{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:35:04Z","timestamp":1789468504804,"version":"build-2803163510"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Traditional medicines embody knowledge on medicinal plants that has been accumulated through cultural evolution over millennia. In the latter half of the 20th century, two approaches to medicinal plant research have been established: the \u201cBench to Bedside\u201d and the \u201cBedside to Bench\u201d approaches which serve primarily for the development of more efficient therapeutics. Here, we propose a third, novel approach: from \u201cTradition to Pathogenesis\u201d which aims to understand the pathogenesis of diseases based on the cultural evolution of their respective empirical treatments. We analyse multiple examples of diseases where the acting mechanism of traditional treatments across multiple cultures points to the pathogenesis of the respective disease. E.g., many cultures traditionally treat rheumatism with anti-bacterial botanical drugs, which is at odds with our current understanding that rheumatism is an aseptic inflammation. Furthermore, gastric ailments have traditionally been treated with anti-infectious botanical drugs indicating local infections, as demonstrated by the discovery of <jats:italic>Helicobacter pylori<\/jats:italic> as a common cause of gastric ulcer. Understanding traditional treatments can thus help to elucidate the pathogenesis of the disease.<\/jats:p>","DOI":"10.3389\/fphar.2021.705077","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T04:51:11Z","timestamp":1635137471000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Tradition to Pathogenesis: A Novel Hypothesis for Elucidating the Pathogenesis of Diseases Based on the Traditional Use of Medicinal Plants"],"prefix":"10.3389","volume":"12","author":[{"given":"Kenny","family":"Kuchta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1002\/hep.23440","article-title":"Nucleotide-binding Oligomerization Domain Containing 2 (NOD2) Variants Are Genetic Risk Factors for Death and Spontaneous Bacterial Peritonitis in Liver Cirrhosis","volume":"51","author":"Appenrodt","year":"2010","journal-title":"Hepatology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.jep.2012.11.033","article-title":"In Vitro anti-Helicobacter pylori Activity of a Flavonoid Rich Extract of Glycyrrhiza Glabra and its Probable Mechanisms of Action","volume":"145","author":"Asha","year":"2013","journal-title":"J. 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