{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:55:03Z","timestamp":1790787303734,"version":"4.1.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia. The relationship between the sensory nervous system and modulation of the renin-angiotensin system has been described, focusing on pain and neurodegeneration in several animal models. We assessed the effect of the RAS modulator, ramipril, an angiotensin converting-enzyme inhibitor in a mouse model of OXP-induced acute pain syndrome. OXP was administered in Swiss mice at a cumulative dose of 15\u00a0mg\/kg (3 x 5\u00a0mg\/kg\/3\u00a0days, i.p.). RAM was administered i.p. every day from 24\u00a0h before the first OXP injection until the end of the experiments. We evaluated OIAS development and treatment effects by sensorimotor tests, intraepidermal nerve fiber and dorsal root ganglia-neuron immunohistochemical analyses, and sciatic nerve ultrastructural analysis. OXP-treated mice showed tactile allodynia and cold hypersensitivity, without motor impairment and evidence of nerve degeneration. RAM prevented cold sensitivity and improved recovery of normal tactile sensitivity in OXP-treated mice. Our finding that RAM alleviates OXP-induced pain is a step towards evaluating its therapeutic potential in patients receiving OXP treatment.<\/jats:p>","DOI":"10.3389\/fphar.2021.712442","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T09:31:22Z","timestamp":1626687082000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice"],"prefix":"10.3389","volume":"12","author":[{"given":"Hichem","family":"Bouchenaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Danigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavien","family":"Bessaguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Sturtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Balayssac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Magy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Demiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2021.03.142","article-title":"Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation","author":"Agnes","year":"2021","journal-title":"The J. Pain"},{"key":"B2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1124\/jpet.114.216382","article-title":"Clinically Relevant Doses of Candesartan Inhibit Growth of Prostate Tumor Xenografts In Vivo through Modulation of Tumor Angiogenesis","volume":"350","author":"Alhusban","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.brainres.2011.02.077","article-title":"Effects of Erythropoietin on Intracellular Calcium Concentration of Rat Primary Cortical Neurons","volume":"1387","author":"Andoh","year":"2011","journal-title":"Brain Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ctrv.2008.01.003","article-title":"A Review on Oxaliplatin-Induced Peripheral Nerve Damage","volume":"34","author":"Argyriou","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-9-53","article-title":"The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy","volume":"9","author":"Azevedo","year":"2013","journal-title":"Mol. Pain"},{"key":"B6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1006\/exnr.1996.0050","article-title":"Neuropeptides and Morphological Changes in Cisplatin-Induced Dorsal Root Ganglion Neuronopathy","volume":"138","author":"Barajon","year":"1996","journal-title":"Exp. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1097\/j.pain.0000000000001361","article-title":"Neuroprotective Effect of Angiotensin II Type 2 Receptor Stimulation in Vincristine-Induced Mechanical Allodynia","volume":"159","author":"Bessaguet","year":"2018","journal-title":"Pain"},{"key":"B8","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neuropharm.2017.08.039","article-title":"Candesartan Prevents Resiniferatoxin-Induced Sensory Small-Fiber Neuropathy in Mice by Promoting Angiotensin II-Mediated AT2 Receptor Stimulation","volume":"126","author":"Bessaguet","year":"2017","journal-title":"Neuropharmacology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1586\/14737175.2016.1150179","article-title":"The Therapeutic Potential of Renin Angiotensin Aldosterone System (RAAS) in Chronic Pain: from Preclinical Studies to Clinical Trials","volume":"16","author":"Bessaguet","year":"2016","journal-title":"Expert Rev. Neurotherapeutics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1016\/j.ejca.2007.07.030","article-title":"Pain in Oxaliplatin-Induced Neuropathy - Sensitisation in the Peripheral and central Nociceptive System","volume":"43","author":"Binder","year":"2007","journal-title":"Eur. J. Cancer"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-10-26","article-title":"A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments","volume":"10","author":"Bonin","year":"2014","journal-title":"Mol. Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.expneurol.2011.02.019","article-title":"Protection against Oxaliplatin-Induced Mechanical Hyperalgesia and Intraepidermal Nerve Fiber Loss by Minocycline","volume":"229","author":"Boyette-Davis","year":"2011","journal-title":"Exp. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.freeradbiomed.2020.09.019","article-title":"Curcumin-cyclodextrin\/cellulose Nanocrystals Improve the Phenotype of Charcot-Marie-Tooth-1a Transgenic Rats through the Reduction of Oxidative Stress","volume":"161","author":"Caillaud","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s00280-008-0689-7","article-title":"Interleukin-6 Protects against Paclitaxel, Cisplatin and Vincristine-Induced Neuropathies without Impairing Chemotherapeutic Activity","volume":"62","author":"Callizot","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3390\/ijms21030821","article-title":"Reciprocal Regulatory Interaction between TRPV1 and Kinin B1 Receptor in a Rat Neuropathic Pain Model","volume":"21","author":"Cernit","year":"2020","journal-title":"Ijms"},{"key":"B16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.niox.2013.12.007","article-title":"Ang-(1-7) Activates the NO\/cGMP and ATP-Sensitive K+ Channels Pathway to Induce Peripheral Antinociception in Rats","volume":"37","author":"Costa","year":"2014","journal-title":"Nitric Oxide"},{"key":"B17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3390\/ph14030175","article-title":"The Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?","volume":"14","author":"Danigo","year":"2021","journal-title":"Pharmaceuticals"},{"key":"B18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/emmm.201100134","article-title":"Oxaliplatin\u2010induced Cold Hypersensitivity Is Due to Remodelling of Ion Channel Expression in Nociceptors","volume":"3","author":"Descoeur","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jpain.2011.11.009","article-title":"Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of Silibinin","volume":"13","author":"Di Cesare Mannelli","year":"2012","journal-title":"J. Pain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fmolb.2020.00096","article-title":"Angiotensin-Converting Enzyme Inhibitor Protects against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice","volume":"7","author":"Estrela","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1523\/JNEUROSCI.2466-04.2005","article-title":"Reduced Nerve Injury-Induced Neuropathic Pain in Kinin B1 Receptor Knock-Out Mice","volume":"25","author":"Ferreira","year":"2005","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1097\/j.pain.0000000000000690","article-title":"Angiotensin-(1-7)\/Mas Receptor as an Antinociceptive Agent in Cancer-Induced Bone Pain","volume":"157","author":"Forte","year":"2016","journal-title":"Pain"},{"key":"B23","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/s0169-328x(98)00079-5","article-title":"Sciatic Nerve Transection Evokes Lasting Up-Regulation of Angiotensin AT2 and AT1 Receptor mRNA in Adult Rat Dorsal Root Ganglia and Sciatic Nerves","volume":"57","author":"Gallinat","year":"1998","journal-title":"Mol. Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1212\/WNL.0000000000004272","article-title":"Chemotherapy-induced Peripheral Neuropathy Clinical Trials","volume":"89","author":"Gewandter","year":"2017","journal-title":"Neurology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1152\/jn.2001.85.5.2293","article-title":"A Possible Explanation for a Neurotoxic Effect of the Anticancer Agent Oxaliplatin on Neuronal Voltage-Gated Sodium Channels","volume":"85","author":"Grolleau","year":"2001","journal-title":"J. Neurophysiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/SPC.0000000000000204","article-title":"Chemotherapy-induced Painful Neuropathy","volume":"10","author":"Hopkins","year":"2016","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"B28","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00280-004-0953-4","article-title":"Oxaliplatin Causes Selective Atrophy of a Subpopulation of Dorsal Root Ganglion Neurons without Inducing Cell Loss","volume":"56","author":"Jamieson","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.annonc.2020.07.003","article-title":"Systemic Anticancer Therapy-Induced Peripheral and central Neurotoxicity: ESMO-EONS-EANO Clinical Practice Guidelines for Diagnosis, Prevention, Treatment and Follow-Up","volume":"31","author":"Jordan","year":"2020","journal-title":"Ann. Oncol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/1470320314556171","article-title":"Ameliorative Potential of Angiotensin-Converting Enzyme Inhibitor (Ramipril) on