{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:06:40Z","timestamp":1791839200442,"version":"4.3.4"},"reference-count":117,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:italic>Houttuynia cordata<\/jats:italic>\n                    Thunb (\n                    <jats:italic>H. cordata<\/jats:italic>\n                    ; Saururaceae) is widely distributed in Asian regions. It plays an important role in traditional health care and disease treatment, as its aboveground stems and leaves have a long medicinal history in China and are used in the treatment of pneumonia and lung abscess. In clinical treatment, it can usually be combined with other drugs to treat dysentery, cold, fever, and mumps; additionally,\n                    <jats:italic>H. cordata<\/jats:italic>\n                    is an edible plant. This review summarizes detailed information on the phytochemistry and pharmacological effects of\n                    <jats:italic>H. cordata<\/jats:italic>\n                    . By searching the keywords \u201c\n                    <jats:italic>H. cordata<\/jats:italic>\n                    and lung\u201d, \u201c\n                    <jats:italic>H. cordata<\/jats:italic>\n                    and heart\u201d, \u201c\n                    <jats:italic>H. cordata<\/jats:italic>\n                    and liver\u201d, and \u201c\n                    <jats:italic>H. cordata<\/jats:italic>\n                    and inflammation\u201d in PubMed, Web of Science and ScienceDirect, we screened out articles with high correlation in the past ten years, sorted out the research contents, disease models and research methods of the articles, and provided a new perspective on the therapeutic effects of\n                    <jats:italic>H. cordata<\/jats:italic>\n                    . A variety of its chemical constituents are characteristic of medicinal plants, the chemical constituents were isolated from\n                    <jats:italic>H. cordata<\/jats:italic>\n                    , including volatile oils, alkaloids, flavonoids, and phenolic acids. Flavonoids and volatile oils are the main active components. In pharmacological studies,\n                    <jats:italic>H. cordata<\/jats:italic>\n                    showed organ protective activity, such as reducing the release of inflammatory factors to alleviate lung injury. Moreover,\n                    <jats:italic>H. cordata<\/jats:italic>\n                    regulates immunity, enhances the immune barriers of the vagina, oral cavity, and intestinal tract, and combined with the antibacterial and antiviral activity of its extract, effectively reduces pathogen infection. Furthermore, experiments\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    showed significant anti-inflammatory activity, and its chemical derivatives exert potential therapeutic activity against rheumatoid arthritis. Antitumour action is also an important pharmacological activity of\n                    <jats:italic>H. cordata<\/jats:italic>\n                    , and studies have shown that\n                    <jats:italic>H. cordata<\/jats:italic>\n                    has a notable effect on lung tumour, liver tumour, colon tumour, and breast tumour. This review categorizes the biological activities of\n                    <jats:italic>H. cordata<\/jats:italic>\n                    according to modern research papers, and provides insights into disease prevention and treatment of\n                    <jats:italic>H. cordata<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fphar.2021.714694","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T21:41:18Z","timestamp":1630705278000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":97,"title":["Houttuynia cordata Thunb: An Ethnopharmacological Review"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1002\/ptr.6893","article-title":"Potential Roles of Medicinal Plants for the Treatment of Viral Diseases Focusing on COVID-19: A Review","volume":"35","author":"Adhikari","year":"2020","journal-title":"Phytother Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/j.bmcl.2017.04.072","article-title":"Alkaloids from Aerial Parts of Houttuynia Cordata and Their Anti-inflammatory Activity","volume":"27","author":"Ahn","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3390\/molecules26061499","article-title":"Anti-Tumor Drug Discovery Based on Natural Product \u03b2-Elemene: Anti-tumor Mechanisms and Structural Modification","volume":"26","author":"Bai","year":"2021","journal-title":"Molecules"},{"key":"B4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/s0944-7113(96)80073-0","article-title":"Cyclooxygenase Inhibitory Constituents from Houttuynia Cordata","volume":"2","author":"Bauer","year":"1996","journal-title":"Phytomedicine"},{"key":"B5","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA. Cancer J. Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1159\/000356594","article-title":"Protective Effects of Bone Marrow-Derived Endothelial Progenitor Cells and Houttuynia Cordata in Lipopolysaccharide-Induced Acute Lung Injury in Rats","volume":"32","author":"Cai","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.95978","article-title":"Human Liver-Kidney Model Elucidates the Mechanisms of Aristolochic Acid Nephrotoxicity","volume":"2","author":"Chang","year":"2017","journal-title":"JCI insight"},{"key":"B8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.antiviral.2011.09.005","article-title":"Houttuynia Cordata Blocks HSV Infection through Inhibition of NF-\u039ab Activation","volume":"92","author":"Chen","year":"2011","journal-title":"Antivir. Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1021\/ol300017m","article-title":"Houttuynoids A-E, Anti-herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia Cordata","volume":"14","author":"Chen","year":"2012","journal-title":"Org. Lett."},{"key":"B10","doi-asserted-by":"publisher","first-page":"22978","DOI":"10.3390\/ijms151222978","article-title":"A Comparative Study of Sodium Houttuyfonate and 2-undecanone for Their In Vitro and In Vivo Anti-inflammatory Activities and Stabilities","volume":"15","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1875-5364(19)30021-4","article-title":"Houttuynia Cordata Polysaccharide Alleviated Intestinal Injury and Modulated Intestinal Microbiota in H1N1 Virus Infected Mice","volume":"17","author":"Chen","year":"2019","journal-title":"Chin. J. Nat. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jat.4198","article-title":"Acute and Subacute Toxicity Evaluation of Houttuynia Cordata Ethanol Extract and Plasma Metabolic Profiling Analysis in Both Male and Female Rats","author":"Chen","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1055\/s-0033-1351051","article-title":"Anti HSV-1 Flavonoid Derivatives Tethered with Houttuynin from Houttuynia Cordata","volume":"79","author":"Chen","year":"2013","journal-title":"Planta Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-021-03301-6","article-title":"A Plant-Based Medicinal Food Inhibits the Growth of Human Gastric Carcinoma by Reversing Epithelial-Mesenchymal Transition via the Canonical Wnt\/\u03b2-Catenin Signaling Pathway","volume":"21","author":"Chen","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1423-0127-20-18","article-title":"Houttuynia Cordata Thunb Extract Modulates G0\/G1 Arrest and Fas\/CD95-Mediated Death Receptor Apoptotic Cell Death in Human Lung Cancer A549 Cells","volume":"20","author":"Chen","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.carbpol.2013.12.048","article-title":"Structural Characterization and Immunomodulatory Effect of a Polysaccharide HCP-2 from Houttuynia Cordata","volume":"103","author":"Cheng","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.apjtm.2015.12.002","article-title":"Evaluation of Antiviral Activities of Houttuynia Cordata Thunb. Extract, Quercetin, Quercetrin and Cinanserin on Murine Coronavirus and Dengue Virus Infection","volume":"9","author":"Chiow","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ejps.2009.03.002","article-title":"Inhibitory Effects of Quercetin 3-rhamnoside on Influenza A Virus Replication","volume":"37","author":"Choi","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1248\/cpb.57.1227","article-title":"The Constituents and Their Bioactivities of Houttuynia Cordata","volume":"57","author":"Chou","year":"2009","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11030-021-10226-2","article-title":"Identification of Phytocompounds from Houttuynia Cordata Thunb. As Potential Inhibitors for SARS-CoV-2 Replication Proteins through GC-MS\/LC-MS Characterization, Molecular Docking and Molecular Dynamics Simulation","author":"Das","year":"2021","journal-title":"Mol. Divers."