{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:45:03Z","timestamp":1793148303608,"version":"4.5.0"},"reference-count":271,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular diseases affecting vasculature in the heart, cerebrovascular disease, atherosclerosis, and diabetic complications have compromised quality of life for affected individuals and increase the burden on health care services. Berberine, a naturally occurring isoquinoline alkaloid form\n                    <jats:italic>Rhizoma coptidis<\/jats:italic>\n                    , is widely used in China as a folk medicine for its antibacterial and anti-inflammatory properties. Promisingly, an increasing number of studies have identified several cellular and molecular targets for berberine, indicating its potential as an alternative therapeutic strategy for vascular diseases, as well as providing novel evidence that supports the therapeutic potential of berberine to combat vascular diseases. The purpose of this review is to comprehensively and systematically describe the evidence for berberine as a therapeutic agent in vascular diseases, including its pharmacological effects, molecular mechanisms, and pharmacokinetics. According to data published so far, berberine shows remarkable anti-inflammatory, antioxidant, antiapoptotic, and antiautophagic activity via the regulation of multiple signaling pathways, including AMP-activated protein kinase (AMPK), nuclear factor \u03baB (NF-\u03baB), mitogen-activated protein kinase silent information regulator 1 (SIRT-1), hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1), vascular endothelial growth factor phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), janus kinase 2 (JAK-2), Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels, and endoplasmic reticulum stress. Moreover, we discuss the existing limitations of berberine in the treatment of vascular diseases, and give corresponding measures. In addition, we propose some research perspectives and challenges, and provide a solid evidence base from which further studies can excavate novel effective drugs from Chinese medicine monomers.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2021.762654","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T07:37:45Z","timestamp":1647243465000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":213,"title":["Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiaopeng","family":"Ai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuling","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianrong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianli","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3389\/fgene.2020.00356","article-title":"Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases","volume":"11","author":"Aggarwal","year":"2020","journal-title":"Front. Genet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrneph.2017.155","article-title":"Dyslipidaemia in Nephrotic Syndrome: Mechanisms and Treatment","volume":"14","author":"Agrawal","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"111992","DOI":"10.1016\/j.jep.2019.111992","article-title":"Amelioration of Dry Eye Syndrome in Db\/db Mice with Diabetes Mellitus by Treatment with Tibetan Medicine Formula Jikan Mingmu Drops","volume":"241","author":"Ai","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"110852","DOI":"10.1016\/j.biopha.2020.110852","article-title":"A Review of Traditional Chinese Medicine on Treatment of Diabetic Retinopathy and Involved Mechanisms","volume":"132","author":"Ai","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1093\/eurheartj\/ehab128","article-title":"Antithrombotic Therapy in Diabetes: Which, when, and for How Long?","volume":"42","author":"Ajjan","year":"2021","journal-title":"Eur. Heart J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1093\/eurheartj\/ehaa770","article-title":"Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1): A Crucial Driver of Atherosclerotic Cardiovascular Disease","volume":"42","author":"Akhmedov","year":"2021","journal-title":"Eur. Heart J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.amepre.2021.03.026","article-title":"Prevalence and Determinants of Difficulty in Accessing Medical Care in U.S. Adults","volume":"61","author":"Al Rifai","year":"2021","journal-title":"Am. J. Prev. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jconrel.2016.12.042","article-title":"Liposome Encapsulated Berberine Treatment Attenuates Cardiac Dysfunction after Myocardial Infarction","volume":"247","author":"Allijn","year":"2017","journal-title":"J. Control Release."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4681041","DOI":"10.1155\/2021\/4681041","article-title":"Doxycycline Hyclate Modulates Antioxidant Defenses, Matrix Metalloproteinases, and COX-2 Activity Accelerating Skin Wound Healing by Secondary Intention in Rats","volume":"2021","author":"Alto\u00e9","year":"2021","journal-title":"Oxid. Med. Cel. Longev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1084\/jem.20170391","article-title":"Development and Plasticity of Meningeal Lymphatic Vessels","volume":"214","author":"Antila","year":"2017","journal-title":"J. Exp. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural Products in Drug Discovery: Advances and Opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.2337\/db20-1257","article-title":"Vaccination against Receptor for Advanced Glycation End Products Attenuates the Progression of Diabetic Kidney Disease","volume":"70","author":"Azegami","year":"2021","journal-title":"Diabetes"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4104965","DOI":"10.1155\/2020\/4104965","article-title":"Preconditioning Effect of High-Intensity Interval Training (HIIT) and Berberine Supplementation on the Gene Expression of Angiogenesis Regulators and Caspase-3 Protein in the Rats with Myocardial Ischemia-Reperfusion (IR) Injury","volume":"2020","author":"Banaei","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13321-016-0162-2","article-title":"Computational Methods for Prediction of In Vitro Effects of New Chemical Structures","volume":"8","author":"Banerjee","year":"2016","journal-title":"J. Cheminform."},{"key":"B15","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1161\/CIRCRESAHA.116.304529","article-title":"Increased Arterial Blood Pressure and Vascular Remodeling in Mice Lacking Salt-Inducible Kinase 1 (SIK1)","volume":"116","author":"Bertorello","year":"2015","journal-title":"Circ. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1161\/CIRCULATIONAHA.120.047978","article-title":"Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension","volume":"144","author":"Bisserier","year":"2021","journal-title":"Circulation"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","article-title":"Autophagy and Mitophagy in Cardiovascular Disease","volume":"120","author":"Bravo-San Pedro","year":"2017","journal-title":"Circ. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e019413","DOI":"10.1161\/JAHA.120.019413","article-title":"Arterial Platelet Adhesion in Atherosclerosis-Prone Arteries of Obese, Insulin-Resistant Nonhuman Primates","volume":"10","author":"Brown","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"B20","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.amjmed.2016.10.022","article-title":"Current Understanding of Atherogenesis","volume":"130","author":"Brown","year":"2017","journal-title":"Am. J. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s10557-012-6422-0","article-title":"Berberine Attenuates Ischemia-Reperfusion Injury via Regulation of Adenosine-5'-Monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat Heart","volume":"26","author":"Chang","year":"2012","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B22","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12967-016-0982-x","article-title":"Lipid Profiling of the Therapeutic Effects of Berberine in Patients with Nonalcoholic Fatty Liver Disease","volume":"14","author":"Chang","year":"2016","journal-title":"J. Transl. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"5529913","DOI":"10.1155\/2021\/5529913","article-title":"Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1\/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress","volume":"2021","author":"Chang","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.biopha.2018.09.140","article-title":"Berberine Attenuates Apoptosis in Rat Retinal M\u00fcller Cells Stimulated with High Glucose via Enhancing Autophagy and the AMPK\/mTOR Signaling","volume":"108","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B25","doi-asserted-by":"publisher","first-page":"114032","DOI":"10.1016\/j.jpba.2021.114032","article-title":"A Comparative Investigation of the Interaction and Pharmacokinetics of Hemoglobin with Berberine and its Oxymetabolite","volume":"199","author":"Chen","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"B26","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1080\/15476286.2019.1676114","article-title":"circDLPAG4\/HECTD1 Mediates Ischaemia\/reperfusion Injury in Endothelial Cells via ER Stress","volume":"17","author":"Chen","year":"2020","journal-title":"RNA Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"17482","DOI":"10.1002\/jcp.28370","article-title":"Berberine Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension via Bone Morphogenetic Protein and Transforming Growth Factor-\u03b2 Signaling","volume":"234","author":"Chen","year":"2019","journal-title":"J. Cell Physiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1208\/s12249-011-9632-z","article-title":"Bioavailability Study of Berberine and the Enhancing Effects of TPGS on Intestinal Absorption in Rats","volume":"12","author":"Chen","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"B29","doi-asserted-by":"publisher","first-page":"8526438","DOI":"10.1155\/2017\/8526438","article-title":"Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke","volume":"2017","author":"Cheng","year":"2017","journal-title":"Oxid Med. Cell Longev"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5915","DOI":"10.1016\/j.bmc.2010.06.085","article-title":"8,8-Dimethyldihydroberberine with Improved Bioavailability and Oral Efficacy on Obese and Diabetic Mouse Models","volume":"18","author":"Cheng","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"9243","DOI":"10.7150\/thno.63354","article-title":"Tissue Factor Cytoplasmic Domain Exacerbates Post-Infarct Left Ventricular Remodeling via Orchestrating Cardiac Inflammation and Angiogenesis","volume":"11","author":"Chong","year":"2021","journal-title":"Theranostics"},{"key":"B32","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.healun.2011.03.010","article-title":"Bosentan Attenuates Right Ventricular Hypertrophy and Fibrosis in Normobaric Hypoxia Model of Pulmonary Hypertension","volume":"30","author":"Choudhary","year":"2011","journal-title":"J. Heart Lung Transpl."},{"key":"B33","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.freeradbiomed.2011.12.001","article-title":"Myeloperoxidase-derived Oxidants Inhibit Sarco\/Endoplasmic Reticulum Ca2+-Atpase Activity and Perturb Ca2+ Homeostasis in Human Coronary Artery Endothelial Cells","volume":"52","author":"Cook","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrclinonc.2015.105","article-title":"Inflammation and Cancer: Advances and New Agents","volume":"12","author":"Crusz","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/jch.12638","article-title":"Diabetes and Hypertension: A Comparative Review of Current Guidelines","volume":"18","author":"Cryer","year":"2016","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"7160","DOI":"10.3892\/mmr.2015.4288","article-title":"Poor Permeability and Absorption Affect the Activity of Four Alkaloids from Coptis","volume":"12","author":"Cui","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/molecules24010103","article-title":"Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability","volume":"24","author":"Cui","year":"2018","journal-title":"Molecules"},{"key":"B38","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1148\/radiol.2503080751","article-title":"Mild Cognitive Impairment and Alzheimer Disease: Patterns of Altered Cerebral Blood Flow at MR Imaging","volume":"250","author":"Dai","year":"2009","journal-title":"Radiology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e183310","DOI":"10.1001\/jamapediatrics.2018.3310","article-title":"Association of Initially Normal Coronary Arteries with Normal Findings on Follow-Up Echocardiography in Patients with Kawasaki Disease","volume":"172","author":"de Ferranti","year":"2018","journal-title":"JAMA Pediatr."},{"key":"B40","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/s0008-6363(02)00708-3","article-title":"Biological Activities of Fibroblast Growth Factor-2 in the Adult Myocardium","volume":"57","author":"Detillieux","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.3390\/ijms21062217","article-title":"Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy","volume":"21","author":"Dewanjee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/all.14032","article-title":"Progress in Understanding Hypersensitivity Reactions to Nonsteroidal Anti\u2010inflammatory Drugs","volume":"75","author":"Do\u00f1a","year":"2020","journal-title":"Allergy"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1016\/j.neurobiolaging.2012.02.016","article-title":"Berberine Ameliorates \u03b2-amyloid Pathology, Gliosis, and Cognitive Impairment in an Alzheimer's Disease Transgenic Mouse Model","volume":"33","author":"Durairajan","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.3892\/etm.2018.5858","article-title":"Berberine Ameliorates Neonatal Necrotizing Enterocolitis by Activating the Phosphoinositide 3-kinase\/protein Kinase B Signaling Pathway","volume":"15","author":"Fang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/1878-0261.13044","article-title":"Secretogranin II Impairs Tumor Growth and Angiogenesis by Promoting Degradation of Hypoxia\u2010inducible Factor\u20101\u03b1 in Colorectal Cancer","volume":"23","author":"Fang","year":"2021","journal-title":"Mol. Oncol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.intimp.2016.12.001","article-title":"Comparative Effect of Berberine and its Derivative 8-Cetylberberine on Attenuating Atherosclerosis in ApoE-\/- Mice","volume":"43","author":"Feng","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"12155","DOI":"10.1038\/srep12155","article-title":"Transforming Berberine into its Intestine-Absorbable Form by the Gut Microbiota","volume":"5","author":"Feng","year":"2015","journal-title":"Sci. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.7150\/thno.30787","article-title":"Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics","volume":"9","author":"Feng","year":"2019","journal-title":"Theranostics"},{"key":"B49","doi-asserted-by":"publisher","first-page":"594852","DOI":"10.3389\/fphar.2020.594852","article-title":"Pharmacokinetics and Excretion of Berberine and its Nine Metabolites in Rats","volume":"11","author":"Feng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"101006","DOI":"10.1016\/j.plipres.2019.101006","article-title":"ATP-citrate Lyase (ACLY) in Lipid Metabolism and Atherosclerosis: An Updated Review","volume":"77","author":"Feng","year":"2020","journal-title":"Prog. Lipid. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-density Lipoproteins Cause Atherosclerotic Cardiovascular Disease. 1. Evidence from Genetic, Epidemiologic, and Clinical Studies. A Consensus Statement from the European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur. Heart J."},{"key":"B52","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/cvr\/cvq379","article-title":"T-type Ca\u00b2+ Signalling Regulates Aldosterone-Induced CREB Activation and Cell Death through PP2A Activation in Neonatal Cardiomyocytes","volume":"90","author":"Ferron","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"B275","doi-asserted-by":"publisher","first-page":"17424","DOI":"10.1016\/j.ejphar.2021.174247","article-title":"Sestrin2 Suppression Aggravates Oxidative Stress and Apoptosis in Endothelial Cells Subjected to Pharmacologically Induced Endoplasmic Reticulum Stress","volume":"907","author":"Fatima","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1161\/CIRCULATIONAHA.104.510354","article-title":"Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts","volume":"111","author":"Frangogiannis","year":"2005","journal-title":"Circulation"},{"key":"B54","doi-asserted-by":"publisher","first-page":"116143","DOI":"10.1016\/j.bmc.2021.116143","article-title":"An Insight into the Medicinal Attributes of Berberine Derivatives: A Review","volume":"38","author":"Gaba","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"ra79","DOI":"10.1126\/scisignal.aaa2581","article-title":"HDL-bound Sphingosine 1-Phosphate Acts as a Biased Agonist for the Endothelial Cell Receptor S1P1 to Limit Vascular Inflammation","volume":"8","author":"Galvani","year":"2015","journal-title":"Sci. Signal."},{"key":"B56","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3892\/ijmm.2019.4441","article-title":"Circular RNA_101237 Mediates Anoxia\/reoxygenation Injury by Targeting let-7a-5p\/IGF2BP3 in C-ardiomyocytes","volume":"45","author":"Gan","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"283","DOI":"10.2174\/1567205014666170417111859","article-title":"Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies","volume":"15","author":"Gao","year":"2018","journal-title":"Curr. Alzheimer. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1038\/s41467-019-11777-7","article-title":"Circular RNA CircFndc3b Modulates Cardiac Repair after Myocardial Infarction via FUS\/VEGF-A Axis","volume":"10","author":"Garikipati","year":"2019","journal-title":"Nat. Commun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"00128","DOI":"10.1016\/j.semcdb.2021.05.019","article-title":"Direct Reprogramming as a Route to Cardiac Repair","author":"Garry","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.3390\/cells9051233","article-title":"The Influence of Palmatine Isolated from Berberis Sibirica Radix on Pentylenetetrazole-Induced Seizures in Zebrafish","volume":"9","author":"Gawel","year":"2020","journal-title":"Cells"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1111\/bph.13466","article-title":"Berberine Improves Mesenteric Artery Insulin Sensitivity through Up-Regulating Insulin Receptor-Mediated Signalling in Diabetic Rats","volume":"173","author":"Geng","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s11883-014-0435-z","article-title":"Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target","volume":"16","author":"Golia","year":"2014","journal-title":"Curr. Atheroscler. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"644121","DOI":"10.3389\/fmed.2021.644121","article-title":"Protective or Harmful: The Dual Roles of Autophagy in Diabetic Retinopathy","volume":"8","author":"Gong","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.2147\/DMSO.S278267","article-title":"Resveratrol Inhibits Lipopolysaccharide-Induced Extracellular Matrix Accumulation and Inflammation in Rat Glomerular Mesangial Cells by SphK1\/S1P2\/NF-\u039ab Pathway","volume":"13","author":"Gong","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2018.02.001","article-title":"Orally Administered Berberine Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice through Promoting Activation of PPAR-\u03b3 and Subsequent Expression of HGF in Colons","volume":"343","author":"Guan","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.critrevonc.2014.07.006","article-title":"Alternative Dosing Schedules for Sunitinib as a Treatment of Patients with Metastatic Renal Cell Carcinoma","volume":"92","author":"Guida","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e1902504","DOI":"10.1002\/adma.201902504","article-title":"Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR-II Fluorescence and Photoacoustic Imaging","volume":"31","author":"Guo","year":"","journal-title":"Adv. Mater."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1038\/s41467-019-09852-0","article-title":"Liver-Target Nanotechnology Facilitates Berberine to Ameliorate Cardio-Metabolic Diseases","volume":"10","author":"Guo","year":"","journal-title":"Nat. Commun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"6983956","DOI":"10.1155\/2016\/6983956","article-title":"Berberine Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Apoptosis by Blocking JNK-Mediated Signaling","volume":"2016","author":"Guo","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jep.2011.08.058","article-title":"Dose-Response of Berberine on Hepatic Cytochromes P450 mRNA Expression and Activities in Mice","volume":"138","author":"Guo","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B272","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/HYPERTENSIONAHA.117.07802","article-title":"Oxidative Stress, Inflammation, and Vascular Aging in Hypertension","volume":"70","author":"Guzik","year":"2017","journal-title":"Hypertension"},{"key":"B71","doi-asserted-by":"publisher","first-page":"104722","DOI":"10.1016\/j.phrs.2020.104722","article-title":"Berberine Pharmacology and the Gut Microbiota: A Hidden Therapeutic Link","volume":"155","author":"Habtemariam","year":"","journal-title":"Pharmacol. Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3390\/biomedicines8040090","article-title":"The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches","volume":"8","author":"Habtemariam","year":"","journal-title":"Biomedicines"},{"key":"B73","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1039\/c9md00036d","article-title":"Novel Carbohydrate Modified Berberine Derivatives: Synthesis and In Vitro Anti-diabetic Investigation","volume":"10","author":"Han","year":"2019","journal-title":"Medchemcomm"},{"key":"B74","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3390\/antiox10060901","article-title":"Mori Ramulus Inhibits Pancreatic \u03b2-Cell Apoptosis and Prevents Insulin Resistance by Restoring Hepatic Mitochondrial Function","volume":"10","author":"Han","year":"","journal-title":"Antioxidants (Basel)"},{"key":"B75","doi-asserted-by":"publisher","first-page":"9987097","DOI":"10.1155\/2021\/9987097","article-title":"Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment","volume":"2021","author":"Han","year":"","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ejphar.2010.12.030","article-title":"Amelioration Effects of Berberine on Diabetic Microendothelial Injury Model by the Combination of High Glucose and Advanced Glycation End Products In Vitro","volume":"654","author":"Hao","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1159\/000493412","article-title":"Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt\/Beta-Catenin Signaling Pathway during Sepsis","volume":"49","author":"He","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s12012-018-9462-2","article-title":"Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders","volume":"18","author":"Henning","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"6831520","DOI":"10.1155\/2019\/6831520","article-title":"Preventive and Therapeutic Roles of Berberine in Gastrointestinal Cancers","volume":"2019","author":"Hu","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"B273","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"B80","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.jpba.2007.03.022","article-title":"Determination of Berberine in Human Plasma by Liquid Chromatography-Electrospray Ionization-Mass Spectrometry","volume":"44","author":"Hua","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"B81","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/bs.acc.2020.08.006","article-title":"Extracellular Vesicles in Cardiovascular Disease","volume":"103","author":"Huang","year":"2021","journal-title":"Adv. Clin. Chem."},{"key":"B82","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ejphar.2017.11.028","article-title":"Capsaicin Prevents Mitochondrial Damage, Protects Cardiomyocytes Subjected to Anoxia\/reoxygenation Injury Mediated by 14-3-3\u03b7\/Bcl-2","volume":"819","author":"Huang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"10273","DOI":"10.1074\/jbc.M109.097907","article-title":"Adipocyte Fatty Acid-Binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving C-Jun NH2-Terminal Kinases and Activator Protein-1","volume":"285","author":"Hui","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/ptr.6252","article-title":"Berberine and Barberry (Berberis Vulgaris): A Clinical Review","volume":"33","author":"Imenshahidi","year":"2019","journal-title":"Phytother. Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.amjmed.2008.10.013","article-title":"The Pathology of Atherosclerosis: Plaque Development and Plaque Responses to Medical Treatment","volume":"122","author":"Insull","year":"2009","journal-title":"Am. J. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report from the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"B87","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.biopha.2017.10.021","article-title":"Quinic Acid Inhibits Vascular Inflammation in TNF-\u03b1-Stimulated Vascular Smooth Muscle Cells","volume":"96","author":"Jang","year":"2017","journal-title":"Biomed. Pharmacotherpharmacother"},{"key":"B88","doi-asserted-by":"publisher","first-page":"5770","DOI":"10.3390\/ijms22115770","article-title":"Antibody-Based Therapeutics for Atherosclerosis and Cardiovascular Diseases","volume":"22","author":"Ji","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"5977","DOI":"10.1007\/s00018-021-03893-9","article-title":"Neurovascular Regulation in Diabetic Retinopathy and Emerging Therapies","volume":"78","author":"Ji","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1111\/j.2042-7158.2012.01529.x","article-title":"Berberine Suppresses Amyloid-Beta-Induced Inflammatory Response in Microglia by Inhibiting Nuclear Factor-kappaB and Mitogen-Activated Protein Kinase Signalling Pathways","volume":"64","author":"Jia","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.mce.2010.07.023","article-title":"Berberine Attenuates Lipopolysaccharide-Induced Extracelluar Matrix Accumulation and Inflammation in Rat Mesangial Cells: Involvement of NF-\u039ab Signaling Pathway","volume":"331","author":"Jiang","year":"2011","journal-title":"Mol. Cel. Endocrinol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1440-1746.2010.06389.x","article-title":"Berberine Inhibits Angiogenic Potential of Hep G2 Cell Line through VEGF Down-Regulation In Vitro","volume":"26","author":"Jie","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1080\/13880209.2018.1548627","article-title":"Berberine Inhibits Angiogenesis in Glioblastoma Xenografts by Targeting the VEGFR2\/ERK Pathway","volume":"56","author":"Jin","year":"2018","journal-title":"Pharm. Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10495-019-01535-x","article-title":"BDNF-mediated Mitophagy Alleviates High-Glucose-Induced Brain Microvascular Endothelial Cell Injury","volume":"24","author":"Jin","year":"2019","journal-title":"Apoptosis"},{"key":"B95","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrcardio.2016.183","article-title":"Role of Gut Microbiota in Atherosclerosis","volume":"14","author":"Jonsson","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.critrevonc.2019.06.008","article-title":"Precision Pharmacology: Mass Spectrometry Imaging and Pharmacokinetic Drug Resistance","volume":"141","author":"Jove","year":"2019","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/antiox8070218","article-title":"LOX-1: Regulation, Signaling and its Role in Atherosclerosis","volume":"8","author":"Kattoor","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"B98","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1097\/FJC.0000000000000650","article-title":"Roles of Endothelin B Receptors and Endothelial Nitric Oxide Synthase in the Regulation of Pulmonary Hemodynamic in Cirrhotic Rats","volume":"73","author":"Khoramzadeh","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.phymed.2008.11.006","article-title":"Silibinin Prevents TPA-Induced MMP-9 Expression and VEGF Secretion by Inactivation of the Raf\/MEK\/ERK Pathway in MCF-7 Human Breast Cancer Cells","volume":"16","author":"Kim","year":"2009","journal-title":"Phytomedicine"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1159\/000356591","article-title":"Berberine Suppresses TPA-Induced Fibronectin Expression through the Inhibition of VEGF Secretion in Breast Cancer Cells","volume":"32","author":"Kim","year":"2013","journal-title":"Cell Physiol. Biochem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.dmpk.2017.11.003","article-title":"Organ\/body-on-a-chip Based on Microfluidic Technology for Drug Discovery","volume":"33","author":"Kimura","year":"2018","journal-title":"Drug Metab. Pharmacokinet."