{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:31:10Z","timestamp":1786422670187,"version":"build-2736575974"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold><jats:italic>Triphala<\/jats:italic> is a traditional polyherbal formula used in Indian Ayurvedic and Chinese Tibetan medicine. A wide range of biological activities have been attributed to <jats:italic>Triphala<\/jats:italic>, but the impact of various extraction methods on efficacy has not been determined.<\/jats:p><jats:p><jats:bold>Purpose:<\/jats:bold> The study aimed to evaluate <jats:italic>Triphala<\/jats:italic> extracts obtained by various methods for their hepatoprotective effects and molecular mechanisms in a mouse model of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)-induced liver injury.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> HPLC fingerprinting was used to characterize the chemical characteristics of <jats:italic>Triphala<\/jats:italic> extracts obtained by (a) 0.5\u00a0h ultrasonication, (b) 2\u00a0h reflux, and (c) 4\u00a0h reflux. Hepatoprotective efficacy was evaluated in a mouse model of CCl<jats:sub>4<\/jats:sub>-induced liver damage. Serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) were measured, as well as the liver antioxidant and inflammatory markers malondialdehyde superoxide dismutase glutathione peroxidase (GSH-Px), TNF-\u03b1, and IL-6. Gene and protein expression of Nrf-2 signaling components Nrf-2, heme oxygenase (HO-1), and NADPH Quinone oxidoreductase (NQO-1) in liver tissue were evaluated by real-time PCR and western blotting.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Chemical analysis showed a clear difference in content between extracts produced by ultrasonic and reflux methods. The pharmacological analysis showed that all three Triphala extracts reduced ALT, AST, MDA, TNF-\u03b1, and IL-6 levels and increased SOD and GSH-Px. Triphala extracts also induced transcript and protein expression of Nrf-2, HO-1, and NQO-1.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Triphala extract prevents CCl<jats:sub>4<\/jats:sub>-induced acute liver injury. The ultrasonic extract of Triphala was most effective, suggesting that hepatoprotection may be related to the larger tannins via activation of Nrf-2 signaling.<\/jats:p>","DOI":"10.3389\/fphar.2021.664607","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T08:51:15Z","timestamp":1625475075000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Hepatoprotective Effects of Different Extracts From Triphala Against CCl4-Induced Acute Liver Injury in Mice"],"prefix":"10.3389","volume":"12","author":[{"given":"Xichuan","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanhu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingkun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"B1","first-page":"454","article-title":"Evaluation of the Effects of the Hydroalcoholic Extract of Terminalia Chebula Fruits on Diazinon-Induced Liver Toxicity and Oxidative Stress in Rats","volume":"7","author":"Ahmadi-Naji","year":"2017","journal-title":"Avicenna J. Phytomed"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.31557\/apjcp.2018.19.11.3137","article-title":"Improving Anti-cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation","volume":"19","author":"Ahmed","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1055\/s-0032-1328089","article-title":"Simultaneous Determination and Characterization of Tannins and Triterpene Saponins from the Fruits of Various Species of Terminalia and Phyllantus Emblica Using a UHPLC-UV-MS Method: Application to Triphala","volume":"79","author":"Avula","year":"2013","journal-title":"Planta Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1007\/s11655-012-1299-x","article-title":"Scientific Validation of the Ethnomedicinal Properties of the Ayurvedic Drug Triphala: a Review","volume":"18","author":"Baliga","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2478\/v10001-010-0009-4","article-title":"Ameliorative Effect of Emblica Officinalis Aqueous Extract on Ochratoxin-Induced Lipid Peroxidation in the Kidney and Liver of Mice","volume":"23","author":"Chakraborty","year":"2010","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3876040","article-title":"Antioxidants ofPhyllanthus emblicaL. Bark Extract Provide Hepatoprotection against Ethanol-Induced Hepatic Damage: A Comparison with Silymarin","volume":"2017","author":"Chaphalkar","year":"2017","journal-title":"Oxidative