{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:13:49Z","timestamp":1788581629331,"version":"build-2803163510"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    -dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson\u2019s disease, Alzheimer\u2019s disease, and Huntington\u2019s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2021.657033","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T02:52:08Z","timestamp":1622775128000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":65,"title":["Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases"],"prefix":"10.3389","volume":"12","author":[{"given":"Qingyun","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.1038\/s41598-018-23408-0","article-title":"Modeling the Effects of Lipid Peroxidation during Ferroptosis on Membrane Properties","volume":"8","author":"Agmon","year":"2018","journal-title":"Sci. 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