{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:46:07Z","timestamp":1792500367545,"version":"4.5.0"},"reference-count":219,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a main hallmark of common neurodegenerative diseases, including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and amyotrophic lateral sclerosis (ALS), among others. The over-activated microglia release pro-inflammatory cytokines, which induces neuronal death and accelerates neurodegeneration. Therefore, inhibition of microglia over-activation and microglia-mediated neuroinflammation has been a promising strategy for the treatment of neurodegenerative diseases. Many drugs have shown promising therapeutic effects on microglia and inflammation. However, the blood\u2013brain barrier (BBB)\u2014a natural barrier preventing brain tissue from contact with harmful plasma components\u2014seriously hinders drug delivery to the microglial cells in CNS. As an emerging useful therapeutic tool in CNS-related diseases, nanoparticles (NPs) have been widely applied in biomedical fields for use in diagnosis, biosensing and drug delivery. Recently, many NPs have been reported to be useful vehicles for anti-inflammatory drugs across the BBB to inhibit the over-activation of microglia and neuroinflammation. Therefore, NPs with good biodegradability and biocompatibility have the potential to be developed as an effective and minimally invasive carrier to help other drugs cross the BBB or as a therapeutic agent for the treatment of neuroinflammation-mediated neurodegenerative diseases. In this review, we summarized various nanoparticles applied in CNS, and their mechanisms and effects in the modulation of inflammation responses in neurodegenerative diseases, providing insights and suggestions for the use of NPs in the treatment of neuroinflammation-related neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fphar.2021.683935","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T05:50:40Z","timestamp":1622008240000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":85,"title":["Nanoparticles: A Hope for the Treatment of Inflammation in CNS"],"prefix":"10.3389","volume":"12","author":[{"given":"Feng-Dan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Gang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Lian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ze","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Guo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.2174\/138161210793176572","article-title":"Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease","volume":"16","author":"Agostinho","year":"2010","journal-title":"Cpd"},{"key":"B2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jconrel.2018.05.011","article-title":"Nose-to-brain Drug Delivery: An Update on Clinical Challenges and Progress towards Approval of Anti-alzheimer Drugs","volume":"281","author":"Agrawal","year":"2018","journal-title":"J. Control. Release"},{"key":"B3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jconrel.2017.05.019","article-title":"Recent Advancements in Liposomes Targeting Strategies to Cross Blood-Brain Barrier (BBB) for the Treatment of Alzheimer's Disease","volume":"260","author":"Agrawal","year":"2017","journal-title":"J. Control. Release"},{"key":"B4","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/glia.23265","article-title":"A Critical Role of TRPM2 Channel in Abeta42 -induced Microglial Activation and Generation of Tumor Necrosis Factor-Alpha","volume":"66","author":"Alawieyah Syed Mortadza","year":"2018","journal-title":"Glia"},{"key":"B5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/1742-2094-9-95","article-title":"Infection and Upregulation of Proinflammatory Cytokines in Human Brain Vascular Pericytes by Human Cytomegalovirus","volume":"9","author":"Alcendor","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tins.2010.12.001","article-title":"Astrocyte-neuron Metabolic Relationships: for Better and for Worse","volume":"34","author":"Allaman","year":"2011","journal-title":"Trends Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"E1968","DOI":"10.1073\/pnas.1616070114","article-title":"Serum-borne Bioactivity Caused by Pulmonary Multiwalled Carbon Nanotubes Induces Neuroinflammation via Blood-Brain Barrier Impairment","volume":"114","author":"Aragon","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.3390\/molecules23112849","article-title":"New Advances in General Biomedical Applications of PAMAM Dendrimers","volume":"23","author":"Araujo","year":"2018","journal-title":"Molecules"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e24374","DOI":"10.1371\/journal.pone.0024374","article-title":"Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles","volume":"6","author":"Arvizo","year":"2011","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.ajpath.2013.11.026","article-title":"Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1","volume":"184","author":"Asai","year":"2014","journal-title":"Am. J. Pathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s41061-020-00302-w","article-title":"Magnetic Nanoparticles as MRI Contrast Agents","volume":"378","author":"Avasthi","year":"2020","journal-title":"Top. Curr. Chem. (Cham)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.ijpharm.2011.10.039","article-title":"Oil Based Nanocarrier System for Transdermal Delivery of Ropinirole: a Mechanistic, Pharmacokinetic and Biochemical Investigation","volume":"422","author":"Azeem","year":"2012","journal-title":"Int. J. Pharm."},{"key":"B13","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1177\/0192623318770608","article-title":"Gold Nanoparticle Toxicity in Mice and Rats: Species Differences","volume":"46","author":"Bahamonde","year":"2018","journal-title":"Toxicol. Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/17425255.2019.1621289","article-title":"Solid Lipid Matrix Mediated Nanoarchitectonics for Improved Oral Bioavailability of Drugs","volume":"15","author":"Banerjee","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e80964","DOI":"10.1371\/journal.pone.0080964","article-title":"Functionalized Carbon Nanotubes in the Brain: Cellular Internalization and Neuroinflammatory Responses","volume":"8","author":"Bardi","year":"2013","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1007\/s00415-020-10291-x","article-title":"Nanoparticles for Drug Delivery in Parkinson's Disease","volume":"268","author":"Baskin","year":"2020","journal-title":"J. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.nano.2018.01.019","article-title":"Epigallocatechin-3-gallate Loaded PEGylated-PLGA Nanoparticles: A New Anti-seizure Strategy for Temporal Lobe Epilepsy","volume":"14","author":"Cano","year":"2018","journal-title":"Nanomedicine"},{"key":"B18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40659-016-0093-4","article-title":"Effects and Molecular Mechanism of Chitosan-Coated Levodopa Nanoliposomes on Behavior of Dyskinesia Rats","volume":"49","author":"Cao","year":"2016","journal-title":"Biol. