"B208","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12868-017-0364-1","article-title":"SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in parkinson\u2019s disease","volume":"18","author":"Singh","year":"","journal-title":"BMC Neurosci."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/2643587","article-title":"Sirtuin-2 protects neural cells from oxidative stress and is elevated in neurodegeneration","volume":"2017","author":"Singh","year":"","journal-title":"Parkinsons. Dis."},{"key":"B210","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1093\/hmg\/ddu010","article-title":"A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington\u2019s disease","volume":"23","author":"Smith","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B211","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s11064-006-9127-6","article-title":"Microtubule deacetylases, SirT2 and HDAC6, in the nervous system","volume":"32","author":"Southwood","year":"2007","journal-title":"Neurochem. Res."},{"key":"B212","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-synuclein in Lewy bodies [8]","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"B213","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fphar.2012.00042","article-title":"Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia","volume":"3","author":"Spires-Jones","year":"2012","journal-title":"Front. Pharmacol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bmcl.2012.10.136","article-title":"Inhibition of the human deacylase Sirtuin 5 by the indole GW5074","volume":"23","author":"Suenkel","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B215","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.bbrc.2014.04.019","article-title":"Taurine attenuates amyloid \u03b2 1-42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells","volume":"447","author":"Sun","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B216","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fnmol.2018.00381","article-title":"MicroRNA-212-5p prevents dopaminergic neuron death by inhibiting SIRT2 in MPTP-induced mouse model of Parkinson\u2019s disease","volume":"11","author":"Sun","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B217","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1021\/acs.jmedchem.6b01690","article-title":"Thienopyrimidinone based sirtuin-2 (SIRT2)-Selective inhibitors bind in the ligand induced selectivity pocket","volume":"60","author":"Sundriyal","year":"2017","journal-title":"J. Med. Chem."},{"key":"B218","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/bcp.12512","article-title":"An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington\u2019s disease","volume":"79","author":"S\u00fcssmuth","year":"2015","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1002\/cmdc.200600162","article-title":"2-Anilinobenzamides as SIRT inhibitors","volume":"1","author":"Suzuki","year":"2006","journal-title":"ChemMedChem"},{"key":"B220","doi-asserted-by":"publisher","first-page":"5900","DOI":"10.1016\/j.bmc.2009.07.001","article-title":"Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors","volume":"17","author":"Suzuki","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"B221","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.1021\/jm3002108","article-title":"Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors","volume":"55","author":"Suzuki","year":"2012","journal-title":"J. Med. Chem."},{"key":"B222","doi-asserted-by":"publisher","first-page":"87","DOI":"10.14348\/molcells.2016.2318","article-title":"Sirt1 and the mitochondria","volume":"39","author":"Tang","year":"2016","journal-title":"Mol. Cell"},{"key":"B223","doi-asserted-by":"publisher","first-page":"6823","DOI":"10.1074\/jbc.M609554200","article-title":"Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1","volume":"282","author":"Tanno","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B224","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.1007\/s00018-008-8357-y","article-title":"Biological and potential therapeutic roles of sirtuin deacetylases","volume":"65","author":"Taylor","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"B225","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1021\/cb100376q","article-title":"A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase","volume":"6","author":"Taylor","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"B226","doi-asserted-by":"publisher","first-page":"18303","DOI":"10.1073\/pnas.1314145110","article-title":"Neuroprotective sirtuin ratio reversed by ApoE4","volume":"110","author":"Theendakara","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B227","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/bdd.1862","article-title":"Pharmacokinetics and safety of the sesame lignans, sesamin and episesamin, in healthy subjects","volume":"34","author":"Tomimori","year":"2013","journal-title":"Biopharm Drug Dispos."},{"key":"B228","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbr.2014.04.055","article-title":"Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice","volume":"271","author":"Torres-Lista","year":"2014","journal-title":"Behav. Brain Res."