{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:55:42Z","timestamp":1791644142557,"version":"4.3.4"},"reference-count":232,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The ovarian system comprises vital organs in females and is of great significance for the maintenance of reproductive potential and endocrine stability. Although complex pathogenesis undoubtedly contributes to ovarian aging, increasing attention is being paid to the extensive influence of oxidative stress. However, the role of oxidative stress in ovarian aging is yet to be fully elucidated. Exploring oxidative stress-related processes might be a promising strategy against ovarian aging. In this review, compelling evidence is shown that oxidative stress plays a role in the etiology of ovarian aging and promotes the development of other ovarian aging-related etiologies, including telomere shortening, mitochondrial dysfunction, apoptosis, and inflammation. In addition, some natural antioxidants such as quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms. These findings raise the prospect of oxidative stress modulator-natural antioxidants as therapeutic interventions for delaying ovarian aging.<\/jats:p>","DOI":"10.3389\/fphar.2020.617843","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T10:33:02Z","timestamp":1610620382000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":200,"title":["The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging"],"prefix":"10.3389","volume":"11","author":[{"given":"Liuqing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"B2","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/ajh\/hpu225","article-title":"Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification","volume":"28","author":"Agharazii","year":"2014","journal-title":"Am. J. Hypertens"},{"key":"B3","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1177\/0748233711425080","article-title":"Antiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation","volume":"28","author":"Aktas","year":"2012","journal-title":"Toxicol. Ind. Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s10517-011-1349-1","article-title":"Effects of NF-\u03baB blocker curcumin on oogenesis and immunocompetent organ cells in immune ovarian injury in mice","volume":"151","author":"Alekseyeva","year":"2011","journal-title":"Bull. Exp. Biol. Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.22074\/ijfs.2015.4591","article-title":"An update on ovarian aging and ovarian reserve tests","volume":"9","author":"Amanvermez","year":"2016","journal-title":"Int. J. Fertil. Steril"},{"key":"B6","doi-asserted-by":"publisher","first-page":"11765","DOI":"10.1038\/s41598-017-12292-9","article-title":"\u03b1-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility","volume":"7","author":"Arcos","year":"2017","journal-title":"Sci. Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13048-018-0435-7","article-title":"Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population?","volume":"11","author":"Arefi","year":"2018","journal-title":"J. Ovarian Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"5276130","DOI":"10.1155\/2016\/5276130","article-title":"Role of antioxidants and natural products in inflammation","volume":"2016","author":"Arulselvan","year":"2016","journal-title":"Oxid. Med. Cell Longev"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201700001","article-title":"Mitochondrial heterogeneity, metabolic scaling and cell death","volume":"39","author":"Aryaman","year":"2017","journal-title":"Bioessays"},{"key":"B10","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/ptr.1749","article-title":"Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents","volume":"19","author":"Assimopoulou","year":"2005","journal-title":"Phytother Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"519","DOI":"10.4149\/gpb_20190281","article-title":"The effect of resveratrol on oxidative ovary-damage induced by methotrexate in rats (Resveratrol oxidative ovary-damage)","volume":"38","author":"Ata","year":"2019","journal-title":"Gen. Physiol. Biophys"},{"key":"B12","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.taap.2016.04.016","article-title":"Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol","volume":"303","author":"Banu","year":"2016","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.3390\/ijms20174215","article-title":"Effects of grape seed extract and proanthocyanidin B2 on in vitro proliferation, viability, steroidogenesis, oxidative stress, and cell signaling in human granulosa cells","volume":"20","author":"Barbe","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e2594","DOI":"10.1038\/cddis.2017.6","article-title":"Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells","volume":"8","author":"Bauer","year":"2017","journal-title":"Cell Death Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/d41586-018-01668-0","article-title":"Find drugs that delay many diseases of old age","volume":"554","author":"Bellantuono","year":"2018","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/gme.0000000000001162","article-title":"A prospective study of inflammatory biomarker levels and risk of early menopause","volume":"26","author":"Bertone-Johnson","year":"2019","journal-title":"Menopause"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.3390\/ijms20051239","article-title":"The role of curcumin in the modulation of ageing","volume":"20","author":"Bielak-Zmijewska","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5698931","DOI":"10.1155\/2016\/5698931","article-title":"Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid. Med. Cell Longev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/antiox8100504","article-title":"Antioxidant and anti-inflammatory effects of curcumin nanoparticles on drug-induced acute myocardial infarction in diabetic rats","volume":"8","author":"Boarescu","year":"2019","journal-title":"Antioxidants"},{"key":"B20","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1080\/09513590.2019.1707796","article-title":"Ameliorative effects of quercetin on folliculogenesis in diabetic mice: a stereological study","volume":"36","author":"Bolouki","year":"2019","journal-title":"Gynecol. Endocrinol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.biopha.2017.12.090","article-title":"A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids","volume":"98","author":"Bukhari","year":"2018","journal-title":"Biomed. Pharmacother"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.3233\/jad-170543","article-title":"Oxidative stress, amyloid-\u03b2 peptide, and altered key molecular pathways in the pathogenesis and progression of alzheimer\u2019s disease","volume":"62","author":"Butterfield","year":"2018","journal-title":"J. Alzheimers Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1210\/jc.2008-2269","article-title":"Correlation of telomere length and telomerase activity with occult ovarian insufficiency","volume":"94","author":"Butts","year":"2009","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"B24","doi-asserted-by":"publisher","first-page":"5340","DOI":"10.3390\/ijms21155340","article-title":"Antioxidant nobiletin enhances oocyte maturation and subsequent embryo development and quality","volume":"21","author":"Cajas","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2016.11.025","article-title":"Risky repair: DNA-protein crosslinks formed by mitochondrial base excision DNA repair enzymes acting on free radical lesions","volume":"107","author":"Caston","year":"2017","journal-title":"Free Radic. Biol. Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.fertnstert.2018.11.021","article-title":"Mitochondrial DNA copy number as a predictor of embryo viability","volume":"111","author":"Cecchino","year":"2019","journal-title":"Fertil. Steril"},{"key":"B27","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1186\/2193-1801-3-464","article-title":"Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals","volume":"3","author":"Chaube","year":"2014","journal-title":"Springerplus"},{"key":"B28","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1093\/humrep\/det004","article-title":"Evaluation of telomere length in cumulus cells as a potential biomarker of oocyte and embryo quality","volume":"28","author":"Cheng","year":"2013","journal-title":"Hum. Reprod"},{"key":"B29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.29252\/ijrm.16.1.19","article-title":"Resveratrol supplementation rescues pool of growing follicles and ovarian stroma from Cisplatin-induced toxicity on the ovary in Sprague-Dawley rats: an experimental study","volume":"16","author":"Chinwe","year":"2018","journal-title":"Int. J. Reprod. Biomed"},{"key":"B30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.14336\/ad.2018.0324","article-title":"Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept","volume":"10","author":"Chung","year":"2019","journal-title":"Aging Dis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3233\/jad-190863","article-title":"Molecular mechanisms and genetics of oxidative stress in alzheimer\u2019s disease","volume":"72","author":"Cioffi","year":"2019","journal-title":"J. Alzheimers Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/cells8010019","article-title":"Oxidative stress induces telomere dysfunction and senescence by replication fork arrest","volume":"8","author":"Coluzzi","year":"2019","journal-title":"Cells"},{"key":"B34","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/molehr\/gaw023","article-title":"Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency","volume":"22","author":"Conca Dioguardi","year":"2016","journal-title":"Mol. Hum. Reprod"},{"key":"B35","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.fertnstert.2005.03.061","article-title":"Predictive value of cumulus cell apoptosis with regard to blastocyst development of corresponding gametes","volume":"84","author":"Corn","year":"2005","journal-title":"Fertil. Steril"},{"key":"B36","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.theriogenology.2010.10.029","article-title":"Tumor necrosis factor \u03b1 knockout increases fertility of mice","volume":"75","author":"Cui","year":"2011","journal-title":"Theriogenology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1093\/humrep\/dew159","article-title":"The association of low ovarian reserve with cardiovascular disease risk: a cross-sectional population-based study","volume":"31","author":"de Kat","year":"2016","journal-title":"Hum. Reprod"},{"key":"B38","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/humupd\/dmq033","article-title":"Effects of cigarette smoking on reproduction","volume":"17","author":"Dechanet","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/8928604","article-title":"The natural carotenoid crocetin and the synthetic tellurium compound AS101 protect the ovary against cyclophosphamide by modulating SIRT1 and mitochondrial markers","volume":"2017","author":"Di Emidio","year":"2017","journal-title":"Oxid. Med. Cell Longev"},{"key":"B40","doi-asserted-by":"publisher","first-page":"7474","DOI":"10.1021\/jf201207m","article-title":"Anti-inflammatory activities of mogrosides from Momordica grosvenori in murine macrophages and a murine ear edema model","volume":"59","author":"Di","year":"2011","journal-title":"J. Agric. Food Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3109\/10715762.2011.653969","article-title":"Mechanisms of free radical-induced damage to DNA","volume":"46","author":"Dizdaroglu","year":"2012","journal-title":"Free Radic. Res"},{"key":"B42","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3390\/antiox9040347","article-title":"The relevance of oxidative stress in the pathogenesis and therapy of retinal dystrophies","volume":"9","author":"Dom\u00e8nech","year":"2020","journal-title":"Antioxidants"},{"key":"B43","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.freeradbiomed.2014.03.038","article-title":"Revisiting an age-old question regarding oxidative stress","volume":"71","author":"Edrey","year":"2014","journal-title":"Free Radic. Biol. Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1177\/0960327119865588","article-title":"Effects of quercetin and rosuvastatin each alone or in combination on cyclophosphamide-induced premature ovarian failure in female albino mice","volume":"38","author":"Elkady","year":"2019","journal-title":"Hum. Exp. Toxicol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2020.02.008","article-title":"Oxidative stress, telomeres and cellular senescence: what non-drug interventions might break the link?","volume":"150","author":"Erusalimsky","year":"2020","journal-title":"Free Radic. Biol. Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3390\/antiox8090338","article-title":"Impact of melatonin supplementation in women with unexplained infertility undergoing fertility treatment","volume":"8","author":"Espino","year":"2019","journal-title":"Antioxidants"},{"key":"B47","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.redox.2015.07.008","article-title":"Antioxidant responses and cellular adjustments to oxidative stress","volume":"6","author":"Espinosa-Diez","year":"2015","journal-title":"Redox Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s10815-019-01446-5","article-title":"Apoptosis of mural granulosa cells is increased in women with diminished ovarian reserve","volume":"36","author":"Fan","year":"2019","journal-title":"J. Assist. Reprod. Genet"},{"key":"B49","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fmed.2018.00061","article-title":"The continuum of aging and age-related diseases: common mechanisms but different rates","volume":"5","author":"Franceschi","year":"","journal-title":"Front. Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune\u2013metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"","journal-title":"Nat. Rev. Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ejogrb.2014.03.036","article-title":"The protective effect of quercetin on IMA levels and apoptosis in experimental ovarian ischemia-reperfusion injury","volume":"177","author":"Gencer","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3389\/fphar.2019.01400","article-title":"The fruits of Siraitia grosvenorii: a review of a Chinese food-medicine","volume":"10","author":"Gong","year":"2019","journal-title":"Front. Pharmacol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1096\/fj.08-111005","article-title":"Life and death by death receptors","volume":"23","author":"Guicciardi","year":"2009","journal-title":"Faseb. J"},{"key":"B54","doi-asserted-by":"publisher","first-page":"13551","DOI":"10.1038\/s41598-020-70309-2","article-title":"Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: co-operative role of ER-\u03b2, TGF-\u03b2, and FOXL-2","volume":"10","author":"Haddad","year":"2020","journal-title":"Sci. Rep"},{"key":"B55","doi-asserted-by":"publisher","first-page":"R159","DOI":"10.1530\/rep-18-0431","article-title":"Mitochondria in early development: linking the microenvironment, metabolism and the epigenome","volume":"157","author":"Harvey","year":"2019","journal-title":"Reproduction"},{"key":"B56","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1177\/1535370217693323","article-title":"Ginsenoside Rg1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice","volume":"242","author":"He","year":"2017","journal-title":"Exp. Biol. Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.3390\/app8101905","article-title":"Extraction optimization of phenolics and antioxidants from black goji berry by accelerated solvent extractor using response surface methodology","volume":"8","author":"He","year":"2018","journal-title":"Appl. Sci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1073\/pnas.1113306109","article-title":"Telomere length in early life predicts lifespan","volume":"109","author":"Heidinger","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B59","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fendo.2020.00160","article-title":"Melatonin application in assisted reproductive technology: a systematic review and meta-analysis of randomized trials","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1089\/clo.2006.0020","article-title":"Effects of granulosa cell mitochondria transfer on the early development of bovine embryos in vitro","volume":"9","author":"Hua","year":"2007","journal-title":"Clon. Stem Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/j.fertnstert.2008.07.1781","article-title":"Effects of cigarette smoke on fertilization and embryo development in vivo","volume":"92","author":"Huang","year":"2009","journal-title":"Fertil. Steril"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.freeradbiomed.2010.03.026","article-title":"Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro","volume":"48","author":"Huang","year":"2010","journal-title":"Free Radic. Biol. Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"11843","DOI":"10.1074\/jbc.M115.711051","article-title":"Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein Bid during TRAIL-induced apoptosis","volume":"291","author":"Huang","year":"2016","journal-title":"J. Biol. Chem"},{"key":"B64","doi-asserted-by":"publisher","first-page":"6392763","DOI":"10.1155\/2019\/6392763","article-title":"The role of the antioxidant response in mitochondrial dysfunction in degenerative diseases: cross-talk between antioxidant defense, autophagy, and apoptosis","volume":"2019","author":"Huang","year":"2019","journal-title":"Oxid. Med. Cell Longev"},{"key":"B65","doi-asserted-by":"publisher","first-page":"8069898","DOI":"10.1155\/2019\/8069898","article-title":"Inflamm-aging: a new mechanism affecting premature ovarian insufficiency","volume":"2019","author":"Huang","year":"2019","journal-title":"J. Immunol. Res"},{"key":"B66","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alexandria J. Med"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.theriogenology.2015.01.029","article-title":"Resveratrol improves the quality of pig oocytes derived from early antral follicles through sirtuin 1 activation","volume":"83","author":"Itami","year":"2015","journal-title":"Theriogenology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"E7619","DOI":"10.1073\/pnas.1604828113","article-title":"The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii","volume":"113","author":"Itkin","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B69","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cryobiol.2020.02.014","article-title":"Resveratrol treatment increases mitochondrial biogenesis and improves viability of porcine germinal-vesicle stage vitrified-warmed oocytes","volume":"93","author":"Ito","year":"2020","journal-title":"Cryobiology"},{"key":"B70","first-page":"73","article-title":"Effect of melatonin on the outcome of assisted reproductive technique cycles in women with diminished ovarian reserve: a double-blinded randomized clinical trial","volume":"42","author":"Jahromi","year":"2017","journal-title":"Iran. J. Med. Sci"},{"key":"B71","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s40675-017-0071-6","article-title":"Shift work: disrupted circadian rhythms and sleep-implications for health and well-being","volume":"3","author":"James","year":"2017","journal-title":"Curr. Sleep Med. Rep"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.2174\/0929867322666150114151720","article-title":"Catalpol: a potential therapeutic for neurodegenerative diseases","volume":"22","author":"Jiang","year":"2015","journal-title":"Curr. Med. Chem"},{"key":"B73","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.3390\/ijms20143605","article-title":"Resveratrol plays a protective role against premature ovarian failure and prompts female germline stem cell survival","volume":"20","author":"Jiang","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.3390\/ijms20102374","article-title":"Role of mitochondrial DNA damage in ROS-mediated pathogenesis of age-related macular degeneration (AMD)","volume":"20","author":"Kaarniranta","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"B75","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","article-title":"Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of alzheimer\u2019s disease: understanding the therapeutics strategies","volume":"53","author":"Kamat","year":"2016","journal-title":"Mol. Neurobiol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"bqaa001","DOI":"10.1210\/endocr\/bqaa001","article-title":"Mitochondrial dysfunction and ovarian aging","volume":"161","author":"Kasapo\u011flu","year":"2020","journal-title":"Endocrinology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cmet.2016.09.017","article-title":"Mammalian mitochondria and aging: an update","volume":"25","author":"Kauppila","year":"2017","journal-title":"Cell Metabol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00018-006-6466-z","article-title":"Telomeres and aging-related meiotic dysfunction in women","volume":"64","author":"Keefe","year":"2007","journal-title":"Cell. Mol. Life Sci"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.3390\/ijms20071635","article-title":"Endogenous and exogenous modulation of Nrf2 mediated oxidative stress response in bovine granulosa cells: potential implication for ovarian function","volume":"20","author":"Khadrawy","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"B80","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.tiv.2018.06.007","article-title":"Effects of cigarette smoke extracts on apoptosis and oxidative stress in two models of ovarian cancer in vitro","volume":"52","author":"Kim","year":"2018","journal-title":"Toxicol. Vitro"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin, an active component of turmeric (Curcuma longa), and its effects on health","volume":"57","author":"Kocaadam","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.18632\/aging.101507","article-title":"Cumulus cell-released tumor necrosis factor (TNF)-\u03b1 promotes post-ovulatory aging of mouse oocytes","volume":"10","author":"Kong","year":"2018","journal-title":"Aging"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/molecules24162930","article-title":"Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects","volume":"24","author":"Kotha","year":"2019","journal-title":"Molecules"},{"key":"B84","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/humrep\/dex043","article-title":"Improving oocyte quality by transfer of autologous mitochondria from fully grown oocytes","volume":"32","author":"Kristensen","year":"2017","journal-title":"Hum. Reprod"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s10495-008-0238-1","article-title":"Life and death of female gametes during oogenesis and folliculogenesis","volume":"13","author":"Krysko","year":"2008","journal-title":"Apoptosis"},{"key":"B86","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.fertnstert.2018.10.036","article-title":"Mitochondria as a tool for oocyte