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"606","DOI":"10.2174\/0929867324666171009120154","article-title":"Recent Advances and Perspectives in Liposomes for Cutaneous Drug Delivery","volume":"25","author":"Carita","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12974-016-0596-5","article-title":"IL4 Induces IL6-producing M2 Macrophages Associated to Inhibition of Neuroinflammation In Vitro and In Vivo","volume":"13","author":"Casella","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nnano.2008.374","article-title":"Carbon Nanotubes Might Improve Neuronal Performance by Favouring Electrical Shortcuts","volume":"4","author":"Cellot","year":"2009","journal-title":"Nat. Nanotechnol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/jnnp-2020-324283","article-title":"The Future of Neuroprotection in Stroke","volume":"92","author":"Chamorro","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"938","DOI":"10.3390\/molecules23040938","article-title":"Dendrimers for Drug Delivery","volume":"23","author":"Chauhan","year":"2018","journal-title":"Molecules"},{"key":"B24","doi-asserted-by":"publisher","first-page":"15148","DOI":"10.1021\/acsami.5b03866","article-title":"Dual-peptide-functionalized Albumin-Based Nanoparticles with Ph-dependent Self-Assembly Behavior for Drug Delivery","volume":"7","author":"Chen","year":"2015","journal-title":"ACS Appl. Mater. Inter."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1021\/acsnano.7b07625","article-title":"Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease","volume":"12","author":"Chen","year":"2018","journal-title":"ACS Nano"},{"key":"B26","doi-asserted-by":"publisher","first-page":"109909","DOI":"10.1016\/j.ecoenv.2019.109909","article-title":"Neurotoxicity of Mn3O4 Nanoparticles: Apoptosis and Dopaminergic Neurons Damage Pathway","volume":"188","author":"Chen","year":"2020","journal-title":"Ecotoxicol Environ. Saf."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1073\/pnas.1218424110","article-title":"Large Alpha-Synuclein Oligomers Inhibit Neuronal SNARE-Mediated Vesicle Docking","volume":"110","author":"Choi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ejrad.2006.06.016","article-title":"Detection of Hepatic Metastasis: Manganese- and Ferucarbotran-Enhanced MR Imaging","volume":"60","author":"Choi","year":"2006","journal-title":"Eur. J. Radiol."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22050790","article-title":"Photoactive Hybrid Catalysts Based on Natural and Synthetic Polymers: A Comparative Overview","volume":"22","author":"Colmenares","year":"2017","journal-title":"Molecules"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e52941","DOI":"10.1371\/journal.pone.0052941","article-title":"Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis","volume":"7","author":"Corcia","year":"2012","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.etap.2019.02.012","article-title":"Effects of the Chronic Exposure to Cerium Dioxide Nanoparticles in Oncorhynchus mykiss: Assessment of Oxidative Stress, Neurotoxicity and Histological Alterations","volume":"68","author":"Correia","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.pneurobio.2014.05.002","article-title":"Engineered Nanoparticles. How Brain Friendly Is This New Guest?","author":"Cupaioli","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"19679","DOI":"10.1073\/pnas.1003103107","article-title":"Dendritic Polyglycerol Sulfates as Multivalent Inhibitors of Inflammation","volume":"107","author":"Dernedde","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"118814","DOI":"10.1016\/j.ijpharm.2019.118814","article-title":"Dendrimers in the Context of Nanomedicine","volume":"573","author":"Dias","year":"2020","journal-title":"Int. J. Pharm."},{"key":"B35","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1080\/1040841X.2016.1267708","article-title":"Iron Oxide Nanoparticles in Modern Microbiology and Biotechnology","volume":"43","author":"Dinali","year":"2017","journal-title":"Crit. Rev. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: the Devil Is in the Details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J. Neurochem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1007\/s12035-019-01780-w","article-title":"Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer's Disease Model","volume":"57","author":"Dos Santos Tramontin","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"12965","DOI":"10.1039\/c9nr03756j","article-title":"Assessment of Neurotoxicity Induced by Different-Sized Stober Silica Nanoparticles: Induction of Pyroptosis in Microglia","volume":"11","author":"Du","year":"2019","journal-title":"Nanoscale"},{"key":"B39","doi-asserted-by":"publisher","first-page":"18682","DOI":"10.3390\/ijms140918682","article-title":"Design of Superparamagnetic Nanoparticles for Magnetic Particle Imaging (MPI)","volume":"14","author":"Du","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.nano.2016.11.001","article-title":"Uptake of Silica Nanoparticles in the Brain and Effects on Neuronal Differentiation Using Different In Vitro Models","volume":"13","author":"Ducray","year":"2017","journal-title":"Nanomedicine"},{"key":"B41","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3390\/pharmaceutics12050448","article-title":"Neuroprotective Effect of Ropinirole Lipid Nanoparticles Enriched Hydrogel for Parkinson's Disease: In Vitro, Ex Vivo, Pharmacokinetic and Pharmacodynamic Evaluation","volume":"12","author":"Dudhipala","year":"2020","journal-title":"Pharmaceutics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"a028035","DOI":"10.1101\/cshperspect.a028035","article-title":"Pathology of Neurodegenerative Diseases","volume":"9","author":"Dugger","year":"2017","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jconrel.2010.06.004","article-title":"Gold Nanoparticle Platforms as Drug and Biomacromolecule Delivery Systems","volume":"148","author":"Duncan","year":"2010","journal-title":"J. Control. Release"},{"key":"B44","doi-asserted-by":"publisher","first-page":"8325","DOI":"10.1021\/acsnano.6b02819","article-title":"Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells","volume":"10","author":"Durfee","year":"2016","journal-title":"ACS Nano"},{"key":"B45","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00011-016-0959-5","article-title":"In vivo proinflammatory Activity of Generations 0-3 (G0-G3) Polyamidoamine (PAMAM) Nanoparticles","volume":"65","author":"Durocher","year":"2016","journal-title":"Inflamm. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/1556-276X-9-393","article-title":"Carbon Nanotubes: Properties, Synthesis, Purification, and Medical Applications","volume":"9","author":"Eatemadi","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"B47","doi-asserted-by":"publisher","first-page":"6913","DOI":"10.1039\/c6tb02108e","article-title":"Advances in Collagen, Chitosan and Silica Biomaterials for Oral Tissue Regeneration: from Basics to Clinical Trials","volume":"4","author":"Echazu","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"B48","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.neuron.2018.07.039","article-title":"Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease","volume":"99","author":"Eftekharzadeh","year":"2018","journal-title":"Neuron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10571-019-00727-y","article-title":"Glioprotective Effect of Chitosan-Coated Rosmarinic Acid Nanoemulsions against Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Rat Astrocyte Primary Cultures","volume":"40","author":"Fachel","year":"","journal-title":"Cell Mol Neurobiol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"104875","DOI":"10.1016\/j.neuint.2020.104875","article-title":"Chitosan-coated Rosmarinic Acid Nanoemulsion Nasal Administration Protects against LPS-Induced Memory Deficit, Neuroinflammation, and Oxidative Stress in Wistar Rats","volume":"141","author":"Fachel","year":"","journal-title":"Neurochem. Int."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1080\/10717544.2018.1461955","article-title":"Curcumin-loaded PLGA-PEG Nanoparticles Conjugated with B6 Peptide for Potential Use in Alzheimer's Disease","volume":"25","author":"Fan","year":"2018","journal-title":"Drug Deliv."