},{"key":"B229","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/cmdc.200700003","article-title":"Structure-activity studies on suramin analogues as inhibitors of NAD +-dependent histone deacetylases (sirtuins)","volume":"2","author":"Trapp","year":"2007","journal-title":"ChemMedChem"},{"key":"B230","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/nchembio.1308","article-title":"Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration","volume":"9","author":"Tsvetkov","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"B231","doi-asserted-by":"publisher","first-page":"e0150682","DOI":"10.1371\/journal.pone.0150682","article-title":"Correction: SIRT1 Activity is linked to its brain region-specific phosphorylation and is impaired in huntington\u2019s disease mice","volume":"11","author":"Tulino","year":"2016","journal-title":"PLoS One"},{"key":"B232","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"B233","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3389\/fnins.2019.00930","article-title":"Intracellular and intercellular mitochondrial dynamics in parkinson\u2019s disease","volume":"13","author":"Valdinocci","year":"2019","journal-title":"Front. Neurosci."},{"key":"B234","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.molmed.2017.02.005","article-title":"Mitochondrial sirtuins and molecular mechanisms of aging","volume":"23","author":"van de Ven","year":"2017","journal-title":"Trends Mol. Med."},{"key":"B235","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.molcel.2004.08.031","article-title":"Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin","volume":"16","author":"Vaquero","year":"2004","journal-title":"Mol. Cell."},{"key":"B236","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1186\/1479-7364-5-5-485","article-title":"The human sirtuin family: evolutionary divergences and functions","volume":"5","author":"Vassilopoulos","year":"2011","journal-title":"Hum. Genom."},{"key":"B237","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0092-8674(01)00527-x","article-title":"hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase","volume":"107","author":"Vaziri","year":"2001","journal-title":"Cell"},{"key":"B238","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.tibs.2010.07.003","article-title":"Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling","volume":"35","author":"Verdin","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"B239","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s10495-017-1397-8","article-title":"KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in leishmania amazonensis","volume":"22","author":"Ver\u00e7oza","year":"2017","journal-title":"Apoptosis"},{"key":"B240","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"B241","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1007\/s11064-016-1981-2","article-title":"SIRT2 plays significant roles in lipopolysaccharides-induced neuroinflammation and brain injury in mice","volume":"41","author":"Wang","year":"2016","journal-title":"Neurochem. Res."},{"key":"B242","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1474-9726.2007.00304.x","article-title":"SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction","volume":"6","author":"Wang","year":"2007","journal-title":"Aging Cell"},{"key":"B243","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.cmet.2013.03.016","article-title":"Metabolic stress modulates Alzheimer\u2019s \u03b2-secretase gene transcription via SIRT1-PPAR\u03b3-PGC-1 in neurons","volume":"17","author":"Wang","year":"2013","journal-title":"Cell Metabol."},{"key":"B244","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1080\/08927022.2020.1757093","article-title":"Molecular dynamics simulations reveal the mechanism of the interactions between the inhibitors and SIRT2 at atom level","volume":"46","author":"Wang","year":"2020","journal-title":"Mol. Simulat."},{"key":"B245","doi-asserted-by":"publisher","first-page":"e13194","DOI":"10.1111\/acel.13194","article-title":"RTN4B-mediated suppression of sirtuin 2 activity ameliorates \u03b2-amyloid pathology and cognitive impairment in alzheimer\u2019s disease mouse model","volume":"19","author":"Wang","year":"2020","journal-title":"Aging Cell"},{"key":"B246","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s12017-014-8291-0","article-title":"The SIRT2 polymorphism rs10410544 and risk of alzheimer\u2019s disease: a meta-analysis","volume":"16","author":"Wei","year":"2014","journal-title":"NeuroMolecular Med."