{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:21:06Z","timestamp":1767651666573,"version":"3.41.2"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673829"],"award-info":[{"award-number":["81673829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Given the wide utilization of Chinese herbal injections in the treatment of nasopharyngeal carcinoma (NPC), this network meta-analysis (NMA) was devised to compare the clinical efficacy and safety of different Chinese herbal injections combined with concurrent chemoradiotherapy (CCRT) against NPC.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Randomized controlled trials (RCTs) were retrieved from seven electronic databases from the date of database establishment to October 5, 2020. Study selection and data extraction conformed to a priori criteria. Focusing on clinical effective rate, performance status, grade \u22653 oral mucositis, nausea and vomiting, leukopenia, and thrombopenia, this NMA was performed with Review Manager 5.3.5, Stata 13.1, WinBUGS 1.4.3, and R 4.0.3 software.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Ten inventions from 37 RCTs involving 2,581 participants with NPC that evaluated the clinical effective rate, nausea and vomiting, leukopenia, thrombopenia, and grade \u22653 oral mucositis were included. Compared with CCRT alone, Elemene injection and Compound Kushen injection were associated with significantly improved clinical effective rates, and Elemene injection plus CCRT had the highest probability in terms of clinical effective rate (78.07%) compared with the other interventions. Shenqifuzheng injection, Xiaoaiping injection, and Shenmai injection ranked the best in terms of performance status (79.02%), nausea and vomiting (86.35%), and grade \u22653 oral mucositis (78.14%) when combined with CCRT. Kangai injection combined with CCRT ranked ahead of the other injections in terms of leukopenia (90.80%) and thrombopenia (91.04%), and had a better impact on improving performance status and reducing leukopenia, thrombopenia, grade \u22653 oral mucositis, and nausea and vomiting in the multidimensional cluster analysis.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Current clinical evidence indicates that Elemene injection combined with CCRT has the best clinical effective rate and that Kangai injection might have a comprehensively better impact on improving performance status and reducing adverse reactions against NPC. Additionally, due to the limitations of this NMA, more multicenter, high-quality, and head-to-head RCTs are needed to properly support our findings.<\/jats:p>","DOI":"10.3389\/fphar.2021.656724","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T09:00:47Z","timestamp":1623402047000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigation on the Efficiency of Chinese Herbal Injections combined with Concurrent Chemoradiotherapy for Treating Nasopharyngeal Carcinoma based on Multidimensional Bayesian Network Meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhishan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/170396","article-title":"Complementary and Alternative Medicine for Cancer Pain: an Overview of Systematic Reviews","volume":"2014","author":"Bao","year":"2014","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S1470-2045(15)70126-9","article-title":"Chemotherapy and Radiotherapy in Nasopharyngeal Carcinoma: an Update of the MAC-NPC Meta-Analysis","volume":"16","author":"Blanchard","year":"2015","journal-title":"Lancet Oncol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA: A Cancer J. Clinicians"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical Tools for Network Meta-Analysis in STATA","volume":"8","author":"Chaimani","year":"2013","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1158\/1055-9965.Epi-06-0353","article-title":"The Enigmatic Epidemiology of Nasopharyngeal Carcinoma","volume":"15","author":"Chang","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/978-94-007-1983-5_13","article-title":"Clinical Observation of Simultaneous Intensity Modulated Radiotherapy and Chemotherapy Combined with Shengmai Injection for Nasopharyngeal Carcinoma","volume":"32","author":"Chen","year":"2017","journal-title":"Pract. J. Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal Carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"The Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"114","DOI":"10.18637\/jss.v032.i11","article-title":"Bayesian Functional Data Analysis Using WinBUGS","volume":"32","author":"Crainiceanu","year":"2010","journal-title":"J. Stat. Softw."