{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:39:32Z","timestamp":1791272372054,"version":"4.1.0"},"reference-count":333,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles relaxations, anti-inflammatory behavior, protective effect and more. Many of these physiological processes are upstream regulated by gut peptides, for instance gastrin, cholecystokinin, secretin, motilin, ghrelin, glucagon-like peptide 1 and 2. The relationship between gasotransmitters and gut hormones is poorly understood. In this review, we discuss the role of NO, CO and H\n                    <jats:sub>2<\/jats:sub>\n                    S on gut peptide release and functioning, and whether manipulation by gasotransmitter substrates or specific blockers leads to physiological alterations.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2021.720703","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T03:54:31Z","timestamp":1626753271000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["The Role of Gasotransmitters in Gut Peptide Actions"],"prefix":"10.3389","volume":"12","author":[{"given":"Wout","family":"Verbeure","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 P.","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"61G","DOI":"10.1016\/0002-9149(92)90028-w","article-title":"Pharmacokinetics of Isosorbide Mononitrate","volume":"70","author":"Abshagen","year":"1992","journal-title":"Am. J. Cardiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3978\/j.issn.2305-5839.2012.12.01","article-title":"The Physiological Roles of Secretin and its Receptor","volume":"1","author":"Afroze","year":"2013","journal-title":"Ann. Transl Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.ejps.2012.07.003","article-title":"Chronic DPP-IV Inhibition with PKF-275-055 Attenuates Inflammation and Improves Gene Expressions Responsible for Insulin Secretion in Streptozotocin Induced Diabetic Rats","volume":"47","author":"Akarte","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1046\/j.1365-2982.2001.00286.x","article-title":"Relaxation of Canine Gallbladder to Nerve Stimulation Involves Adrenergic and Non-adrenergic Non-cholinergic Mechanisms","volume":"13","author":"Alcon","year":"2001","journal-title":"Neurogastroenterol Motil."},{"key":"B5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.4149\/gpb_2016056","article-title":"Gastroprotective Effect of Ghrelin against Indomethacin-Induced Gastric Injury in Rats: Possible Role of Heme Oxygenase-1 Pathway","volume":"36","author":"Allam","year":"2017","journal-title":"gpb"},{"key":"B6","doi-asserted-by":"publisher","first-page":"G1038","DOI":"10.1152\/ajpgi.00282.2010","article-title":"Role of Cholinergic Neurons in the Motor Effects of Glucagon-like Peptide-2 in Mouse colon","volume":"299","author":"Amato","year":"2010","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.2337\/diabetes.52.2.252","article-title":"Role of Leptin in the Regulation of Glucagon-like Peptide-1 Secretion","volume":"52","author":"Anini","year":"2003","journal-title":"Diabetes"},{"key":"B8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1113\/expphysiol.2006.033639","article-title":"Pentagastrin-induced Protein Synthesis in the Parotid Gland of the Anaesthetized Rat, and its Dependence on CCK-A and -B Receptors and Nitric Oxide Generation","volume":"91","author":"Aras","year":"2006","journal-title":"Exp. Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/bf02159660","article-title":"The Effects of Secretin on Urinary Volume and Electrolytes in normal Subjects and Patients with Chronic Pancreatic Disease","volume":"14","author":"Baron","year":"1958","journal-title":"Experientia"},{"key":"B10","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0014-2999(95)00286-t","article-title":"Nitric Oxide and Sensory Afferent Neurones Modulate the Protective Effects of Low-Dose Endotoxin on Rat Gastric Mucosal Damage","volume":"280","author":"Barrachina","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1476-5381.1995.tb14898.x","article-title":"Endotoxin Inhibition of Distension-Stimulated Gastric Acid Secretion in Rat: Mediation by NO in the central Nervous System","volume":"114","author":"Barrachina","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bcp.2018.01.004","article-title":"Hydrogen Sulfide in the Regulation of Insulin Secretion and Insulin Sensitivity: Implications for the Pathogenesis and Treatment of Diabetes Mellitus","volume":"149","author":"Beltowski","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1038\/sj.bjp.0702717","article-title":"Synthesis of Nitric Oxide in the Dorsal Motor Nucleus of the Vagus Mediates the Inhibition of Gastric Acid Secretion by central Bombesin","volume":"127","author":"Beltr\u00e1n","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen Sulfide Mediates the Vasoactivity of Garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-230x-4-16","article-title":"Nitric Oxide-An Endogenous Inhibitor of Gastric Acid Secretion in Isolated Human Gastric Glands","volume":"4","author":"Berg","year":"2004","journal-title":"BMC Gastroenterol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2165\/11596860-000000000-00000","article-title":"The Effect of Nitric-Oxide-Related Supplements on Human Performance","volume":"42","author":"Besc\u00f3s","year":"2012","journal-title":"Sports Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"563","DOI":"10.33549\/physiolres.931234","article-title":"Role of Ghrelin in the Regulation of Gastric Acid Secretion Involving Nitrergic Mechanisms in Rats","volume":"57","author":"Bilgin","year":"2008","journal-title":"Physiol. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0167-0115(94)90166-x","article-title":"Role of Endogenous Nitric Oxide in the Control of Gastric Acid Secretion, Blood Flow and Gastrin Release in Conscious Dogs","volume":"53","author":"Bilski","year":"1994","journal-title":"Regul. Peptides"},{"key":"B19","doi-asserted-by":"publisher","first-page":"S84","DOI":"10.1038\/jp.2008.161","article-title":"Role of iNO in the Modulation of Pulmonary Vascular Resistance","volume":"28","author":"Bin-Nun","year":"2008","journal-title":"J. Perinatol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/mco.0000000000000526","article-title":"Cysteine-derived Hydrogen Sulfide and Gut Health","volume":"22","author":"Blachier","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/s0140-6736(74)90869-1","article-title":"Inhibition of Gastrin and Gastric-Acid Secretion by Growth-Hormone Release-Inhibiting Hormone","volume":"304","author":"Bloom","year":"1974","journal-title":"The Lancet"},{"key":"B22","volume-title":"Use of Secretin and Secretin Analogs to Treat Affective Disorders","author":"Boismenu","year":"2004"},{"key":"B23","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3109\/00365528708991914","article-title":"In Man, Only Activity Fronts that Originate in the Stomach Correlate with Motilin Peaks","volume":"22","author":"Bormans","year":"1987","journal-title":"Scand. J. Gastroenterol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/0016-5085(94)90230-5","article-title":"Cholecystokinin and Nitric Oxide in Transient Lower Esophageal Sphincter Relaxation to Gastric Distention in Dogs","volume":"107","author":"Boulant","year":"1994","journal-title":"Gastroenterology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1373\/clinchem.2005.065243","article-title":"Smoking Acutely Increases Plasma Ghrelin Concentrations","volume":"52","author":"Bouros","year":"2006","journal-title":"Clin. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/713783681","article-title":"Cholecystokinin and Panic Disorder: Past and Future Clinical Research Strategies","volume":"61","author":"Bradwejn","year":"2001","journal-title":"Scli"},{"key":"B27","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1080\/00365520802538195","article-title":"Glucagon-like Peptide-2 Increases Mesenteric Blood Flow in Humans","volume":"44","author":"Bremholm","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/s0167-0115(99)00029-4","article-title":"Acceleration of Ulcer Healing by Cholecystokinin (CCK): Role of CCK-A Receptors, Somatostatin, Nitric Oxide and Sensory Nerves","volume":"82","author":"Brzozowski","year":"1999","journal-title":"Regul. Pept."},{"key":"B29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1159\/000201277","article-title":"Healing of Chronic Gastric Ulcerations by L-Arginine","volume":"56","author":"Brzozowski","year":"1995","journal-title":"Digestion"},{"key":"B30","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1749-6632.2002.tb04080.x","article-title":"Nitric Oxide-Releasing Drugs","volume":"962","author":"Burgaud","year":"2002","journal-title":"Ann. N. Y Acad. Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/s0016-5085(19)33707-2","article-title":"Comparison of Effects of Gastrin, Cholecystokininpancreozymin, Secretin, and Glucagon on Human Stomach Muscle In Vitro","volume":"59","author":"Cameron","year":"1970","journal-title":"Gastroenterology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1113\/jphysiol.2014.270892","article-title":"Physiological Underpinnings of Irritable Bowel Syndrome: Neurohormonal Mechanisms","volume":"592","author":"Camilleri","year":"2014","journal-title":"J. Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e13697","DOI":"10.1111\/nmo.13697","article-title":"Duodenal Nutrient Exposure Contributes to Enhancing Gastric Accommodation","volume":"31","author":"Carbone","year":"2019","journal-title":"Neurogastroenterol Motil."},{"key":"B34","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1001\/archinte.1978.03630260010005","article-title":"Gastrin and Lower Esophageal Sphincter Tone","volume":"138","author":"Castell","year":"1978","journal-title":"Arch. Intern. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"888","DOI":"10.2337\/db11-1073","article-title":"Glucagon-like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide-dependent Mechanism","volume":"61","author":"Chai","year":"2012","journal-title":"Diabetes"},{"key":"B36","doi-asserted-by":"publisher","first-page":"G467","DOI":"10.1152\/ajpgi.00169.2013","article-title":"Hydrogen Sulfide-Based Therapeutics and Gastrointestinal Diseases: Translating Physiology to Treatments","volume":"305","author":"Chan","year":"2013","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/med.0b013e3280122850","article-title":"Cholecystokinin","volume":"14","author":"Chandra","year":"2007","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"B38","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1677\/joe.0.1480381","article-title":"Signal Transduction Systems Employed by Synthetic GH-Releasing Peptides in Somatotrophs","volume":"148","author":"Chen","year":"1996","journal-title":"J. Endocrinol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.metabol.2012.09.014","article-title":"Ghrelin Induces Cell Migration through GHSR1a-Mediated PI3K\/Akt\/eNOS\/NO Signaling Pathway in Endothelial Progenitor Cells","volume":"62","author":"Chen","year":"2013","journal-title":"Metabolism"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1053\/hupa.2002.128251","article-title":"Distribution of Carbon Monoxide-Producing Neurons in Human colon and in Hirschsprung's Disease Patients","volume":"33","author":"Chen","year":"2002","journal-title":"Hum. Pathol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000055831","article-title":"Neural Hormonal Regulation of Exocrine Pancreatic Secretion","volume":"1","author":"Chey","year":"2001","journal-title":"Pancreatology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/01.mpa.0000437325.29728.d6","article-title":"Secretin: Historical Perspective and Current Status","volume":"43","author":"Chey","year":"2014","journal-title":"Pancreas"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s00535-003-1235-3","article-title":"Secretin, 100 Years Later","volume":"38","author":"Chey","year":"2003","journal-title":"J. Gastroenterol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/shk.0b013e3181f48a37","article-title":"Ghrelin Suppresses Inflammation and Neuronal Nitric Oxide Synthase in Focal Cerebral Ischemia via the Vagus Nerve","volume":"35","author":"Cheyuo","year":"2011","journal-title":"Shock"},{"key":"B45","doi-asserted-by":"publisher","first-page":"H103","DOI":"10.1152\/ajpheart.1977.232.2.h103","article-title":"Comparison of Vascular Effects of Gastrointestinal Hormones on Various Organs","volume":"232","author":"Chou","year":"1977","journal-title":"Am. J. Physiology-Heart Circulatory Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1172\/jci5217","article-title":"Dynamic Regulation of Gastric Surface pH by Luminal pH","volume":"103","author":"Chu","year":"1999","journal-title":"J. Clin. Invest."