},{"key":"B52","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.phrs.2009.12.012","article-title":"From Iron Oxide Nanoparticles towards Advanced Iron-Based Inorganic Materials Designed for Biomedical Applications","volume":"62","author":"Figuerola","year":"2010","journal-title":"Pharmacol. Res."},{"key":"B53","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-804598-5.00008-8","article-title":"The Applications, Neurotoxicity, and Related Mechanism of Gold Nanoparticles","volume-title":"Neurotoxicity of Nanomaterials and Nanomedicine","author":"Flora","year":"2017"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5577","DOI":"10.2147\/IJN.S36111","article-title":"The Role of Surface Charge in Cellular Uptake and Cytotoxicity of Medical Nanoparticles","volume":"7","author":"Frohlich","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"B55","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.drup.2016.10.003","article-title":"New Insights and Evolving Role of Pegylated Liposomal Doxorubicin in Cancer Therapy","volume":"29","author":"Gabizon","year":"2016","journal-title":"Drug Resist. Updat"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.3390\/molecules24061170","article-title":"Antineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Models","volume":"24","author":"Ganesan","year":"2019","journal-title":"Molecules"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1007\/s00259-016-3311-y","article-title":"Imaging of Brain TSPO Expression in a Mouse Model of Amyotrophic Lateral Sclerosis with (18)F-DPA-714 and Micro-PET\/CT","volume":"43","author":"Gargiulo","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nano.2018.08.011","article-title":"L-DOPA Functionalized, Multi-Branched Gold Nanoparticles as Brain-Targeted Nano-Vehicles","volume":"15","author":"Gonzalez-Carter","year":"2019","journal-title":"Nanomedicine"},{"key":"B59","doi-asserted-by":"publisher","first-page":"20205","DOI":"10.1007\/s11356-016-7234-8","article-title":"The Effect of Titanium Dioxide Nanoparticles on Neuroinflammation Response in Rat Brain","volume":"23","author":"Grissa","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"5262","DOI":"10.1096\/fj.201902191RR","article-title":"Cobalt Nanoparticles Trigger Ferroptosis-like Cell Death (Oxytosis) in Neuronal Cells: Potential Implications for Neurodegenerative Disease","volume":"34","author":"Gupta","year":"2020","journal-title":"FASEB J."},{"key":"B61","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ijbiomac.2019.02.156","article-title":"Nanoparticle Formulations in the Diagnosis and Therapy of Alzheimer's Disease","volume":"130","author":"Gupta","year":"2019","journal-title":"Int. J. Biol. Macromol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e1625","DOI":"10.1002\/wnan.1625","article-title":"Emerging Methods in Therapeutics Using Multifunctional Nanoparticles","volume":"12","author":"Habibi","year":"2020","journal-title":"Wiley Interdiscip. Rev. Nanomed Nanobiotechnol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2019.05.018","article-title":"Stimulus-responsive Polymeric Nanogels as Smart Drug Delivery Systems","volume":"92","author":"Hajebi","year":"2019","journal-title":"Acta Biomater."},{"key":"B64","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1743-8977-10-57","article-title":"Effect of MWCNT Size, Carboxylation, and Purification on In Vitro and In Vivo Toxicity, Inflammation and Lung Pathology","volume":"10","author":"Hamilton","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/j.nano.2016.03.005","article-title":"Targeted Drug Delivery to Ischemic Stroke via Chlorotoxin-Anchored, Lexiscan-Loaded Nanoparticles","volume":"12","author":"Han","year":"2016","journal-title":"Nanomedicine"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1021\/acs.biomac.5b00643","article-title":"Phosphorus-Based Dendrimer ABP Treats Neuroinflammation by Promoting IL-10-Producing CD4(+) T Cells","volume":"16","author":"Hayder","year":"2015","journal-title":"Biomacromolecules"},{"key":"B67","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.apsb.2018.06.005","article-title":"Adapting Liposomes for Oral Drug Delivery","volume":"9","author":"He","year":"2019","journal-title":"Acta Pharm. Sin B"},{"key":"B68","doi-asserted-by":"publisher","first-page":"36063","DOI":"10.1007\/s11356-019-06707-5","article-title":"The Anti-inflammatory Influence of Cinnamomum Burmannii against Multi-Walled Carbon Nanotube-Induced Liver Injury in Rats","volume":"26","author":"HelmyAbdou","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B69","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1021\/nl035193d","article-title":"Chemically Functionalized Carbon Nanotubes as Substrates for Neuronal Growth","volume":"4","author":"Hu","year":"2004","journal-title":"Nano Lett."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1039\/c9mt00103d","article-title":"AMPK Mediates the Neurotoxicity of Iron Oxide Nanoparticles Retained in Mitochondria or Lysosomes","volume":"11","author":"Huang","year":"2019","journal-title":"Metallomics"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e48752","DOI":"10.1371\/journal.pone.0048752","article-title":"Preparation, Biodistribution and Neurotoxicity of Liposomal Cisplatin Following Convection Enhanced Delivery in Normal and F98 Glioma Bearing Rats","volume":"7","author":"Huo","year":"2012","journal-title":"PLoS One"},{"key":"B72","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1002\/jemt.20928","article-title":"Gold Nanoparticles and Quantum Dots for Bioimaging","volume":"74","author":"Hutter","year":"2011","journal-title":"Microsc. Res. Tech."},{"key":"B73","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 Inflammasome Activation Drives Tau Pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081929","article-title":"Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders","volume":"1929","author":"Islam","year":"2020","journal-title":"Molecules"},{"key":"B75","doi-asserted-by":"publisher","first-page":"141384","DOI":"10.1016\/j.scitotenv.2020.141384","article-title":"Multi-walled Carbon Nanotubes Decrease Neuronal NO Synthase in 3D Brain Organoids","volume":"748","author":"Jiang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"B76","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.coph.2014.08.002","article-title":"Superparamagnetic Iron Oxide Nanoparticles for MR Imaging and Therapy: Design Considerations and Clinical Applications","volume":"18","author":"Jin","year":"2014","journal-title":"Curr. Opin. Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/cns.12580","article-title":"Use of PEGylated Immunoliposomes to Deliver Dopamine across the Blood-Brain Barrier in a Rat Model of Parkinson's Disease","volume":"22","author":"Kang","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"130ra146","DOI":"10.1126\/scitranslmed.3003162","article-title":"Dendrimer-based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model","volume":"4","author":"Kannan","year":"2012","journal-title":"Sci. Transl Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1055\/a-0654-4867","article-title":"Optimization of Olive Oil-Based Nanoemulsion Preparation for Intravenous Drug Delivery","volume":"69","author":"Karami","year":"","journal-title":"Drug Res. (Stuttg)"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.drudis.2019.03.021","article-title":"Nanoemulsions in CNS Drug Delivery: Recent Developments, Impacts and Challenges","volume":"24","author":"Karami","year":"","journal-title":"Drug Discov. Today"},{"key":"B81","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1080\/10717544.2018.1428243","article-title":"Therapeutic Strategies and Nano-Drug Delivery Applications in Management of Ageing Alzheimer's Disease","volume":"25","author":"Karthivashan","year":"2018","journal-title":"Drug Deliv."