Med. Cell Longevity"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5176090","article-title":"Active Constituent in the Ethyl Acetate Extract Fraction of Terminalia Bellirica Fruit Exhibits Antioxidation, Antifibrosis, and Proapoptosis Capabilities In Vitro","volume":"2019","author":"Chen","year":"2019","journal-title":"Oxidative Med. Cell Longevity"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/517350","article-title":"Hepatoprotective Effect ofTerminalia Chebulaagainstt-BHP-Induced Acute Liver Injury in C57\/BL6 Mice","volume":"2015","author":"Choi","year":"2015","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.2174\/1389557518666180330114010","article-title":"Probing Gallic Acid for its Broad Spectrum Applications","volume":"18","author":"Choubey","year":"2018","journal-title":"Mini Rev Med Chem."},{"key":"B10","first-page":"555","article-title":"Chemopreventive Potential of Triphala (A Composite Indian Drug) on Benzo(a)pyrene Induced Forestomach Tumorigenesis in Murine Tumor Model System","volume":"24","author":"Deep","year":"2005","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/978-3-319-41334-1_20","article-title":"Ellagic Acid and its Role in Chronic Diseases","volume":"928","author":"Derosa","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.2174\/092986711803414368","article-title":"Antioxidant Therapy: Current Status and Future Prospects","volume":"18","author":"Firuzi","year":"2011","journal-title":"Curr Med Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7824684","article-title":"Epicatechin Gallate Protects HBMVECs from Ischemia\/Reperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization","volume":"2019","author":"Fu","year":"2019","journal-title":"Oxidative Med. Cell Longevity"},{"key":"B14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.4103\/0974-8520.169000","article-title":"Experimental Studies on Glycolytic Enzyme Inhibitory and Antiglycation Potential of Triphala","volume":"36","author":"Ganeshpurkar","year":"2015","journal-title":"Ayu"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4916","article-title":"Simultaneous Determination of Gallic Acid, Methyl Gallate, and 1,3,6\u2010tri\u2010 O \u2010galloyl\u2010 \u03b2 \u2010 D \u2010glucose from Turkish Galls in Rat Plasma Using Liquid Chromatography\u2010tandem Mass Spectrometry and its Application to Pharmacokinetics Study","volume":"34","author":"Gong","year":"2020","journal-title":"Biomed. Chromatogr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1017\/s1462399411002110","article-title":"Molecular Mechanisms Underlying Chemical Liver Injury","volume":"14","author":"Gu","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"key":"B17","first-page":"38","article-title":"Triphala and its Constituents Ameliorate Visceral Adiposity from a High-Fat Diet in Mice with Diet-Induced Obesity","volume":"18","author":"Gurjar","year":"2012","journal-title":"Altern. Ther. Health Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.fct.2012.02.020","article-title":"Ellagic Acid Protects Human Keratinocyte (HaCaT) Cells against UVA-Induced Oxidative Stress and Apoptosis through the Upregulation of the HO-1 and Nrf-2 Antioxidant Genes","volume":"50","author":"Hseu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1039\/c6fo01585a","article-title":"The Hepatoprotective Effect of Phyllanthus Emblica L. Fruit on High Fat Diet-Induced Non-alcoholic Fatty Liver Disease (NAFLD) in SD Rats","volume":"8","author":"Huang","year":"2017","journal-title":"Food Funct."},{"key":"B20","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jpba.2018.06.008","article-title":"Study on the Stability Control Strategy of Triphala Solution Based on the Balance of Physical Stability and Chemical Stabilities","volume":"158","author":"Huang","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"B21","first-page":"581","article-title":"Tannin Transformation during the Reflux Process of Phyllanthus Emblica L. And Discussion of the Content Determination Method in Chinese Pharmacopoeia","volume":"54","author":"Huang","year":"2019","journal-title":"Chin. Pharm. J."