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.phyplu.2021.100031","article-title":"Clinical Study on Treatment of Fufangkushen Combined with Concurrent Chemoradiotherapy in Advanced Nasopharyngeal Cancer","volume":"7","author":"Cui","year":"2010","journal-title":"Med. Innov. China"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.3760\/cma.j.issn.1006-9801.2013.08.012","article-title":"Clinical Observation of Kangai Injection Combined with Synchronous Chemoradiotherapy in the Treatment of Locally Advanced Nasopharyngeal Carcinoma","volume":"5","author":"Dai","year":"2010","journal-title":"Med. Inf."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1155\/2017\/7102514","article-title":"Clinical Observation of Compound Kushen Injection Combined with Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Nasopharyngeal Carcinoma","volume":"40","author":"Fei","year":"2012","journal-title":"Tian Med. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"B13","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/annonc\/mdx770","article-title":"A Randomized Trial of Induction Docetaxel-Cisplatin-5fu Followed by Concomitant Cisplatin-RT versus Concomitant Cisplatin-RT in Nasopharyngeal Carcinoma (GORTEC 2006-02)","volume":"29","author":"Frikha","year":"2018","journal-title":"Ann. Oncol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3760\/cma.j.issn.1673-422X.2013.07.023","article-title":"Effect of Aidi Injection on Adverse Reactions of Radiotherapy and Chemotherapy in Patients with Nasopharyngeal Carcinoma","volume":"20","author":"Fu","year":"2010","journal-title":"Zhejiang J. Integr. Tradit. Chin. West. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3760\/cma.j.issn.0253-3766.2018.08.002","article-title":"Incidence and Mortality of Nasopharyngeal Carcinoma in China, 2014","volume":"40","author":"Fu","year":"2018","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"B16","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's Tool for Assessing Risk of Bias in Randomised Trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1186\/s40880-019-0415-3","article-title":"Radiotherapy Combined with AiDi for Nasopharynx Cancer and the Prognostic Factor","volume":"19","author":"Hu","year":"2013","journal-title":"Int. Med. Health Guid. News"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1016\/j.biopha.2020.109947","article-title":"Preliminary Study on the Toxin-Reducing and Effect-Increasing of Kanglaite Injection Combined with Concurrent Chemoradiotherapy to Locally Advanced Nasopharyngeal Carcinoma","volume":"32","author":"Hua","year":"2011","journal-title":"J. Qiqihar Med. Univ."},{"key":"B19","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/m14-2385","article-title":"The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-Analyses of Health Care Interventions: Checklist and Explanations","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1142\/9789812709301_0001","article-title":"Clinical Efficacy of Compound Sophorae Injection Combined with Synchronous Chemotherapy and Radiotherapy on Patients with Locally Advanced Nasopharyngeal Carcinoma and its Influence on Immune Function","volume":"27","author":"Jin","year":"","journal-title":"Hainan Med. J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.3969\/j.issn.1672-4992.2016.12.010","article-title":"Curative Effect of Compound Sophorae Injection in the Treatment of Acute Oral Mucosa Injury with Locally Advanced Nasopharyngeal Carcinoma Caused by Synchronous Chemotherapy and Radiotherapy","volume":"24","author":"Jin","year":"","journal-title":"J. Mod. Oncol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3969\/j.issn.1673-5269.2004.04.020","article-title":"Observation on Efficacy of Aidi Injection Combined with Radiotherapy Plus Chemotherapy in Advanced Nasopharyngeal Carcinoma","volume":"11","author":"Li","year":"2004","journal-title":"Chin. J. Cancer Prev. Treat."},{"key":"B23","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12885-018-4210-3","article-title":"Clinical Research of Kangai Injection Combined with Concurrent Chemoradiotherapy in the Treatment of 70 Cases of Locally Advanced Nasopharyngeal Carcinoma","volume":"21","author":"Liu","year":"2013","journal-title":"China Med. Eng."