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e383","DOI":"10.1111\/j.1365-2982.2011.01750.x","article-title":"GLP-2 Receptor Expression in Excitatory and Inhibitory Enteric Neurons and its Role in Mouse Duodenum Contractility","volume":"23","author":"Cinci","year":"2011","journal-title":"Neurogastroenterol Motil."},{"key":"B48","doi-asserted-by":"publisher","first-page":"92","DOI":"10.2174\/187152811794776231","article-title":"Hydrogen Sulfide in Gastrointestinal and Liver Physiopathology","volume":"10","author":"Cipriani","year":"2011","journal-title":"Iadt"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1093\/jn\/132.9.2570","article-title":"Acute Enteral Glutamine Infusion Enhances Heme Oxygenase-1 Expression in Human Duodenal Mucosa","volume":"132","author":"Co\u00ebffier","year":"2002","journal-title":"J. Nutr."},{"key":"B50","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3390\/ijms18040798","article-title":"Therapeutic Potential of Targeting the Ghrelin Pathway","volume":"18","author":"Collden","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1139\/y81-031","article-title":"Changes in Plasma Motilin Concentration in Response to Manipulation of Intragastric and Intraduodenal Contents in Man","volume":"59","author":"Collins","year":"1981","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s40618-015-0340-5","article-title":"Phosphodiesterase Type 5 Inhibitors: Back and Forward from Cardiac Indications","volume":"39","author":"Corinaldesi","year":"2016","journal-title":"J. Endocrinol. Invest."},{"key":"B53","doi-asserted-by":"publisher","first-page":"F355","DOI":"10.1152\/ajprenal.00729.2010","article-title":"Mechanisms Mediating the Diuretic and Natriuretic Actions of the Incretin Hormone Glucagon-like Peptide-1","volume":"301","author":"Crajoinas","year":"2011","journal-title":"Am. J. Physiology-Renal Physiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/0196-9781(94)90104-x","article-title":"Biological Actions of Cholecystokinin","volume":"15","author":"Crawley","year":"1994","journal-title":"Peptides"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.2337\/diabetes.50.8.1714","article-title":"A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans","volume":"50","author":"Cummings","year":"2001","journal-title":"Diabetes"},{"key":"B56","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1111\/j.1572-0241.2005.00339.x","article-title":"Influence of Motilin on Gastric Fundus Tone and on Meal-Induced Satiety in Man: Role of Cholinergic Pathways","volume":"101","author":"Cuomo","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.pbb.2010.05.027","article-title":"Hypothalamic Paraventricular 5-hydroxytryptamine Inhibits the Effects of Ghrelin on Eating and Energy Substrate Utilization","volume":"97","author":"Currie","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B58","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10557-013-6463-z","article-title":"Glucagon-like Peptide-1 Receptor Agonist Liraglutide Inhibits Endothelin-1 in Endothelial Cell by Repressing Nuclear Factor-Kappa B Activation","volume":"27","author":"Dai","year":"2013","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B59","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/s0306-4522(03)00327-0","article-title":"Growth Hormone Secretagogue Receptors in Rat and Human Gastrointestinal Tract and the Effects of Ghrelin","volume":"120","author":"Dass","year":"2003","journal-title":"Neuroscience"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4255","DOI":"10.1210\/endo.141.11.7757","article-title":"Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans1","volume":"141","author":"Date","year":"2000","journal-title":"Endocrinology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1053\/gast.2002.35954","article-title":"The Role of the Gastric Afferent Vagal Nerve in Ghrelin-Induced Feeding and Growth Hormone Secretion in Rats","volume":"123","author":"Date","year":"2002","journal-title":"Gastroenterology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrgastro.2012.57","article-title":"The Migrating Motor Complex: Control Mechanisms and its Role in Health and Disease","volume":"9","author":"Deloose","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/s41574-019-0155-0","article-title":"Motilin: from Gastric Motility Stimulation to Hunger Signalling","volume":"15","author":"Deloose","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1111\/j.1365-2036.2004.02003.x","article-title":"Influence of a Lipase Inhibitor on Gastric Sensitivity and Accommodation to an Orally Ingested Meal","volume":"19","author":"Demarchi","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B65","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.2337\/diabetes.53.12.3142","article-title":"Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in -Cells: Implication in the Glycemic Control in Rodents","volume":"53","author":"Dezaki","year":"2004","journal-title":"Diabetes"},{"key":"B66","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1046\/j.1432-1327.1999.00677.x","article-title":"Interaction of Heme Oxygenase-2 with Nitric Oxide Donors. Is the Oxygenase an Intracellular 'sink' for NO?","volume":"264","author":"Ding","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"806","DOI":"10.5114\/aoms.2014.44872","article-title":"Experimental Research Effects of Ghrelin on Protein Expression of Antioxidative Enzymes and iNOS in the Rat Liver","volume":"4","author":"Dobutovic","year":"2014","journal-title":"aoms"},{"key":"B68","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1097\/00006676-199009000-00019","article-title":"Effect of Synthetic Human Cholecystokinin-33 on Pancreatic Blood Flow in Dogs","volume":"5","author":"Doi","year":"1990","journal-title":"Pancreas"},{"key":"B69","first-page":"274","article-title":"Endogenous Motilin and Lower Esophageal Sphincter Pressure in Man: Clue to an Association","volume":"23","author":"Domschke","year":"1976","journal-title":"Acta Hepatogastroenterol (Stuttg)"},{"key":"B70","doi-asserted-by":"publisher","first-page":"E222","DOI":"10.1152\/ajpendo.00473.2012","article-title":"Protein Kinase A Mediates Glucagon-like Peptide 1-induced Nitric Oxide Production and Muscle Microvascular Recruitment","volume":"304","author":"Dong","year":"2013","journal-title":"Am. J. Physiology-Endocrinology Metab."},{"key":"B71","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1146\/annurev-physiol-021113-170317","article-title":"Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-like Peptide-2","volume":"76","author":"Drucker","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"E460","DOI":"10.1152\/ajpendo.00149.2007","article-title":"Frontiers in Glucagon-like Peptide-2: Multiple Actions, Multiple Mediators","volume":"293","author":"Dub\u00e9","year":"2007","journal-title":"Am. J. Physiology-Endocrinology Metab."},{"key":"B73","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev.pharmtox.44.101802.121844","article-title":"The Regulation and Pharmacology of Endothelial Nitric Oxide Synthase","volume":"46","author":"Dudzinski","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1152\/physrev.00014.2005","article-title":"Cholecystokinin and Gastrin Receptors","volume":"86","author":"Dufresne","year":"2006","journal-title":"Physiol. Rev."},{"key":"B75","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1365-2362.1992.tb01464.x","article-title":"Glucagon-like Peptide-1 Cells in the Gastrointestinal Tract and Pancreas of Rat, Pig and Man","volume":"22","author":"Eissele","year":"1992","journal-title":"Eur. J. Clin. Invest."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1128\/jb.112.3.1310-1315.1972","article-title":"Carbon Monoxide Production from Heme Compounds by Bacteria","volume":"112","author":"Engel","year":"1972","journal-title":"J. Bacteriol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mce.2010.04.022","article-title":"Exendin-4 Stimulates Proliferation of Human Coronary Artery Endothelial Cells through eNOS-, PKA- and PI3K\/Akt-dependent Pathways and Requires GLP-1 Receptor","volume":"325","author":"Erdogdu","year":"2010","journal-title":"Mol. Cell Endocrinol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s10620-008-0400-1","article-title":"The Effects of Capsaicin on Gastrin Secretion in Isolated Human Antral Glands: before and after Ingestion of Red Chilli","volume":"54","author":"Ericson","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"14839","DOI":"10.1073\/pnas.93.25.14839","article-title":"Inhibition of Gastric Acid Secretion by Stress: a Protective Reflex Mediated by Cerebral Nitric Oxide","volume":"93","author":"Esplugues","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/0306-3623(87)90039-5","article-title":"Influence of Peripherally-Administered Peptides on Ethanol-Induced Gastric Ulcers in the Rat","volume":"18","author":"Evangelista","year":"1987","journal-title":"Gen. Pharmacol. Vasc. Syst."},{"key":"B81","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1476-5381.1991.tb12142.x","article-title":"Protection Induced by Cholecystokinin-8 (CCK-8) in Ethanol-Induced Gastric Lesions Is Mediated via Vagal Capsaicin-Sensitive Fibres and CCKA Receptors","volume":"102","author":"Evangelista","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/1044-7431(92)90068-d","article-title":"In Situ hybridization and Immunohistochemical Localization of Heme Oxygenase-2 mRNA and Protein in normal Rat Brain: Differential Distribution of Isozyme 1 and 2","volume":"3","author":"Ewing","year":"1992","journal-title":"Mol. Cell Neurosci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/s1532-0456(03)00144-3","article-title":"CCK-nitric Oxide Interaction in Rat Cortex, Striatum and Pallidum","volume":"135","author":"Ferraro","year":"2003","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1053\/j.gastro.2005.07.060","article-title":"Inhibition of Hydrogen Sulfide Generation Contributes to Gastric Injury Caused by Anti-inflammatory Nonsteroidal Drugs","volume":"129","author":"Fiorucci","year":"2005","journal-title":"Gastroenterology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"G760","DOI":"10.1152\/ajpgi.1990.259.5.g760","article-title":"Gastrin-releasing Peptide Directly Releases Pepsinogen from guinea Pig Chief Cells","volume":"259","author":"Fiorucci","year":"1990","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1053\/gast.2003.50096","article-title":"Gastrointestinal Safety of NO-Aspirin (NCX-4016) in Healthy Human Volunteers: a Proof of Concept Endoscopic Study","volume":"124","author":"Fiorucci","year":"2003","journal-title":"Gastroenterology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1172\/jci107297","article-title":"The Hormonal Regulation of Pyloric Sphincter Function","volume":"52","author":"Fisher","year":"1973","journal-title":"J. Clin. Invest."