{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:55:08Z","timestamp":1790949308998,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa Do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/12671-5 2018\/04157-5"],"award-info":[{"award-number":["2016\/12671-5 2018\/04157-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> To analyze the pain modulation capacity profile in a Brazilian population, the relationship between opioid receptor (<jats:italic>OPRM1<\/jats:italic>) and Catechol-O-methyltransferase (<jats:italic>COMT<\/jats:italic>) 1polymorphisms and pain modulation capacity was determined through preoperative pain modulation tests and acute postoperative pain control evaluation, swelling, and trismus in 200 volunteers undergoing lower third molar removal.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Psychologic and clinical parameters were measured. Patient DNA was sequenced for single nucleotide polymorphisms in <jats:italic>OPRM1<\/jats:italic> and <jats:italic>COMT<\/jats:italic>, and the salivary concentration of interleukin (IL)-2 (IL)-6, interferon (IFN)-\u03b3 and tumor necrosis factor (TNF)-\u03b1 was evaluated. Primary outcomes were the influence of all predictors on the fluctuation of pain intensity using a visual analogue scale (VAS), and swelling and trismus on the 2nd and 7th postoperative days. Preoperative pain modulation capacity (CPM), pain catastrophizing scale (PCS), body mass index (BMI), and surgery duration and difficulty were evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Salivary concentration of IFN-\u03b3 and IL-2 as well as the duration of surgery influenced the fluctuation of postoperative pain in the VAS, and in the sum of the differences in pain intensity test at 8, 48, and 96\u00a0h. BMI influenced swelling, while both BMI and <jats:italic>COMT<\/jats:italic> haplotype influenced trismus on the 2nd postoperative day.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Polymorphisms in <jats:italic>COMT<\/jats:italic>, salivary concentrations of IL-2 and IFN-\u03b3, BMI, and duration of surgery were predictors for pain fluctuation, swelling, and trismus on the 2nd day after lower third molar extraction. This therapy was effective in controlling inflammatory symptomatology after lower third molar extraction and ibuprofen was well tolerated by patients.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration:<\/jats:bold><jats:ext-link>www.ClinicalTrials.gov<\/jats:ext-link>, identifier NCT03169127.<\/jats:p>","DOI":"10.3389\/fphar.2021.643874","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T20:19:25Z","timestamp":1618517965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Multifocal Analysis of Acute Pain After Third Molar Removal"],"prefix":"10.3389","volume":"12","author":[{"given":"Giovana Maria","family":"Weckwerth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Jos\u00e9","family":"Dion\u00edsio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri Martins","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Zupelari-Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Moraes","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elza Ara\u00fajo","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Rigoldi","family":"Bonjardim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio Augusto Cardoso","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Maria","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin Michael","family":"Absher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Ferreira","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e149","DOI":"10.4317\/medoral.19518","article-title":"Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study","volume":"19","author":"Akbulut","year":"2014","journal-title":"Med. 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