},{"key":"B102","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/5584_2016_90","article-title":"Endothelial Dysfunction and Hypertension","volume":"956","author":"Konukoglu","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.3390\/ijms19061724","article-title":"Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension","volume":"19","author":"Kostov","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.3390\/ijms20184411","article-title":"Vascular Endothelial Cell Biology: An Update","volume":"20","author":"Kr\u00fcger-Genge","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ejphar.2015.05.068","article-title":"Current Knowledge and Pharmacological Profile of Berberine: An Update","volume":"761","author":"Kumar","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"16707","DOI":"10.1038\/s41598-018-35148-2","article-title":"Amelioration of Diabetic Nephropathy in Db\/db Mice Treated with Tibetan Medicine Formula Siwei Jianghuang Decoction Powder Extract","volume":"8","author":"Lai","year":"2018","journal-title":"Sci. Rep."},{"key":"B107","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jep.2018.04.027","article-title":"Network Pharmacology-Based Prediction of Active Compounds and Molecular Targets in Yijin-Tang Acting on Hyperlipidaemia and Atherosclerosis","volume":"221","author":"Lee","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.physbeh.2016.07.003","article-title":"Effect of Hypoxia on Cerebrovascular and Cognitive Function during Moderate Intensity Exercise","volume":"165","author":"Lefferts","year":"2016","journal-title":"Physiol. Behav."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.2174\/1871520619666190503121820","article-title":"Berberine as Source of Antiproliferative Hybrid Compounds: In Vitro Antiproliferative Activity and Quantitative Structure-Activity Relationship","volume":"19","author":"Leyva-Peralta","year":"2019","journal-title":"Anticancer Agents Med. Chem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"104603","DOI":"10.1016\/j.phrs.2019.104603","article-title":"Oxyberberine, a Novel Gut Microbiota-Mediated Metabolite of Berberine, Possesses superior Anti-colitis Effect: Impact on Intestinal Epithelial Barrier, Gut Microbiota Profile and TLR4-MyD88-NF-\u039ab Pathway","volume":"152","author":"Li","year":"","journal-title":"Pharmacol. Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/jdi.12516","article-title":"Berberine Activates Peroxisome Proliferator-Activated Receptor Gamma to Increase Atherosclerotic Plaque Stability in Apoe-\/- Mice with Hyperhomocysteinemia","volume":"7","author":"Li","year":"","journal-title":"J. Diabetes Investig."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1161\/CIRCULATIONAHA.116.017949","article-title":"Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 In Vivo","volume":"134","author":"Li","year":"","journal-title":"Circulation"},{"key":"B113","doi-asserted-by":"publisher","first-page":"6770","DOI":"10.1021\/acsnano.9b01346","article-title":"Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"key":"B114","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1248\/bpb.b14-00828","article-title":"Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome","volume":"38","author":"Li","year":"","journal-title":"Biol. Pharm. Bull."},{"key":"B115","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s12967-015-0629-3","article-title":"Effect of Berberine on Promoting the Excretion of Cholesterol in High-Fat Diet-Induced Hyperlipidemic Hamsters","volume":"13","author":"Li","year":"","journal-title":"J. Transl. Med."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.07.009","article-title":"Succinate Induces Synovial Angiogenesis in Rheumatoid Arthritis through Metabolic Remodeling and HIF-1\u03b1\/VEGF axis","volume":"126","author":"Li","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1142\/S0192415X18500878","article-title":"Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio\/Cerebral Vascular Disease","volume":"46","author":"Li","year":"","journal-title":"Am. J. Chin. Med."},{"key":"B119","doi-asserted-by":"publisher","first-page":"118460","DOI":"10.1016\/j.lfs.2020.118460","article-title":"Berberine Reduces Gut-Vascular Barrier Permeability via Modulation of ApoM\/S1P Pathway in a Model of Polymicrobial Sepsis","volume":"261","author":"Li","year":"","journal-title":"Life Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1523\/JNEUROSCI.2117-15.2016","article-title":"Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease","volume":"36","author":"Lian","year":"2016","journal-title":"J. Neurosci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12989-020-00391-x","article-title":"The Critical Role of Endothelial Function in Fine Particulate Matter-Induced Atherosclerosis","volume":"17","author":"Liang","year":"2020","journal-title":"Part. Fibre. Toxicol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3390\/molecules25030677","article-title":"Synthesis and In Vitro Photocytotoxicity of 9-\/13-Lipophilic Substituted Berberine Derivatives as Potential Anticancer Agents","volume":"25","author":"Lin","year":"2020","journal-title":"Molecules"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1253\/circj.CJ-16-0924","article-title":"Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis","volume":"80","author":"Linton","year":"2016","journal-title":"Circ. J."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1001\/jama.2021.6524","article-title":"General Health Checks in Adult Primary Care: A Review","volume":"325","author":"Liss","year":"2021","journal-title":"JAMA"},{"key":"B125","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.fitote.2016.02.001","article-title":"Research Progress on Berberine with a Special Focus on its Oral Bioavailability","volume":"109","author":"Liu","year":"2016","journal-title":"Fitoterapia"},{"key":"B126","first-page":"753","article-title":"Effect of Berberine on Angiogenesis and HIF-1\u03b1\/VEGF Signal Transduction Pathway in Rats with Cerebral Ischemia - Reperfusion Injury","volume":"28","author":"Liu","year":"2018","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"B127","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.bbrc.2015.02.028","article-title":"Berberine Improves Endothelial Function by Inhibiting Endoplasmic Reticulum Stress in the Carotid Arteries of Spontaneously Hypertensive Rats","volume":"458","author":"Liu","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B128","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.yexcr.2019.02.022","article-title":"Inhibition of Src Activation Reverses Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension via Akt\/mTOR\/HIF-1 Signaling Pathway","volume":"380","author":"Liu","year":"2019","journal-title":"Exp. Cell Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"5580","DOI":"10.3892\/mmr.2015.4061","article-title":"Berberine Inhibits Tumor Necrosis Factor-\u03b1-Induced Expression of Inflammatory Molecules and Activation of Nuclear Factor-\u039ab via the Activation of AMPK in Vascular Endothelial Cells","volume":"12","author":"Liu","year":"","journal-title":"Mol. Med. Rep."},{"key":"B130","doi-asserted-by":"publisher","first-page":"388","DOI":"10.5483\/bmbrep.2014.47.7.186","article-title":"Berberine Suppresses In Vitro Migration of Human Aortic Smooth Muscle Cells through the Inhibitions of MMP-2\/9, u-PA, AP-1, and NF-\u039ab","volume":"47","author":"Liu","year":"2014","journal-title":"BMB Rep."},{"key":"B131","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ejphar.2010.04.033","article-title":"Effects of Berberine on Matrix Accumulation and NF-Kappa B Signal Pathway in Alloxan-Induced Diabetic Mice with Renal Injury","volume":"638","author":"Liu","year":"","journal-title":"Eur. J. Pharmacol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.apsb.2020.02.003","article-title":"Berberine Prevents Primary Peritoneal Adhesion and Adhesion Reformation by Directly Inhibiting TIMP-1","volume":"10","author":"Liu","year":"2020","journal-title":"Acta Pharm. Sin. B."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1124\/dmd.110.033936","article-title":"Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain its Low Plasma Levels in Rats","volume":"38","author":"Liu","year":"","journal-title":"Drug Metab. Dispos."