{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:21:27Z","timestamp":1790655687303,"version":"4.1.0"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010868","name":"Key Laboratory of Forensic Toxicology, Ministry of Public Security, People\u2019s Republic of China (Beijing Municipal Public Security Bureau","doi-asserted-by":"publisher","award":["2019FTDWFX06"],"award-info":[{"award-number":["2019FTDWFX06"]}],"id":[{"id":"10.13039\/501100010868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:italic>Catha edulis<\/jats:italic> (Vahl) Endl., known as <jats:italic>Catha edulis<\/jats:italic> or Khat is a traditional and regional plant for chewing, smoking and drinking, that has posed a worldwide public health problem due to its recent emerging abused consumption. In the face of the massive use of <jats:italic>Catha edulis<\/jats:italic>, we reviewed related publications to analyze the progress and research trends through bibliometric methods. After screening, a total of 514 scientific publications published from 1997 to 2020 were included by systematic retrieval from the Web of Science (WoS) database. According to further scientometric analysis, the annual number of publications output kept rising in most of the years. Ethiopia and the United States of America (USA) have been devoting significant contributions to the field. Though the research emphasis had been the chemical composition and pharmacological and toxicological effects for several years, the hot spots were transferred; the mechanism investigations of <jats:italic>Catha edulis<\/jats:italic> have been the focus in recent years, which might be continued in the future. Furthermore, co-operations of multi-disciplinary researchers are needed to minimize abuse harms and maximize the medicinal benefits of <jats:italic>Catha edulis<\/jats:italic> to human beings.<\/jats:p>","DOI":"10.3389\/fphar.2021.705376","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T15:16:54Z","timestamp":1636643814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Shuang","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1080\/10601325.2019.1593792","article-title":"A Novel Method to Prepare Microporous and Nanofibrous Hydrogel Scaffolds as Neural Tissue Engineering","volume":"56","author":"Abdel Bary","year":"","journal-title":"J. Macromolecular Sci. 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