Chronic Constriction Injury of Sciatic Nerve Induced Neuropathic Pain in Mice","volume":"16","author":"Kaur","year":"2015","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-8-7","article-title":"L Type Ca2+ Channel Blockers Prevent Oxaliplatin-Induced Cold Hyperalgesia and TRPM8 Overexpression in Rats","volume":"8","author":"Kawashiri","year":"2012","journal-title":"Mol. Pain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"7408","DOI":"10.1007\/s12035-019-1616-0","article-title":"Losartan, an Angiotensin II Type 1 Receptor Antagonist, Alleviates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain by Inhibiting Inflammatory Cytokines in the Dorsal Root Ganglia","volume":"56","author":"Kim","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B33","first-page":"4413","article-title":"Intraepidermal Nerve Fibre Density in Cancer Patients Receiving Adjuvant Chemotherapy","volume":"31","author":"Koskinen","year":"2011","journal-title":"Anticancer Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/j.1468-1331.2005.01260.x","article-title":"EFNS Guidelines on the Use of Skin Biopsy in the Diagnosis of Peripheral Neuropathy","volume":"12","author":"Lauria","year":"2005","journal-title":"Eur. J. Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1200\/JCO.20.01399","article-title":"Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update","volume":"38","author":"Loprinzi","year":"2020","journal-title":"Jco"},{"key":"B36","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1084\/jem.188.4.661","article-title":"The Angiotensin II Type 2 (AT2) Receptor Promotes Axonal Regeneration in the Optic Nerve of Adult Rats","volume":"188","author":"Lucius","year":"1998","journal-title":"J. Exp. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.pain.2011.02.051","article-title":"Oxaliplatin Elicits Mechanical and Cold Allodynia in Rodents via TRPA1 Receptor Stimulation","volume":"152","author":"Nassini","year":"2011","journal-title":"Pain"},{"key":"B38","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/ejp.1341","article-title":"Anti\u2010hypersensitive Effect of Angiotensin (1\u20107) on Streptozotocin\u2010induced Diabetic Neuropathic Pain in Mice","volume":"23","author":"Ogata","year":"2019","journal-title":"Eur. J. Pain"},{"key":"B39","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/oby.2007.19","article-title":"Attenuation of Vascular\/Neural Dysfunction in Zucker Rats Treated with Enalapril or Rosuvastatin","volume":"16","author":"Oltman","year":"2008","journal-title":"Obesity"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3416","DOI":"10.1200\/JCO.2014.58.8533","article-title":"Clinical Course of Oxaliplatin-Induced Neuropathy: Results from the Randomized Phase III Trial N08CB (Alliance)","volume":"33","author":"Pachman","year":"2015","journal-title":"Jco"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1200\/JCO.2008.19.3425","article-title":"Acute Abnormalities of Sensory Nerve Function Associated with Oxaliplatin-Induced Neurotoxicity","volume":"27","author":"Park","year":"2009","journal-title":"Jco"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e18469","DOI":"10.1371\/journal.pone.0018469","article-title":"Dose Effects of Oxaliplatin on Persistent and Transient Na+ Conductances and the Development of Neurotoxicity","volume":"6","author":"Park","year":"2011","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.critrevonc.2006.01.001","article-title":"Oxaliplatin-related Neurotoxicity: How and Why?","volume":"59","author":"Pasetto","year":"2006","journal-title":"Crit. Rev. Oncology\/Hematology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.regpep.2010.03.004","article-title":"Intraneuronal Angiotensinergic System in Rat and Human Dorsal Root Ganglia","volume":"162","author":"Patil","year":"2010","journal-title":"Regul. Peptides"},{"key":"B45","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s10571-013-9934-7","article-title":"Effect of Subpressor Dose of Angiotensin II on Pain-Related Behavior in Relation with Neuronal Injury and Activation of Satellite Glial Cells in the Rat Dorsal Root Ganglia","volume":"33","author":"Pavel","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e3000411","DOI":"10.1371\/journal.pbio.3000411","article-title":"Reporting Animal Research: Explanation and Elaboration for the ARRIVE Guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"Plos Biol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02361-6","article-title":"Epigenetics Involvement in Oxaliplatin-Induced Potassium Channel Transcriptional Downregulation and Hypersensitivity","author":"Pereira","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-7-29","article-title":"Multimodal Assessment of Painful