},{"key":"B88","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00134-008-1011-1","article-title":"Use of Carbon Monoxide as a Therapeutic Agent: Promises and Challenges","volume":"34","author":"Foresti","year":"2008","journal-title":"Intensive Care Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/sj.bjp.0707339","article-title":"Cholecystokinin CCK2 Receptors Mediate the Peptide's Inhibitory Actions on the Contractile Activity of Human Distal colon via the Nitric Oxide Pathway","volume":"151","author":"Fornai","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/BF00172772","article-title":"Nitric Oxide Synthase: Expression and Expressional Control of the Three Isoforms","volume":"352","author":"F\u00f6rstermann","year":"1995","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1210\/jc.2007-2289","article-title":"Acyl and Total Ghrelin Are Suppressed Strongly by Ingested Proteins, Weakly by Lipids, and Biphasically by Carbohydrates","volume":"93","author":"Foster-Schubert","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B92","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1079\/bjn19950022","article-title":"Adaptation to High-Fat Diets: Effects on Eating Behaviour and Plasma Cholecystokinin","volume":"73","author":"French","year":"1995","journal-title":"Br. J. Nutr."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/j.1365-2982.2008.01201.x","article-title":"The Gaseous Mediator, Hydrogen Sulphide, Inhibitsin Vitromotor Patterns in the Human, Rat and Mouse colon and Jejunum","volume":"20","author":"Gallego","year":"2008","journal-title":"Neurogastroenterol Motil."},{"key":"B94","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00520-012-1500-1","article-title":"Therapeutic Potential of Anamorelin, a Novel, Oral Ghrelin Mimetic, in Patients with Cancer-Related Cachexia: a Multicenter, Randomized, Double-Blind, Crossover, Pilot Study","volume":"21","author":"Garcia","year":"2013","journal-title":"Support Care Cancer."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/sj.bjp.0703436","article-title":"Role of central Glutamate Receptors, Nitric Oxide and Soluble Guanylyl Cyclase in the Inhibition by Endotoxin of Rat Gastric Acid Secretion","volume":"130","author":"Garc\u00eda-Zaragoz\u00e1","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1210\/jc.2012-4247","article-title":"The Human Experience with Ghrelin Administration","volume":"98","author":"Garin","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B97","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/s0196-9781(03)00160-8","article-title":"Ghrelin-induced Feeding Is Dependent on Nitric Oxide","volume":"24","author":"Gaskin","year":"2003","journal-title":"Peptides"},{"key":"B98","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0016-5085(80)90582-x","article-title":"Intraluminal Pressure Recording from the Human Sphincter of Oddi","volume":"78","author":"Geenen","year":"1980","journal-title":"Gastroenterology"},{"key":"B99","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1159\/000312664","article-title":"Release of Satiety Hormones in Response to Specific Dietary Proteins Is Different between Human and Murine Small Intestinal Mucosa","volume":"56","author":"Geraedts","year":"2010","journal-title":"Ann. Nutr. Metab."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1210\/jcem.87.6.8739","article-title":"The Tissue Distribution of the mRNA of Ghrelin and Subtypes of its Receptor, GHS-R, in Humans","volume":"87","author":"Gnanapavan","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B101","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1111\/j.1460-9568.1995.tb00650.x","article-title":"Distribution of GLP-1 Binding Sites in the Rat Brain: Evidence that Exendin-4 Is a Ligand of Brain GLP-1 Binding Sites","volume":"7","author":"G\u00f6ke","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.abb.2008.08.001","article-title":"GLP-1 and Related Peptides Cause Concentration-dependent Relaxation of Rat Aorta through a Pathway Involving KATP and cAMP","volume":"478","author":"Green","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"B103","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3181\/00379727-140-36384","article-title":"Feedback Regulation of Pancreatic Enzyme Secretion as a Mechanism for Trypsin Inhibitor-Induced Hypersecretion in Rats","volume":"140","author":"Green","year":"1972","journal-title":"Exp. Biol. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1152\/japplphysiol.00625.2010","article-title":"Intracoronary Gastrin 17 Increases Cardiac Perfusion and Function through Autonomic Nervous System, CCK Receptors, and Nitric Oxide in Anesthetized Pigs","volume":"110","author":"Grossini","year":"1985","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B105","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.mce.2011.11.018","article-title":"CCK Receptors-Related Signaling Involved in Nitric Oxide Production Caused by Gastrin 17 in Porcine Coronary Endothelial Cells","volume":"350","author":"Grossini","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1600-079x.2011.00886.x","article-title":"Intracoronary Melatonin Increases Coronary Blood Flow and Cardiac Function through \u03b2-adrenoreceptors, MT1\/MT2 Receptors, and Nitric Oxide in Anesthetized Pigs","volume":"51","author":"Grossini","year":"2011","journal-title":"J. Pineal Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1053\/j.gastro.2005.11.005","article-title":"GLP-2 Receptor Localizes to Enteric Neurons and Endocrine Cells Expressing Vasoactive Peptides and Mediates Increased Blood Flow","volume":"130","author":"Guan","year":"2006","journal-title":"Gastroenterology"},{"key":"B108","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/s0016-5085(03)00667-x","article-title":"GLP-2-mediated Up-Regulation of Intestinal Blood Flow and Glucose Uptake Is Nitric Oxide-dependent in TPN-Fed Piglets 1 1This Work Is a Publication of the USDA\/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas","volume":"125","author":"Guan","year":"2003","journal-title":"Gastroenterology"},{"key":"B109","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0006-8993(03)03016-6","article-title":"Excitatory Effects of Motilin in the hippocampus on Gastric Motility in Rats","volume":"984","author":"Guan","year":"2003","journal-title":"Brain Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/oxfordjournals.eurheartj.a062037","article-title":"Haemodynamic Effects of Pharmacological Doses of Secretin in Patients with Impaired Left Ventricular Function","volume":"7","author":"Gunnes","year":"1986","journal-title":"Eur. Heart J."},{"key":"B111","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3109\/00365518309168843","article-title":"Cardiovascular Effects of Secretin Infusion in Man","volume":"43","author":"Gunnes","year":"1983","journal-title":"Scli"},{"key":"B112","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1210\/jc.2003-031403","article-title":"Glucagon-like Peptide 1 Induces Natriuresis in Healthy Subjects and in Insulin-Resistant Obese Men","volume":"89","author":"Gutzwiller","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B113","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.drudis.2006.04.003","article-title":"Vascular NADPH Oxidases as Drug Targets for Novel Antioxidant Strategies","volume":"11","author":"Guzik","year":"2006","journal-title":"Drug Discov. Today"},{"key":"B114","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/s0300-5089(21)00474-0","article-title":"Secretin","volume":"9","author":"Hacki","year":"1980","journal-title":"Clin. Gastroenterol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1088\/0967-3334\/17\/4\/004","article-title":"Half-life of Nitric Oxide in Aqueous Solutions with and without Haemoglobin","volume":"17","author":"Hakim","year":"1996","journal-title":"Physiol. Meas."},{"key":"B116","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/apha.12554","article-title":"Nitric Oxide Regulation of Migrating Motor Complex: Randomized Trial of NG-Monomethyl-L-Arginine Effects in Relation to Muscarinic and Serotonergic Receptor Blockade","volume":"215","author":"Halim","year":"2015","journal-title":"Acta Physiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.redox.2013.10.003","article-title":"The Role of Nitric Oxide Signaling in Food Intake; Insights from the Inner Mitochondrial Membrane Peptidase 2 Mutant Mice","volume":"1","author":"Han","year":"2013","journal-title":"Redox Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.diabres.2012.04.001","article-title":"Exendin-4 Directly Improves Endothelial Dysfunction in Isolated Aortas from Obese Rats through the cAMP or AMPK-eNOS Pathways","volume":"97","author":"Han","year":"2012","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B119","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1677\/jme-09-0095","article-title":"Stepwise Loss of Motilin and its Specific Receptor Genes in Rodents","volume":"44","author":"He","year":"2010","journal-title":"J. Mol. Endocrinol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jvs.2008.08.065","article-title":"Growth Hormone-Releasing Peptide Ghrelin Inhibits Homocysteine-Induced Endothelial Dysfunction in Porcine Coronary Arteries and Human Endothelial Cells","volume":"49","author":"Hedayati","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1111\/j.1476-5381.1995.tb15064.x","article-title":"Mediation by CCKB Receptors of the CCK-Evoked Hyperaemia in Rat Gastric Mucosa","volume":"116","author":"Heinemann","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"G253","DOI":"10.1152\/ajpgi.1996.270.2.g253","article-title":"CCK-evoked Hyperemia in Rat Gastric Mucosa Involves Neural Mechanisms and Nitric Oxide","volume":"270","author":"Heinemann","year":"1996","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B123","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-30338-8","volume-title":"Gasotransmitters - Physiology and Pathophysiology","author":"Hermann","year":"2012"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","article-title":"The Physiology of Glucagon-like Peptide 1","volume":"87","author":"Holst","year":"2007","journal-title":"Physiol. Rev."