},{"key":"B82","doi-asserted-by":"publisher","first-page":"364ps318","DOI":"10.1126\/scitranslmed.aal2074","article-title":"Neurodegeneration: From Cellular Concepts to Clinical Applications","volume":"8","author":"Katsnelson","year":"2016","journal-title":"Sci. Transl Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.1111\/bph.12421","article-title":"Toxicological Effect of Engineered Nanomaterials on the Liver","volume":"171","author":"Kermanizadeh","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1016\/j.biomaterials.2013.01.087","article-title":"Monodisperse Magnetite Nanoparticle Tracers for In Vivo Magnetic Particle Imaging","volume":"34","author":"Khandhar","year":"2013","journal-title":"Biomaterials"},{"key":"B85","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3109\/08958378.2014.953275","article-title":"The Increases in Relative mRNA Expressions of Inflammatory Cytokines and Chemokines in Splenic Macrophages from Rats Exposed to Multi-Walled Carbon Nanotubes by Whole-Body Inhalation for 13 Weeks","volume":"26","author":"Kido","year":"2014","journal-title":"Inhal Toxicol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1039\/b9nr00112c","article-title":"Multimodal Drug Delivery Using Gold Nanoparticles","volume":"1","author":"Kim","year":"2009","journal-title":"Nanoscale"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e1802309","DOI":"10.1002\/adma.201802309","article-title":"Synthesis and Biomedical Applications of Multifunctional Nanoparticles","volume":"30","author":"Kim","year":"","journal-title":"Adv. Mater."},{"key":"B88","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41565-018-0179-y","article-title":"Graphene Quantum Dots Prevent Alpha-Synucleinopathy in Parkinson's Disease","volume":"13","author":"Kim","year":"","journal-title":"Nat. Nanotechnol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1016\/j.nano.2017.06.022","article-title":"Enhanced Neuroprotection of Anthocyanin-Loaded PEG-Gold Nanoparticles against Abeta1-42-Induced Neuroinflammation and Neurodegeneration via the NF-KB\/JNK\/GSK3beta Signaling Pathway","volume":"13","author":"Kim","year":"2017","journal-title":"Nanomedicine"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.nano.2013.05.002","article-title":"In vivo nanoneurotoxicity Screening Using Oxidative Stress and Neuroinflammation Paradigms","volume":"9","author":"Kim","year":"2013","journal-title":"Nanomedicine"},{"key":"B91","doi-asserted-by":"publisher","first-page":"9838","DOI":"10.1523\/JNEUROSCI.2557-04.2004","article-title":"Microglial Phagocytosis of Fibrillar Beta-Amyloid through a Beta1 Integrin-dependent Mechanism","volume":"24","author":"Koenigsknecht","year":"2004","journal-title":"J. Neurosci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1021\/acschemneuro.9b00343","article-title":"Design and Biological Evaluation of Lipoprotein-Based Donepezil Nanocarrier for Enhanced Brain Uptake through Oral Delivery","volume":"10","author":"Krishna","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.colsurfb.2009.09.001","article-title":"Biodegradable Polymeric Nanoparticles Based Drug Delivery Systems","volume":"75","author":"Kumari","year":"2010","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"B94","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1166\/jnn.2012.5796","article-title":"Repeated Oral Dose Toxicity of Iron Oxide Nanoparticles: Biochemical and Histopathological Alterations in Different Tissues of Rats","volume":"12","author":"Kumari","year":"2012","journal-title":"J. Nanosci Nanotechnol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1002\/anie.201107425","article-title":"Tuning Complex Shapes in Platinum Nanoparticles: from Cubic Dendrites to Fivefold Stars","volume":"51","author":"Lacroix","year":"2012","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"B96","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.biomaterials.2016.06.016","article-title":"A Drug Delivery Hydrogel System Based on Activin B for Parkinson's Disease","volume":"102","author":"Li","year":"2016","journal-title":"Biomaterials"},{"key":"B97","doi-asserted-by":"publisher","first-page":"4015","DOI":"10.1039\/c3nr33849e","article-title":"Focusing on Luminescent Graphene Quantum Dots: Current Status and Future Perspectives","volume":"5","author":"Li","year":"2013","journal-title":"Nanoscale"},{"key":"B98","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.ejmech.2019.01.007","article-title":"Composition Design and Medical Application of Liposomes","volume":"164","author":"Li","year":"","journal-title":"Eur. J. Med. Chem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jconrel.2018.09.001","article-title":"Drug Nanocrystallisation within Liposomes","volume":"288","author":"Li","year":"2018","journal-title":"J. Control. Release"},{"key":"B100","doi-asserted-by":"publisher","first-page":"4222","DOI":"10.1080\/21691401.2019.1687501","article-title":"AuNPs as an Important Inorganic Nanoparticle Applied in Drug Carrier Systems","volume":"47","author":"Li","year":"","journal-title":"Artif. Cell Nanomed Biotechnol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/1061186X.2016.1184272","article-title":"Nano Carriers for Drug Transport across the Blood-Brain Barrier","volume":"25","author":"Li","year":"2017","journal-title":"J. Drug Target."},{"key":"B102","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1016\/j.biomaterials.2012.02.004","article-title":"A Dual-Targeting Nanocarrier Based on Poly(amidoamine) Dendrimers Conjugated with Transferrin and Tamoxifen for Treating Brain Gliomas","volume":"33","author":"Li","year":"2012","journal-title":"Biomaterials"},{"key":"B103","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12989-018-0274-0","article-title":"Neuroinflammation Is Induced by Tongue-Instilled ZnO Nanoparticles via the Ca(2+)-dependent NF-kappaB and MAPK Pathways","volume":"15","author":"Liang","year":"2018","journal-title":"Part. Fibre Toxicol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1021\/am405219u","article-title":"In vitro and In Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier","volume":"6","author":"Liu","year":"2014","journal-title":"ACS Appl. Mater. Inter."},{"key":"B105","doi-asserted-by":"publisher","first-page":"135809","DOI":"10.1016\/j.scitotenv.2019.135809","article-title":"Neurotoxicity and Biomarkers of Zinc Oxide Nanoparticles in Main Functional Brain Regions and Dopaminergic Neurons","volume":"705","author":"Liu","year":"","journal-title":"Sci. Total Environ."},{"key":"B106","doi-asserted-by":"publisher","first-page":"122312","DOI":"10.1016\/j.jhazmat.2020.122312","article-title":"Neurotoxicity of Aluminum Oxide Nanoparticles and Their Mechanistic Role in Dopaminergic Neuron Injury Involving P53-Related Pathways","volume":"392","author":"Liu","year":"","journal-title":"J. Hazard. Mater."},{"key":"B107","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4172\/1939-067X.1000140","article-title":"Acute Bioenergetic Intervention or Pharmacological Preconditioning Protects Neuron against Ischemic Injury","volume":"6","author":"Liu","year":"","journal-title":"J. Exp. Stroke Transl Med."