},{"key":"B247","doi-asserted-by":"publisher","first-page":"4612","DOI":"10.1007\/s12035-017-0646-8","article-title":"Inhibition of poly(ADP-ribose) polymerase-1 enhances gene expression of selected sirtuins and APP cleaving enzymes in amyloid beta cytotoxicity","volume":"55","author":"Wencel","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B248","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/bcp.12513","article-title":"Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers","volume":"79","author":"Westerberg","year":"2015","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B249","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.3390\/ijms20164052","article-title":"Neuroprotective properties of linagliptin: focus on biochemical mechanisms in cerebral ischemia, vascular dysfunction and certain neurodegenerative diseases","volume":"20","author":"Wici\u0144ski","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B250","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/1567205015666181109103742","article-title":"Alterations in the expression of amyloid precursor protein cleaving enzymes mRNA in alzheimer peripheral blood","volume":"16","author":"Wongchitrat","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"B251","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nature02789","article-title":"Sirtuin activators mimic caloric restriction and delay ageing in metazoans","volume":"430","author":"Wood","year":"2004","journal-title":"Nature"},{"key":"B252","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3389\/fonc.2020.00657","article-title":"Sirtuin 1 inhibiting thiocyanates (S1th)\u2014a new class of isotype selective inhibitors of NAD+ dependent lysine deacetylases","volume":"10","author":"W\u00f6ssner","year":"2020","journal-title":"Front. Oncol."},{"key":"B253","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11910-017-0739-9","article-title":"Huntington\u2019s disease\u2014update on treatments","volume":"17","author":"Wyant","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B254","doi-asserted-by":"publisher","first-page":"4942","DOI":"10.1002\/jcb.27769","article-title":"Administration of resveratrol improved Parkinson\u2019s disease-like phenotype by suppressing apoptosis of neurons via modulating the MALAT1\/miR-129\/SNCA signaling pathway","volume":"120","author":"Xia","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"B255","doi-asserted-by":"publisher","first-page":"7251","DOI":"10.1007\/s12035-016-0173-z","article-title":"Downregulation of NAD-dependent deacetylase SIRT2 protects mouse brain against ischemic stroke","volume":"54","author":"Xie","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B256","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ejmech.2017.05.042","article-title":"Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1\u03b1 pathway","volume":"137","author":"Xu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"B257","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.ejmech.2018.06.041","article-title":"X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells","volume":"155","author":"Yang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"B258","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ejmech.2017.04.010","article-title":"Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors","volume":"134","author":"Yang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"B259","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1021\/jm701001c","article-title":"Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells","volume":"50","author":"Yang","year":"2007","journal-title":"J. Med. Chem."},{"key":"B260","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3390\/ijms18040852","article-title":"Fisetin protects PC12 cells from tunicamycin-mediated cell death via reactive oxygen species scavenging and modulation of Nrf2-driven gene expression, SIRT1 and MAPK signaling in PC12 cells","volume":"18","author":"Yen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B261","doi-asserted-by":"publisher","first-page":"103403","DOI":"10.1016\/j.bioorg.2019.103403","article-title":"Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor","volume":"94","author":"Yeong","year":"2020","journal-title":"Bioorg. Chem."},{"key":"B262","doi-asserted-by":"publisher","first-page":"5556","DOI":"10.1007\/s12035-019-1469-6","article-title":"Procyanidins and alzheimer\u2019s disease","volume":"56","author":"Zhao","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B263","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1021\/acs.jmedchem.6b00130","article-title":"Correction: the 2.5 \u00c5 crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition","volume":"2013","author":"Zhao","year":"2016","journal-title":"J. Med. Chem."},{"key":"B264","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000438620","article-title":"1,2,3-Triazole-Dithiocarbamate hybrids, a group of novel cell active SIRT1 inhibitors","volume":"38","author":"Zheng","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"B265","doi-asserted-by":"publisher","first-page":"4058","DOI":"10.3892\/mmr.2016.5034","article-title":"NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity","volume":"13","author":"Zou","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B266","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in huntington\u2019s disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Prog. Neurobiol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2020.585821\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T08:33:53Z","timestamp":1612168433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2020.585821\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":267,"alternative-id":["10.3389\/fphar.2020.585821"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.585821","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,12]]},"article-number":"585821"}}