rejuvenation","volume":"111","author":"Labarta","year":"2019","journal-title":"Fertil. Steril"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1002\/ptr.6181","article-title":"Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: a brief overview","volume":"32","author":"Leone","year":"2018","journal-title":"Phytother Res"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1111\/jog.13680","article-title":"Mechanism of resveratrol in improving ovarian function in a rat model of premature ovarian insufficiency","volume":"44","author":"Li","year":"2018","journal-title":"J. Obstet. Gynaecol. Res"},{"key":"B89","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.reprotox.2020.01.006","article-title":"Trichostatin A alleviated ovarian tissue damage caused by cigarette smoke exposure","volume":"93","author":"Li","year":"2020","journal-title":"Reprod. Toxicol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"4234061","DOI":"10.1155\/2016\/4234061","article-title":"Insights into the role and interdependence of oxidative stress and inflammation in liver diseases","volume":"2016","author":"Li","year":"2016","journal-title":"Oxid. Med. Cell Longev"},{"key":"B91","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","article-title":"Quercetin, inflammation and immunity","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"key":"B92","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1177\/0748233717712409","article-title":"Reactive oxygen species trigger NF-\u03baB-mediated NLRP3 inflammasome activation induced by zinc oxide nanoparticles in A549 cells","volume":"33","author":"Liang","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"B93","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2147\/cia.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"B94","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1095\/biolreprod.110.088583","article-title":"Oxidative damage increases and antioxidant gene expression decreases with aging in the mouse ovary","volume":"84","author":"Lim","year":"2011","journal-title":"Biol. Reprod"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.02.011","article-title":"Reactive oxygen species and the free radical theory of aging","volume":"60","author":"Liochev","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"845","DOI":"10.4155\/fmc-2017-0255","article-title":"Pharmacological activities of mogrosides","volume":"10","author":"Liu","year":"2018","journal-title":"Future Med. Chem"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1007\/s13197-018-3105-2","article-title":"Antiglycation and antioxidant activities of mogroside extract from Siraitia grosvenorii (Swingle) fruits","volume":"55","author":"Liu","year":"2018","journal-title":"J. Food Sci. Technol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1093\/humrep\/des437","article-title":"Resveratrol protects against age-associated infertility in mice","volume":"28","author":"Liu","year":"2013","journal-title":"Hum. Reprod"},{"key":"B99","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/ptr.6538","article-title":"Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress","volume":"34","author":"Liu","year":"2020","journal-title":"Phytother. Res"},{"key":"B100","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target Ther"},{"key":"B101","doi-asserted-by":"publisher","first-page":"9390810","DOI":"10.1155\/2018\/9390810","article-title":"Grape seed proanthocyanidin extract prevents ovarian aging by inhibiting oxidative stress in the hens","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxid. Med. Cell Longev"},{"key":"B102","doi-asserted-by":"publisher","first-page":"6233","DOI":"10.18632\/oncotarget.14056","article-title":"Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"B103","doi-asserted-by":"publisher","first-page":"109937","DOI":"10.1016\/j.ecoenv.2019.109937","article-title":"ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells","volume":"189","author":"Long","year":"2020","journal-title":"Ecotoxicol. Environ. Saf"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"B105","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1095\/biolreprod.114.122820","article-title":"Accumulation of electrophilic aldehydes during postovulatory aging of mouse oocytes causes reduced fertility, oxidative stress, and apoptosis","volume":"92","author":"Lord","year":"2015","journal-title":"Biol. Reprod"},{"key":"B106","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12958-018-0391-5","article-title":"A novel and compact review on the role of oxidative stress in female reproduction","volume":"16","author":"Lu","year":"2018","journal-title":"Reprod. Biol. Endocrinol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1073\/pnas.1820533116","article-title":"No further evidence for paternal leakage of mitochondrial DNA in humans yet","volume":"116","author":"Lutz-Bonengel","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B108","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/tog.12558","article-title":"Early ovarian ageing","volume":"21","author":"Maclaran","year":"2019","journal-title":"Obstet. Gynaecol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1177\/0748233718818692","article-title":"Vitamins E and C prevent apoptosis of testicular and ovarian tissues following mancozeb exposure in the first-generation mouse pups","volume":"35","author":"Mahdi","year":"2019","journal-title":"Toxicol. Ind. Health"},{"key":"B110","doi-asserted-by":"publisher","first-page":"e95945","DOI":"10.1371\/journal.pone.0095945","article-title":"The effects of cigarette smoke extract on ovulation, oocyte morphology and ovarian gene expression in mice","volume":"9","author":"Mai","year":"2014","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1474-9726.2011.00691.x","article-title":"Transplantation of young ovaries restored cardioprotective influence in postreproductive-aged mice","volume":"10","author":"Mason","year":"2011","journal-title":"Aging Cell"},{"key":"B112","doi-asserted-by":"publisher","first-page":"56638","DOI":"10.3791\/56638","article-title":"Orthotopic ovarian transplantation procedures to investigate the life- and health-span influence of ovarian senescence in female mice","volume":"132","author":"Mason","year":"2018","journal-title":"J. Vis. Exp"},{"key":"B113","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/molehr\/gap034","article-title":"Superoxide dismutase expression in human cumulus oophorus cells","volume":"15","author":"Matos","year":"2009","journal-title":"Mol. Hum. Reprod"},{"key":"B114","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/humupd\/dmw028","article-title":"Ovarian ageing: the role of mitochondria in oocytes and follicles","volume":"22","author":"May-Panloup","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"B115","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13048-018-0409-9","article-title":"Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model","volume":"11","author":"Melekoglu","year":"2018","journal-title":"J. Ovarian Res"},{"key":"B116","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/foods9030340","article-title":"Health benefits and molecular mechanisms of resveratrol: a narrative review","volume":"9","author":"Meng","year":"2020","journal-title":"Foods"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1096\/fj.201700908R","article-title":"Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress","volume":"32","author":"Miao","year":"2018","journal-title":"Faseb. J"},{"key":"B118","first-page":"352","article-title":"The effect of curcumin on TNF-\u03b1, IL-6 and CRP expression in a model of polycystic ovary syndrome as an inflammation