{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:00:11Z","timestamp":1792548011073,"version":"4.5.0"},"reference-count":178,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074002 81673578 81872985"],"award-info":[{"award-number":["82074002 81673578 81872985"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    The Wnt\/\u03b2-catenin signaling pathway plays important roles in embryonic development and tissue homeostasis. Wnt signaling is induced, and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -catenin is activated, associated with the development and progression of renal fibrosis. Wnt\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -catenin controls the expression of various downstream mediators such as snail1, twist, matrix metalloproteinase-7, plasminogen activator inhibitor-1, transient receptor potential canonical 6, and renin-angiotensin system components in epithelial cells, fibroblast, and macrophages. In addition, Wnt\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -catenin is usually intertwined with other signaling pathways to promote renal interstitial fibrosis. Actually, given the crucial of Wnt\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -catenin signaling in renal fibrogenesis, blocking this signaling may benefit renal interstitial fibrosis. There are several antagonists of Wnt signaling that negatively control Wnt activation, and these include soluble Fzd-related proteins, the family of Dickkopf 1 proteins, Klotho and Wnt\u2002inhibitory factor-1. Furthermore, numerous emerging small-molecule\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -catenin inhibitors cannot be ignored to prevent and treat renal fibrosis. Moreover, we reviewed the knowledge focusing on anti-fibrotic effects of natural products commonly used in kidney disease by inhibiting the Wnt\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -catenin signaling pathway. Therefore, in this review, we summarize recent advances in the regulation, downstream targets, role, and mechanisms of Wnt\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -catenin signaling in renal fibrosis pathogenesis. We also discuss the therapeutic potential of targeting this pathway to treat renal fibrosis; this may shed new insights into effective treatment strategies to prevent and treat renal fibrosis.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2021.719880","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T01:39:46Z","timestamp":1629077986000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":97,"title":["Targeting the Wnt\/\u03b2-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis"],"prefix":"10.3389","volume":"12","author":[{"given":"Shan-Shan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ru","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.tcb.2016.07.009","article-title":"\u03b2-Catenin-Independent Roles of Wnt\/LRP6 Signaling","volume":"26","author":"Acebron","year":"2016","journal-title":"Trends Cel Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.bbadis.2017.12.001","article-title":"Inhibition of Canonical WNT Signaling Pathway by \u03b2-catenin\/CBP Inhibitor ICG-001 Ameliorates Liver Fibrosis In Vivo through Suppression of Stromal CXCL12","volume":"1864","author":"Akcora","year":"2018","journal-title":"Biochim. 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