},{"key":"B134","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jaad.2018.02.040","article-title":"Interleukin 17, Inflammation, and Cardiovascular Risk in Patients with Psoriasis","volume":"79","author":"Lockshin","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"109794","DOI":"10.1016\/j.biopha.2019.109794","article-title":"Berberine Associated Photodynamic Therapy Promotes Autophagy and Apoptosis via ROS Generation in Renal Carcinoma Cells","volume":"123","author":"Lopes","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B136","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nrneph.2016.51","article-title":"Long Noncoding RNAs in Kidney and Cardiovascular Diseases","volume":"12","author":"Lorenzen","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.yjmcc.2015.10.011","article-title":"Attenuation of Cardiac Dysfunction and Remodeling of Myocardial Infarction by microRNA-130a Are Mediated by Suppression of PTEN and Activation of PI3K Dependent Signaling","volume":"89","author":"Lu","year":"2015","journal-title":"J. Mol. Cel. Cardiol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1098617","DOI":"10.1155\/2018\/1098617","article-title":"Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis","volume":"2018","author":"Lu","year":"2018","journal-title":"Oxid. Med. Cel. Longev."},{"key":"B139","doi-asserted-by":"publisher","first-page":"BSR20181995","DOI":"10.1042\/BSR20181995","article-title":"AMPK Is Associated with the Beneficial Effects of Antidiabetic Agents on Cardiovascular Diseases","volume":"39","author":"Lu","year":"2019","journal-title":"Biosci. Rep."},{"key":"B140","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12967-021-02906-2","article-title":"Oxidative Stress Response in Regulatory and Conventional T Cells: A Comparison between Patients with Chronic Coronary Syndrome and Healthy Subjects","volume":"19","author":"Lundberg","year":"2021","journal-title":"J. Transl. Med."},{"key":"B141","doi-asserted-by":"publisher","first-page":"112910","DOI":"10.1016\/j.ejmech.2020.112910","article-title":"Structure-Guided Modification of Isoxazole-type FXR Agonists: Identification of a Potent and Orally Bioavailable FXR Modulator","volume":"209","author":"Luo","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"9750","DOI":"10.1002\/jcp.26940","article-title":"Berberine Attenuates Pulmonary Arterial Hypertension via Protein Phosphatase 2A Signaling Pathway Both In Vivo and In Vitro","volume":"233","author":"Luo","year":"2018","journal-title":"J. Cel. Physiol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1021\/acsami.0c19468","article-title":"Treatment of Rheumatoid Arthritis by Serum Albumin Nanoparticles Coated with Mannose to Target Neutrophils","volume":"13","author":"Lyu","year":"2021","journal-title":"ACS Appl. Mater. Inter."},{"key":"B144","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.1002\/jps.23718","article-title":"Excretion of Berberine and its Metabolites in Oral Administration in Rats","volume":"102","author":"Ma","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/j.apsb.2020.03.005","article-title":"Functional Nano-Vector Boost Anti-atherosclerosis Efficacy of Berberine in Apoe (-\/-) Mice","volume":"10","author":"Ma","year":"2020","journal-title":"Acta Pharm. Sin. B."},{"key":"B146","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1530\/JME-17-0014","article-title":"Berberine Reduced Blood Pressure and Improved Vasodilation in Diabetic Rats","volume":"59","author":"Ma","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12933-016-0382-9","article-title":"Berberine Alleviates the Cerebrovascular Contractility in Streptozotocin-Induced Diabetic Rats through Modulation of Intracellular Ca\u00b2\u207a Handling in Smooth Muscle Cells","volume":"15","author":"Ma","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1055\/s-0039-1688474","article-title":"Impact of Intermittent Functional Internal Iliac Artery Occlusion on Spinal Cord Blood Supply during TEVAR","volume":"68","author":"Maier","year":"2020","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"B149","doi-asserted-by":"publisher","first-page":"721338","DOI":"10.3389\/fcell.2021.721338","article-title":"Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)","volume":"9","author":"Malik","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3389\/fphys.2018.00718","article-title":"Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium","volume":"9","author":"Martinez","year":"2018","journal-title":"Front. Physiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"17358","DOI":"10.1038\/s41598-020-73661-5","article-title":"Exposure to the Natural Alkaloid Berberine Affects Cardiovascular System Morphogenesis and Functionality during Zebrafish Development","volume":"10","author":"Martini","year":"2020","journal-title":"Sci. Rep."},{"key":"B152","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","article-title":"FTO-dependent N6-Methyladenosine Regulates Cardiac Function during Remodeling and Repair","volume":"139","author":"Mathiyalagan","year":"2019","journal-title":"Circulation"},{"key":"B153","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.3390\/molecules24234386","article-title":"Curcumin and its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers","volume":"24","author":"Mbese","year":"2019","journal-title":"Molecules"},{"key":"B154","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/cns.13042","article-title":"DPP-4 Inhibitors Promote Proliferation and Migration of Rat Brain Microvascular Endothelial Cells under Hypoxic\/High-Glucose Conditions, Potentially through the SIRT1\/HIF-1\/VEGF Pathway","volume":"25","author":"Mi","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"B155","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1038\/s41467-019-11199-5","article-title":"A Murine Neonatal Model of Necrotizing Enterocolitis Caused by Anemia and Red Blood Cell Transfusions","volume":"10","author":"MohanKumar","year":"2019","journal-title":"Nat. Commun."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1093\/cvr\/cvz154","article-title":"Endothelial Function and Dysfunction in the Cardiovascular System: The Long Non-coding Road","volume":"115","author":"Monteiro","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"B157","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S2213-8587(19)30119-6","article-title":"The Role of Blood Volume in Cardiac Dysfunction and Reduced Exercise Tolerance in Patients with Diabetes","volume":"7","author":"Montero","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/13543784.2018.1538352","article-title":"Targeting Inflammation in Diabetic Nephropathy: A Tale of Hope","volume":"27","author":"Moreno","year":"2018","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B159","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1161\/01.RES.0000215576.27615.fd","article-title":"Role of Nuclear Ca2+\/Calmodulin-Stimulated Phosphodiesterase 1A in Vascular Smooth Muscle Cell Growth and Survival","volume":"98","author":"Nagel","year":"2006","journal-title":"Circ. Res."},{"key":"B160","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3389\/fphar.2018.00557","article-title":"Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders","volume":"9","author":"Neag","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"14727","DOI":"10.1038\/ncomms14727","article-title":"Dopamine Neuronal Loss Contributes to Memory and Reward Dysfunction in a Model of Alzheimer's Disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nat. Commun."},{"key":"B162","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.kint.2017.02.013","article-title":"Beta 2-Adrenergic Receptor Agonists Are Novel Regulators of Macrophage Activation in Diabetic Renal and Cardiovascular Complications","volume":"92","author":"Noh","year":"2017","journal-title":"Kidney Int."},{"key":"B163","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","article-title":"Amyloid Precursor Protein Processing and Alzheimer's Disease","volume":"34","author":"O'Brien","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"B164","doi-asserted-by":"publisher","first-page":"104893","DOI":"10.1016\/j.phrs.2020.104893","article-title":"Pharmacological Management of Vascular Endothelial Dysfunction in Diabetes: TCM and Western Medicine Compared Based on Biomarkers and Biochemical Parameters","volume":"158","author":"Oduro","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic Effects of Statins on the Cardiovascular System","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ. Res."},{"key":"B166","doi-asserted-by":"publisher","first-page":"e001803","DOI":"10.1136\/bmjdrc-2020-001803","article-title":"Peripheral Artery Disease, Lower Limb Revascularization, and Amputation in Diabetes Patients with and without Coronary Artery Disease: A Cohort Study from the Western Denmark Heart Registry","volume":"9","author":"Olesen","year":"2021","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1161\/CIRCULATIONAHA.119.043385","article-title":"Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity","volume":"141","author":"Ottolini","year":"2020","journal-title":"Circulation"},{"key":"B168","doi-asserted-by":"publisher","first-page":"e1448","DOI":"10.1002\/wsbm.1448","article-title":"Calcium Signals that Determine Vascular Resistance","volume":"11","author":"Ottolini","year":"2019","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.3390\/biom10091297","article-title":"Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression","volume":"10","author":"Parikh","year":"2020","journal-title":"Biomolecules"},{"key":"B276","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.freeradbiomed.2018.10.453","article-title":"Berberine Mitigates High Glucose-Potentiated Platelet Aggregation and Apoptosis by Modulating Aldose Reductase and NADPH Oxidase Activity","volume":"130","author":"Paul","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00125-019-4909-y","article-title":"Type 2 Diabetes: A Multifaceted Disease","volume":"62","author":"Pearson","year":"2019","journal-title":"Diabetologia"},{"key":"B171","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.cjca.2017.12.005","article-title":"Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms","volume":"34","author":"Petrie","year":"2018","journal-title":"Can. J. Cardiol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"7348372","DOI":"10.1155\/2017\/7348372","article-title":"Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases","volume":"2017","author":"Pierelli","year":"2017","journal-title":"Oxid. Med. Cel. Longev."