},{"key":"B125","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/978-3-662-29272-3_45","article-title":"Gastrointestinal Effect of Calcitonin: Inhibition of Gastrin Secretion","volume":"21","author":"Hornum","year":"1976","journal-title":"Calcif Tissue Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s004180050237","article-title":"Contribution of Carbon Monoxide-Producing Cells in the Gastric Mucosa of Rat and Monkey","volume":"109","author":"Hu","year":"1998","journal-title":"Histochem. Cell Biol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.3748\/wjg.v10.i12.1789","article-title":"Heme Oxygenase-1 in Cholecystokinin-Octapeptipe Attenuated Injury of Pulmonary Artery Smooth Muscle Cells Induced by Lipopolysaccharide and its Signal Transduction Mechanism","volume":"10","author":"Huang","year":"2004","journal-title":"Wjg"},{"key":"B128","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/nu9010053","article-title":"B-vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study","volume":"9","author":"Hughes","year":"2017","journal-title":"Nutrients"},{"key":"B129","doi-asserted-by":"publisher","first-page":"E756","DOI":"10.1152\/ajpendo.00570.2006","article-title":"Ghrelin Has Novel Vascular Actions that Mimic PI 3-kinase-dependent Actions of Insulin to Stimulate Production of NO from Endothelial Cells","volume":"292","author":"Iantorno","year":"2007","journal-title":"Am. J. Physiology-Endocrinology Metab."},{"key":"B130","doi-asserted-by":"publisher","first-page":"8547364","DOI":"10.1155\/2018\/8547364","article-title":"An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules","volume":"2018","author":"Ismailova","year":"2018","journal-title":"Bioinorg Chem. Appl."},{"key":"B131","first-page":"648","article-title":"The Negative Feedback Mechanism of Gastric Acid Secretion: Significance of Acid in the Gastric Juice in Man and Dog","volume":"77","author":"Itoh","year":"1975","journal-title":"Surgery"},{"key":"B132","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/s0196-9781(96)00333-6","article-title":"Motilin and Clinical Application","volume":"18","author":"Itoh","year":"1997","journal-title":"Peptides"},{"key":"B133","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.regpep.2003.07.002","article-title":"Effect of Exogenous Cholecystokinin on Islet Blood Flow in Anesthetized Rats","volume":"116","author":"Iwase","year":"2003","journal-title":"Regul. Pept."},{"key":"B134","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/apt.12092","article-title":"Review Article: a Comparison of Glucagon-like Peptides 1 and 2","volume":"37","author":"Janssen","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B135","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1080\/00365521.1984.12005799","article-title":"Radioimmunoassayable Plasma Motilin in Man","volume":"19","author":"Jenssen","year":"1984","journal-title":"Scand. J. Gastroenterol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3109\/00365528609003076","article-title":"Evidence of Somatostatin as a Humoral Modulator of Motilin Release in Man: A Study of Plasma Motilin and Somatostatin during Intravenous Infusion of Somatostatin, Secretin, Cholecystokinin, and Gastric Inhibitory Polypeptide","volume":"21","author":"Jenssen","year":"1986","journal-title":"Scand. J. Gastroenterol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00441-004-1013-4","article-title":"Glucose Stimulates the Expression and Activities of Nitric Oxide Synthases in Incubated Rat Islets: an Effect Counteracted by GLP-1 through the Cyclic AMP\/PKA Pathway","volume":"319","author":"Jimenez-Feltstrom","year":"2005","journal-title":"Cell Tissue Res"},{"key":"B138","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/00006676-200005000-00011","article-title":"Endogenous Nitric Oxide Mediates Pancreatic Exocrine Secretion Stimulated by Secretin and Cholecystokinin in Rats","volume":"20","author":"Jyotheeswaran","year":"2000","journal-title":"Pancreas"},{"key":"B139","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1046\/j.1365-2125.2003.01812.x","article-title":"The Effect of Motilin on the Rectum in Healthy Volunteers","volume":"55","author":"Kamerling","year":"2003","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1385\/jmn:18:1-2:07","article-title":"Interactions of Glucagon-like Peptide-1 (GLP-1) with the Blood-Brain Barrier","volume":"18","author":"Kastin","year":"2002","journal-title":"J. Mol. Neurosci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev.pharmtox.46.120604.141053","article-title":"CO as a Cellular Signaling Molecule","volume":"46","author":"Kim","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and Physiological Effects of Hydrogen Sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antioxid. Redox Signaling"},{"key":"B143","doi-asserted-by":"publisher","first-page":"9","DOI":"10.15369\/sujms.28.9","article-title":"Pleiotropic Effects of Linagliptin Monotherapy on Levels of Nitric Oxide, Nitric Oxide Synthase, and Superoxide Dismutase in Hemodialysis Patients with Diabetes","volume":"28","author":"Kimura","year":"2016","journal-title":"Showa Univ. J. Med. Sci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1136\/gut.2005.085365","article-title":"Impaired Gastric Accommodation and its Role in Dyspepsia","volume":"55","author":"Kindt","year":"2006","journal-title":"Gut"},{"key":"B145","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/cne.903420111","article-title":"NADPH Diaphorase (Nitric Oxide Synthase)-Containing Nerves in the Enteropancreatic Innervation: Sources, Co-stored Neuropeptides, and Pancreatic Function","volume":"342","author":"Kirchgessner","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1365-2982.2002.00298.x","article-title":"Potentiation of Motilin-Induced Contraction by Nitric Oxide Synthase Inhibition in the Isolated Chicken Gastrointestinal Tract","volume":"14","author":"Kitazawa","year":"2002","journal-title":"Neurogastroenterol Motil."},{"key":"B147","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin Is a Growth-Hormone-Releasing Acylated Peptide from Stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"B148","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: Structure and Function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol. Rev."},{"key":"B149","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1136\/gut.40.1.86","article-title":"Role of Endogenous Nitric Oxide in the Control of Exocrine and Endocrine Pancreatic Secretion in Humans","volume":"40","author":"Konturek","year":"1997","journal-title":"Gut"},{"key":"B150","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejphar.2006.02.032","article-title":"Ghrelin-induced Gastroprotection against Ischemia-Reperfusion Injury Involves an Activation of Sensory Afferent Nerves and Hyperemia Mediated by Nitric Oxide","volume":"536","author":"Konturek","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0014-2999(94)00674-v","article-title":"Exogenous and Endogenous Cholecystokinin Protects Gastric Mucosa against the Damage Caused by Ethanol in Rats","volume":"273","author":"Konturek","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/0016-5085(93)91028-g","article-title":"Role of Endogenous Nitric Oxide in the Control of Canine Pancreatic Secretion and Blood Flow","volume":"104","author":"Konturek","year":"1993","journal-title":"Gastroenterology"},{"key":"B153","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0014-2999(95)00120-a","article-title":"Role of Endogenous Gastrin in Gastroprotection","volume":"278","author":"Konturek","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3109\/00365529509096303","article-title":"Comparison of Cholecystokinin, Pentagastrin, and Duodenal Oleate in Gastroprotection in Rats","volume":"30","author":"Konturek","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/s1734-1140(12)70846-0","article-title":"L-NAME in the Cardiovascular System - Nitric Oxide Synthase Activator?","volume":"64","author":"Kopincov\u00e1","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.2337\/db14-0976","article-title":"Exenatide Protects against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans","volume":"64","author":"Koska","year":"2015","journal-title":"Diabetes"},{"key":"B157","doi-asserted-by":"publisher","first-page":"e97554","DOI":"10.1371\/journal.pone.0097554","article-title":"Glucagon-like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism","volume":"9","author":"Krasner","year":"2014","journal-title":"PLoS One"},{"key":"B158","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0014-2999(96)00516-x","article-title":"Presynaptic Modulation by VIP, Secretin and Isoproterenol of Somatostatin Release from Enriched Enteric Synaptosomes: Role of cAMP","volume":"314","author":"Kurjak","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/bf00318921","article-title":"Is Motilin a Cerebellar Peptide in the Rat?","volume":"173","author":"Lange","year":"1986","journal-title":"Anat. Embryol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1007\/bf02064202","article-title":"Ileal Release of Glucagon-like Peptide-1 (GLP-1)","volume":"40","author":"Layer","year":"1995","journal-title":"Dig. Dis Sci"},{"key":"B161","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.mehy.2009.03.030","article-title":"Calcium Sulfide (CaS), a Donor of Hydrogen Sulfide (H2S): A New Antihypertensive Drug?","volume":"73","author":"Li","year":"2009","journal-title":"Med. Hypotheses"},{"key":"B162","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.2337\/db06-s020","article-title":"Glucagon-Like Peptide 1 Secretion by the L-Cell: The View from within","volume":"55","author":"Lim","year":"2006","journal-title":"Diabetes"},{"key":"B163","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1210\/en.2008-0726","article-title":"Insulin Regulates Glucagon-like Peptide-1 Secretion from the Enteroendocrine L Cell","volume":"150","author":"Lim","year":"2009","journal-title":"Endocrinology"},{"key":"B164","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1089\/ars.2013.5312","article-title":"Hydrogen Sulfide Signaling in the Gastrointestinal Tract","volume":"20","author":"Linden","year":"2014","journal-title":"Antioxid. Redox Signaling"},{"key":"B165","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1021\/acs.jmedchem.6b01153","article-title":"Carbon Monoxide and its Controlled Release: Therapeutic Application, Detection, and Development of Carbon Monoxide Releasing Molecules (CORMs)","volume":"61","author":"Ling","year":"2018","journal-title":"J. Med. Chem."},{"key":"B166","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3748\/wjg.7.667","article-title":"Effect of Cholecystokinin on Cytokines during Endotoxic Shock in Rats","volume":"7","author":"Ling","year":"2001","journal-title":"Wjg"},{"key":"B167","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1159\/000096976","article-title":"Change of Plasma Ghrelin Level in Acute Pancreatitis","volume":"6","author":"Liu","year":"2006","journal-title":"Pancreatology"},{"key":"B168","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/fjc.0000000000000176","article-title":"Protective Effects of Glucagon-like Peptide 1 on Endothelial Function in Hypertension","volume":"65","author":"Liu","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/S1000-1948(08)60013-1","article-title":"[Distribution and Role of Motilin Receptor in the Amygdala of Rats]","volume":"25","author":"Liu","year":"2005","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"B170","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/1755-5922.12000","article-title":"GLP \u20101 Receptor Agonists: Effects on Cardiovascular Risk Reduction","volume":"31","author":"Lorber","year":"2013","journal-title":"Cardiovasc. Ther."},{"key":"B171","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jchemneu.2009.06.007","article-title":"CCK as a Modulator of Cardiovascular Function","volume":"38","author":"Lovick","year":"2009","journal-title":"J. Chem. Neuroanat."