},{"key":"B108","doi-asserted-by":"publisher","first-page":"19060","DOI":"10.1039\/c5nr06282a","article-title":"Graphene Quantum Dots for the Inhibition of Beta Amyloid Aggregation","volume":"7","author":"Liu","year":"2015","journal-title":"Nanoscale"},{"key":"B109","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1021\/bc400055h","article-title":"B6 Peptide-Modified PEG-PLA Nanoparticles for Enhanced Brain Delivery of Neuroprotective Peptide","volume":"24","author":"Liu","year":"","journal-title":"Bioconjug. Chem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"6316","DOI":"10.1016\/j.biomaterials.2011.05.020","article-title":"Carbon Nanotube Nanoreservior for Controlled Release of Anti-inflammatory Dexamethasone","volume":"32","author":"Luo","year":"2011","journal-title":"Biomaterials"},{"key":"B111","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1021\/acs.accounts.0c00589","article-title":"Self-Assembling Supramolecular Dendrimers for Biomedical Applications: Lessons Learned from Poly(amidoamine) Dendrimers","volume":"53","author":"Lyu","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1074\/jbc.M110.135244","article-title":"Amyloid-beta Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity","volume":"286","author":"Maezawa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B113","doi-asserted-by":"publisher","first-page":"7322","DOI":"10.1039\/c2nr31657a","article-title":"Graphene Oxide Strongly Inhibits Amyloid Beta Fibrillation","volume":"4","author":"Mahmoudi","year":"2012","journal-title":"Nanoscale"},{"key":"B114","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12868-018-0406-3","article-title":"Solid Lipid Curcumin Particles Provide Greater Anti-amyloid, Anti-inflammatory and Neuroprotective Effects Than Curcumin in the 5xFAD Mouse Model of Alzheimer's Disease","volume":"19","author":"Maiti","year":"2018","journal-title":"BMC Neurosci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"693851","DOI":"10.1155\/2014\/693851","article-title":"Proliferation in the Alzheimer hippocampus Is Due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition","volume":"2014","author":"Marlatt","year":"2014","journal-title":"Neural Plast."},{"key":"B116","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.aca.2018.06.075","article-title":"Curcumin-graphene Quantum Dots for Dual Mode Sensing Platform: Electrochemical and Fluorescence Detection of APOe4, Responsible of Alzheimer's Disease","volume":"1036","author":"Mars","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"B117","doi-asserted-by":"publisher","first-page":"119289","DOI":"10.1016\/j.ijpharm.2020.119289","article-title":"Protein-based Nanoparticles for Drug Delivery Purposes","volume":"581","author":"Martinez-Lopez","year":"2020","journal-title":"Int. J. Pharm."},{"key":"B118","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1263\/jbb.103.216","article-title":"Neurite Outgrowths of Neurons with Neurotrophin-Coated Carbon Nanotubes","volume":"103","author":"Matsumoto","year":"2007","journal-title":"J. Biosci. Bioeng."},{"key":"B119","doi-asserted-by":"publisher","first-page":"102247","DOI":"10.1016\/j.nano.2020.102247","article-title":"Treatment with shCCL20-CCR6 Nanodendriplexes and Human Mesenchymal Stem Cell Therapy Improves Pathology in Mice with Repeated Traumatic Brain Injury","volume":"29","author":"Mayilsamy","year":"2020","journal-title":"Nanomedicine"},{"key":"B120","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1021\/acschemneuro.7b00301","article-title":"Dendritic Polyglycerol Sulfates in the Prevention of Synaptic Loss and Mechanism of Action on Glia","volume":"9","author":"Maysinger","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1749-6632.2009.05108.x","article-title":"Advances in the Treatment of Neurodegenerative Disorders Employing Nanotechnology","volume":"1184","author":"Modi","year":"2010","journal-title":"Ann. N. Y Acad. Sci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.addr.2019.07.006","article-title":"Subchronic and Chronic Toxicity Evaluation of Inorganic Nanoparticles for Delivery Applications","volume":"144","author":"Mohammadpour","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B123","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3233\/JAD-131843","article-title":"Tau Oligomers and Fibrils Induce Activation of Microglial Cells","volume":"37","author":"Morales","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"B124","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pharmthera.2014.09.003","article-title":"Neuroprotection for Ischaemic Stroke: Current Status and Challenges","volume":"146","author":"Moretti","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"B125","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/17425247.2019.1583205","article-title":"Blood-brain Barrier Receptors and Transporters: an Insight on Their Function and How to Exploit Them through Nanotechnology","volume":"16","author":"Moura","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"B126","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.msec.2017.03.283","article-title":"Gold Nanoparticles Prevent Cognitive Deficits, Oxidative Stress and Inflammation in a Rat Model of Sporadic Dementia of Alzheimer's Type","volume":"77","author":"Muller","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"B127","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.1039\/c4nr06849a","article-title":"Uptake and Bio-Reactivity of Polystyrene Nanoparticles Is Affected by Surface Modifications, Ageing and LPS Adsorption: In Vitro Studies on Neural Tissue Cells","volume":"7","author":"Murali","year":"2015","journal-title":"Nanoscale"},{"key":"B128","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nature25456","article-title":"High Performance Plasma Amyloid-Beta Biomarkers for Alzheimer's Disease","volume":"554","author":"Nakamura","year":"2018","journal-title":"Nature"},{"key":"B129","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.addr.2012.08.015","article-title":"Surface Engineering of Inorganic Nanoparticles for Imaging and Therapy","volume":"65","author":"Nam","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B130","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12974-017-1004-5","article-title":"Dendrimer-mediated Delivery of N-Acetyl Cysteine to Microglia in a Mouse Model of Rett Syndrome","volume":"14","author":"Nance","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"B131","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3389\/fnins.2020.00494","article-title":"Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs","volume":"14","author":"Naqvi","year":"2020","journal-title":"Front. Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.ijbiomac.2020.11.207","article-title":"Chitosan Coated Synergistically Engineered Nanoemulsion of Ropinirole and Nigella Oil in the Management of Parkinson's Disease: Formulation Perspective and In vitro and In vivo Assessment","volume":"167","author":"Nehal","year":"2021","journal-title":"Int. J. Biol. Macromol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"W302","DOI":"10.2214\/AJR.14.12733","article-title":"Iron-based Superparamagnetic Nanoparticle Contrast Agents for MRI of Infection and Inflammation","volume":"204","author":"Neuwelt","year":"2015","journal-title":"AJR Am. J. Roentgenol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"117394","DOI":"10.1016\/j.lfs.2020.117394","article-title":"Nanoemulsions for Targeting the Neurodegenerative Diseases: Alzheimer's, Parkinson's and Prion's","volume":"245","author":"Nirale","year":"2020","journal-title":"Life Sci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson's Disease: Focus on Astrocytes","volume":"49","author":"Niranjan","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1365-2990.2012.01306.x","article-title":"Review: Microglia of the Aged Brain: Primed to Be Activated and Resistant to Regulation","volume":"39","author":"Norden","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.2217\/nnm.12.33","article-title":"In vivo degradation of Functionalized Carbon Nanotubes after Stereotactic Administration in the Brain Cortex","volume":"7","author":"Nunes","year":"2012","journal-title":"Nanomedicine (Lond)"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3390\/md15110322","article-title":"Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer's Disease","volume":"15","author":"Ouyang","year":"2017","journal-title":"Mar. Drugs"},{"key":"B139","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s13205-019-1739-z","article-title":"Synthesis of Gold and Silver Nanoparticles Using Flavonoid Quercetin and Their Effects on Lipopolysaccharide Induced Inflammatory Response in Microglial Cells","volume":"9","author":"Ozdal","year":"2019","journal-title":"3 Biotech."