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3722","DOI":"10.1016\/s0254-6272(16)30002-4","article-title":"Preventive Effect of Compound Kushen Injection on Radiochemotherapy-Induced Adverse Reaction in Patients with Advanced Nasopharyngeal Cancer","volume":"37","author":"Liu","year":"","journal-title":"Hebei Med. J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1063\/1.5110855","article-title":"Preventive Effect of Shenqi Fuzheng Injection on Radiochemotherapy-Induced Adverse Reaction in Patients with Advanced Nasopharyngeal Cancer","volume":"47","author":"Liu","year":"","journal-title":"J. New Chin. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"9701","DOI":"10.3892\/mmr.2017.7822","article-title":"Oxymatrine Induces Nasopharyngeal Cancer Cell Death through Inhibition of PI3K\/AKT and NF-\u039ab Pathways","volume":"16","author":"Ni","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"873","DOI":"10.6004\/jnccn.2020.0031","article-title":"Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology","volume":"18","author":"Pfister","year":"2020","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"B28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3969\/j.issn.1005-0019.2019.10.110","article-title":"Effect of Addie Injection Combined with Chemoradiotherapy in the Treatment of Advanced Nasopharyngeal Carcinoma","volume":"12","author":"Shi","year":"2019","journal-title":"China Health Vis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/s0254-6272(16)30002-4","article-title":"Compound Kushen Injection Combined with Concurrent Radiochemotherapy for Patients with Locally Advanced Nasopharyngeal Carcinoma","volume":"6","author":"Song","year":"2014","journal-title":"Chin. J. Surg. Oncol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4158","DOI":"10.3892\/mmr.2015.3276","article-title":"Matrine Inhibits the Migratory and Invasive Properties of Nasopharyngeal Carcinoma Cells","volume":"11","author":"Sun","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3969\/j.issn.1674-4152.2005.04.019","article-title":"Clinical Analysis of the Curative Effects of Radioactivity-Chemotherapy Combined with Shenqifuzheng Injection for Nasopharyngeal Carcinoma","volume":"3","author":"Sun","year":"2005","journal-title":"Appl. J. Gen. Pract."},{"key":"B32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.31525\/ct1-nct04084158","article-title":"Clinical Research on Elemene Combined with Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma","volume":"46","author":"Tian","year":"2017","journal-title":"J. Med. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/1471-2288-12-150","article-title":"Adjustment for Reporting Bias in Network Meta-Analysis of Antidepressant Trials","volume":"12","author":"Trinquart","year":"2012","journal-title":"BMC. Med. Res. Methodol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"666","DOI":"10.7326\/m15-2521","article-title":"Uncertainty in Treatment Rankings: Reanalysis of Network Meta-Analyses of Randomized Trials","volume":"164","author":"Trinquart","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e007103","DOI":"10.1136\/bmjopen-2014-007103","article-title":"Methods and Characteristics of Published Network Meta-Analyses Using Individual Patient Data: Protocol for a Scoping Review","volume":"5","author":"Veroniki","year":"2015","journal-title":"BMJ Open"},{"key":"B36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.5353\/th_b4129067","article-title":"Effect of Compound Kushen Injection Combined with Concurrent Chemoradiotherapy in the Treatment of Advanced Nasopharyngeal Carcinoma","volume":"2","author":"Wang","year":"2015","journal-title":"Diet. Health"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.32388\/3q1frb","article-title":"Effect of Composite Matrine Injection on cyclinB2 in Blood of Patients with Advanced Nasopharyngeal Squamous Cell Carcinoma","volume":"20","author":"Wang","year":"2011","journal-title":"Chin. J. New Drugs"},{"key":"B38","doi-asserted-by":"publisher","first-page":"549","DOI":"10.32388\/9a7mtk","article-title":"Curative Effect Observation of Disodium Aidi Injection to Improve the Cancer-Related Fatigue in Nasopharyngeal Carcinoma Patients of \u2162-IVB Stage Undergoing Radiotherapy and Chemotherapy","volume":"40","author":"Wang","year":"2013","journal-title":"J. Int. Oncol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/aps.2015.24","article-title":"Anti-tumor Activities of Active Ingredients in Compound Kushen Injection","volume":"36","author":"Wang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8407683","article-title":"Ginsenoside