},{"key":"B172","doi-asserted-by":"publisher","first-page":"e12443","DOI":"10.1111\/cpr.12443","article-title":"Glucagon-like Peptide 2 Decreases Osteoclasts by Stimulating Apoptosis Dependent on Nitric Oxide Synthase","volume":"51","author":"Lu","year":"2018","journal-title":"Cell Prolif"},{"key":"B173","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/j.1365-2982.2009.01271.x","article-title":"Secretin-induced Gastric Relaxation Is Mediated by Vasoactive Intestinal Polypeptide and Prostaglandin Pathways","volume":"21","author":"Lu","year":"2009","journal-title":"Neurogastroenterol Motil."},{"key":"B174","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.neuroscience.2014.08.020","article-title":"Mechanism of Motilin-Mediated Inhibition on Voltage-dependent Potassium Currents in Hippocampal Neurons","volume":"284","author":"Lu","year":"2015","journal-title":"Neuroscience"},{"key":"B175","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1136\/gut.42.6.830","article-title":"Motilin Induces Gall Bladder Emptying and Antral Contractions in the Fasted State in Humans","volume":"42","author":"Luiking","year":"1998","journal-title":"Gut"},{"key":"B176","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.regpep.2004.09.001","article-title":"The Discovery of Glucagon-like Peptide 1","volume":"128","author":"Lund","year":"2005","journal-title":"Regul. Peptides"},{"key":"B177","doi-asserted-by":"publisher","first-page":"E1055","DOI":"10.1152\/ajpendo.00498.2002","article-title":"Carbon Monoxide Stimulates Insulin Release and Propagates Ca2+ Signals between Pancreatic \u03b2-cells","volume":"285","author":"Lundquist","year":"2003","journal-title":"Am. J. Physiology-Endocrinology Metab."},{"key":"B178","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1096\/fasebj.2.10.3290025","article-title":"Heme Oxygenase: Function, Multiplicity, Regulatory Mechanisms, and Clinical Applications","volume":"2","author":"Maines","year":"1988","journal-title":"FASEB j."},{"key":"B179","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","article-title":"The Heme Oxygenase System:A Regulator of Second Messenger Gases","volume":"37","author":"Maines","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000097340","article-title":"The Role of Carbon Monoxide in the Regulation of Neuroendocrine Function","volume":"4","author":"Mancuso","year":"1997","journal-title":"Neuroimmunomodulation"},{"key":"B181","doi-asserted-by":"publisher","first-page":"480921","DOI":"10.1155\/2014\/480921","article-title":"Antisecretory Effect of Hydrogen Sulfide on Gastric Acid Secretion and the Involvement of Nitric Oxide","volume":"2014","author":"Mard","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"B182","first-page":"57","article-title":"Duodenal Acidification Stimulates Gastric H2S Release through Upregulating mRNA Expression of Cystathionine Gamma Lyase","volume":"20","author":"Mard","year":"2016","journal-title":"Physiol. Pharmacol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1111\/nmo.12867","article-title":"Delayed Gastric Emptying in Diabetic Rats Caused by Decreased Expression of Cystathionine Gamma Lyase and H2S Synthesis:in Vitroandin Vivostudies","volume":"28","author":"Mard","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"B184","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s12576-015-0392-5","article-title":"Gastric Acid Induces Mucosal H2S Release in Rats by Upregulating mRNA and Protein Expression of Cystathionine Gamma Lyase","volume":"65","author":"Mard","year":"2015","journal-title":"J. Physiol. Sci."},{"key":"B185","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0014-2999(92)90191-6","article-title":"The Role of Nitric Oxide and Platelet-Activating Factor in the Inhibition by Endotoxin of Pentagastrin-Stimulated Gastric Acid Secretion","volume":"218","author":"Martinez-Cuesta","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1210\/jc.2003-031328","article-title":"The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure","volume":"89","author":"Marzullo","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B187","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1136\/gut.30.6.866","article-title":"Reversible Gall Bladder Dysfunction in Severe Pancreatic Insufficiency","volume":"30","author":"Masclee","year":"1989","journal-title":"Gut"},{"key":"B188","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1006\/bbrc.2000.3568","article-title":"Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats","volume":"276","author":"Masuda","year":"2000","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B189","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jacc.2011.07.053","article-title":"A Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice","volume":"59","author":"Matsubara","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.acthis.2009.01.001","article-title":"Heme-oxygenase-2 Immunolabelling in Pig Jejunum","volume":"112","author":"Matsuda","year":"2010","journal-title":"Acta Histochem."},{"key":"B191","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/s0016-5085(99)70227-1","article-title":"Fatty Acid Chain Length Determines Cholecystokinin Secretion and Effect on Human Gastric Motility","volume":"116","author":"McLaughlin","year":"1999","journal-title":"Gastroenterology"},{"key":"B192","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1345\/aph.19113","article-title":"Secretin for the Treatment of Autism","volume":"36","author":"McQueen","year":"2002","journal-title":"Ann. Pharmacother."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1002\/ibd.21528","article-title":"Emerging Role of Hydrogen Sulfide in Colonic Physiology and Pathophysiology","volume":"17","author":"Medani","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"B194","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ejphar.2012.07.004","article-title":"Role of KATP Channels and TRPV1 Receptors in Hydrogen Sulfide-Enhanced Gastric Emptying of Liquid in Awake Mice","volume":"693","author":"Medeiros","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1007\/s12325-017-0491-1","article-title":"The Role of the Pharmacist in Managing Type 2 Diabetes with Glucagon-like Peptide-1 Receptor Agonists as Add-On Therapy","volume":"34","author":"Meece","year":"2017","journal-title":"Adv. Ther."},{"key":"B196","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1046\/j.1365-2982.1997.d01-7.x","article-title":"Gastric Secretion but Not Nitric Oxide Is Involved in Pentagastrin-Induced Gastric Relaxation in Conscious Dogs","volume":"9","author":"Meulemans","year":"1997","journal-title":"Neurogastroenterol Motil."},{"key":"B197","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.pharmthera.2008.05.001","article-title":"Structural Basis of Cholecystokinin Receptor Binding and Regulation","volume":"119","author":"Miller","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"B198","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1046\/j.1365-2982.2001.00255.x","article-title":"Haem Oxygenase in Enteric Nervous System of Human Stomach and Jejunum and Co-localization with Nitric Oxide Synthase","volume":"13","author":"Miller","year":"2001","journal-title":"Neurogastroenterol Motil."},{"key":"B199","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1136\/gut.18.6.468","article-title":"Effect of Secretin on Plasma Motilin in Man","volume":"18","author":"Mitznegg","year":"1977","journal-title":"Gut"},{"key":"B200","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/s0140-6736(76)92101-2","article-title":"Release of Motilin after Duodenal Acidification","volume":"307","author":"Mitznegg","year":"1976","journal-title":"The Lancet"},{"key":"B201","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s0167-0115(97)01004-5","article-title":"Effect of Nitric Oxide Synthase Inhibition on Plasma Motilin Release in Fasted Dogs","volume":"71","author":"Mizumoto","year":"1997","journal-title":"Regul. Peptides"},{"key":"B202","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1016\/j.peptides.2011.09.004","article-title":"Effect of Different Doses of GLP-2 (Teduglutide) on Acute Esophageal Lesion Due to Acid-Pepsin Perfusion in Male Rats","volume":"32","author":"Moloudi","year":"2011","journal-title":"Peptides"},{"key":"B203","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1210\/me.2002-0074","article-title":"Insulin Receptor Substrate-1 and Phosphoinositide-dependent Kinase-1 Are Required for Insulin-Stimulated Production of Nitric Oxide in Endothelial Cells","volume":"16","author":"Montagnani","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/s0014-2999(01)01542-4","article-title":"Renal Effects of Glucagon-like Peptide in Rats","volume":"434","author":"Moreno","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.peptides.2010.12.015","article-title":"Nitric Oxide Is a central Component in Neuropeptide Regulation of Appetite","volume":"32","author":"Morley","year":"2011","journal-title":"Peptides"},{"key":"B206","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/s0167-0115(01)00383-4","article-title":"Pharmacological Characterization of Cholecystokinin Receptors Mediating Contraction of Human Gallbladder and Ascending colon","volume":"105","author":"Morton","year":"2002","journal-title":"Regul. Peptides"},{"key":"B207","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1161\/01.res.83.5.568","article-title":"Heme Oxygenase-1-Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo","volume":"83","author":"Motterlini","year":"1998","journal-title":"Circ. Res."},{"key":"B208","doi-asserted-by":"publisher","first-page":"C1039","DOI":"10.1152\/ajpcell.00252.2014","article-title":"A Novel Role for Carbon Monoxide as a Potent Regulator of Intracellular Ca2+and Nitric Oxide in Rat Pancreatic Acinar Cells","volume":"307","author":"Moustafa","year":"2014","journal-title":"Am. J. Physiology-Cell Physiol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1089\/ars.2012.5108","article-title":"Hydrogen Sulfide Regulates Ca2+ Homeostasis Mediated by Concomitantly Produced Nitric Oxide via a Novel Synergistic Pathway in Exocrine Pancreas","volume":"20","author":"Moustafa","year":"2014","journal-title":"Antioxid. Redox Signaling"},{"key":"B210","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.abb.2015.06.020","article-title":"Multiple Targets of Carbon Monoxide Gas in the Intestinal Inflammation","volume":"595","author":"Naito","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"B211","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/35051587","article-title":"A Role for Ghrelin in the central Regulation of Feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"B212","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1006\/niox.1999.0247","article-title":"Different Distributions of Nitric Oxide Synthase-Containing Neurons in the Mouse and Rat Hypothalamus","volume":"3","author":"Ng","year":"1999","journal-title":"Nitric Oxide"},{"key":"B213","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1093\/hmg\/ddl402","article-title":"Secretin Receptor-Deficient Mice Exhibit Impaired Synaptic Plasticity and Social Behavior","volume":"15","author":"Nishijima","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"B214","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/00006676-199908000-00001","article-title":"Cholecystokinin A and B Receptor mRNA Expression in Human Pancreas","volume":"19","author":"Nishimori","year":"1999","journal-title":"Pancreas"},{"key":"B215","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1023\/a:1005570507166","article-title":"Acid-sensitive and Alkaline-Sensitive Sensory Neurons Regulate pH Dependent Gastrin Secretion in Rat","volume":"45","author":"Nojima","year":"2000","journal-title":"Dig. Dis. Sci."