},{"key":"B173","doi-asserted-by":"publisher","first-page":"113856","DOI":"10.1016\/j.expneurol.2021.113856","article-title":"AIM2 Inflammasome Mediates Apoptotic and Pyroptotic Death in the Cerebellum Following Chronic Hypoperfusion","volume":"346","author":"Poh","year":"2021","journal-title":"Exp. Neurol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s12015-018-9863-4","article-title":"Endothelial Progenitor Cells Biology in Diabetes Mellitus and Peripheral Arterial Disease and Their Therapeutic Potential","volume":"15","author":"Py\u0161n\u00e1","year":"2019","journal-title":"Stem Cell Rev Rep"},{"key":"B176","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1124\/dmd.108.021659","article-title":"Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans","volume":"36","author":"Qiu","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"B177","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/13880209.2016.1257642","article-title":"Effect of Berberine on PPAR\u03b1-NO Signalling Pathway in Vascular Smooth Muscle Cell Proliferation Induced by Angiotensin IV","volume":"55","author":"Qiu","year":"2017","journal-title":"Pharm. Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/FJC.0000000000001015","article-title":"Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors","volume":"77","author":"Rajabi","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"106436","DOI":"10.1016\/j.prostaglandins.2020.106436","article-title":"Sphingosine 1-Phosphate Signaling in Ischemia and Reperfusion Injury","volume":"149","author":"Raza","year":"2020","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"B180","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00125-014-3462-y","article-title":"Epigenetic Mechanisms in Diabetic Complications and Metabolic Memory","volume":"58","author":"Reddy","year":"2015","journal-title":"Diabetologia"},{"key":"B181","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic Reticulum Stress and Unfolded Protein Response in Cardiovascular Diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3389\/fphar.2019.00753","article-title":"Salvia Miltiorrhiza in Treating Cardiovascular Diseases: A Review on its Pharmacological and Clinical Applications","volume":"10","author":"Ren","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative Stress, Inflammation, and Cancer: How Are They Linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"B184","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cvr\/cvab173","article-title":"Dietary Recommendations for Prevention of Atherosclerosis","volume":"173","author":"Riccardi","year":"2021","journal-title":"Cardiovasc. Res. Cvab"},{"key":"B185","doi-asserted-by":"publisher","first-page":"3096470","DOI":"10.1155\/2020\/3096470","article-title":"Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay its Progression: The Importance of Oxidative Stress and Inflammation","volume":"2020","author":"Robles-Rivera","year":"2020","journal-title":"Oxid. Med. Cel. Longev."},{"key":"B186","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1039\/c7lc00815e","article-title":"Recent Advances in Microfluidic Technologies for Cell-To-Cell Interaction Studies","volume":"18","author":"Rothbauer","year":"2018","journal-title":"Lab. Chip"},{"key":"B187","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/imm.13002","article-title":"Properties and Functions of Adipose Tissue Macrophages in Obesity","volume":"155","author":"Russo","year":"2018","journal-title":"Immunology"},{"key":"B188","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s12272-012-0612-y","article-title":"Discrimination of Phellodendron Amurense and P. Chinense Based on DNA Analysis and the Simultaneous Analysis of Alkaloids","volume":"35","author":"Ryuk","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"B189","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrcardio.2017.155","article-title":"Arterial Stiffness as a Risk Factor for Clinical Hypertension","volume":"15","author":"Safar","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.sjbs.2020.10.006","article-title":"Bioavailability and Hepatoprotection Enhancement of Berberine and its Nanoparticles Prepared by Liquid Antisolvent Method","volume":"28","author":"Sahibzada","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory Mechanisms Linking Obesity and Metabolic Disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B192","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3390\/ijms22010418","article-title":"Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction","volume":"22","author":"Salvio","year":"2021","journal-title":"Ijms"},{"key":"B193","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1475-2840-9-8","article-title":"Intracellular Ca2+ Regulating Proteins in Vascular Smooth Muscle Cells Are Altered with Type 1 Diabetes Due to the Direct Effects of Hyperglycemia","volume":"9","author":"Searls","year":"2010","journal-title":"Cardiovasc. Diabetol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1161\/HYPERTENSIONAHA.116.07110","article-title":"Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-dependent Hyperpolarization in Hypertension","volume":"69","author":"Seki","year":"2017","journal-title":"Hypertension"},{"key":"B195","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.metabol.2012.09.009","article-title":"Berberine Analogue IMB-Y53 Improves Glucose-Lowering Efficacy by Averting Cellular Efflux Especially P-Glycoprotein Efflux","volume":"62","author":"Shan","year":"2013","journal-title":"Metabolism"},{"key":"B196","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1080\/14756366.2020.1804383","article-title":"Design, Synthesis and Biological Evaluation of a New Thieno[2,3-D]pyrimidine-Based Urea Derivative with Potential Antitumor Activity against Tamoxifen Sensitive and Resistant Breast Cancer Cell Lines","volume":"35","author":"Sharaky","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"B197","doi-asserted-by":"publisher","first-page":"641310","DOI":"10.3389\/fphys.2021.641310","article-title":"Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension","volume":"12","author":"Sharifi Kia","year":"2021","journal-title":"Front. Physiol."},{"key":"B274","doi-asserted-by":"publisher","first-page":"11389","DOI":"10.1016\/j.ejmech.2021.113839","article-title":"Plant Isoquinoline Alkaloids: Advances in the Chemistry and Biology of Berberine","volume":"226","author":"Singh","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"B198","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.autrev.2010.07.016","article-title":"From Endothelial Dysfunction to Atherosclerosis","volume":"9","author":"Sitia","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"B199","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1093\/brain\/aww016","article-title":"Eliminating Microglia in Alzheimer's Mice Prevents Neuronal Loss without Modulating Amyloid-\u03b2 Pathology","volume":"139","author":"Spangenberg","year":"2016","journal-title":"Brain"},{"key":"B200","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1021\/np400607k","article-title":"Berberine and its Metabolites: Relationship between Physicochemical Properties and Plasma Levels after Administration to Human Subjects","volume":"77","author":"Spinozzi","year":"2014","journal-title":"J. Nat. Prod."},{"key":"B202","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1161\/HYPERTENSIONAHA.118.11766","article-title":"Loss of Renal Peritubular Capillaries in Hypertensive Patients Is Detectable by Urinary Endothelial Microparticle Levels","volume":"72","author":"Sun","year":"2016","journal-title":"Hypertension"},{"key":"B203","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/s41440-021-00675-5","article-title":"Melatonin Ameliorates Hypertension in Hypertensive Pregnant Mice and Suppresses the Hypertension-Induced Decrease in Ca2+-Activated K+ Channels in Uterine Arteries","volume":"44","author":"Sun","year":"2021","journal-title":"Hypertens. Res."},{"key":"B204","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1161\/CIRCRESAHA.110.224766","article-title":"The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis","volume":"107","author":"Tabas","year":"2010","journal-title":"Circ. Res."},{"key":"B205","doi-asserted-by":"publisher","first-page":"e0247621","DOI":"10.1371\/journal.pone.0247621","article-title":"Berberine Ameliorates Vascular Dysfunction by a Global Modulation of lncRNA and mRNA Expression Profiles in Hypertensive Mouse Aortae","volume":"16","author":"Tan","year":"2021","journal-title":"PLoS One"},{"key":"B206","doi-asserted-by":"publisher","first-page":"8683404","DOI":"10.1155\/2020\/8683404","article-title":"Improvement of Endothelial Dysfunction of Berberine in Atherosclerotic Mice and Mechanism Exploring through TMT-Based Proteomics","volume":"2020","author":"Tan","year":"2020","journal-title":"Oxid. Med. Cel. Longev."