Rg3 Inhibits Migration and Invasion of Nasopharyngeal Carcinoma Cells and Suppresses Epithelial Mesenchymal Transition","volume":"2019","author":"Wang","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"B41","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3760\/cma.j.issn.0253-3766.2011.05.020","article-title":"Efficacy of Yanshu Injection (A Compound Chinese Traditional Medicine) Combined with Concurrent Radiochemotherapy in Patients with Stage III Nasopharyngeal Carcinoma","volume":"33","author":"Wei","year":"2011","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"B42","doi-asserted-by":"publisher","first-page":"87","DOI":"10.5353\/th_b4129067","article-title":"Effect of Compound Kushen Injection Combined with Concurrent Chemoradiotherapy in the Treatment of Local Advanced Nasopharyngeal Carcinoma","volume":"3","author":"Wei","year":"2015","journal-title":"Cardiovasc. Dis. J. Integr. Tradit. Chin. West. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijrobp.2005.03.057","article-title":"Intensity-modulated Radiation Therapy (IMRT) for Nasopharynx Cancer: Update of the Memorial Sloan-Kettering Experience","volume":"64","author":"Wolden","year":"2006","journal-title":"Int. J. Radiat. Oncology*Biology*Physics"},{"key":"B44","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4268\/cjcmm20130934","article-title":"The Effect Observation of Elemene Injection Combined with Chemoradiotherapy on Serum VEGF and COX-2 in Patients with Nasopharyngeal Cancer","volume":"11","author":"Wu","year":"2018","journal-title":"Chin. J. Clin. Ration. Drug Use"},{"key":"B45","doi-asserted-by":"publisher","first-page":"38283","DOI":"10.18632\/oncotarget.5711","article-title":"Traditional Chinese Patent Medicines for Cancer Treatment in China: a Nationwide Medical Insurance Data Analysis","volume":"6","author":"Wu","year":"2015","journal-title":"Oncotarget"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e0154501","DOI":"10.1371\/journal.pone.0154501","article-title":"Tumor Regression and Patterns of Distant Metastasis of T1-T2 Nasopharyngeal Carcinoma with Intensity-Modulated Radiotherapy","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41598-017-00626-6","article-title":"Interplay of DNA Methyltransferase 1 and EZH2 through Inactivation of Stat3 Contributes to \u03b2-elemene-inhibited Growth of Nasopharyngeal Carcinoma Cells","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1002\/cam4.2108","article-title":"Traditional Chinese Medicine as a Cancer Treatment: Modern Perspectives of Ancient but Advanced Science","volume":"8","author":"Xiang","year":"2019","journal-title":"Cancer Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1002\/cncr.25754","article-title":"Local Control, Survival, and Late Toxicities of Locally Advanced Nasopharyngeal Carcinoma Treated by Simultaneous Modulated Accelerated Radiotherapy Combined with Cisplatin Concurrent Chemotherapy","volume":"117","author":"Xiao","year":"2011","journal-title":"Cancer"},{"key":"B50","first-page":"22","article-title":"Clinical Observation of Aidi Injection Combined with Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma","author":"Xiao","year":"2012"},{"key":"B51","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3969\/j.issn.1674-4985.2014.28.018","article-title":"Clinical Observation of Xiaoaiping Combined with Radiation and Chemotherapy in Treatment of Nasopharyngeal Carcinoma (NPC)","volume":"14","author":"Xiao","year":"2014","journal-title":"Med. Innov. China"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.4268\/cjcmm20162405","article-title":"Clinical Analysis of Concurrent Chemoradiotherapy Combined with Shenqi Fuzheng Injection in the Treatment of 30 Cases of Locally Advanced Nasopharyngeal Carcinoma","volume":"39","author":"Xie","year":"2010","journal-title":"Chongqing Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12885-018-4210-3","article-title":"Effect of Compound Kushen Injection Combined with Concurrent Chemoradiotherapy on Locally Advanced Nasopharyngeal Carcinoma","volume":"19","author":"Xie","year":"2012","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/14651858.cd010667.pub2","article-title":"Effects of Compound Kushen Injection Assisted Concurrent Chemoradiotherapy on Levels of Matrix Metalloproteinase-2, Bone Alkaline Phosphatase and Vascular Endothelial Growth Factor in Peripheral Blood of Patients with Locally Advanced Nasopharyngeal Carcinoma","volume":"19","author":"Xu","year":"2019","journal-title":"Eval. Anal. Drug-use Hosp. China"},{"key":"B55","doi-asserted-by":"publisher","first-page":"8114","DOI":"10.4268\/cjcmm20162405","article-title":"Application of Shenqi Fuzheng Combined with Chemoradiotherapy in the Treatment of Nasopharyngeal Carcinoma","volume":"10","author":"Yan","year":"2010","journal-title":"Chin. J. Misdiagn."