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In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.<\/jats:p>","DOI":"10.3389\/fphar.2020.596099","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T06:02:30Z","timestamp":1611900150000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective"],"prefix":"10.3389","volume":"11","author":[{"given":"Mengjie","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeke","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingnan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengrui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"B2","doi-asserted-by":"publisher","first-page":"e1801236","DOI":"10.1002\/adhm.201801236","article-title":"Tissue engineering for the temporomandibular joint","volume":"8","author":"Acri","year":"2019","journal-title":"Adv Healthc Mater"},{"key":"B3","doi-asserted-by":"publisher","first-page":"20130287","DOI":"10.1098\/rsif.2013.0287","article-title":"Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc","volume":"10","author":"Ahtiainen","year":"2013","journal-title":"J R Soc Interface"},{"key":"B4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1089\/ten.teb.2017.0341","article-title":"Preclinical animal models for temporomandibular joint tissue engineering","volume":"24","author":"Almarza","year":"2018","journal-title":"Tissue Eng B Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.biopha.2018.02.117","article-title":"The efficacy of a lectin from Abelmoschus Esculentus depends on central opioid receptor activation to reduce temporomandibular joint hypernociception in rats","volume":"101","author":"Alves","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"B6","doi-asserted-by":"publisher","first-page":"ZE06","DOI":"10.7860\/JCDR\/2015\/13535.5826","article-title":"Temporomandibular disorders (TMD) in edentulous patients: a review and proposed classification (dr. 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