},{"key":"B207","doi-asserted-by":"publisher","first-page":"e77969","DOI":"10.1371\/journal.pone.0077969","article-title":"Tissue Distribution of Berberine and its Metabolites after Oral Administration in Rats","volume":"8","author":"Tan","year":"2013","journal-title":"PLoS One"},{"key":"B208","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/1753-0407.12349","article-title":"Renoprotective Effects of Berberine and its Potential Effect on the Expression of \u03b2-arrestins and Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Streptozocin-Diabetic Nephropathy Rats","volume":"8","author":"Tang","year":"2016","journal-title":"J. Diabetes"},{"key":"B209","doi-asserted-by":"publisher","first-page":"670913","DOI":"10.3389\/fcell.2021.670913","article-title":"TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair","volume":"9","author":"Tang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41581-019-0234-4","article-title":"Innate Immunity in Diabetic Kidney Disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"111051","DOI":"10.1016\/j.nut.2020.111051","article-title":"Effect of Phytosterol Capsule Supplementation Associated with the National Cholesterol Education Program Step 2 Diet on Low-Density Lipoprotein in Children and Adolescents with Dyslipidemia: A Double-Blind Crossover Trial","volume":"82","author":"Tavares","year":"2021","journal-title":"Nutrition"},{"key":"B212","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/MOL.0000000000000654","article-title":"Apolipoprotein M: New Connections with Diet, Adipose Tissue and Metabolic Syndrome","volume":"31","author":"Tavernier","year":"2020","journal-title":"Curr. Opin. Lipidol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1161\/HYPERTENSIONAHA.115.05536","article-title":"Renal Resistive Index and Mortality in Chronic Kidney Disease","volume":"66","author":"Toledo","year":"2015","journal-title":"Hypertension"},{"key":"B214","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3389\/fonc.2019.00364","article-title":"Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1\u03b2 and IL-18 Release","volume":"9","author":"Tong","year":"2019","journal-title":"Front. Oncol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"1750306","DOI":"10.1155\/2017\/1750306","article-title":"Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals","volume":"2017","author":"Trevi\u00f1o-Salda\u00f1a","year":"2017","journal-title":"Oxid. Med. Cel. Longev."},{"key":"B216","doi-asserted-by":"publisher","first-page":"eaan6735","DOI":"10.1126\/scitranslmed.aan6735","article-title":"Surgical Adhesions in Mice Are Derived from Mesothelial Cells and Can Be Targeted by Antibodies against Mesothelial Markers","volume":"10","author":"Tsai","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"B217","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jvir.2019.10.019","article-title":"Endovascular Pressure Measurements to Assess the Functional Severity of Mesenteric Arterial Stenoses","volume":"31","author":"van Dijk","year":"2020","journal-title":"J. Vasc. Interv. Radiol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/sj.bjp.0706042","article-title":"Endothelium-Dependent Contractions in Hypertension","volume":"144","author":"Vanhoutte","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/apha.12646","article-title":"Endothelial Dysfunction and Vascular Disease - a 30th Anniversary Update","volume":"219","author":"Vanhoutte","year":"2017","journal-title":"Acta Physiol. (Oxf)"},{"key":"B220","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.3324\/haematol.2018.208819","article-title":"A Novel Combinatorial Technique for Simultaneous Quantification of Oxygen Radicals and Aggregation Reveals Unexpected Redox Patterns in the Activation of Platelets by Different Physiopathological Stimuli","volume":"104","author":"Vara","year":"2019","journal-title":"Haematologica"},{"key":"B221","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.3390\/nu12102982","article-title":"Gut Microbiota in Hypertension and Atherosclerosis: A Review","volume":"12","author":"Verhaar","year":"2020","journal-title":"Nutrients"},{"key":"B222","doi-asserted-by":"publisher","first-page":"8528","DOI":"10.1038\/s41598-021-87990-6","article-title":"Individuals with Controlled Hypertension Show Endothelial Integrity Following a Bout of Moderate-Intensity Exercise: Randomized Clinical Trial","volume":"11","author":"Waclawovsky","year":"2021","journal-title":"Sci. Rep."},{"key":"B223","doi-asserted-by":"publisher","first-page":"111910","DOI":"10.1016\/j.yexcr.2020.111910","article-title":"Berberine Alleviates Pulmonary Hypertension through Trx1 and \u03b2-catenin Signaling Pathways in Pulmonary Artery Smooth Muscle Cells","volume":"390","author":"Wande","year":"2020","journal-title":"Exp. Cel. Res."},{"key":"B224","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1038\/s41467-021-22771-3","article-title":"FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Are Involved in Angiogenesis and Neoangiogenesis","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"B225","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1111\/jcmm.12645","article-title":"Berberine via Suppression of Transient Receptor Potential Vanilloid 4 Channel Improves Vascular Stiffness in Mice","volume":"19","author":"Wang","year":"2015","journal-title":"J. Cel. Mol. Med."},{"key":"B226","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/13880209.2019.1577466","article-title":"Coptidis Rhizoma: A Comprehensive Review of its Traditional Uses, Botany, Phytochemistry, Pharmacology and Toxicology","volume":"57","author":"Wang","year":"2019","journal-title":"Pharm. Biol."},{"key":"B227","doi-asserted-by":"publisher","first-page":"118253","DOI":"10.1016\/j.lfs.2020.118253","article-title":"Berberine Inhibits Proliferation and Apoptosis of Vascular Smooth Muscle Cells Induced by Mechanical Stretch via the PDI\/ERS and MAPK Pathways","volume":"259","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"B228","doi-asserted-by":"publisher","first-page":"e25436","DOI":"10.1371\/journal.pone.0025436","article-title":"Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"B229","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1111\/bph.13888","article-title":"Endoplasmic Reticulum Stress in the Heart: Insights into Mechanisms and Drug Targets","volume":"175","author":"Wang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"B230","first-page":"14896","article-title":"Berberine Protects Vascular Endothelial Cells in Hypertensive Rats","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"B231","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/cvr\/cvp078","article-title":"Berberine Prevents Hyperglycemia-Induced Endothelial Injury and Enhances Vasodilatation via Adenosine Monophosphate-Activated Protein Kinase and Endothelial Nitric Oxide Synthase","volume":"82","author":"Wang","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"B232","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s10753-014-9909-y","article-title":"Berberine Ameliorates Collagen-Induced Arthritis in Rats Associated with Anti-inflammatory and Anti-angiogenic Effects","volume":"37","author":"Wang","year":"2014","journal-title":"Inflammation"},{"key":"B234","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"Immunity and Inflammation in Atherosclerosis","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ. Res."},{"key":"B235","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1161\/CIRCRESAHA.119.315558","article-title":"VSMC-specific Deletion of FAM3A Attenuated Ang II-Promoted Hypertension and Cardiovascular Hypertrophy","volume":"126","author":"Xiang","year":"2020","journal-title":"Circ. Res."},{"key":"B236","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.2174\/1389557517666170321103139","article-title":"Berberine Derivatives with Different Pharmacological Activities via Structural Modifications","volume":"18","author":"Xiao","year":"2018","journal-title":"Mini Rev. Med. Chem."},{"key":"B237","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3390\/biom9100512","article-title":"HMGB1-triggered Inflammation Inhibition of Notoginseng Leaf Triterpenes against Cerebral Ischemia and Reperfusion Injury via MAPK and NF-\u039ab Signaling Pathways","volume":"9","author":"Xie","year":"2019","journal-title":"Biomolecules"},{"key":"B238","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.colsurfb.2019.06.006","article-title":"Nanoemulsion Improves Hypoglycemic Efficacy of Berberine by Overcoming its Gastrointestinal Challenge","volume":"181","author":"Xu","year":"2019","journal-title":"Colloids Surf. B Biointerfaces."},{"key":"B239","doi-asserted-by":"publisher","first-page":"106660","DOI":"10.1016\/j.vph.2020.106660","article-title":"Berberine Protects Kawasaki Disease-Induced Human Coronary Artery Endothelial Cells Dysfunction by Inhibiting of Oxidative and Endoplasmic Reticulum Stress","volume":"127","author":"Xu","year":"2020","journal-title":"Vascul. Pharmacol."},{"key":"B240","first-page":"4375","article-title":"Impacts of Berberine on Oxidized LDL-Induced Proliferation of Human Umbilical Vein Endothelial Cells","volume":"9","author":"Xu","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"B241","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1111\/1750-3841.15505","article-title":"Ginsenoside Rb2 Alleviates Myocardial Ischemia\/Reperfusion Injury in Rats through SIRT1 Activation","volume":"85","author":"Xue","year":"2020","journal-title":"J. Food Sci."