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In overnutrition diseases, SGLT2 inhibitors affect the autophagy <jats:italic>via<\/jats:italic> various signaling pathways, including mammalian target of rapamycin (mTOR), sirtuin 1 (SIRT1), and hypoxia-inducible factor (HIF) pathways. Recently, it turned out that not only stagnation but also overactivation of autophagy causes cellular damages, indicating that therapeutic interventions which simply enhance or stagnate autophagy activity might be a \u201cdouble-edged sword\u201d in some situations. A small number of studies suggest that SGLT2 inhibitors not only activate but also suppress the autophagy flux depending on the situation, indicating that SGLT2 inhibitors can \u201cregulate\u201d autophagic activity and help achieve the appropriate autophagy flux in each organ. Considering the complicated control and bilateral characteristics of autophagy, the potential of SGLT2 inhibitors as the regulator of autophagic activity would be beneficial in the treatment of autophagy deficiency.<\/jats:p>","DOI":"10.3389\/fphar.2021.761842","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T05:22:36Z","timestamp":1634793756000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Sodium\u2013Glucose Cotransporter 2 Inhibitors Work as a \u201cRegulator\u201d of Autophagic Activity in Overnutrition Diseases"],"prefix":"10.3389","volume":"12","author":[{"given":"Kazuhiko","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"109368","DOI":"10.1016\/j.cbi.2021.109368","article-title":"Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Experimental Inflammatory Bowel Disease in Rats: Targeting AMPK\/mTOR, HMGB1\/RAGE and Nrf2\/HO-1 Pathways","volume":"335","author":"Arab","year":"2021","journal-title":"Chem. 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