{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:33:44Z","timestamp":1792553624545,"version":"4.5.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. are commonly linked with topical biofilm-associated infections such as those found on chronic wounds. These biofilms are notoriously difficult to treat, highlighting the grave need to discover and study new broad-spectrum agents to combat associated infections. Here we report that the kinase inhibitor Bay 11-7085 exhibited bactericidal activity against multidrug-resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    with a minimum inhibitory concentration (MIC) of 4\u00a0\u03bcg\/ml. In addition,\n                    <jats:italic>S. aureus<\/jats:italic>\n                    strain MW2 did not acquire resistance to antibiotic pressure. Furthermore, Bay 11-7085 exhibited potency against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and the emerging pathogen\n                    <jats:italic>Candida auris<\/jats:italic>\n                    with a MIC of 0.5\u20131\u00a0\u03bcg\/ml. Bay 11-7085 partially inhibited and eradicated biofilm formation of various pathogens, such as VRSA (vancomycin-resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ), as well as antifungal-resistant\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. isolates. Notably, Bay 11-7085 partially inhibited initial cell attachment and formation of a VRSA-\n                    <jats:italic>C. albicans<\/jats:italic>\n                    polymicrobial biofilm\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In contrast to\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , inhibition of VRSA biofilm was linked to initial cell attachment independent of its bactericidal activity. Finally, Bay 11-7085 was effective\n                    <jats:italic>in vivo<\/jats:italic>\n                    at increasing the lifespan of\n                    <jats:italic>C. elegans<\/jats:italic>\n                    during an\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and a\n                    <jats:italic>C. albicans<\/jats:italic>\n                    infection. Our work proposes kinase inhibitor Bay 11-7085 as a potential compound capable of combating biofilms associated with primary multidrug-resistant bacteria and yeast pathogens associated with wound infections.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2021.675300","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T01:40:17Z","timestamp":1620178817000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Repurposing Kinase Inhibitor Bay 11-7085 to Combat Staphylococcus aureus and Candida albicans Biofilms"],"prefix":"10.3389","volume":"12","author":[{"given":"Iliana E.","family":"Escobar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Cristina","family":"Possamai Rossatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooseong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Mylonakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/1471-2334-14-190","article-title":"Biofilms and Persistent Wound Infections in United States Military Trauma Patients: a Case-Control Analysis","volume":"14","author":"Akers","year":"2014","journal-title":"BMC Infect. 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