},{"key":"B140","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.2147\/IJN.S195218","article-title":"Anti-neuroinflammatory Effects of Ephedra Sinica Stapf Extract-Capped Gold Nanoparticles in Microglia","volume":"14","author":"Park","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"B141","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/fcp.12244","article-title":"Nanoliposome Containing Cyclosporine A Reduced Neuroinflammation Responses and Improved Neurological Activities in Cerebral Ischemia\/reperfusion in Rat","volume":"31","author":"Partoazar","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s40263-016-0405-9","article-title":"Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain","volume":"31","author":"Patel","year":"2017","journal-title":"CNS Drugs"},{"key":"B143","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.2217\/nnm.14.156","article-title":"Poly(lactic Acid) and Poly(lactic-Co-Glycolic Acid) Particles as Versatile Carrier Platforms for Vaccine Delivery","volume":"9","author":"Pavot","year":"2014","journal-title":"Nanomedicine (Lond)"},{"key":"B144","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1080\/1061186X.2019.1678168","article-title":"Gold Nanoparticles Potentiates N-Acetylcysteine Effects on Neurochemicals Alterations in Rats after Polymicrobial Sepsis","volume":"28","author":"Petronilho","year":"2020","journal-title":"J. Drug Target."},{"key":"B145","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nrd2591","article-title":"Strategies in the Design of Nanoparticles for Therapeutic Applications","volume":"9","author":"Petros","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"B146","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1126\/science.1154663","article-title":"Chaotic Dirac Billiard in Graphene Quantum Dots","volume":"320","author":"Ponomarenko","year":"2008","journal-title":"Science"},{"key":"B147","doi-asserted-by":"publisher","first-page":"6417","DOI":"10.1021\/acs.nanolett.8b02785","article-title":"Peroxidase-Mimicking Nanoassembly Mitigates Lipopolysaccharide-Induced Endotoxemia and Cognitive Damage in the Brain by Impeding Inflammatory Signaling in Macrophages","volume":"18","author":"Rajendrakumar","year":"2018","journal-title":"Nano Lett."},{"key":"B148","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.drudis.2019.01.004","article-title":"Solid Nanoparticles for Oral Antimicrobial Drug Delivery: a Review","volume":"24","author":"Raza","year":"2019","journal-title":"Drug Discov. Today"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.critrevonc.2018.06.008","article-title":"Pharmacokinetics Variability: Why Nanoparticles Are Not Just Magic-Bullets in Oncology","volume":"129","author":"Rodallec","year":"2018","journal-title":"Crit. Rev. oncology\/hematology"},{"key":"B150","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ejphar.2014.11.014","article-title":"Neuroprotective Potential of Sesamol and its Loaded Solid Lipid Nanoparticles in ICV-STZ-Induced Cognitive Deficits: Behavioral and Biochemical Evidence","volume":"747","author":"Sachdeva","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2174\/2211738505666171023152928","article-title":"Cytotoxicity of Nanomaterials: Using Nanotoxicology to Address the Safety Concerns of Nanoparticles","volume":"6","author":"Saifi","year":"2018","journal-title":"Pharm. Nanotechnol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s0065-2776(10)06002-5","article-title":"Nuclear Receptors, Inflammation, and Neurodegenerative Diseases","volume":"106","author":"Saijo","year":"2010","journal-title":"Adv. Immunol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.molimm.2005.02.006","article-title":"Complement Activation and Protein Adsorption by Carbon Nanotubes","volume":"43","author":"Salvador-Morales","year":"2006","journal-title":"Mol. Immunol."},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3390\/ma13030570","article-title":"Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems","volume":"13","author":"Sandoval-Yanez","year":"2020","journal-title":"Materials (Basel)"},{"key":"B155","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11910-017-0733-2","article-title":"Neuroinflammation in Neurodegenerative Disorders-A Review","volume":"17","author":"Schain","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B156","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jconrel.2014.11.024","article-title":"Iron Oxide-Loaded Nanotheranostics: Major Obstacles to In Vivo Studies and Clinical Translation","volume":"198","author":"Schleich","year":"2015","journal-title":"J. Control. Release"},{"key":"B157","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.2147\/IJN.S245300","article-title":"Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices","volume":"15","author":"Schmitt","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"B158","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.7150\/thno.29039","article-title":"Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia Using Dendrimer-Based Therapeutics","volume":"8","author":"Sharma","year":"2018","journal-title":"Theranostics"},{"key":"B159","doi-asserted-by":"publisher","first-page":"eaay8514","DOI":"10.1126\/sciadv.aay8514","article-title":"Dense Hydroxyl Polyethylene Glycol Dendrimer Targets Activated Glia in Multiple CNS Disorders","volume":"6","author":"Sharma","year":"","journal-title":"Sci. Adv."},{"key":"B160","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1166\/jnn.2009.gr01","article-title":"A Special Section on Nanoneuroscience: Nanoneurotoxicity and Nanoneuroprotection","volume":"9","author":"Sharma","year":"2009","journal-title":"J. Nanosci Nanotechnol"},{"key":"B161","doi-asserted-by":"publisher","first-page":"5073","DOI":"10.1166\/jnn.2009.gr10","article-title":"Chronic Treatment with Nanoparticles Exacerbate Hyperthermia Induced Blood-Brain Barrier Breakdown, Cognitive Dysfunction and Brain Pathology in the Rat. Neuroprotective Effects of Nanowired-Antioxidant Compound H-290\/51","volume":"9","author":"Sharma","year":"2009","journal-title":"J. Nanosci Nanotechnol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jconrel.2020.04.036","article-title":"Dendrimer Mediated Targeted Delivery of Sinomenine for the Treatment of Acute Neuroinflammation in Traumatic Brain Injury","volume":"323","author":"Sharma","year":"","journal-title":"J. Control. Release"},{"key":"B163","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1021\/acs.bioconjchem.7b00569","article-title":"Activated Microglia Targeting Dendrimer-Minocycline Conjugate as Therapeutics for Neuroinflammation","volume":"28","author":"Sharma","year":"2017","journal-title":"Bioconjug. Chem."},{"key":"B164","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.ijpharm.2018.07.030","article-title":"Dendrimers: A Versatile Nanocarrier for Drug Delivery and Targeting","volume":"548","author":"Sherje","year":"2018","journal-title":"Int. J. Pharm."