},{"key":"B242","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1248\/bpb.b17-00989","article-title":"Anticancer Efficacy of the Combination of Berberine and PEGylated Liposomal Doxorubicin in Meth A Sarcoma-Bearing Mice","volume":"41","author":"Yahuafai","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"B243","doi-asserted-by":"publisher","first-page":"12953","DOI":"10.1021\/acs.jafc.8b05047","article-title":"Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis","volume":"66","author":"Yang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"B244","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.yjmcc.2020.03.009","article-title":"Abnormal Ca2+ Handling Contributes to the Impairment of Aortic Smooth Muscle Contractility in Zucker Diabetic Fatty Rats","volume":"141","author":"Yang","year":"2020","journal-title":"J. Mol. Cel. Cardiol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"654670","DOI":"10.3389\/fcvm.2021.654670","article-title":"Ginsenoside Rb1 Enhances Plaque Stability and Inhibits Adventitial Vasa Vasorum via the Modulation of miR-33 and PEDF","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"B246","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.3390\/cells10051161","article-title":"Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and \u03b2-Amyloid Accumulation in an APP\/tau\/PS1 Mouse Model of Alzheimer's Disease","volume":"10","author":"Ye","year":"2021","journal-title":"Cells"},{"key":"B247","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.lfs.2016.09.025","article-title":"Inhibition of M1 Macrophage Activation in Adipose Tissue by Berberine Improves Insulin Resistance","volume":"166","author":"Ye","year":"2016","journal-title":"Life Sci."},{"key":"B248","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1080\/10641963.2018.1545846","article-title":"Berberine Suppresses the Ectopic Expression of miR-133a in Endothelial Cells to Improve Vascular Dementia in Diabetic Rats","volume":"41","author":"Yin","year":"2019","journal-title":"Clin. Exp. Hypertens."},{"key":"B249","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1691\/ph.2021.01012","article-title":"Berberine Prevents Diabetic Retinopathy through Inhibiting HIF-1\u03b1\/VEGF\/NF-\u03ba B Pathway in Db\/db Mice","volume":"76","author":"Yin","year":"2021","journal-title":"Pharmazie"},{"key":"B250","doi-asserted-by":"publisher","first-page":"1689602","DOI":"10.1155\/2016\/1689602","article-title":"Berberine Attenuates Myocardial Ischemia\/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1","volume":"2016","author":"Yu","year":"2016","journal-title":"Oxid. Med. Cel. Longev"},{"key":"B251","doi-asserted-by":"publisher","first-page":"4227","DOI":"10.3892\/mmr.2020.11505","article-title":"Berberine Protects against Diabetic Retinopathy by Inhibiting Cell Apoptosis via Deactivation of the NF-\u03baB S-ignaling P-athway","volume":"22","author":"Zhai","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"B252","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.3390\/molecules21081094","article-title":"Compositions, Formation Mechanism, and Neuroprotective Effect of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang","volume":"21","author":"Zhang","year":"","journal-title":"Molecules"},{"key":"B253","doi-asserted-by":"publisher","first-page":"119365","DOI":"10.1016\/j.lfs.2021.119365","article-title":"Glutamine Switches Vascular Smooth Muscle Cells to Synthetic Phenotype through Inhibiting miR-143 Expression and Upregulating THY1 Expression","volume":"277","author":"Zhang","year":"","journal-title":"Life Sci."},{"key":"B254","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/10641963.2019.1632339","article-title":"Berberine Reduces Endothelial Injury and Arterial Stiffness in Spontaneously Hypertensive Rats","volume":"42","author":"Zhang","year":"2020","journal-title":"Clin. Exp. Hypertens."},{"key":"B255","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.neuropharm.2017.08.013","article-title":"Berberine Modulates Amyloid-\u03b2 Peptide Generation by Activating AMP-Activated Protein Kinase","volume":"125","author":"Zhang","year":"2017","journal-title":"Neuropharmacology"},{"key":"B256","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.1096\/fj.201701257R","article-title":"Apelin Impairs Myogenic Response to Induce Diabetic Nephropathy in Mice","volume":"32","author":"Zhang","year":"2018","journal-title":"FASEB J."},{"key":"B257","doi-asserted-by":"publisher","first-page":"588517","DOI":"10.3389\/fcimb.2020.588517","article-title":"Effects of Berberine on the Gastrointestinal Microbiota","volume":"10","author":"Zhang","year":"","journal-title":"Front. Cel. Infect. Microbiol."},{"key":"B258","doi-asserted-by":"publisher","first-page":"4799","DOI":"10.1016\/j.bmcl.2016.08.027","article-title":"Synthesis and Hypoglycemic Activity of 9-O-(lipophilic Group Substituted) Berberine Derivatives","volume":"26","author":"Zhang","year":"","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B259","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3109\/00498254.2010.529180","article-title":"Intestinal Absorption Mechanisms of Berberine, Palmatine, Jateorhizine, and Coptisine: Involvement of P-Glycoprotein","volume":"41","author":"Zhang","year":"2011","journal-title":"Xenobiotica"},{"key":"B260","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/HYPERTENSIONAHA.117.09801","article-title":"Trends in the Prevalence, Awareness, Treatment, and Control of Hypertension Among Young Adults in the United States, 1999 to 2014","volume":"70","author":"Zhang","year":"2017","journal-title":"Hypertension"},{"key":"B261","doi-asserted-by":"publisher","first-page":"7593608","DOI":"10.1155\/2019\/7593608","article-title":"Berberine Alleviates Amyloid \u03b2-Induced Mitochondrial Dysfunction and Synaptic Loss","volume":"2019","author":"Zhao","year":"","journal-title":"Oxid. Med. Cel. Longev."},{"key":"B262","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/aps.2015.136","article-title":"Berberine Protects Rat Heart from Ischemia\/Reperfusion Injury via Activating JAK2\/STAT3 Signaling and Attenuating Endoplasmic Reticulum Stress","volume":"37","author":"Zhao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"B263","doi-asserted-by":"publisher","first-page":"112140","DOI":"10.1016\/j.jep.2019.112140","article-title":"Berberine Restored Nitrergic and Adrenergic Function in Mesenteric and Iliac Arteries from Streptozotocin-Induced Diabetic Rats","volume":"244","author":"Zhao","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B264","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1038\/s41467-021-25952-2","article-title":"Berberine Is an Insulin Secretagogue Targeting the KCNH6 Potassium Channel","volume":"12","author":"Zhao","year":"","journal-title":"Nat. Commun."},{"key":"B265","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1248\/bpb.35.796","article-title":"Protective Effects of Berberine on Doxorubicin-Induced Hepatotoxicity in Mice","volume":"35","author":"Zhao","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"B266","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3892\/etm.2018.6949","article-title":"Berberine Protects Myocardial Cells against Anoxia-Reoxygenation Injury via P38 MAPK-Mediated NF-\u039ab Signaling Pathways","volume":"17","author":"Zhao","year":"","journal-title":"Exp. Ther. Med."},{"key":"B267","doi-asserted-by":"publisher","first-page":"680351","DOI":"10.3389\/fphar.2021.680351","article-title":"NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway","volume":"12","author":"Zhao","year":"","journal-title":"Front. Pharmacol."},{"key":"B268","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1039\/d1fo00155h","article-title":"Naringenin Prevents TNF-\u03b1-Induced Gut-Vascular Barrier Disruption Associated with Inhibiting the NF-\u039ab-Mediated MLCK\/p-MLC and NLRP3 Pathways","volume":"12","author":"Zhong","year":"2021","journal-title":"Food Funct."},{"key":"B269","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41569-021-00559-8","article-title":"Global Epidemiology, Health Burden and Effective Interventions for Elevated Blood Pressure and Hypertension","volume":"18","author":"Zhou","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"B270","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.atherosclerosis.2017.11.023","article-title":"Berberine Treatment Increases Akkermansia in the Gut and Improves High-Fat Diet-Induced Atherosclerosis in Apoe-\/- Mice","volume":"268","author":"Zhu","year":"2018","journal-title":"Atherosclerosis"},{"key":"B271","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1080\/10641963.2017.1313853","article-title":"Berberine Promotes Ischemia-Induced Angiogenesis in Mice Heart via Upregulation of microRNA-29b","volume":"39","author":"Zhu","year":"2017","journal-title":"Clin. Exp. Hypertens."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.762654\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T07:37:54Z","timestamp":1647243474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.762654\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":271,"alternative-id":["10.3389\/fphar.2021.762654"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.762654","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,3]]},"article-number":"762654"}}