{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:14:55Z","timestamp":1790781295165,"version":"4.1.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Purpose of Review:<\/jats:bold> Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies.<\/jats:p><jats:p><jats:bold>Recent Findings:<\/jats:bold> Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered.<\/jats:p><jats:p><jats:bold>Summary:<\/jats:bold> Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options.<\/jats:p>","DOI":"10.3389\/fphar.2021.769909","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T05:00:25Z","timestamp":1643605225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Topical Therapeutic Options in Corneal Neuropathic Pain"],"prefix":"10.3389","volume":"12","author":[{"given":"Jeremy","family":"Nortey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerami D.","family":"Seitzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.jtos.2019.01.009","article-title":"Efficacy of Autologous Serum Tears for Treatment of Neuropathic Corneal Pain","volume":"17","author":"Aggarwal","year":"2019","journal-title":"Ocul. 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