},{"key":"B165","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1084\/jem.20190980","article-title":"Microglia Drive APOE-dependent Neurodegeneration in a Tauopathy Mouse Model","volume":"216","author":"Shi","year":"2019","journal-title":"J. Exp. Med."},{"key":"B166","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.nano.2019.02.023","article-title":"Foxp3 Plasmid-Encapsulated PLGA Nanoparticles Attenuate Pain Behavior in Rats with Spinal Nerve Ligation","volume":"18","author":"Shin","year":"2019","journal-title":"Nanomedicine"},{"key":"B167","doi-asserted-by":"publisher","first-page":"3809","DOI":"10.1021\/acs.biomac.9b00889","article-title":"Sulfated Dendritic Polyglycerol Is a Potent Complement Inhibitor","volume":"20","author":"Silberreis","year":"2019","journal-title":"Biomacromolecules"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176070","article-title":"Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders","volume":"21","author":"Sim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jconrel.2015.11.009","article-title":"Nanogels: An Overview of Properties, Biomedical Applications and Obstacles to Clinical Translation","volume":"240","author":"Soni","year":"2016","journal-title":"J. Control. Release"},{"key":"B170","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/187221112799219125","article-title":"Advances in the Treatment of Neurodegenerative Disorders Employing Nanoparticles","volume":"6","author":"Spuch","year":"2012","journal-title":"Recent Pat Drug Deliv. Formul"},{"key":"B171","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","article-title":"Aggregated Tau Activates NLRP3-ASC Inflammasome Exacerbating Exogenously Seeded and Non-exogenously Seeded Tau Pathology In Vivo","volume":"137","author":"Stancu","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/imm.12922","article-title":"Inflammation in CNS Neurodegenerative Diseases","volume":"154","author":"Stephenson","year":"2018","journal-title":"Immunology"},{"key":"B173","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbi.2015.10.012","article-title":"Microglia in Dementia with Lewy Bodies","volume":"55","author":"Streit","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1750005","DOI":"10.1142\/s1793984417500052","article-title":"Prostaglandin E2 Produced by Alginate-Encapsulated Mesenchymal Stromal Cells Modulates the Astrocyte Inflammatory Response","volume":"7","author":"Stucky","year":"2017","journal-title":"Nano Life"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.jcyt.2015.05.002","article-title":"Alginate Micro-encapsulation of Mesenchymal Stromal Cells Enhances Modulation of the Neuro-Inflammatory Response","volume":"17","author":"Stucky","year":"2015","journal-title":"Cytotherapy"},{"key":"B176","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a Strategy for Improving Nanoparticle-Based Drug and Gene Delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B177","doi-asserted-by":"publisher","first-page":"12320","DOI":"10.1002\/anie.201403036","article-title":"Engineered Nanoparticles for Drug Delivery in Cancer Therapy","volume":"53","author":"Sun","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"B178","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1039\/c8cs00805a","article-title":"Emerging Blood-Brain-Barrier-Crossing Nanotechnology for Brain Cancer Theranostics","volume":"48","author":"Tang","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"B179","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3390\/nano9010096","article-title":"Neurotoxicity of Nanomaterials: An Up-To-Date Overview","volume":"9","author":"Teleanu","year":"2019","journal-title":"Nanomaterials (Basel)"},{"key":"B180","doi-asserted-by":"publisher","first-page":"490","DOI":"10.3390\/jcm7120490","article-title":"Impact of Nanoparticles on Brain Health: An up to Date Overview","volume":"7","author":"Teleanu","year":"2018","journal-title":"J. Clin. Med."},{"key":"B181","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1021\/nn405077y","article-title":"Curcumin-loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer's Disease Model via Canonical Wnt\/beta-Catenin Pathway","volume":"8","author":"Tiwari","year":"2014","journal-title":"ACS Nano"},{"key":"B182","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/17425247.2020.1698544","article-title":"Nanoparticles as Carriers for Drug Delivery of Macromolecules across the Blood-Brain Barrier","volume":"17","author":"Tosi","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"B183","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuropharm.2018.11.030","article-title":"Graphene Quantum Dots Inhibit T Cell-Mediated Neuroinflammation in Rats","volume":"146","author":"Tosic","year":"2019","journal-title":"Neuropharmacology"},{"key":"B184","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.nbd.2003.12.012","article-title":"Evidence of Widespread Cerebral Microglial Activation in Amyotrophic Lateral Sclerosis: an [11C](R)-PK11195 Positron Emission Tomography Study","volume":"15","author":"Turner","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.2116\/analsci.26.1219","article-title":"Polymer-functionalized Gold Nanoparticles as Versatile Sensing Materials","volume":"26","author":"Uehara","year":"2010","journal-title":"Anal. Sci."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.3762\/bjnano.6.181","article-title":"Nanotechnology in the Real World: Redeveloping the Nanomaterial Consumer Products Inventory","volume":"6","author":"Vance","year":"2015","journal-title":"Beilstein J. Nanotechnol"},{"key":"B187","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1146\/annurev-biochem-061516-045049","article-title":"Propagation of Protein Aggregation in Neurodegenerative Diseases","volume":"88","author":"Vaquer-Alicea","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"B188","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ijpharm.2009.04.050","article-title":"Anti-inflammatory and Anti-oxidant Activity of Anionic Dendrimer-N-Acetyl Cysteine Conjugates in Activated Microglial Cells","volume":"377","author":"Wang","year":"2009","journal-title":"Int. J. Pharm."},{"key":"B189","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1002\/chem.201704593","article-title":"Differential Modulating Effect of MoS2 on Amyloid Peptide Assemblies","volume":"24","author":"Wang","year":"2018","journal-title":"Chemistry"},{"key":"B190","doi-asserted-by":"publisher","first-page":"4194","DOI":"10.1073\/pnas.1100976108","article-title":"In vivo demonstration that Alpha-Synuclein Oligomers Are Toxic","volume":"108","author":"Winner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B191","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1016\/j.addr.2013.08.005","article-title":"Carbon Nanotubes for Delivery of Small Molecule Drugs","volume":"65","author":"Wong","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B192","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1743-8977-10-46","article-title":"Iron Oxide Nanoparticles Suppress the Production of IL-1beta via the Secretory Lysosomal Pathway in Murine Microglial Cells","volume":"10","author":"Wu","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.2147\/IJN.S15660","article-title":"Biocompatibility of Fe3O4\/DNR Magnetic Nanoparticles in the Treatment of Hematologic Malignancies","volume":"5","author":"Wu","year":"2010","journal-title":"Int. J. Nanomedicine"},{"key":"B194","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1021\/acs.nanolett.9b04216","article-title":"Dihydrolipoic Acid-Gold Nanoclusters Regulate Microglial Polarization and Have the Potential to Alter Neurogenesis","volume":"20","author":"Xiao","year":"2020","journal-title":"Nano Lett."