{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:56Z","timestamp":1787027036388,"version":"build-2736575974"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Drug overdoses (fatal and non-fatal) are among the leading causes of death in population with substance use disorders. The aim of the current study was to identify risk factors for fatal and non-fatal drug overdose for predominantly opioid-dependent treatment\u2013seeking population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Data were collected from 640 adult patients using a self-reported 25-item Overdose Risk (OdRi) questionnaire pertaining to drug use and identified related domains. The exploratory factor analysis (EFA) was primarily used to improve the interpretability of this questionnaire. Two sets of EFA were conducted; in the first set of analysis, all items were included, while in the second set, items related to the experience of overdose were removed. Logistic regression was used for the assessment of latent factors\u2019 association with both fatal and non-fatal overdoses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    EFA suggested a three-factor solution accounting for 75 and 97% of the variance for items treated in the first and second sets of analysis, respectively. Factor 1 was common for both sets of EFA analysis, containing six items (Cronbach\u2019s\n                    <jats:italic>\u03b1<\/jats:italic>\n                    = 0.70) focusing around \u201cillicit drug use and lack of treatment.\u201d In the first set of analysis, Factors 2 (Cronbach\u2019s\n                    <jats:italic>\u03b1<\/jats:italic>\n                    = 0.60) and 3 (Cronbach\u2019s\n                    <jats:italic>\u03b1<\/jats:italic>\n                    = 0.34) were focusing around \u201cmental health and emotional trauma\u201d and \u201cchronic drug use and frequent overdose\u201d domains, respectively. The increase of Factor 2 was found to be a risk factor for fatal drug overdose (adjusted coefficient = 1.94,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.038). In the second set of analysis, Factors 2 (Cronbach\u2019s\n                    <jats:italic>\u03b1<\/jats:italic>\n                    = 0.65) and 3 (Cronbach\u2019s\n                    <jats:italic>\u03b1<\/jats:italic>\n                    = 0.59) as well as Factor 1 were found to be risk factors for non-fatal drug overdose ever occurring. Only Factors 1 and 3 were positively associated with non-fatal overdose (one in a past year).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The OdRi tool developed here could be helpful for clinical studies for the overdose risk assessment. However, integrating validated tools for mental health can probably help refining the accuracy of latent variables and the questionnaire\u2019s consistency. Mental health and life stress appear as important predictors of both fatal and non-fatal overdoses.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2021.693673","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T03:09:31Z","timestamp":1632798571000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Understanding Fatal and Non-Fatal Drug Overdose Risk Factors: Overdose Risk Questionnaire Pilot Study\u2014Validation"],"prefix":"10.3389","volume":"12","author":[{"given":"Radhouene","family":"Doggui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyrellous","family":"Adib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Baldacchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/10550880802545192","article-title":"The Risk of Emergency Room Treatment Due to Overdose in Injection Drug Users","volume":"28","author":"Backmund","year":"2009","journal-title":"J. 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