},{"key":"B56","doi-asserted-by":"publisher","first-page":"663","DOI":"10.4268\/cjcmm20151829","article-title":"Effectiveness and Safety of Chinese Medical Injections in Combination with Radiotherapy for Esophageal Carcinoma: a Network Meta Analysis","volume":"23","author":"Yang","year":"2016","journal-title":"Pract. Prev. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.21203\/rs.3.rs-21288\/v1","article-title":"Analysis of Short-Term Efficacy of Simultaneous Intensity Modulated Radiotherapy and Chemotherapy Combined with Shengmai Injection for Nasopharyngeal Carcinoma","volume":"51","author":"Yang","year":"2019","journal-title":"Inner Mongolia Med. J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"34","DOI":"10.7287\/peerj.3912v0.1\/reviews\/1","article-title":"Toxin-reducing Effect of Shenmai Injection in Chemoradiotherapy of Nasopharyngeal Carcinoma","volume":"40","author":"Yao","year":"2009","journal-title":"Jiangxi J. Tradit. Chin. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/s0254-6272(09)60062-5","article-title":"Clinical Experience and Research Progress of Traditional Chinese Medicine Treatment for Nasopharyngeal Carcinoma","volume":"1","author":"Zhang","year":"2019","journal-title":"J. Oncol. Chin. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"39","DOI":"10.5353\/th_b4129067","article-title":"Effect of Shenqi Fuzheng Injection on Tolerance of Concurrent Chemoradiotherapy in Nasopharyngeal Carcinoma","volume":"40","author":"Zhang","year":"2009","journal-title":"Jiangxi J. Tradit. Chin. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4268\/cjcmm20162405","article-title":"Clinical Observation of Shenqi Fuzheng Injection Combined with Chemoradiotherapy in the Treatment of Advanced Nasopharyngeal Carcinoma","volume":"35","author":"Zhang","year":"2014","journal-title":"J. Qiqihar Med. Univ."},{"key":"B62","doi-asserted-by":"publisher","first-page":"68873","DOI":"10.18632\/oncotarget.20320","article-title":"Comparative Efficacy and Safety of Chinese Herbal Injections Combined with the FOLFOX Regimen for Treating Gastric Cancer in China: a Network Meta-Analysis","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.31525\/ct1-nct03930498","article-title":"Application of Elemene Injection Combined with Chemoradiotherapy in Nasopharyngeal Carcinoma","volume":"31","author":"Zhang","year":"2020","journal-title":"Mod. Diagn. Treat."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1016\/s1053-4296(98)80022-2","article-title":"Elemene Injection Combined with Chemotherapy and Radiotherapy in Patients with Nasopharyngeal Carcinoma and its Effect on Serum VEGF and Nm23h1","volume":"32","author":"Zheng","year":"2014","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3969\/j.issn.1009-0460.2009.11.017","article-title":"Clinical Observation of Xiaoaiping Combined with Concurrent Chemoradiotherapy in Advanced Nasopharyngeal Cancer","volume":"14","author":"Zhou","year":"2009","journal-title":"Chin. Clin. Oncol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/s1053-4296(98)80022-2","article-title":"Curative Effect Analysis of Xiaoaiping Combined with Radiation and Chemotherapy in Treatment of Nasopharyngeal Carcinoma","volume":"18","author":"Zhou","year":"2015","journal-title":"J. Changsha Med. Univ."},{"key":"B67","doi-asserted-by":"publisher","first-page":"462","DOI":"10.12659\/msm.903170","article-title":"Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax\/Bcl-2 Ratio and Caspases","volume":"23","author":"Zhou","year":"2017","journal-title":"Med. Sci. Monit."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.656724\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T09:00:54Z","timestamp":1623402054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.656724\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":67,"alternative-id":["10.3389\/fphar.2021.656724"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.656724","relation":{},"ISSN":["1663-9812"],"issn-type":[{"type":"electronic","value":"1663-9812"}],"subject":[],"published":{"date-parts":[[2021,6,11]]},"article-number":"656724"}}