},{"key":"B216","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0083-6729(06)77007-8","article-title":"Ghrelin and Feedback Systems","volume":"77","author":"Nonogaki","year":"2008","journal-title":"Vitam Horm."},{"key":"B217","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.regpep.2004.08.024","article-title":"Glucagon-like Peptide-1 Relaxes Rat Conduit Arteries via an Endothelium-independent Mechanism","volume":"125","author":"Nystrom","year":"2005","journal-title":"Regul. Pept."},{"key":"B218","doi-asserted-by":"publisher","first-page":"E1209","DOI":"10.1152\/ajpendo.00237.2004","article-title":"Effects of Glucagon-like Peptide-1 on Endothelial Function in Type 2 Diabetes Patients with Stable Coronary Artery Disease","volume":"287","author":"Nystr\u00f6m","year":"2004","journal-title":"Am. J. Physiology-Endocrinology Metab."},{"key":"B219","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1097\/00005344-200206000-00001","article-title":"Vasodilatory Effect of Ghrelin, an Endogenous Peptide from the Stomach","volume":"39","author":"Okumura","year":"2002","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B220","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3390\/ijerph17020528","article-title":"Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review","volume":"17","author":"Pan","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B221","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/0016-5085(95)90222-8","article-title":"Role of Nitric Oxide in the Relationship of Pancreatic Blood Flow and Exocrine Secretion in Cats","volume":"108","author":"Patel","year":"1995","journal-title":"Gastroenterology"},{"key":"B222","first-page":"418","article-title":"Systemic Circulatory Effects of Pentagastrin","volume":"38","author":"Pawlik","year":"1987","journal-title":"Acta Physiol. Pol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0167-0115(88)90025-0","article-title":"Comparison of Motilin Binding to Crude Homogenates of Human and Canine Gastrointestinal Smooth Muscle Tissue","volume":"23","author":"Peeters","year":"1988","journal-title":"Regul. Peptides"},{"key":"B224","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0016-5085(92)91788-6","article-title":"Effect of Motilin on Gastric Emptying in Patients with Diabetic Gastroparesis","volume":"102","author":"Peeters","year":"1992","journal-title":"Gastroenterology"},{"key":"B225","doi-asserted-by":"publisher","first-page":"3285074","DOI":"10.1155\/2016\/3285074","article-title":"Implications of Hydrogen Sulfide in Glucose Regulation: How H2S Can Alter Glucose Homeostasis through Metabolic Hormones","volume":"2016","author":"Pichette","year":"2016","journal-title":"Oxid Med. Cel Longev"},{"key":"B226","doi-asserted-by":"publisher","first-page":"3416","DOI":"10.1210\/en.2017-00391","article-title":"Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice","volume":"158","author":"Pichette","year":"2017","journal-title":"Endocrinology"},{"key":"B227","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/nmo.12712","article-title":"Glucagon-like Peptide 2 Counteracts the Mucosal Damage and the Neuropathy Induced by Chronic Treatment with Cisplatin in the Mouse Gastric Fundus","volume":"28","author":"Pini","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"B228","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/0016-5085(92)91797-8","article-title":"Endogenous Nitric Oxide as a Mediator of Gastric Mucosal Vasodilatation during Acid Secretion","volume":"102","author":"Pique","year":"1992","journal-title":"Gastroenterology"},{"key":"B229","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A Review of Hydrogen Sulfide (H2S) Donors: Chemistry and Potential Therapeutic Applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"B230","doi-asserted-by":"publisher","first-page":"G250","DOI":"10.1152\/ajpgi.1985.249.2.g250","article-title":"Postprandial Regulation of Intestinal Blood Flow: Role of Gastrointestinal Hormones","volume":"249","author":"Premen","year":"1985","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B231","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1073\/pnas.90.5.2087","article-title":"Amplification of Nitric Oxide Signaling by Interstitial Cells Isolated from Canine colon","volume":"90","author":"Publicover","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B232","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.regpep.2004.12.018","article-title":"Ghrelin Activates Neuronal Constitutive Nitric Oxide Synthase in Pancreatic Islet Cells while Inhibiting Insulin Release and Stimulating Glucagon Release","volume":"128","author":"Qader","year":"2005","journal-title":"Regul. Peptides"},{"key":"B233","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/sj.bjp.0704258","article-title":"A Cerebral Nitrergic Pathway Modulates Endotoxin-Induced Changes in Gastric Motility","volume":"134","author":"Quintana","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"B234","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3109\/00365529509093249","article-title":"Increases in Plasma Motilin Follow Each Episode of Gallbladder Emptying during the Interdigestive Period, and Changes in Serum Bile Acid Concentration Correlate to Plasma Motilin","volume":"30","author":"Qvist","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"B235","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1152\/physrev.1998.78.4.1087","article-title":"The New Biology of Gastrointestinal Hormones","volume":"78","author":"Rehfeld","year":"1998","journal-title":"Physiol. Rev."},{"key":"B236","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/s0016-5085(97)70131-8","article-title":"Localization of Cholecystokinin A and Cholecystokinin B-Gastrin Receptors in the Human Stomach","volume":"112","author":"Reubi","year":"1997","journal-title":"Gastroenterology"},{"key":"B237","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/s1357-2725(96)00167-7","article-title":"Nitric Oxide","volume":"29","author":"Robbins","year":"1997","journal-title":"Int. J. Biochem. Cel Biol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1196\/annals.1327.087","article-title":"Ghrelin Induces Growth Hormone (GH) Secretion via Nitric Oxide (NO)\/cGMP Signaling","volume":"1040","author":"Rodr\u00edguez-pacheco","year":"2005","journal-title":"Ann. N. Y Acad. Sci."},{"key":"B239","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.peptides.2010.09.028","article-title":"Glucagon-like Peptide-1 Relaxes Gastric Antrum through Nitric Oxide in Mice","volume":"32","author":"Rotondo","year":"2011","journal-title":"Peptides"},{"key":"B240","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1152\/ajpgi.00039.2011","article-title":"The \"cryptic\" Mechanism of Action of Glucagon-like Peptide-2","volume":"301","author":"Rowland","year":"2011","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.regpep.2006.06.006","article-title":"Vasodilatory Effects of Cholecystokinin: New Role for an Old Peptide?","volume":"137","author":"Ruiz-Gayo","year":"2006","journal-title":"Regul. Peptides"},{"key":"B242","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/oby.21107","article-title":"GLP \u20101 Receptor Agonists: Nonglycemic Clinical Effects in Weight Loss and beyond","volume":"23","author":"Ryan","year":"2015","journal-title":"Obesity"},{"key":"B243","doi-asserted-by":"publisher","first-page":"896029","DOI":"10.1155\/2014\/896029","article-title":"Cholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal Macrophages","volume":"2014","author":"Saia","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B244","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/shk.0b013e3182793e2e","article-title":"Cardiovascular and Inflammatory Response to Cholecystokinin during Endotoxemic Shock","volume":"39","author":"Saia","year":"2013","journal-title":"Shock"},{"key":"B245","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1124\/jpet.117.242586","article-title":"New Peptide Inhibitor of Dipeptidyl Peptidase IV, EMDB-1 Extends the Half-Life of GLP-2 and Attenuates Colitis in Mice after Topical Administration","volume":"363","author":"Salaga","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B246","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/01.WCB.0000043948.67811.8F","article-title":"Cholecystokinin Induces Cerebral Vasodilatation via Presynaptic CCK2 Receptors: New Implications for the Pathophysiology of Panic","volume":"23","author":"S\u00e1nchez-Fern\u00e1ndez","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B247","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.regpep.2004.04.018","article-title":"A Novel Role for Cholecystokinin: Regulation of Mesenteric Vascular Resistance","volume":"121","author":"Sanchez-Fernandez","year":"2004","journal-title":"Regul. Pept."},{"key":"B248","doi-asserted-by":"publisher","first-page":"G641","DOI":"10.1152\/ajpgi.1983.245.5.g641","article-title":"Regulation of Pepsinogen Release from Canine Chief Cells in Primary Monolayer Culture","volume":"245","author":"Sanders","year":"1983","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B249","doi-asserted-by":"publisher","first-page":"G759","DOI":"10.1152\/ajpgi.1993.265.4.g759","article-title":"Nitric Oxide Regulates Migrating Motor Complex Cycling and its Postprandial Disruption","volume":"265","author":"Sarna","year":"1993","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B250","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.regpep.2006.12.016","article-title":"Glucagon-like Peptide 1 Receptor Expression in Primary Porcine Proximal Tubular Cells","volume":"141","author":"Schlatter","year":"2007","journal-title":"Regul. Pept."},{"key":"B251","doi-asserted-by":"publisher","first-page":"G197","DOI":"10.1152\/ajpgi.1991.260.2.g197","article-title":"Role of CCK in Regulation of Pancreaticobiliary Functions and GI Motility in Humans: Effects of Loxiglumide","volume":"260","author":"Schmidt","year":"1991","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B252","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s0167-0115(01)00307-x","article-title":"Cellular Expression of CCK-A and CCK-B\/gastrin Receptors in Human Gastric Mucosa","volume":"102","author":"Schmitz","year":"2001","journal-title":"Regul. Pept."},{"key":"B253","doi-asserted-by":"publisher","first-page":"79S","DOI":"10.1007\/bf02300378","article-title":"Nitric Oxide and Gastric Relaxation","volume":"39","author":"Schuurkes","year":"1994","journal-title":"Dig. Dis. Sci."