},{"key":"B195","doi-asserted-by":"publisher","first-page":"9364","DOI":"10.1016\/j.biomaterials.2011.08.053","article-title":"Polymer Encapsulated Upconversion Nanoparticle\/iron Oxide Nanocomposites for Multimodal Imaging and Magnetic Targeted Drug Delivery","volume":"32","author":"Xu","year":"2011","journal-title":"Biomaterials"},{"key":"B196","doi-asserted-by":"publisher","first-page":"111635","DOI":"10.1016\/j.jphotobiol.2019.111635","article-title":"Neuroprotective Effect of Biosynthesised Gold Nanoparticles Synthesised from Root Extract of Paeonia Moutan against Parkinson Disease - In vitro &In vivo Model","volume":"200","author":"Xue","year":"2019","journal-title":"J. Photochem. Photobiol. B"},{"key":"B197","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.nano.2015.12.374","article-title":"Intranasal Brain Delivery of Cationic Nanoemulsion-Encapsulated TNFalpha siRNA in Prevention of Experimental Neuroinflammation","volume":"12","author":"Yadav","year":"2016","journal-title":"Nanomedicine"},{"key":"B198","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1523\/JNEUROSCI.1698-16.2016","article-title":"Large Soluble Oligomers of Amyloid Beta-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate","volume":"37","author":"Yang","year":"2017","journal-title":"J. Neurosci."},{"key":"B199","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cis.2015.08.011","article-title":"Multi-liposomal Containers","volume":"226","author":"Yaroslavov","year":"2015","journal-title":"Adv. Colloid Interf. Sci"},{"key":"B200","doi-asserted-by":"publisher","first-page":"8600","DOI":"10.1021\/acsnano.7b03426","article-title":"Core-Cross-Linked Nanoparticles Reduce Neuroinflammation and Improve Outcome in a Mouse Model of Traumatic Brain Injury","volume":"11","author":"Yoo","year":"","journal-title":"ACS Nano"},{"key":"B201","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/nnano.2017.133","article-title":"Electromagnetized Gold Nanoparticles Mediate Direct Lineage Reprogramming into Induced Dopamine Neurons In Vivo for Parkinson's Disease Therapy","volume":"12","author":"Yoo","year":"","journal-title":"Nat. Nanotechnol"},{"key":"B202","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/marc.200900592","article-title":"Endocytosis and Intracellular Distribution of PLGA Particles in Endothelial Cells: Effect of Particle Geometry","volume":"31","author":"Yoo","year":"2010","journal-title":"Macromol Rapid Commun."},{"key":"B203","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12989-018-0263-3","article-title":"Silica Nanoparticles Induce Neurodegeneration-like Changes in Behavior, Neuropathology, and Affect Synapse through MAPK Activation","volume":"15","author":"You","year":"2018","journal-title":"Part. Fibre Toxicol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ijbiomac.2018.11.064","article-title":"A Review on Versatile Applications of Blends and Composites of CNC with Natural and Synthetic Polymers with Mathematical Modeling","volume":"124","author":"Younas","year":"2019","journal-title":"Int. J. Biol. Macromol"},{"key":"B205","doi-asserted-by":"publisher","first-page":"102125","DOI":"10.1016\/j.cis.2020.102125","article-title":"Dendrimers as Efficient Nanocarriers for the Protection and Delivery of Bioactive Phytochemicals","volume":"278","author":"Yousefi","year":"2020","journal-title":"Adv. Colloid Interf. Sci"},{"key":"B206","doi-asserted-by":"publisher","first-page":"e0134722","DOI":"10.1371\/journal.pone.0134722","article-title":"Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats","volume":"10","author":"Yuan","year":"2015","journal-title":"PLoS One"},{"key":"B207","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/jcbfm.2012.209","article-title":"Nanoparticles for Targeted Delivery of Antioxidant Enzymes to the Brain after Cerebral Ischemia and Reperfusion Injury","volume":"33","author":"Yun","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B208","doi-asserted-by":"publisher","first-page":"19151","DOI":"10.1007\/s11356-019-05211-0","article-title":"Nanoparticles and its Biomedical Applications in Health and Diseases: Special Focus on Drug Delivery","volume":"27","author":"Zahin","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B209","doi-asserted-by":"publisher","first-page":"110674","DOI":"10.1016\/j.ecoenv.2020.110674","article-title":"Silver Nanoparticles Induce Size-dependent and Particle-specific Neurotoxicity to Primary Cultures of Rat Cerebral Cortical Neurons","volume":"198","author":"Zhang","year":"2020","journal-title":"Ecotoxicol Environ. Saf."},{"key":"B210","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.7150\/thno.19979","article-title":"Direct Macromolecular Drug Delivery to Cerebral Ischemia Area Using Neutrophil-Mediated Nanoparticles","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"key":"B211","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12974-016-0529-3","article-title":"Microglial Migration and Interactions with Dendrimer Nanoparticles Are Altered in the Presence of Neuroinflammation","volume":"13","author":"Zhang","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"B212","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jconrel.2014.03.026","article-title":"PEG-PLGA Copolymers: Their Structure and Structure-Influenced Drug Delivery Applications","volume":"183","author":"Zhang","year":"2014","journal-title":"J. Control. Release"},{"key":"B213","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1021\/mp200600t","article-title":"Transferrin-modified c[RGDfK]-Paclitaxel Loaded Hybrid Micelle for Sequential Blood-Brain Barrier Penetration and Glioma Targeting Therapy","volume":"9","author":"Zhang","year":"2012","journal-title":"Mol. Pharm."},{"key":"B214","doi-asserted-by":"publisher","first-page":"8655","DOI":"10.1021\/acsnano.5b03184","article-title":"Physical Principles of Nanoparticle Cellular Endocytosis","volume":"9","author":"Zhang","year":"2015","journal-title":"ACS Nano"},{"key":"B215","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1038\/s41467-019-09601-3","article-title":"Directed Self-Assembly of Herbal Small Molecules into Sustained Release Hydrogels for Treating Neural Inflammation","volume":"10","author":"Zheng","year":"2019","journal-title":"Nat. Commun."},{"key":"B216","doi-asserted-by":"publisher","first-page":"5828","DOI":"10.3390\/md13095828","article-title":"Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of Beta-Amyloid","volume":"13","author":"Zhou","year":"2015","journal-title":"Mar. Drugs"},{"key":"B217","doi-asserted-by":"publisher","first-page":"6592","DOI":"10.1021\/nn301629v","article-title":"Photo-Fenton Reaction of Graphene Oxide: a New Strategy to Prepare Graphene Quantum Dots for DNA Cleavage","volume":"6","author":"Zhou","year":"2012","journal-title":"ACS Nano"},{"key":"B218","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jconrel.2017.12.015","article-title":"Crossing the Blood-Brain Barrier with Nanoparticles","volume":"270","author":"Zhou","year":"2018","journal-title":"J. Control. Release"},{"key":"B219","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.3390\/molecules25163731","article-title":"Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology","volume":"25","author":"Zielinska","year":"2020","journal-title":"Molecules"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.683935\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T05:50:45Z","timestamp":1622008245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.683935\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":219,"alternative-id":["10.3389\/fphar.2021.683935"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.683935","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"article-number":"683935"}}