},{"key":"B21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1200\/JCO.2008.19.9844","article-title":"Prognosis of Women with Metastatic Breast Cancer by HER2 Status and Trastuzumab Treatment: An Institutional-Based Review","volume":"28","author":"Dawood","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ircmb.2016.09.008","article-title":"Breast Cancer Immunology and Immunotherapy: Current Status and Future Perspectives","volume":"331","author":"de la Cruz-Merino","year":"2017","journal-title":"Int. Rev. Cel Mol. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/molecules25010006","article-title":"Growing Importance of Natural Products Research","volume":"25","author":"Drasar","year":"2020","journal-title":"Molecules"},{"key":"B24","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.intimp.2012.03.011","article-title":"Houttuynia Cordata Inhibits Lipopolysaccharide-Induced Rapid Pulmonary Fibrosis by Up-Regulating IFN-\u03b3 and Inhibiting the TGF-\u03b21\/Smad Pathway","volume":"13","author":"Du","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/med.21793","article-title":"The Yin and Yang of Traditional Chinese and Western Medicine","author":"Fu","year":"2021","journal-title":"Med. Res. Rev"},{"key":"B26","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1211\/jpp\/61.05.0018","article-title":"Effect of Sodium Houttuyfonate on Myocardial Hypertrophy in Mice and Rats","volume":"61","author":"Gao","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1139\/Y10-049","article-title":"Effect of Sodium Houttuyfonate on Inhibiting Ventricular Remodeling Induced by Abdominal Aortic Banding in Rats","volume":"88","author":"Gao","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"576463","DOI":"10.3389\/fphys.2020.576463","article-title":"Autophagy and Inflammation Regulation in Acute Kidney Injury","volume":"11","author":"Gong","year":"2020","journal-title":"Front. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/j.fct.2009.04.025","article-title":"Houttuynia Cordata Water Extract Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Response by Inhibiting Multiple Steps of FcepsilonRI Signaling in Mast Cells","volume":"47","author":"Han","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/S1875-5364(16)30095-4","article-title":"Screening and Evaluation of Commonly-Used Anti-influenza Chinese Herbal Medicines Based on Anti-neuraminidase Activity","volume":"14","author":"Han","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ijbiomac.2018.08.061","article-title":"Structural Characterization and Anti-a549 Lung Cancer Cells Bioactivity of a Polysaccharide from Houttuynia Cordata","volume":"120","author":"Han","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"112230","DOI":"10.1016\/j.jep.2019.112230","article-title":"Best Practice in Research - Overcoming Common Challenges in Phytopharmacological Research","volume":"246","author":"Heinrich","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s00394-015-0994-y","article-title":"Houttuynia Cordata Aqueous Extract Attenuated Glycative and Oxidative Stress in Heart and Kidney of Diabetic Mice","volume":"55","author":"Hsu","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"B34","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.bmcl.2014.10.072","article-title":"Sodium Houttuyfonate and EDTA-Na\u2082 in Combination Effectively Inhibits Pseudomonas aeruginosa, Staphylococcus aureus and Candida Albicans In Vitro and In Vivo","volume":"25","author":"Huang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e0115475","DOI":"10.1371\/journal.pone.0115475","article-title":"Houttuynia Cordata Targets the Beginning Stage of Herpes Simplex Virus Infection","volume":"10","author":"Hung","year":"2015","journal-title":"PLoS One"},{"key":"B36","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1080\/14786410903339044","article-title":"Caffeic Acid and Quercitrin Purified from Houttuynia Cordata Inhibit DNA Topoisomerase I Activity","volume":"25","author":"Jang","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-019-1152-9","article-title":"Sodium New Houttuyfonate Suppresses Metastasis in NSCLC Cells through the Linc00668\/miR-147a\/slug