},{"key":"B254","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.coph.2013.10.001","article-title":"Gastrointestinal HCO3\u2212 Transport and Epithelial protection in the Gut: New Techniques, Transport Pathways and Regulatory Pathways","volume":"13","author":"Seidler","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"B255","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1475-2840-13-69","article-title":"Exenatide Induces Aortic Vasodilation Increasing Hydrogen Sulphide, Carbon Monoxide and Nitric Oxide Production","volume":"13","author":"S\u00e9lley","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"B256","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signaling"},{"key":"B257","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1210\/jcem.87.1.8129","article-title":"Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion","volume":"87","author":"Shiiya","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B258","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1210\/endo-121-3-1076","article-title":"Identification and Localization of Glucagon-like Peptide-1 and its Receptor in Rat Brain","volume":"121","author":"Shimizu","year":"1987","journal-title":"Endocrinology"},{"key":"B259","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1097\/01.hjh.0000163146.20330.bc","article-title":"Nitric Oxide Synthase Inhibition Exaggerates the Hypotensive Response to Ghrelin: Role of Calcium-Activated Potassium Channels","volume":"23","author":"Shinde","year":"2005","journal-title":"J. Hypertens."},{"key":"B260","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2337\/diabetes.50.2.227","article-title":"Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide that Antagonizes Leptin Action through the Activation of Hypothalamic Neuropeptide Y\/Y1 Receptor Pathway","volume":"50","author":"Shintani","year":"2001","journal-title":"Diabetes"},{"key":"B261","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1210\/en.2002-220756","article-title":"Ghrelin Protects against Ethanol-Induced Gastric Ulcers in Rats: Studies on the Mechanisms of Action","volume":"144","author":"Sibilia","year":"2003","journal-title":"Endocrinology"},{"key":"B262","first-page":"367","article-title":"Influence of Nitric Oxide on the Cardiovascular Action of Secretin in Intact Rats. Part A. Does Nitric Oxide Influence the Effect of Secretin on Arterial Blood Pressure?","volume":"52","author":"Sitniewska","year":"2000","journal-title":"Pol. J. Pharmacol."},{"key":"B263","first-page":"375","article-title":"Influence of Nitric Oxide on the Cardiovascular Action of Secretin in Intact Rats. Part B. Does Nitric Oxide Influence the Effect of Secretin on Isolated Heart Function?","volume":"52","author":"Sitniewska","year":"2000","journal-title":"Pol. J. Pharmacol."},{"key":"B264","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0167-0115(00)00131-2","article-title":"Influence of Secretin and L-NAME on Vascular Permeability in the Coronary Circulation of Intact and Diabetic Rats","volume":"96","author":"Sitniewska","year":"2001","journal-title":"Regul. Peptides"},{"key":"B265","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/s0167-0115(02)00018-6","article-title":"Diabetes-induced Changes of Nitric Oxide Influence on the Cardiovascular Action of Secretin","volume":"105","author":"Sitniewska","year":"2002","journal-title":"Regul. Peptides"},{"key":"B266","doi-asserted-by":"publisher","first-page":"e13870","DOI":"10.14814\/phy2.13870","article-title":"Hydrogen Sulfide Suppresses Ghrelin Secretion In Vitro and Delays Postprandial Ghrelin Secretion while Reducing Appetite in Mice","volume":"6","author":"Slade","year":"2018","journal-title":"Physiol. Rep."},{"key":"B267","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1161\/atvbaha.115.305447","article-title":"GLP-1 Receptor Agonist Exenatide Increases Capillary Perfusion Independent of Nitric Oxide in Healthy Overweight Men","volume":"35","author":"Smits","year":"2015","journal-title":"Atvb"},{"key":"B268","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jconrel.2016.08.030","article-title":"Prevention of Colitis by Controlled Oral Drug Delivery of Carbon Monoxide","volume":"239","author":"Steiger","year":"2016","journal-title":"J. Controlled Release"},{"key":"B269","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/med.0b013e3282f43a73","article-title":"Enteroendocrine Cells: a Site of 'taste' in Gastrointestinal Chemosensing","volume":"15","author":"Sternini","year":"2008","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"B270","doi-asserted-by":"publisher","first-page":"5636","DOI":"10.1021\/bi00184a036","article-title":"Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States","volume":"33","author":"Stone","year":"1994","journal-title":"Biochemistry"},{"key":"B271","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1016\/0014-2999(94)90019-1","article-title":"Nitric Oxide as Mediator of the Gastroprotection by Cholecystokinin-8 and Pentagastrin","volume":"260","author":"Stroff","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"B272","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1001\/archsurg.1970.01340200089019","article-title":"Distension of the Pyloric Antrum as a Stimulus for Gastrin Release","volume":"100","author":"Sugawara","year":"1970","journal-title":"Arch. Surg."},{"key":"B273","doi-asserted-by":"publisher","first-page":"R1071","DOI":"10.1152\/ajpregu.00490.2006","article-title":"Endogenous Cholecystokinin Reduces Food Intake and Increases Fos-like Immunoreactivity in the Dorsal Vagal Complex but Not in the Myenteric Plexus by CCK1 Receptor in the Adult Rat","volume":"292","author":"Sullivan","year":"2007","journal-title":"Am. J. Physiology-Regulatory, Integr. Comp. Physiol."},{"key":"B274","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.diabres.2015.07.015","article-title":"Impact of GLP-1 Receptor Agonists on Blood Pressure, Heart Rate and Hypertension Among Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis","volume":"110","author":"Sun","year":"2015","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B275","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3164\/jcbn.10-16GFR","article-title":"Ghrelin and Oxidative Stress in Gastrointestinal Tract","volume":"48","author":"Suzuki","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"key":"B276","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1023\/b:ddas.0000007861.91075.b3","article-title":"Effect of Motilin on Endogenous Release of Insulin in Conscious Dogs in the Fed State","volume":"48","author":"Suzuki","year":"2003","journal-title":"Dig. Dis. Sci."},{"key":"B277","doi-asserted-by":"publisher","first-page":"G87","DOI":"10.1152\/ajpgi.1998.274.1.g87","article-title":"Motilin Controls Cyclic Release of Insulin through Vagal Cholinergic Muscarinic Pathways in Fasted Dogs","volume":"274","author":"Suzuki","year":"1998","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B278","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2169\/internalmedicine.56.7403","article-title":"Clinical Implication of Plasma Hydrogen Sulfide Levels in Japanese Patients with Type 2 Diabetes","volume":"56","author":"Suzuki","year":"2017","journal-title":"Intern. Med."},{"key":"B279","first-page":"59","article-title":"Studies on the Causal Relationship between Gall-Bladder Emptying and Motilin Release in Man","volume":"520","author":"Svenberg","year":"1984","journal-title":"Acta Chir Scand. Suppl."},{"key":"B280","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1136\/gutjnl-2014-308472","article-title":"Motilin-induced Gastric Contractions Signal Hunger in Man","volume":"65","author":"Tack","year":"2016","journal-title":"Gut"},{"key":"B281","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/gut.51.2.219","article-title":"Role of Nitric Oxide in the Gastric Accommodation Reflex and in Meal Induced Satiety in Humans","volume":"51","author":"Tack","year":"2002","journal-title":"Gut"},{"key":"B282","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1080\/10715762.2016.1189546","article-title":"Carbon Monoxide Promotes Gastric Wound Healing in Mice via the Protein Kinase C Pathway","volume":"50","author":"Takagi","year":"2016","journal-title":"Free Radic. Res."},{"key":"B283","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s00535-005-1688-7","article-title":"In Vivo recording of Colonic Motility in Conscious Rats with Deficiency of Interstitial Cells of Cajal, with Special Reference to the Effects of Nitric Oxide on Colonic Motility","volume":"40","author":"Takahashi","year":"2005","journal-title":"J. Gastroenterol."},{"key":"B284","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3389\/fphys.2012.00324","article-title":"TRP Channels: Sensors and Transducers of Gasotransmitter Signals","volume":"3","author":"Takahashi","year":"2012","journal-title":"Front. Physiol."},{"key":"B285","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.niox.2014.11.001","article-title":"H2S-induced HCO3\u2212 Secretion in the Rat Stomach - Involvement of Nitric Oxide, Prostaglandins, and Capsaicin-Sensitive Sensory Neurons","volume":"46","author":"Takeuchi","year":"2015","journal-title":"Nitric Oxide"},{"key":"B286","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1538\/expanim.54.309","article-title":"Effects of Nitric Oxide Synthase Inhibitor on the Digestive System Measured by Simultaneous Monitoring of Gastric Motility, Gastric Emptying Activity and Postprandial Pancreaticobiliary Secretion in Dogs","volume":"54","author":"Tanaka","year":"2005","journal-title":"Exp. Anim."},{"key":"B287","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12020-015-0852-y","article-title":"Effects of Glucagon-like Peptide-1 on Advanced Glycation Endproduct-Induced Aortic Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats: Possible Roles of Rho Kinase- and AMP Kinase-Mediated Nuclear Factor \u03baB Signaling Pathways","volume":"53","author":"Tang","year":"2016","journal-title":"Endocrine"},{"key":"B288","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1365-2613.2003.00357.x","article-title":"Roles of Inducible Nitric Oxide Synthase in the Development and Healing of Experimentally Induced Gastric Ulcers","volume":"84","author":"Tatemichi","year":"2003","journal-title":"Int. J. Exp. Pathol."},{"key":"B289","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1111\/j.1572-0241.2004.30291.x","article-title":"Effect of Helicobacter pylori Infection on Ghrelin Expression in Human Gastric Mucosa","volume":"99","author":"Tatsuguchi","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"B290","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1161\/circulationaha.105.553883","article-title":"Ghrelin Improves Endothelial Function in Patients with Metabolic Syndrome","volume":"112","author":"Tesauro","year":"2005","journal-title":"Circulation"},{"key":"B291","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1161\/hypertensionaha.109.137729","article-title":"Ghrelin Restores the Endothelin 1\/nitric Oxide Balance in Patients with Obesity-Related Metabolic Syndrome","volume":"54","author":"Tesauro","year":"2009","journal-title":"Hypertension"},{"key":"B292","doi-asserted-by":"publisher","first-page":"F854","DOI":"10.1152\/ajprenal.00258.2017","article-title":"Renal Hemodynamic Effects of Glucagon-like Peptide-1 Agonist Are Mediated by Nitric Oxide but Not Prostaglandin","volume":"313","author":"Thomson","year":"2017","journal-title":"Am. J. Physiology-Renal Physiol."},{"key":"B293","doi-asserted-by":"publisher","first-page":"F137","DOI":"10.1152\/ajprenal.00064.2012","article-title":"Glucagon-like Peptide-1 Receptor Stimulation Increases GFR and Suppresses Proximal Reabsorption in the Rat","volume":"304","author":"Thomson","year":"2013","journal-title":"Am. J. Physiology-Renal Physiol."},{"key":"B294","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2174\/1389203043486946","article-title":"Glucagon-like Peptide 2 (GLP-2), an Intestinotrophic Mediator","volume":"5","author":"Thulesen","year":"2004","journal-title":"Curr. Protein Pept. Sci."