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Although there is as yet no effective antiviral agent, like tamiflu against influenza, to block SARS-CoV-2 infection to its host cells, various candidates to mitigate or treat the disease are currently being investigated. Several drugs are being screened for the ability to block virus entry on cell surfaces and\/or block intracellular replication in host cells. Vaccine development is being pursued, invoking a better elucidation of the life cycle of the virus. SARS-CoV-2 recognizes O-acetylated neuraminic acids and also several membrane proteins, such as ACE2, as the result of evolutionary switches of O-Ac SA recognition specificities. To provide information related to the current development of possible anti\u2013SARS-COV-2 viral agents, the current review deals with the known inhibitory compounds with low molecular weight. The molecules are mainly derived from natural products of plant sources by screening or chemical synthesis via molecular simulations. Artificial intelligence\u2013based computational simulation for drug designation and large-scale inhibitor screening have recently been performed. Structure\u2013activity relationship of the anti\u2013SARS-CoV-2 natural compounds is discussed.<\/jats:p>","DOI":"10.3389\/fphar.2021.590509","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T13:00:45Z","timestamp":1622206845000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["Anti\u2013SARS-CoV-2 Natural Products as Potentially Therapeutic Agents"],"prefix":"10.3389","volume":"12","author":[{"given":"Cheorl-Ho","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8017","DOI":"10.1128\/jvi.00998-13","article-title":"Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry that Act by Three Distinct Mechanisms","volume":"87","author":"Adedeji","year":"2013","journal-title":"J. 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