axis","volume":"38","author":"Jiang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B38","first-page":"s41","article-title":"Recent Advances in the Management of Lung Cancer","volume-title":"Clin. Med","author":"Jones","year":"2018"},{"key":"B39","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1142\/S0192415X14500426","article-title":"Houttuynia Cordata Attenuates Lipid Accumulation via Activation of AMP-Activated Protein Kinase Signaling Pathway in HepG2 Cells","volume":"42","author":"Kang","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jep.2007.02.010","article-title":"The Inhibitory Effect of Houttuynia Cordata Extract on Stem Cell Factor-Induced HMC-1 Cell Migration","volume":"112","author":"Kim","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1177\/1534735416670987","article-title":"Houttuynia Cordata Thunb Promotes Activation of HIF-1a-FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells","volume":"16","author":"Kim","year":"2017","journal-title":"Integr. Cancer Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/0973-7847.125525","article-title":"A Current Update on the Phytopharmacological Aspects of Houttuynia Cordata Thunb","volume":"8","author":"Kumar","year":"2014","journal-title":"Pharmacogn. Rev."},{"key":"B43","first-page":"3549","article-title":"Houttuynia Cordata Thunb Extract Inhibits Cell Growth and Induces Apoptosis in Human Primary Colorectal Cancer Cells","volume":"30","author":"Lai","year":"2010","journal-title":"Anticancer Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jep.2008.03.018","article-title":"Immunomodulatory and Anti-SARS Activities of Houttuynia Cordata","volume":"118","author":"Lau","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jep.2008.01.013","article-title":"Suppressive Effects of Houttuynia Cordata Thunb (Saururaceae) Extract on Th2 Immune Response","volume":"117","author":"Lee","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3892\/mmr.2013.1585","article-title":"Houttuynia Cordata Thunb Inhibits the Production of Pro-inflammatory Cytokines through Inhibition of the NF\u03baB Signaling Pathway in HMC-1 Human Mast Cells","volume":"8","author":"Lee","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1007\/s12272-015-0585-8","article-title":"Flavonoids from the Aerial Parts of Houttuynia Cordata Attenuate Lung Inflammation in Mice","volume":"38","author":"Lee","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/etm.2015.2467","article-title":"Anti-inflammatory Functions of Houttuynia Cordata Thunb. And its Compounds: A Perspective on its Potential Role in Rheumatoid Arthritis","volume":"10","author":"Li","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1248\/bpb.28.1864","article-title":"Inhibitory Effects of Houttuynia Cordata Water Extracts on Anaphylactic Reaction and Mast Cell Activation","volume":"28","author":"Li","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"B50","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.jep.2010.10.048","article-title":"Houttuynia Cordata, a Novel and Selective COX-2 Inhibitor with Anti-inflammatory Activity","volume":"133","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1002\/ptr.4905","article-title":"Houttuynia Cordata Thunb. Volatile Oil Exhibited Anti-inflammatory Effects In Vivo and Inhibited Nitric Oxide and Tumor Necrosis Factor-\u03b1 Production in LPS-Stimulated Mouse Peritoneal Macrophages In Vitro","volume":"27","author":"Li","year":"2013","journal-title":"Phytother Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.3892\/etm.2014.1636","article-title":"Inhibitory Effect of Sodium Houttuyfonate on Synovial Proliferation In Vitro in Cells from a Patient with Rheumatoid Arthritis","volume":"7","author":"Li","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1021\/acs.jnatprod.7b00620","article-title":"Houttuynoid M, an Anti-HSV Active Houttuynoid from Houttuynia Cordata Featuring a Bis-Houttuynin Chain Tethered to a Flavonoid Core","volume":"80","author":"Li","year":"","journal-title":"J. Nat. Prod."},{"key":"B54","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.antiviral.2017.06.010","article-title":"Anti-herpes Simplex Virus Type 1 Activity of Houttuynoid A, a Flavonoid from Houttuynia Cordata Thunb","volume":"144","author":"Li","year":"","journal-title":"Antivir. Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"9026901","DOI":"10.1155\/2020\/9026901","article-title":"Houttuynia Cordata Extract Ameliorates Bladder Damage and Improves Bladder Symptoms via Anti-inflammatory Effect in Rats with Interstitial Cystitis","volume":"2020","author":"Li","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"153150","DOI":"10.1016\/j.phymed.2019.153150","article-title":"Flavonoids from Houttuynia Cordata Attenuate H1N1-Induced Acute Lung Injury in Mice via Inhibition of Influenza Virus and Toll-like Receptor Signalling","volume":"67","author":"Ling","year":"2020","journal-title":"Phytomedicine"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01635581.2020.1737153","article-title":"Effect of Heat Treatment on the Anticancer Activity of Houttuynia Cordata Thunb Aerial Stem Extract in Human Gastric Cancer SGC-7901 Cells","volume":"73","author":"Liu","year":"2020","journal-title":"Nutr. Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-019-1255-3","article-title":"Houttuynia Cordata Thunb. And its Bioactive Compound 2-undecanone Significantly Suppress Benzo(a)pyrene-Induced Lung Tumorigenesis by Activating the Nrf2-HO-1\/NQO-1 Signaling Pathway","volume":"38","author":"Lou","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/nejm199808203390806","article-title":"Staphylococcus aureusInfections","volume":"339","author":"Lowy","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1248\/cpb.54.936","article-title":"Variation in Chemical Composition and Antibacterial Activities of Essential Oils from Two Species of Houttuynia THUNB","volume":"54","author":"Lu","year":"2006","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1002\/elps.201100162","article-title":"Polystyrene\/graphene Composite Electrode Fabricated by In Situ Polymerization for Capillary Electrophoretic Determination of Bioactive Constituents in Herba Houttuyniae","volume":"32","author":"Lu","year":"2011","journal-title":"Electrophoresis"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e68053","DOI":"10.1371\/journal.pone.0068053","article-title":"In Vitro Activity of Sodium New Houttuyfonate Alone and in Combination with Oxacillin or Netilmicin against Methicillin-Resistant Staphylococcus aureus","volume":"8","author":"Lu","year":"2013","journal-title":"PLoS One"},{"key":"B63","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.apsb.2017.11.003","article-title":"Beneficial Effects of Houttuynia Cordata Polysaccharides on \"Two-Hit\" Acute Lung Injury and Endotoxic Fever in Rats Associated with Anti-complementary Activities","volume":"8","author":"Lu","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.2217\/fon-2019-0416","article-title":"Radiation-induced Intestinal Damage: Latest Molecular and Clinical Developments","volume":"15","author":"Lu","year":"2019","journal-title":"Future Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/978-1-4614-0980-9_9","article-title":"Influenza Virus Entry","volume":"726","author":"Luo","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jep.2016.11.013","article-title":"Bioactive Alkaloids from the Aerial Parts of Houttuynia Cordata","volume":"195","author":"Ma","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"173578","DOI":"10.1016\/j.ejphar.2020.173578","article-title":"A Comprehensive Review of Natural Products to Fight Liver Fibrosis: Alkaloids, Terpenoids, Glycosides, Coumarins and Other Compounds","volume":"5","author":"Ma","year":"","journal-title":"Eur. J. Pharmacol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1002\/ptr.6621","article-title":"Natural Products for the Prevention and Treatment of Cholestasis: A Review","volume":"34","author":"Ma","year":"","journal-title":"Phytother Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.anai.2018.10.018","article-title":"Challenges in Allergy Immunology Practice: Solutions Needed for Persistent Patient Problems","volume":"121","author":"Marshall","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1039\/c3np70114j","article-title":"Naturally Occurring Aristolochic Acid Analogues and Their Toxicities","volume":"31","author":"Michl","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11274-019-2739-1","article-title":"Metabolomic Studies of Pseudomonas aeruginosa","volume":"35","author":"Mielko","year":"2019","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4103\/2225-4110.126635","article-title":"Anti-inflammatory and Antimicrobial