state","volume":"18","author":"Mohammadi","year":"2017","journal-title":"J. Reprod. Infertil"},{"key":"B119","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.tjog.2012.11.004","article-title":"A comparative study of saffron aqueous extract and its active ingredient, crocin on the in vitro maturation, in vitro fertilization, and in vitro culture of mouse oocytes","volume":"53","author":"Mokhber Maleki","year":"2014","journal-title":"Taiwan. J. Obstet. Gynecol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"53","DOI":"10.22074\/ijfs.2016.4769","article-title":"Effects of crocin supplementation during in vitro maturation of mouse oocytes on glutathione synthesis and cytoplasmic maturation","volume":"10","author":"Mokhber Maleki","year":"2016","journal-title":"Int. J. Fertil. Steril"},{"key":"B121","first-page":"185","article-title":"Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release","volume":"34","author":"Monian","year":"2012","journal-title":"Exp. Oncol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/cr.2008.31","article-title":"TNF\u03b1 and reactive oxygen species in necrotic cell death","volume":"18","author":"Morgan","year":"2008","journal-title":"Cell Res"},{"key":"B123","doi-asserted-by":"publisher","first-page":"pe39","DOI":"10.1126\/scisignal.2003386","article-title":"Modulating mitochondrial intracellular location as a redox signal","volume":"5","author":"Murphy","year":"2012","journal-title":"Sci. Signal"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.26.062646","article-title":"Inhibition of the NLRP3 inflammasome prevents ovarian aging","author":"Navarro-Pando","year":"2020","journal-title":"bioRxiv"},{"key":"B125","doi-asserted-by":"publisher","first-page":"8362","DOI":"10.18632\/aging.102324","article-title":"Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation","volume":"11","author":"Nie","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"B126","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.theriogenology.2019.09.010","article-title":"Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development","volume":"141","author":"Nie","year":"2020","journal-title":"Theriogenology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jacc.2017.05.043","article-title":"Oxidative stress and cardiovascular risk: obesity, diabetes, smoking, and pollution: Part 3 of a 3-Part Series","volume":"70","author":"Niemann","year":"2017","journal-title":"J. Am. Coll. Cardiol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.fct.2017.02.010","article-title":"Quercetin exerts preventive, ameliorative and prophylactic effects on cadmium chloride \u2013 induced oxidative stress in the uterus and ovaries of female Wistar rats","volume":"102","author":"Nna","year":"2017","journal-title":"Food Chem. Toxicol"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1177\/1933719115612137","article-title":"Oogonial precursor cell-derived autologous mitochondria injection to improve outcomes in women with multiple IVF failures due to low oocyte quality: a clinical translation","volume":"22","author":"Oktay","year":"2015","journal-title":"Reprod. Sci"},{"key":"B130","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1093\/humrep\/deg450","article-title":"Antioxidants and reactive oxygen species in follicular fluid of women undergoing IVF: relationship to outcome","volume":"18","author":"Oyawoye","year":"2003","journal-title":"Hum. Reprod"},{"key":"B131","doi-asserted-by":"publisher","first-page":"6","DOI":"10.5152\/eurasianjmed.2019.19044","article-title":"Do resveratrol and dehydroepiandrosterone increase diminished ovarian reserve?","volume":"52","author":"Ozatik","year":"2020","journal-title":"Eurasian J. Med"},{"key":"B132","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3390\/antiox8090327","article-title":"Induction of G2\/M cell cycle arrest and apoptosis by genistein in human bladder cancer T24 cells through inhibition of the ROS-dependent PI3k\/akt signal transduction pathway","volume":"8","author":"Park","year":"2019","journal-title":"Antioxidants"},{"key":"B133","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.exger.2017.03.002","article-title":"Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice","volume":"92","author":"Parkinson","year":"2017","journal-title":"Exp. Gerontol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1093\/biolre\/ioy248","article-title":"Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans\u2020","volume":"100","author":"Pasquariello","year":"2019","journal-title":"Biol. Reprod"},{"key":"B135","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1089\/ars.2019.7986","article-title":"Autophagy in female fertility: a role in oxidative stress and aging","volume":"32","author":"Peters","year":"2020","journal-title":"Antioxid Redox Signal"},{"key":"B136","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1071\/rd16333","article-title":"Restoration of immune and renal function in aged females by re-establishment of active ovarian function","volume":"29","author":"Peterson","year":"2017","journal-title":"Reprod. Fertil. Dev"},{"key":"B137","doi-asserted-by":"publisher","first-page":"20191917","DOI":"10.1098\/rspb.2019.1917","article-title":"Antioxidant supplementation slows telomere shortening in free-living white stork chicks","volume":"287","author":"Pineda-Pampliega","year":"2020","journal-title":"Proc. Biol. Sci"},{"key":"B138","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.freeradbiomed.2015.05.005","article-title":"Mechanisms linking mtDNA damage and aging","volume":"85","author":"Pinto","year":"2015","journal-title":"Free Radic. Biol. Med"},{"key":"B139","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1262\/jrd.2018-077","article-title":"Resveratrol supplementation during in vitro maturation improves embryo development of prepubertal goat oocytes selected by brilliant cresyl blue staining","volume":"65","author":"Piras","year":"2019","journal-title":"J. Reprod. Dev"},{"key":"B140","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.mad.2017.04.004","article-title":"Telomere shortening during aging: attenuation by antioxidants and anti-inflammatory agents","volume":"164","author":"Prasad","year":"2017","journal-title":"Mech. Ageing Develop"},{"key":"B141","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12929-016-0253-4","article-title":"Impact of stress on oocyte quality and reproductive outcome","volume":"23","author":"Prasad","year":"2016","journal-title":"J. Biomed. Sci"},{"key":"B142","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1179\/1351000215y.0000000003","article-title":"Nitric oxide signals postovulatory aging-induced abortive spontaneous egg activation in rats","volume":"20","author":"Premkumar","year":"2015","journal-title":"Redox Rep"},{"key":"B143","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/s1875-5364(17)30062-6","article-title":"Novel natural product therapeutics targeting both inflammation and cancer","volume":"15","author":"Qin","year":"2017","journal-title":"Chin. J. Nat. Med"},{"key":"B144","doi-asserted-by":"publisher","first-page":"e0127551","DOI":"10.1371\/journal.pone.0127551","article-title":"Oxidative stress induced by zearalenone in porcine granulosa cells and its rescue by curcumin in vitro","volume":"10","author":"Qin","year":"2015","journal-title":"PLoS One"},{"key":"B145","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.fertnstert.2018.07.1152","article-title":"Cardiovascular health and ovarian aging","volume":"110","author":"Quinn","year":"2018","journal-title":"Fertil. Steril"},{"key":"B146","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/antiox2040340","article-title":"Antioxidant defenses