Peripheral Neuropathy Induced by Chronic Oxaliplatin-Based Chemotherapy in Mice","volume":"7","author":"Renn","year":"2011","journal-title":"Mol. Pain"},{"key":"B49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0006-8993(86)90835-8","article-title":"Cardiovascular Effects of Microinjections of Angiotensin II into the Nucleus Tractus Solitarii","volume":"364","author":"Rettig","year":"1986","journal-title":"Brain Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"281","DOI":"10.36076\/ppj.2017.292","article-title":"Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Modulate the Function of Myelinated Fibers after Chemotherapy: A Quantitative Sensory Testing Study","volume":"4","author":"Roldan","year":"2017","journal-title":"Pain Phys."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.3390\/jcm9082400","article-title":"Long-Term Prevalence of Sensory Chemotherapy-Induced Peripheral Neuropathy for 5 Years after Adjuvant FOLFOX Chemotherapy to Treat Colorectal Cancer: A Multicenter Cross-Sectional Study","volume":"9","author":"Selvy","year":"2020","journal-title":"Jcm"},{"key":"B52","doi-asserted-by":"publisher","first-page":"11199","DOI":"10.1073\/pnas.1305321110","article-title":"Oxaliplatin-induced Neurotoxicity Is Dependent on the Organic Cation Transporter OCT2","volume":"110","author":"Sprowl","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1002\/ana.24951","article-title":"Chemotherapy-induced Peripheral Neuropathy: A Current Review","volume":"81","author":"Staff","year":"2017","journal-title":"Ann. Neurol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-5-9","article-title":"Mice with Cisplatin and Oxaliplatin-Induced Painful Neuropathy Develop Distinct Early Responses to thermal Stimuli","volume":"5","author":"Ta","year":"2009","journal-title":"Mol. Pain"},{"key":"B55","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/01.anes.0000435634.34709.65","article-title":"Characterization of Acute and Chronic Neuropathies Induced by Oxaliplatin in Mice and Differential Effects of a Novel Mitochondria-Targeted Antioxidant on the Neuropathies","volume":"120","author":"Toyama","year":"2014","journal-title":"Anesthesiology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.clinthera.2018.05.011","article-title":"Preventive Effects of Renin-Angiotensin System Inhibitors on Oxaliplatin-Induced Peripheral Neuropathy: A Retrospective Observational Study","volume":"40","author":"Uchida","year":"2018","journal-title":"Clin. Ther."},{"key":"B57","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0895-7061(99)00105-3","article-title":"Interrupting the Renin-Angiotensin System: the Role of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Ii Receptor Antagonists in the Treatment of Hypertension","volume":"12","author":"Weber","year":"1999","journal-title":"Am. J. Hypertens."},{"key":"B58","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.neuroscience.2011.12.023","article-title":"Characterization of Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy in the Rat and Comparison with the Neuropathy Induced by Paclitaxel","volume":"203","author":"Xiao","year":"2012","journal-title":"Neuroscience"},{"key":"B59","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3109\/00207454.2014.948115","article-title":"Investigation of the Effect of Telmisartan on Experimentally Induced Peripheral Nerve Injury in Rats","volume":"125","author":"Yuksel","year":"2015","journal-title":"Int. J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1248\/bpb.b19-00862","article-title":"Curcumin Alleviates Oxaliplatin-Induced Peripheral Neuropathic Pain through Inhibiting Oxidative Stress-Mediated Activation of NF-\u039ab and Mitigating Inflammation","volume":"43","author":"Zhang","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-8-55","article-title":"Acute Cold Hypersensitivity Characteristically Induced by Oxaliplatin Is Caused by the Enhanced Responsiveness of TRPA1 in Mice","volume":"8","author":"Zhao","year":"2012","journal-title":"Mol. Pain"},{"key":"B62","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1254\/jphs.13249SC","article-title":"Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice","volume":"124","author":"Zhao","year":"2014","journal-title":"J. Pharmacol. Sci."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.712442\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T09:31:26Z","timestamp":1626687086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.712442\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":61,"alternative-id":["10.3389\/fphar.2021.712442"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.712442","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,19]]},"article-number":"712442"}}