{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:43:30Z","timestamp":1792755810443,"version":"4.5.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Vitamin D was reported to be associated with non\u2212alcoholic fatty liver disease (NAFLD). This systematic review and meta\u2212analysis aimed to investigate the effects of the vitamin D supplementation on anthropometric and biochemical indices in patient with NAFLD.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> PubMed, Web of science, Scopus, and Embase databases were explored to identify all randomized controlled trial (RCT) investigating the effects of vitamin D supplementation on anthropometric and biochemical indices in patients with NAFLD. A random\u2212effects model was used to pool weighted mean difference (WMD) and corresponding 95% confidence intervals (CIs). The statistical heterogeneity among the studies was assessed using I2 statistic (high \u2265 50%, low &amp;lt; 50%) and Cochran\u2019s Q\u2212test.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Sixteen RCTs were included in this meta\u2212analysis. The results identified that high\u2212density lipoprotein\u2212cholesterol (HDL\u2212C) level significantly increased following vitamin D supplementation (<jats:italic>P<\/jats:italic> = 0.008). Vitamin D reduced body weight (<jats:italic>P<\/jats:italic> = 0.007), body mass index (<jats:italic>P<\/jats:italic> = 0.002), waist circumstance (WC) (<jats:italic>P<\/jats:italic> = 0.02), serum alanine transaminase (ALT) (<jats:italic>P<\/jats:italic> = 0.01), fasting blood sugar (FBS) (<jats:italic>P<\/jats:italic> = 0.01), homeostatic model assessment for insulin resistance (HOMA\u2212IR) (<jats:italic>P<\/jats:italic> = 0.004), and calcium (<jats:italic>P<\/jats:italic> = 0.01). No significant changes were found on body fat, triglyceride (TG), total cholesterol, low\u2212density lipoprotein\u2212cholesterol (LDL\u2212C), aspartate transaminase, alkaline phosphatase, gamma\u2212glutamyl transferase, and adiponectin following vitamin D supplementation.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Vitamin D had significant effects on anthropometric and biochemical indices including HDL\u2212C, body weight, BMI, WC, serum ALT, serum FBS, HOMA\u2212IR, and calcium. Vitamin D supplementation can be considered as an effective strategy in management of patients with NAFLD.<\/jats:p><jats:p><jats:bold>Systematic Review Registration<\/jats:bold>: [website], identifier [registration number]<\/jats:p>","DOI":"10.3389\/fphar.2021.732496","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T06:36:12Z","timestamp":1635921372000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["The Effects of Vitamin D Supplementation on Anthropometric and Biochemical Indices in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Shahla","family":"Rezaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Tabrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Nowrouzi-Sohrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Shabani-Borujeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Modaresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Gholamalizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Doaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"B1","first-page":"0","article-title":"Regression of Non\u2212alcoholic Fatty Liver by Vitamin D Supplement: a Double\u2212Blind Randomized Controlled Clinical Trial","volume":"19","author":"Amiri","year":"2016","journal-title":"Arch. 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