},{"key":"B22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jep.2006.07.033","article-title":"Protective Effect of Terminalia Belerica Roxb. And Gallic Acid against Carbon Tetrachloride Induced Damage in Albino Rats","volume":"109","author":"Jadon","year":"2007","journal-title":"J. Ethnopharmacology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jep.2016.06.052","article-title":"Botanical Drugs in Ayurveda and Traditional Chinese Medicine","volume":"194","author":"Jaiswal","year":"2016","journal-title":"J. Ethnopharmacology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.yrtph.2017.04.002","article-title":"In vivo toxicity Evaluation of Aqueous Acetone Extract of Terminalia Bellirica (Gaertn.) Roxb. Fruit","volume":"86","author":"Jayesh","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12291-017-0732-8","article-title":"Protective Role of Terminalia Bellirica (Gaertn.) Roxb Fruits against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model","volume":"34","author":"Jayesh","year":"2019","journal-title":"Ind. J. Clin. Biochem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/2008-2231-20-33","article-title":"Efficacy of 'Itrifal Saghir', a Combination of Three Medicinal Plants in the Treatment of Obesity; A Randomized Controlled Trial","volume":"20","author":"Kamali","year":"2012","journal-title":"DARU J. Pharm. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.biopha.2017.06.080","article-title":"Terminalia Bellirica (Gaertn.) Roxb. Fruit Mitigates CCl4 Induced Oxidative Stress and Hepatotoxicity in Rats","volume":"93","author":"Kuriakose","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B28","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.etap.2015.05.009","article-title":"Effects of N-Butylphthalide on the Activation of Keap1\/Nrf-2 Signal Pathway in Rats after Carbon Monoxide Poisoning","volume":"40","author":"Li","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fphar.2018.00029","article-title":"Natural Medicines Used in the Traditional Tibetan Medical System for the Treatment of Liver Diseases","volume":"9","author":"Li","year":"","journal-title":"Front. Pharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.biopha.2018.01.030","article-title":"Corilagin, a Promising Medicinal Herbal Agent","volume":"99","author":"Li","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e43934","DOI":"10.1371\/journal.pone.0043934","article-title":"Triphala and its Active Constituent Chebulinic Acid Are Natural Inhibitors of Vascular Endothelial Growth Factor-A Mediated Angiogenesis","volume":"7","author":"Lu","year":"2012","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e4425","DOI":"10.1002\/bmc.4425","article-title":"A Liquid Chromatography-Tandem Mass Spectrometry Method for Preclinical Pharmacokinetics and Tissue Distribution of Hydrolyzable Tannins Chebulinic Acid and Chebulagic Acid in Rats","volume":"33","author":"Lu","year":"2019","journal-title":"Biomed. Chromatogr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"104409","DOI":"10.1016\/j.phrs.2019.104409","article-title":"Natural Medicines for the Treatment of Fatigue: Bioactive Components, Pharmacology, and Mechanisms","volume":"148","author":"Luo","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/cbf.1581","article-title":"Effect ofTerminalia Chebulaaqueous Extract on Oxidative Stress and Antioxidant Status in the Liver and Kidney of Young and Aged Rats","volume":"27","author":"Mahesh","year":"2009","journal-title":"Cell Biochem. Funct."},{"key":"B35","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1142\/S0192415X06004004","article-title":"Hepatoprotective Effect of Phyllanthus in Taiwan on Acute Liver Damage Induced by Carbon Tetrachloride","volume":"34","author":"M.S.","year":"2006","journal-title":"Am. J. Chin. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/j.sjbs.2018.02.013","article-title":"Development of Response Surface Methodology for Optimization of Parameters and Quantitative Analysis of Chebulinic Acid from Composition of Medicinal Herbs by HPLC","volume":"26","author":"Munawar","year":"2019","journal-title":"Saudi J. Biol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.1016\/j.fct.2010.08.019","article-title":"Mushroom Insoluble Polysaccharides Prevent Carbon Tetrachloride-Induced Hepatotoxicity in Rat","volume":"48","author":"Nada","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejphar.2018.12.036","article-title":"Anti-inflammatory Effects of New Catechin Derivatives in a Hapten-Induced Mouse Contact Dermatitis Model","volume":"845","author":"Nakano","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"682","DOI":"10.4103\/0250-474x.100252","article-title":"Comparison of Gastroprotective Effects of Triphala Formulations on Stress-Induced Ulcer in Rats","volume":"73","author":"Nariya","year":"2011","journal-title":"Indian J. Pharm. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1002\/ptr.6702","article-title":"Fruits of Terminalia Chebula Retz.: A Review on Traditional Uses, Bioactive Chemical Constituents and Pharmacological Activities","volume":"34","author":"Nigam","year":"2020","journal-title":"Phytotherapy Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"8456","DOI":"10.3390\/nu7105406","article-title":"In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: A Case of Padma Hepaten Formulation","volume":"7","author":"Olennikov","year":"2015","journal-title":"Nutrients"},{"key":"B42","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ptr.2356","article-title":"Protective Effect ofTinospora Cordifolia, Phyllanthus Emblica and Their Combination against Antitubercular Drugs Induced Hepatic Damage: an Experimental Study","volume":"22","author":"Panchabhai","year":"2008","journal-title":"Phytother. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"382","DOI":"10.4103\/0250-474x.57286","article-title":"Development of a RP-HPLC Method for Analysis ofTriphala Curnaand its Applicability to Test Variations inTriphala Curnapreparations","volume":"71","author":"Pawar","year":"2009","journal-title":"Indian J. Pharm. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1089\/acm.2017.0083","article-title":"Therapeutic Uses of Triphala in Ayurvedic Medicine","volume":"23","author":"Peterson","year":"2017","journal-title":"J. Altern. Complement. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.joim.2019.10.002","article-title":"Study of the Safety of Oral Triphala Aqueous Extract on Healthy Volunteers","volume":"18","author":"Phetkate","year":"2020","journal-title":"J. Integr. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3390\/antiox9010072","article-title":"Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala","volume":"9","author":"Prasad","year":"2020","journal-title":"Antioxidants"},{"key":"B47","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.jep.2009.10.019","article-title":"Hepatoprotective Activity of Ethanolic Extracts of Bark of Zanthoxylum Armatum DC in CCl4 Induced Hepatic Damage in Rats","volume":"127","author":"Ranawat","year":"2010","journal-title":"J. Ethnopharmacology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/ptr.2183","article-title":"Antiinflammatory Effect of the Indian Ayurvedic Herbal Formulation Triphala on Adjuvant-Induced Arthritis in Mice","volume":"21","author":"Rasool","year":"2007","journal-title":"Phytother. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4103\/0974-8520.153787","article-title":"Effect of Triphala on Dextran Sulphate Sodium-Induced Colitis in Rats","volume":"35","author":"Rayudu","year":"2014","journal-title":"Ayu"},{"key":"B50","first-page":"3739","article-title":"Differential Cytotoxicity of Triphala and its Phenolic Constituent Gallic Acid on Human Prostate Cancer LNCap and Normal Cells","volume":"31","author":"Russell","year":"2011","journal-title":"Anticancer Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1248\/yakushi.127.385","article-title":"Hypolipidemic Effect of Triphala in Experimentally Induced Hypercholesteremic Rats","volume":"127","author":"Saravanan","year":"2007","journal-title":"Yakugaku Zasshi"},{"key":"B52","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1177\/0748233713483195","article-title":"Amelioration of Iron Overload-Induced Liver Toxicity by a Potent Antioxidant and Iron chelator,Emblica officinalisGaertn","volume":"31","author":"Sarkar","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"B53","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/1472-6882-12-144","article-title":"Reducing Power and Iron Chelating Property of Terminalia Chebula (Retz.) Alleviates Iron Induced Liver Toxicity in Mice","volume":"12","author":"Sarkar","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"B54","first-page":"145","article-title":"Protective Effects of phyllanthus Emblica Leaf Extract on Sodium Arsenite-Mediated Adverse Effects in Mice","volume":"77","author":"Sayed","year":"2015","journal-title":"Nagoya J. Med. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cccn.2004.04.029","article-title":"Bioavailability of Ellagic Acid in Human Plasma after Consumption of Ellagitannins from Pomegranate (Punica Granatum L.) Juice","volume":"348","author":"Seeram","year":"2004","journal-title":"Clinica Chim. Acta"},{"key":"B56","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s12291-011-0138-y","article-title":"Chemoprotective Role of Triphala against 1,2-dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver","volume":"26","author":"Sharma","year":"2011","journal-title":"Ind. J. Clin. Biochem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"181","DOI":"10.4103\/0975-9476.146553","article-title":"Protective Effect of Triphala Rasayana against Paracetamol-Induced Hepato-Renal Toxicity in Mice","volume":"6","author":"Singh","year":"2015","journal-title":"J. Ayurveda Integr. Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s10787-018-0525-6","article-title":"Phytofabricated Silver Nanoparticles of Phyllanthus Emblica Attenuated Diethylnitrosamine-Induced Hepatic Cancer via Knock-Down Oxidative Stress and Inflammation","volume":"27","author":"Singh","year":"2019","journal-title":"Inflammopharmacol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e6322","DOI":"10.7717\/peerj.6322","article-title":"Chemical Composition, Antioxidant and Hepatoprotective Activities of Methanol Extracts from Leaves ofTerminalia belliricaandTerminalia sericea(Combretaceae)","volume":"7","author":"Sobeh","year":"2019","journal-title":"PeerJ"},{"key":"B60","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.micpath.2018.08.041","article-title":"Serum and Hepatic Oxidative Damage Induced by a Diet Contaminated with Fungal Mycotoxin in Freshwater Silver Catfish Rhamdia quelen: Involvement on Disease Pathogenesis","volume":"124","author":"Souza","year":"2018","journal-title":"Microb. Pathogenesis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11010-006-2271-0","article-title":"Effect of Triphala on Oxidative Stress and on Cell-Mediated Immune Response against Noise Stress in Rats","volume":"283","author":"Srikumar","year":"2006","journal-title":"Mol. Cel Biochem"},{"key":"B62","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00534-002-0824-5","article-title":"Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Various Rat Tissues after Carbon Tetrachloride Intoxication","volume":"10","author":"Szymonik-Lesiuk","year":"2003","journal-title":"J. Hepato-Biliary-Pancreatic Surg."},{"key":"B63","doi-asserted-by":"publisher","first-page":"50","DOI":"10.4103\/0974-8490.91040","article-title":"Hepatoprotective Effect of Poly Herbal Formulation against Various Hepatotoxic Agents in Rats","volume":"4","author":"Tatiya","year":"2012","journal-title":"Phcog Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1186\/s12906-018-2412-5","article-title":"Chebulinic Acid Derived from Triphala Is a Promising Antitumour Agent in Human Colorectal Carcinoma Cell Lines","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Complement. Altern. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.fct.2007.01.011","article-title":"Hepatoprotective and Antioxidative Effects of Total Phenolics from Laggera Pterodonta on Chemical-Induced Injury in Primary Cultured Neonatal Rat Hepatocytes","volume":"45","author":"Wu","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3390\/antiox9090771","article-title":"Chebulic Acid Prevents Methylglyoxal-Induced Mitochondrial Dysfunction in INS-1 Pancreatic \u03b2-Cells","volume":"9","author":"Yoo","year":"2020","journal-title":"Antioxidants"},{"key":"B67","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.intimp.2014.01.019","article-title":"Protective Effects of the Total Saponins from Dioscorea Nipponica Makino against Carbon Tetrachloride-Induced Liver Injury in Mice through Suppression of Apoptosis and Inflammation","volume":"19","author":"Yu","year":"2014","journal-title":"Int. Immunopharmacology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/950890","article-title":"Anticancer Properties ofPhyllanthus Emblica(Indian Gooseberry)","volume":"2015","author":"Zhao","year":"2015","journal-title":"Oxidative Med. Cell Longevity"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.664607\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T08:51:20Z","timestamp":1625475080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.664607\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,5]]},"references-count":68,"alternative-id":["10.3389\/fphar.2021.664607"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.664607","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,5]]},"article-number":"664607"}}