{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:57:56Z","timestamp":1780599476919,"version":"3.54.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> To evaluate anterior segment optical coherence tomography (AS-OCT) to detect the wound healing process as per monitoring the effectiveness of cenegermin to treat moderate to severe neurotrophic keratoplasty.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A retrospective chart review was realized to identify patients treated with cenegermin at the Clinica Oculistica, University of Genoa, Italy. All patients underwent careful examinations at baseline and follow-up visits. AS-OCT scans centered on the minimum corneal thickness (CT) area were always performed. We compared findings of AS-OCT with the findings from the slit-lamp examination. A linear regression analysis was used to evaluate factors associated with corneal healing. A further analysis, including a control group treated with 50% autologous serum (AS), was done to investigate and compare the efficacy of cenegermin.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Data from 16 eyes were studied. The average patients' age was 60.9 \u00b1 21.1\u00a0years; five (31.2%) eyes experienced persistent epithelial defect and 11 (68.8%) eyes had neurotrophic corneal ulcer. The average reepithelialization time was 3.9 \u00b1 0.5 weeks in the cenegermin group versus 5.9 \u00b1 1.9\u00a0weeks in the AS group (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). The AS\u2010OCT scans revealed an average CT at the thinnest point of 276.3 \u00b1 74.1\u00a0\u03bcm before treatment with an average increase of 176.5 \u00b1 60.3\u00a0\u03bcm at the end of the cenegermin treatment (B = \u22120.15; <jats:italic>p<\/jats:italic> = 0.035). The AS-OCT percentage increase in corneal thickness between the two groups was statistically significant (<jats:italic>p<\/jats:italic> &amp;lt; 0.02).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Understanding the cascade of events involved in the nerve growth factor\u2013driven corneal wound healing process is clinically meaningful for the clinician. AS-OCT is an effective tool for systematic anterior segment imaging, allowing the detailed detection of the front-to-back layered corneal structure for quantitative analysis and monitoring of the healing process.<\/jats:p>","DOI":"10.3389\/fphar.2021.760507","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T09:37:02Z","timestamp":1643362622000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Recombinant Human Nerve Growth Factor (Cenegermin)\u2013Driven Corneal Wound Healing Process: An Evidence-Based Analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Chiara","family":"Bonzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Olivari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Cutolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Macr\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Sindaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Borroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bonzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Enrico","family":"Traverso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1177\/1120672120968724","article-title":"Contact Lens Induced Bacterial Keratitis in LCD II: Management and Multimodal Imaging: a Case Report and Review of Literature","volume":"31","author":"Alafaleq","year":"2021","journal-title":"Eur. 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