},{"key":"B295","first-page":"681","article-title":"Effects of Pure Natural Cholecystokinin on Splanchnic Circulation in the Dog","volume":"139","author":"Thulin","year":"1973","journal-title":"Acta Chir Scand."},{"key":"B296","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s10753-016-0466-4","article-title":"Effects of CCK-8 and Cystathionine \u03b3-Lyase\/Hydrogen Sulfide System on Acute Lung Injury in Rats","volume":"40","author":"Tian","year":"2017","journal-title":"Inflammation"},{"key":"B297","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1210\/jcem.86.8.7750","article-title":"Determinants of the Impaired Secretion of Glucagon-like Peptide-1 in Type 2 Diabetic Patients","volume":"86","author":"Toft-Nielsen","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B298","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0167-0115(00)00220-2","article-title":"The Inhibitory Mechanism of GLP-1, but Not Glucagon, on Fasted Gut Motility Is Dependent on the L-Arginine\/nitric Oxide Pathway","volume":"98","author":"Tolessa","year":"2001","journal-title":"Regul. Pept."},{"key":"B299","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1172\/jci942","article-title":"Inhibitory Effect of Glucagon-like Peptide-1 on Small Bowel Motility. Fasting but Not Fed Motility Inhibited via Nitric Oxide Independently of Insulin and Somatostatin","volume":"102","author":"Tolessa","year":"1998","journal-title":"J. Clin. Invest."},{"key":"B300","first-page":"213","article-title":"Ghrelin, an Endogenous Ligand for the Growth Hormone-Secretagogue Receptor, Is Expressed in the Human Adrenal Cortex","volume":"12","author":"Tortorella","year":"2003","journal-title":"Int. J. Mol. Med."},{"key":"B301","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1254\/jphs.09056fp","article-title":"Polaprezinc (Zinc L-Carnosine) Is a Potent Inducer of Anti-oxidative Stress Enzyme, Heme Oxygenase (HO)-1 - a New Mechanism of Gastric Mucosal protection","volume":"110","author":"Ueda","year":"2009","journal-title":"J. Pharmacol. Sci."},{"key":"B302","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.1210\/endo.140.12.7170","article-title":"Endotoxin Stimulates Nitric Oxide Production in the Paraventricular Nucleus of the Hypothalamus through Nitric Oxide Synthase I: Correlation with Hypothalamic-Pituitary-Adrenal Axis Activation1","volume":"140","author":"Uribe","year":"1999","journal-title":"Endocrinology"},{"key":"B303","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1046\/j.1365-2982.1997.d01-59.x","article-title":"Effects of Gastrin-Releasing Peptide (GRP) on the Mechanical Activity of the Human Ileocaecal Region In Vitro","volume":"9","author":"Vadokas","year":"1997","journal-title":"Neurogastroenterol Motil."},{"key":"B304","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/s0016-5085(71)80122-1","article-title":"The Effect of Secretin on Gastric Emptying in Man","volume":"60","author":"Vagne","year":"1971","journal-title":"Gastroenterology"},{"key":"B305","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/s0016-5085(76)80445-3","article-title":"Effect of Gastrin on Pancreatic Enzyme Secretion and Gallbladder Emptying in Man","volume":"71","author":"Valenzuela","year":"1976","journal-title":"Gastroenterology"},{"key":"B306","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/cvr\/23.12.1053","article-title":"Nitric Oxide Synthesised from L-Arginine Mediates Endothelium Dependent Dilatation in Human Veins In Vivo","volume":"23","author":"Vallance","year":"1989","journal-title":"Cardiovasc. Res."},{"key":"B307","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fpsyt.2020.00172","article-title":"The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review","volume":"11","author":"Van den Houte","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B308","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1523\/jneurosci.1787-13.2014","article-title":"Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of FosB","volume":"34","author":"Vialou","year":"2014","journal-title":"J. Neurosci."},{"key":"B309","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00000658-197607000-00016","article-title":"Suppression of Gastrin Release and Gastric Secretion by Gastric Inhibitory Polypeptide (GIP) and Vasoactive Intestinal Polypeptide (VIP)","volume":"184","author":"Villar","year":"1976","journal-title":"Ann. Surg."},{"key":"B310","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1381612822666151119144458","article-title":"Human Ghrelin: A Gastric Hormone with Cardiovascular Properties","volume":"22","author":"Virdis","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"B311","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1152\/jappl.1975.38.4.661","article-title":"Renal Response to Secretin","volume":"38","author":"Viteri","year":"1975","journal-title":"J. Appl. Physiol."},{"key":"B312","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1210\/jcem.87.3.8279","article-title":"Expression of Ghrelin and of the GH Secretagogue Receptor by Pancreatic Islet Cells and Related Endocrine Tumors","volume":"87","author":"Volante","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B313","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1098\/rspb.1990.0085","article-title":"Endothelium-derived Relaxing Factor Participates in the Increased Blood Flow in Response to Pentagastrin in the Rat Stomach Mucosa","volume":"241","author":"Walder","year":"1990","journal-title":"Proc. Biol. Sci."},{"key":"B314","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1007\/s10620-012-2119-2","article-title":"Hydrogen Sulfide: a rescue Molecule for Mucosal Defence and Repair","volume":"57","author":"Wallace","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"B315","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's Company, Three's a Crowd: Can H2S Be the Third Endogenous Gaseous Transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB j."},{"key":"B316","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1073\/pnas.0308695100","article-title":"Carbon Monoxide Mediates Vasoactive Intestinal Polypeptide-Associated Nonadrenergic\/noncholinergic Neurotransmission","volume":"101","author":"Watkins","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B317","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/nrc2014","article-title":"Gastrin - Active Participant or Bystander in Gastric Carcinogenesis?","volume":"6","author":"Watson","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"B318","doi-asserted-by":"publisher","first-page":"4010395","DOI":"10.1155\/2018\/4010395","article-title":"The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease","volume":"2018","author":"Wen","year":"2018","journal-title":"Oxid Med. Cel Longev"},{"key":"B319","doi-asserted-by":"publisher","first-page":"G399","DOI":"10.1152\/ajpgi.00130.2002","article-title":"Cholecystokinin Secretagogue-Induced Gastroprotection: Role of Nitric Oxide and Blood Flow","volume":"284","author":"West","year":"2003","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B320","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1210\/jc.2006-2756","article-title":"Ghrelin and Motilin Are Cosecreted from a Prominent Endocrine Cell Population in the Small Intestine","volume":"92","author":"Wierup","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B321","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/sj.bjp.0704815","article-title":"Comparison of Vasodilators in Human Internal Mammary Artery: Ghrelin Is a Potent Physiological Antagonist of Endothelin-1","volume":"136","author":"Wiley","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"B322","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"B323","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/s0016-5085(99)70555-x","article-title":"Secretion of the Intestinotropic Hormone Glucagon-like Peptide 2 Is Differentially Regulated by Nutrients in Humans","volume":"117","author":"Xiao","year":"1999","journal-title":"Gastroenterology"},{"key":"B324","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1210\/en.2008-0255","article-title":"Molecular Mechanisms of Ghrelin-Mediated Endothelial Nitric Oxide Synthase Activation","volume":"149","author":"Xu","year":"2008","journal-title":"Endocrinology"},{"key":"B325","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0891-0618(96)00133-0","article-title":"Immunohistochemical Mapping of Nitric Oxide Synthase in the Rat Hypothalamus and Colocalization with Neuropeptides","volume":"10","author":"Yamada","year":"1996","journal-title":"J. Chem. Neuroanat."},{"key":"B326","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/j.neuroscience.2008.04.037","article-title":"Impaired Hippocampal Synaptic Function in Secretin Deficient Mice","volume":"154","author":"Yamagata","year":"2008","journal-title":"Neuroscience"},{"key":"B327","doi-asserted-by":"publisher","first-page":"R927","DOI":"10.1152\/ajpregu.00600.2003","article-title":"Secretin Depolarizes Nucleus Tractus Solitarius Neurons through Activation of a Nonselective Cationic Conductance","volume":"286","author":"Yang","year":"2004","journal-title":"Am. J. Physiology-Regulatory, Integr. Comp. Physiol."},{"key":"B328","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s42003-019-0431-5","article-title":"Non-enzymatic Hydrogen Sulfide Production from Cysteine in Blood Is Catalyzed by Iron and Vitamin B6","volume":"2","author":"Yang","year":"2019","journal-title":"Commun. Biol."},{"key":"B329","doi-asserted-by":"publisher","first-page":"e23788","DOI":"10.1371\/journal.pone.0023788","article-title":"Expression of Cystathionine Beta-Synthase and Cystathionine Gamma-Lyase in Human Pregnant Myometrium and Their Roles in the Control of Uterine Contractility","volume":"6","author":"You","year":"2011","journal-title":"PLoS One"},{"key":"B330","doi-asserted-by":"publisher","first-page":"G1266","DOI":"10.1152\/ajpgi.1998.275.6.g1266","article-title":"Endogenous Cholecystokinin in Postprandial Lower Esophageal Sphincter Function and Fundic Tone in Humans","volume":"275","author":"Zerbib","year":"1998","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B331","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1038\/s41598-018-19444-5","article-title":"The Motilin Agonist Erythromycin Increases Hunger by Modulating Homeostatic and Hedonic Brain Circuits in Healthy Women: a Randomized, Placebo-Controlled Study","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci. Rep."},{"key":"B332","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/cne.20823","article-title":"Expression of Ghrelin Receptor mRNA in the Rat and the Mouse Brain","volume":"494","author":"Zigman","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"B333","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00430-014-0328-3","article-title":"Cholecystokinin Protects Rats against Sepsis Induced by Staphylococcus aureus","volume":"203","author":"Zuelli","year":"2014","journal-title":"Med. Microbiol. Immunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.720703\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T03:54:53Z","timestamp":1626753293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.720703\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,20]]},"references-count":333,"alternative-id":["10.3389\/fphar.2021.720703"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.720703","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,20]]},"article-number":"720703"}}