Effects of Heat-Clearing Chinese Herbs: A Current Review","volume":"4","author":"Muluye","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1142\/S0192415X07004989","article-title":"Protective Effect of Houttuynia Cordata Extract on Bleomycin-Induced Pulmonary Fibrosis in Rats","volume":"35","author":"Ng","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"eaan6446","DOI":"10.1126\/scitranslmed.aan6446","article-title":"Aristolochic Acids and Their Derivatives Are Widely Implicated in Liver Cancers in Taiwan and throughout Asia","volume":"9","author":"Ng","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.foodchem.2009.04.071","article-title":"Rapid Screening and Identification of Antioxidants in Aqueous Extracts of Houttuynia Cordata Using LC-ESI-MS Coupled with DPPH Assay","volume":"117","author":"Nuengchamnong","year":"2009","journal-title":"Food Chem."},{"key":"B74","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jep.2010.06.020","article-title":"Effects of Sodium Houttuyfonate on Expression of NF-\u039ab and MCP-1 in Membranous Glomerulonephritis","volume":"131","author":"Pan","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules22020293","article-title":"Purification of Houttuynia Cordata Thunb. Essential Oil Using Macroporous Resin Followed by Microemulsion Encapsulation to Improve its Safety and Antiviral Activity","volume":"22","author":"Pang","year":"2017","journal-title":"Molecules"},{"key":"B76","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1142\/S0192415X05003028","article-title":"Anti-inflammatory Activity of Herbal Medicines: Inhibition of Nitric Oxide Production and Tumor Necrosis Factor-Alpha Secretion in an Activated Macrophage-like Cell Line","volume":"33","author":"Park","year":"2005","journal-title":"Am. J. Chin. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1055\/s-2006-961554","article-title":"Aristolactams and a 4,5-dioxoaporphine Derivative from Houttuynia Cordata","volume":"58","author":"Pr\u00f4bstle","year":"1992","journal-title":"Planta Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.7314\/APJCP.2012.13.5.1977","article-title":"Houttuynia Cordata Thunb Fraction Induces Human Leukemic Molt-4 Cell Apoptosis through the Endoplasmic Reticulum Stress Pathway","volume":"13","author":"Prommaban","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules25102432","article-title":"Chemical Composition and Determination of the Antibacterial Activity of Essential Oils in Liquid and Vapor Phases Extracted from Two Different Southeast Asian Herbs-Houttuynia Cordata (Saururaceae) and Persicaria Odorata (Polygonaceae)","volume":"25","author":"\u0158eb\u00ed\u010dkov\u00e1","year":"2020","journal-title":"Molecules"},{"key":"B80","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3109\/13880209.2010.505242","article-title":"The Effect of Houttuynia Cordata Injection on Pseudorabies Herpesvirus (PrV) Infection In Vitro","volume":"49","author":"Ren","year":"2011","journal-title":"Pharm. Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/sji.12970","article-title":"An Inflammation Classification System Using Cytokine Parameters","volume":"93","author":"Roe","year":"2021","journal-title":"Scand. J. Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/odi.12313","article-title":"Houttuynia Cordata Modulates Oral Innate Immune Mediators: Potential Role of Herbal Plant on Oral Health","volume":"21","author":"Satthakarn","year":"","journal-title":"Oral Dis."},{"key":"B83","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12906-015-0701-9","article-title":"Vaginal Innate Immune Mediators Are Modulated by a Water Extract of Houttuynia Cordata Thunb","volume":"15","author":"Satthakarn","year":"","journal-title":"BMC Complement. Altern. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-319-57613-8_1","article-title":"The Role of the Immune System beyond the Fight against Infection","volume":"1003","author":"Sattler","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1080\/09168451.2016.1151339","article-title":"Anti-bacterial and Anti-inflammatory Effects of Ethanol Extract from Houttuynia Cordata Poultice","volume":"80","author":"Sekita","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/2850947","article-title":"Antibiofilm and Anti-inflammatory Activities of Houttuynia Cordata Decoction for Oral Care","volume":"2017","author":"Sekita","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1111\/bph.13631","article-title":"Anti-ageing Active Ingredients from Herbs and Nutraceuticals Used in Traditional Chinese Medicine: Pharmacological Mechanisms and Implications for Drug Discovery","volume":"174","author":"Shen","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ijbiomac.2020.04.211","article-title":"Regulating the Balance of Th17\/Treg Cells in Gut-Lung axis Contributed to the Therapeutic Effect of Houttuynia Cordata Polysaccharides on H1N1-Induced Acute Lung Injury","volume":"158","author":"Shi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1134\/S0006297921030068","article-title":"Molecular and Cellular Mechanisms of Respiratory Syncytial Viral Infection: Using Murine Models to Understand Human Pathology","volume":"86","author":"Shilovskiy","year":"2021","journal-title":"Biochem. Mosc."},{"key":"B90","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1089\/jmf.2007.0684","article-title":"Down-regulation of FcepsilonRI Expression by Houttuynia Cordata Thunb Extract in Human Basophilic KU812F Cells","volume":"12","author":"Shim","year":"2009","journal-title":"J. Med. Food"},{"key":"B91","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4142\/jvs.2010.11.3.273","article-title":"Anti-inflammatory Effects of a Houttuynia Cordata Supercritical Extract","volume":"11","author":"Shin","year":"2010","journal-title":"J. Vet. Sci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jep.2018.03.038","article-title":"Therapeutic Potentials of Houttuynia Cordata Thunb. Against Inflammation and Oxidative Stress: A Review","volume":"220","author":"Shingnaisui","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3390\/molecules25051196","article-title":"The Effects of Houttuynia Cordata Thunb and Piper Ribesioides Wall Extracts on Breast Carcinoma Cell Proliferation, Migration, Invasion and Apoptosis","volume":"25","author":"Subhawa","year":"2020","journal-title":"Molecules"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3892\/or.10.3892\/or_00000535","article-title":"Houttuynia Cordata Thunb Extract Induces Apoptosis through Mitochondrial-dependent Pathway in HT-29 Human colon Adenocarcinoma Cells","volume":"22","author":"Tang","year":"2009","journal-title":"Oncol. Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.1021\/jf3008376","article-title":"Chemical Composition and Hepatoprotective Effects of Polyphenol-Rich Extract from Houttuynia Cordata tea","volume":"60","author":"Tian","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"B96","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jep.2016.09.010","article-title":"Screening Study on the Anti-angiogenic Effects of Traditional Chinese Medicine - Part I: Heat-Clearing and Detoxicating TCM","volume":"194","author":"Tu","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"e1700189","DOI":"10.1002\/cbdv.201700189","article-title":"Chemical Composition and Allelopathic, Antibacterial, Antifungal, and Antiacetylcholinesterase Activity of Fish-Mint (Houttuynia cordataThunb.) from India","volume":"14","author":"Verma","year":"2017","journal-title":"Chem. Biodivers."},{"key":"B98","first-page":"1609","article-title":"Houttuynia Cordata Thunb Reverses Oxaliplatin-Induced Neuropathic Pain in Rat by Regulating Th17\/Treg Balance","volume":"8","author":"Wan","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1756-5391.2010.01091.x","article-title":"Adverse Events to Houttuynia Injection: A Systematic Review","volume":"3","author":"Wang","year":"2010","journal-title":"J. Evid. Based. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/genes8100239","article-title":"Houttuynia Cordata Facilitates Metformin on Ameliorating Insulin Resistance Associated with Gut Microbiota Alteration in OLETF Rats","volume":"8","author":"Wang","year":"2017","journal-title":"Genes (Basel)"},{"key":"B101","doi-asserted-by":"publisher","first-page":"e0230645","DOI":"10.1371\/journal.pone.0230645","article-title":"Anti-inflammatory Activity of the Dietary Supplement Houttuynia Cordata Fermentation Product in RAW264.7 Cells and Wistar Rats","volume":"15","author":"Woranam","year":"2020","journal-title":"PLoS One"},{"key":"B102","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/s1875-5364(09)60042-x10.3724\/sp.j.1009.2009.00040","article-title":"Quantitive Variation of Flavonoids in Houttuynia Cordata from Different Geographic Origins in China","volume":"7","author":"Wu","year":"2009","journal-title":"Chin. J. Nat. Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2014.00635","article-title":"Sodium Houttuyfonate Affects Production of N-Acyl Homoserine Lactone and Quorum Sensing-Regulated Genes Expression in Pseudomonas aeruginosa","volume":"5","author":"Wu","year":"2014","journal-title":"Front. Microbiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3892\/etm.2015.2562","article-title":"Sodium Houttuyfonate Inhibits Biofilm Formation and Alginate Biosynthesis-Associated Gene Expression in a Clinical Strain of Pseudomonas aeruginosa In Vitro","volume":"10","author":"Wu","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1007\/s10753-017-0650-1","article-title":"Effects of Sodium Houttuyfonate on Pulmonary Inflammation in COPD Model Rats","volume":"40","author":"Wu","year":"2017","journal-title":"Inflammation"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.3892\/etm.2018.7079","article-title":"Therapeutic Effects of Houttuynia Eye Drops Combined with Olopatadine Hydrochloride Eye Drops on vernal Keratoconjunctivitis","volume":"17","author":"Xu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"B107","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.talanta.2005.05.027","article-title":"Determination of Flavonoids in Houttuynia Cordata Thunb. And Saururus Chinensis (Lour.) Bail. by Capillary Electrophoresis with Electrochemical Detection","volume":"68","author":"Xu","year":"2006","journal-title":"Talanta"},{"key":"B108","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/09546634.2019.1657792","article-title":"Clinical Efficacy of Herbal Extracts in Treatment of Mild to Moderate Acne Vulgaris: an 8-week, Double-Blinded, Randomized, Controlled Trial","volume":"32","author":"Yang","year":"2021","journal-title":"J. Dermatolog. Treat."},{"key":"B109","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/03079457.2011.605107","article-title":"In Vitro and In Vivo Effects of Houttuynia Cordata on Infectious Bronchitis Virus","volume":"40","author":"Yin","year":"2011","journal-title":"Avian Pathol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1089\/jmf.2017.4043","article-title":"A Blend of Extracts from Houttuynia Cordata, nelumbo Nucifera, and Camellia Sinensis Protects against Ethanol-Induced Liver Damage in C57BL\/6 Mice","volume":"21","author":"You","year":"2018","journal-title":"J. Med. Food"},{"key":"B111","doi-asserted-by":"publisher","first-page":"107058","DOI":"10.1016\/j.intimp.2020.107058","article-title":"Sodium Houttuyfonate Enhances the Intestinal Barrier and Attenuates Inflammation Induced by Salmonella typhimurium through the NF-\u039ab Pathway in Mice","volume":"89","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2020.572375","article-title":"Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors of Pseudomonas aeruginosa Controlled by Quorum Sensing","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2018.01092","article-title":"Sodium Houttuyfonate Alleviates Post-infarct Remodeling in Rats via AMP-Activated Protein Kinase Pathway","volume":"9","author":"Zheng","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.lfs.2012.03.035","article-title":"Houttuyninum, an Active Constituent of Chinese Herbal Medicine, Inhibits Phosphorylation of HER2\/neu Receptor Tyrosine Kinase and the Tumor Growth of HER2\/neu-Overexpressing Cancer Cells","volume":"90","author":"Zhou","year":"2012","journal-title":"Life Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jep.2018.02.016","article-title":"Houttuynia Cordata Polysaccharides Ameliorate Pneumonia Severity and Intestinal Injury in Mice with Influenza Virus Infection","volume":"218","author":"Zhu","year":"2018","journal-title":"J. Ethnopharmacol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.714694\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T21:41:23Z","timestamp":1630705283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.714694\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":117,"alternative-id":["10.3389\/fphar.2021.714694"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.714694","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,1]]},"article-number":"714694"}}