{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:03:42Z","timestamp":1791565422831,"version":"4.3.4"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), a neurodegenerative disorder, is a major health concern in the increasingly aged population worldwide. Currently, no clinically effective drug can halt the progression of AD. <jats:italic>Panax ginseng<\/jats:italic> C.A. Mey<jats:italic>.<\/jats:italic> is a well-known medicinal plant that contains ginsenosides, gintonin, and other components and has neuroprotective effects against a series of pathological cascades in AD, including beta-amyloid formation, neuroinflammation, oxidative stress, and mitochondrial dysfunction. In this review, we summarize the effects and mechanisms of these major components and formulas containing <jats:italic>P. ginseng<\/jats:italic> in neuronal cells and animal models. Moreover, clinical findings regarding the prevention and treatment of AD with <jats:italic>P. ginseng<\/jats:italic> or its formulas are discussed. This review can provide new insights into the possible use of ginseng in the prevention and treatment of AD.<\/jats:p>","DOI":"10.3389\/fphar.2021.688490","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T08:25:43Z","timestamp":1622622343000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Neuroprotective Potentials of Panax Ginseng Against Alzheimer\u2019s Disease: A Review of Preclinical and Clinical Evidences"],"prefix":"10.3389","volume":"12","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1080\/1061186x.2017.1354002","article-title":"Neuroprotective Effects of a Biodegradable Poly(lactic-Co-Glycolic Acid)-Ginsenoside Rg3 Nanoformulation: a Potential Nanotherapy for Alzheimer's Disease?","volume":"26","author":"Aalinkeel","year":"2018","journal-title":"J. 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