in plants with attention to prunus and citrus spp","volume":"2","author":"Racchi","year":"2013","journal-title":"Antioxidants"},{"key":"B147","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1055\/s-0037-1603571","article-title":"Ovary as a biomarker of health and longevity: insights from genetics","volume":"35","author":"Rajkovic","year":"2017","journal-title":"Semin. Reprod. Med"},{"key":"B148","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.repbio.2019.07.002","article-title":"Quercetin protects human granulosa cells against oxidative stress via thioredoxin system","volume":"19","author":"Rashidi","year":"2019","journal-title":"Reprod. Biol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Res"},{"key":"B150","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fendo.2018.00061","article-title":"Granulosa cell apoptosis in the ovarian follicle-A changing view","volume":"9","author":"Regan","year":"","journal-title":"Front. Endocrinol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.mce.2017.11.002","article-title":"The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development","volume":"470","author":"Regan","year":"","journal-title":"Mol. Cell. Endocrinol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1439-0531.2011.01891.x","article-title":"Roles of reactive oxygen species in female reproduction","volume":"47","author":"Rizzo","year":"2012","journal-title":"Reprod. Domest. Anim"},{"key":"B153","doi-asserted-by":"publisher","first-page":"6569","DOI":"10.1038\/srep06569","article-title":"Maternally transmitted mitochondrial DNA mutations can reduce lifespan","volume":"4","author":"Ross","year":"2014","journal-title":"Sci. Rep"},{"key":"B154","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1023\/a:1009422323306","article-title":"Effects of aging on ovarian fecundity in terms of the incidence of apoptotic granulosa cells","volume":"17","author":"Sadraie","year":"2000","journal-title":"J. Assist. Reprod. Genet"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.3390\/ijms18071544","article-title":"Correlation between oxidative stress, nutrition, and cancer initiation","volume":"18","author":"Saha","year":"2017","journal-title":"Int. J. Mol. Sci"},{"key":"B156","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bcp.2016.01.019","article-title":"Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1)","volume":"103","author":"Said","year":"2016","journal-title":"Biochem. Pharmacol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s00210-019-01662-x","article-title":"Mechanistic perspective of protective effects of resveratrol against cisplatin-induced ovarian injury in rats: emphasis on anti-inflammatory and anti-apoptotic effects","volume":"392","author":"Said","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.ijsu.2013.06.007","article-title":"The protective effect of curcumin on ischemia-reperfusion injury in rat ovary","volume":"11","author":"Sak","year":"2013","journal-title":"Int. J. Surg"},{"key":"B159","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ejphar.2016.07.026","article-title":"Ovario-protective effects of genistein against cyclophosphamide toxicity in rats: role of anti-m\u00fcllerian hormone and oestradiol","volume":"789","author":"Saleh","year":"2016","journal-title":"Eur. J. Pharmacol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3389\/fendo.2019.00811","article-title":"Impact of oxidative stress on age-associated decline in oocyte developmental competence","volume":"10","author":"Sasaki","year":"2019","journal-title":"Front. Endocrinol"},{"key":"B161","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3389\/fphys.2017.00428","article-title":"Role of mitochondrial reverse electron transport in ROS signaling: potential roles in health and disease","volume":"8","author":"Scial\u00f2","year":"2017","journal-title":"Front. Physiol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1089\/109662003772519831","article-title":"Polyphenolics in grape seeds-biochemistry and functionality","volume":"6","author":"Shi","year":"2003","journal-title":"J. Med. Food"},{"key":"B163","doi-asserted-by":"publisher","first-page":"e0162194","DOI":"10.1371\/journal.pone.0162194","article-title":"Long-term moderate oxidative stress decreased ovarian reproductive function by reducing follicle quality and progesterone production","volume":"11","author":"Shi","year":"2016","journal-title":"PLoS One"},{"key":"B164","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1017\/s0967199418000485","article-title":"Quercetin influences in vitro maturation, apoptosis and metabolically active mitochondria of goat oocytes","volume":"26","author":"Silva","year":"2018","journal-title":"Zygote"},{"key":"B165","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.3390\/ijms20174258","article-title":"Oxidative stress: role and response of short guanine tracts at genomic locations","volume":"20","author":"Singh","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"B166","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1101\/gad.316042.118","article-title":"Telomerase can\u2019t handle the stress","volume":"32","author":"Smith","year":"2018","journal-title":"Genes Dev"},{"key":"B167","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00018-019-03369-x","article-title":"Structural biology of telomeres and telomerase","volume":"77","author":"Smith","year":"2020","journal-title":"Cell. Mol. Life Sci"},{"key":"B168","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1530\/rep-18-0583","article-title":"Obesity induces ovarian inflammation and reduces oocyte quality","volume":"158","author":"Snider","year":"2019","journal-title":"Reproduction"},{"key":"B169","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.taap.2013.05.009","article-title":"Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress","volume":"271","author":"Sobinoff","year":"2013","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00441-019-02990-3","article-title":"Oxidative stress modulates the expression of apoptosis-associated microRNAs in bovine granulosa cells in vitro","volume":"376","author":"Sohel","year":"2019","journal-title":"Cell Tissue Res"},{"key":"B171","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3945\/an.114.008052","article-title":"Genistein and cancer: current status, challenges, and future directions","volume":"6","author":"Spagnuolo","year":"2015","journal-title":"Adv. Nutr"},{"key":"B172","doi-asserted-by":"publisher","first-page":"7246","DOI":"10.1038\/s41598-018-25516-3","article-title":"Additional mitochondrial DNA influences the interactions between the nuclear and mitochondrial genomes in a bovine embryo model of nuclear transfer","volume":"8","author":"Srirattana","year":"2018","journal-title":"Sci. Rep"},{"key":"B173","doi-asserted-by":"publisher","first-page":"7092151","DOI":"10.1155\/2019\/7092151","article-title":"Vascular inflammation and oxidative stress: major triggers for cardiovascular disease","volume":"2019","author":"Steven","year":"2019","journal-title":"Oxid. Med. Cell Longev"},{"key":"B174","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/humrep\/dey390","article-title":"Rotating night shift work and menopausal age","volume":"34","author":"Stock","year":"2019","journal-title":"Hum. Reprod"},{"key":"B175","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/bf03016135","article-title":"Reactive oxygen species in ovarian physiology","volume":"4","author":"Sugino","year":"2005","journal-title":"Reprod. Med. Biol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1262\/jrd.2015-001","article-title":"Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows","volume":"61","author":"Sugiyama","year":"2015","journal-title":"J. Reprod. Dev"},{"key":"B177","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.3892\/etm.2018.6592","article-title":"Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation","volume":"16","author":"Sun","year":"2018","journal-title":"Exp. Ther. Med"},{"key":"B178","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.3390\/cells8101132","article-title":"Roles of resveratrol in improving the quality of postovulatory aging oocytes in vitro","volume":"8","author":"Sun","year":"2019","journal-title":"Cells"},{"key":"B179","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1071\/rd15228","article-title":"Age-associated deterioration in follicular fluid induces a decline in bovine oocyte quality","volume":"29","author":"Takeo","year":"2017","journal-title":"Reprod. Fertil. Dev"},{"key":"B180","first-page":"177","article-title":"Molecular mechanisms of action of genistein in cancer: recent advances","volume":"27","author":"Tang","year":"2019","journal-title":"Front. Pharmacol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00412-017-0656-3","article-title":"Telomere chromatin establishment and its maintenance during mammalian development","volume":"127","author":"Tardat","year":"2018","journal-title":"Chromosoma"},{"key":"B182","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1093\/molehr\/gal080","article-title":"Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells","volume":"12","author":"Tatone","year":"2006","journal-title":"Mol. Hum. Reprod"},{"key":"B183","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/ncb3165","article-title":"ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation","volume":"17","author":"Teixeira","year":"2015","journal-title":"Nat. Cell Biol"},{"key":"B184","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1038\/s41598-019-40989-6","article-title":"Night workers have lower levels of antioxidant defenses and higher levels of oxidative stress damage when compared to day workers","volume":"9","author":"Teixeira","year":"2019","journal-title":"Sci. Rep"},{"key":"B185","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/s10495-015-1136-y","article-title":"Apoptosis in mammalian oocytes: a review","volume":"20","author":"Tiwari","year":"2015","journal-title":"Apoptosis"},{"key":"B186","doi-asserted-by":"publisher","first-page":"99","DOI":"10.20455\/ros.2016.817","article-title":"Involvement of reactive oxygen species in meiotic cell cycle regulation and apoptosis in mammalian oocytes","volume":"1","author":"Tiwari","year":"2016","journal-title":"React. Oxygen Species"},{"key":"B187","doi-asserted-by":"publisher","first-page":"104618","DOI":"10.1016\/j.phrs.2019.104618","article-title":"Resveratrol derivative excited postsynaptic potentiation specifically via PKC\u03b2-NMDA receptor mediation","volume":"152","author":"Tong","year":"2020","journal-title":"Pharmacol. Res"},{"key":"B188","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/chromsci\/bmu114","article-title":"Separation of catalpol from Rehmannia glutinosa Libosch. by high-speed countercurrent chromatography","volume":"53","author":"Tong","year":"2015","journal-title":"J. Chromatogr. Sci"},{"key":"B189","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/2229-516x.112238","article-title":"An increase of granulosa cell apoptosis mediates aqueous neem (Azadirachta indica) leaf extract-induced oocyte apoptosis in rat","volume":"3","author":"Tripathi","year":"2013","journal-title":"Int. J. Appl. Basic Med. Res"},{"key":"B190","doi-asserted-by":"publisher","first-page":"604","DOI":"10.2174\/1570161117666190122101611","article-title":"Premature ovarian insufficiency and long-term health consequences","volume":"17","author":"Tsiligiannis","year":"2019","journal-title":"Curr. Vasc. Pharmacol"},{"key":"B191","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3390\/cells8010073","article-title":"Telomere biology and human phenotype","volume":"8","author":"Turner","year":"2019","journal-title":"Cells"},{"key":"B192","doi-asserted-by":"publisher","first-page":"38631","DOI":"10.18632\/oncotarget.16219","article-title":"Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPF activity","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"B193","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.theriogenology.2018.10.028","article-title":"Effects of icariin on ovarian function in d-galactose-induced aging mice","volume":"125","author":"Wang","year":"2019","journal-title":"Theriogenology"},{"key":"B194","doi-asserted-by":"publisher","first-page":"4371714","DOI":"10.1155\/2017\/4371714","article-title":"The role of antioxidant enzymes in the ovaries","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxid. Med. Cell Longev"},{"key":"B195","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","article-title":"Single-cell transcriptomic atlas of primate ovarian aging","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12651","article-title":"Mitochondrial dysfunction and ovarian aging","volume":"77","author":"Wang","year":"2017","journal-title":"Am. J. Reprod. Immunol"},{"key":"B197","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/carcin\/bgy063","article-title":"Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms","volume":"39","author":"Wang","year":"2018","journal-title":"Carcinogenesis"},{"key":"B198","doi-asserted-by":"publisher","first-page":"108759","DOI":"10.1016\/j.cbi.2019.108759","article-title":"Hyperoside protects rat ovarian granulosa cells against hydrogen peroxide-induced injury by sonic hedgehog signaling pathway","volume":"310","author":"Wang","year":"2019","journal-title":"Chem. Biol. Interact"},{"key":"B199","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.4103\/0366-6999.204927","article-title":"Protective effects of curcumin against sodium arsenite-induced ovarian oxidative injury in a mouse model","volume":"130","author":"Wang","year":"2017","journal-title":"Chin Med. J. (Engl)"},{"key":"B200","doi-asserted-by":"publisher","first-page":"5535","DOI":"10.18632\/aging.102136","article-title":"HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress","volume":"11","author":"Wang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"B201","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1248\/bpb.b14-00064","article-title":"Ovarian failure-resistant effects of catalpol in aged female rats","volume":"37","author":"Wei","year":"2014","journal-title":"Biol. Pharm. Bull"},{"key":"B202","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.fertnstert.2017.10.007","article-title":"Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential","volume":"108","author":"Wells","year":"2017","journal-title":"Fertil. Steril"},{"key":"B203","doi-asserted-by":"publisher","first-page":"15122","DOI":"10.1073\/pnas.1902452116","article-title":"Telomere shortening rate predicts species life span","volume":"116","author":"Whittemore","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B204","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.fertnstert.2004.06.013","article-title":"Oxidative stress indices in follicular fluid as measured by the thermochemiluminescence assay correlate with outcome parameters in in vitro fertilization","volume":"82","author":"Wiener-Megnazi","year":"2004","journal-title":"Fertil. Steril"},{"key":"B205","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.18632\/aging.101808","article-title":"Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice","volume":"11","author":"Wu","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"B206","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.4049\/jimmunol.1201725","article-title":"Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-\u03b3 and lipopolysaccharide in human pancreatic cancer cell lines","volume":"190","author":"Wu","year":"2013","journal-title":"J. Immunol"},{"key":"B207","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s13238-014-0089-1","article-title":"Mitochondria-mediated apoptosis in mammals","volume":"5","author":"Xiong","year":"2014","journal-title":"Protein Cell"},{"key":"B208","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.3390\/molecules24061123","article-title":"Antioxidant activities of quercetin and its complexes for medicinal application","volume":"24","author":"Xu","year":"2019","journal-title":"Molecules"},{"key":"B209","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3390\/ijms18010096","article-title":"Natural antioxidants in foods and medicinal plants: extraction, assessment and resources","volume":"18","author":"Xu","year":"2017","journal-title":"Int. J. Mol. Sci"},{"key":"B210","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/humrep\/dew283","article-title":"Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency","volume":"32","author":"Xu","year":"2017","journal-title":"Hum. Reprod"},{"key":"B211","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12929-018-0438-0","article-title":"Germ cell depletion from mammalian ovary: possible involvement of apoptosis and autophagy","volume":"25","author":"Yadav","year":"2018","journal-title":"J. Biomed. Sci"},{"key":"B212","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1477-7827-11-108","article-title":"Age-associated telomere shortening in mouse oocytes","volume":"11","author":"Yamada-Fukunaga","year":"2013","journal-title":"Reprod. Biol. Endocrinol"},{"key":"B213","doi-asserted-by":"publisher","first-page":"BSR20194032","DOI":"10.1042\/bsr20194032","article-title":"Catalpol protects rat ovarian granulosa cells against oxidative stress and apoptosis through modulating the PI3K\/Akt\/mTOR signaling pathway","volume":"40","author":"Yan","year":"2020","journal-title":"Biosci. Rep"},{"key":"B214","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1530\/jme-17-0214","article-title":"Curcumin exerts a protective effect against premature ovarian failure in mice","volume":"60","author":"Yan","year":"2018","journal-title":"J. Mol. Endocrinol"},{"key":"B215","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.exer.2007.06.013","article-title":"Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells","volume":"85","author":"Yang","year":"2007","journal-title":"Exp. Eye Res"},{"key":"B216","doi-asserted-by":"publisher","first-page":"25310","DOI":"10.18632\/oncotarget.15813","article-title":"Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"B217","doi-asserted-by":"publisher","first-page":"e13206","DOI":"10.1111\/acel.13206","article-title":"Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH\/NAD(+) redox","volume":"19","author":"Yang","year":"2020","journal-title":"Aging Cell"},{"key":"B218","doi-asserted-by":"publisher","first-page":"10130","DOI":"10.1038\/s41598-018-28497-5","article-title":"Mito-TEMPO improves development competence by reducing superoxide in preimplantation porcine embryos","volume":"8","author":"Yang","year":"2018","journal-title":"Sci. Rep"},{"key":"B219","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3389\/fimmu.2018.00784","article-title":"Role of TNF-TNF receptor 2 signal in regulatory T cells and its therapeutic implications","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Immunol"},{"key":"B220","doi-asserted-by":"publisher","first-page":"8609213","DOI":"10.1155\/2020\/8609213","article-title":"Molecular mechanisms linking oxidative stress and diabetes mellitus","volume":"2020","author":"Yaribeygi","year":"2020","journal-title":"Oxid. Med. Cell Longev"},{"key":"B221","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1097\/gme.0000000000000423","article-title":"Association between some inflammatory markers and primary ovarian insufficiency","volume":"22","author":"Yldrm","year":"2015","journal-title":"Menopause"},{"key":"B222","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3389\/fphar.2020.00984","article-title":"Targeting \u03b2-catenin signaling by natural products for cancer prevention and therapy","volume":"11","author":"Yu","year":"2020","journal-title":"Front. Pharmacol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3390\/antiox9080732","article-title":"Comparison of in vitro and in vivo antioxidant activities of six flavonoids with similar structures","volume":"9","author":"Zeng","year":"2020","journal-title":"Antioxidants"},{"key":"B224","first-page":"29","article-title":"Mitochondria in oocyte aging: current understanding","volume":"9","author":"Zhang","year":"2017","journal-title":"Facts Views Vis. Obgyn"},{"key":"B225","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2015.05.036","article-title":"Oxidative stress response and Nrf2 signaling in aging","volume":"88","author":"Zhang","year":"2015","journal-title":"Free Radic. Biol. Med"},{"key":"B226","doi-asserted-by":"publisher","first-page":"6147345","DOI":"10.1155\/2016\/6147345","article-title":"Critical role of FoxO1 in granulosa cell apoptosis caused by oxidative stress and protective effects of grape seed procyanidin B2","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell Longev"},{"key":"B227","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.4238\/2015.March.30.6","article-title":"Protective effect of proanthocyanidin against oxidative ovarian damage induced by 3-nitropropionic acid in mice","volume":"14","author":"Zhang","year":"2015","journal-title":"Genet. Mol. Res"},{"key":"B228","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/sj.cr.7310095","article-title":"Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles","volume":"16","author":"Zhang","year":"2006","journal-title":"Cell Res"},{"key":"B229","doi-asserted-by":"publisher","first-page":"2876350","DOI":"10.1155\/2018\/2876350","article-title":"Activating the PGC-1\u03b1\/TERT pathway by catalpol ameliorates atherosclerosis via modulating ROS production, DNA damage, and telomere function: implications on mitochondria and telomere link","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxid. Med. Cell Longev"},{"key":"B230","doi-asserted-by":"publisher","first-page":"5058609","DOI":"10.1155\/2017\/5058609","article-title":"Neuroprotection of catalpol for experimental acute focal ischemic stroke: preclinical evidence and possible mechanisms of antioxidation, anti-inflammation, and antiapoptosis","volume":"2017","author":"Zheng","year":"2017","journal-title":"Oxid. Med. Cell Longev"},{"key":"B231","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.fitote.2010.06.018","article-title":"Effects of genistein on ovarian follicular development and ovarian life span in rats","volume":"81","author":"Zhuang","year":"2010","journal-title":"Fitoterapia"},{"key":"B232","doi-asserted-by":"publisher","first-page":"4472","DOI":"10.3390\/ijms20184472","article-title":"Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments","volume":"20","author":"Zuo","year":"2019","journal-title":"Int. J. Mol. Sci"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2020.617843\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T16:42:10Z","timestamp":1611592930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2020.617843\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":232,"alternative-id":["10.3389\/fphar.2020.617843"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.617843","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"article-number":"617843"}}