{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:16:40Z","timestamp":1792196200023,"version":"4.4.0"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Vincristine (VCR) is the first-line chemotherapeutic medication often co-administered with other drugs to treat childhood acute lymphoblastic leukemia. Dose-dependent neurotoxicity is the main factor restricting VCR\u2019s clinical application. VCR-induced peripheral neuropathy (VIPN) sometimes results in dose reduction or omission, leading to clinical complications or affecting the patient\u2019s quality of life. With regard to the genetic basis of drug responses, preemptive pharmacogenomic testing and simultaneous blood level monitoring could be helpful for the transformation of various findings into individualized therapies. In this review, we discussed the potential associations between genetic variants in genes contributing to the pharmacokinetics\/pharmacodynamics of VCR and VIPN incidence and severity in patients with acute lymphoblastic leukemia. Of note, genetic variants in the <jats:italic>CEP72<\/jats:italic> gene have great potential to be translated into clinical practice. Such a genetic biomarker may help clinicians diagnose VIPN earlier. Besides, genetic variants in other genes, such as <jats:italic>CYP3A5, ABCB1, ABCC1, ABCC2, TTPA, ACTG1, CAPG, SYNE2, SLC5A7, COCH,<\/jats:italic> and <jats:italic>MRPL47,<\/jats:italic> have been reported to be associated with the VIPN, but more evidence is needed to validate the findings in the future. In fact, a variety of complex factors jointly determine the VIPN. In implementing precision medicine, the combination of genetic, environmental, and personal variables, along with therapeutic drug monitoring, will allow for a better understanding of the mechanisms of VIPN, improving the effectiveness of VCR treatment, reducing adverse reactions, and improving patients\u2019 quality of life.<\/jats:p>","DOI":"10.3389\/fphar.2021.771487","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T13:30:30Z","timestamp":1639056630000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Vincristine-Induced Peripheral Neuropathy in Childhood Acute Lymphoblastic Leukemia: Genetic Variation as a Potential Risk Factor"],"prefix":"10.3389","volume":"12","author":[{"given":"Qing-Yan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Li","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Rong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Man","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ren","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.2217\/pgs-2018-0093","article-title":"Genetic Risk Factors for VIPN in Childhood Acute Lymphoblastic Leukemia Patients Identified Using Whole-Exome Sequencing","volume":"19","author":"Abaji","year":"2018","journal-title":"Pharmacogenomics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1365-2125.2010.03867.x","article-title":"Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Leukemia Maintenance Therapy","volume":"71","author":"Adam de Beaumais","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1046\/j.1365-2141.2003.04430.x","article-title":"CYP3A Genotypes and Treatment Response in Paediatric Acute Lymphoblastic Leukaemia","volume":"122","author":"Aplenc","year":"2003","journal-title":"Br. J. Haematol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.critrevonc.2011.04.012","article-title":"Chemotherapy-induced Peripheral Neurotoxicity (CIPN): an Update","volume":"82","author":"Argyriou","year":"2012","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2147\/CMAR.S44261","article-title":"Chemotherapy-induced Peripheral Neuropathy in Adults: a Comprehensive Update of the Literature","volume":"6","author":"Argyriou","year":"2014","journal-title":"Cancer Manag. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1471-2202-6-61","article-title":"RLIP76, a Non-ABC Transporter, and Drug Resistance in Epilepsy","volume":"6","author":"Awasthi","year":"","journal-title":"BMC Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"6022","DOI":"10.1158\/0008-5472.Can-05-0968","article-title":"RLIP76 Is a Major Determinant of Radiation Sensitivity","volume":"65","author":"Awasthi","year":"","journal-title":"Cancer Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00424-006-0160-8","article-title":"Portrait of Multifaceted Transporter, the Multidrug Resistance-Associated Protein 1 (MRP1\/ABCC1)","volume":"453","author":"Bakos","year":"2007","journal-title":"Pflugers Arch."},{"key":"B9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1517\/14740338.2011.543417","article-title":"Chemotherapy-induced Peripheral Neuropathies: from Clinical Relevance to Preclinical Evidence","volume":"10","author":"Balayssac","year":"2011","journal-title":"Expert Opin. Drug Saf."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.ajhg.2012.09.019","article-title":"Defective Presynaptic Choline Transport Underlies Hereditary Motor Neuropathy","volume":"91","author":"Barwick","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3233\/jpn-2009-0333","article-title":"Electrophysiological Consequences of Vincristine Contained Chemotherapy in Children: A Cohort Study","volume":"7","author":"Barzegar","year":"2015","journal-title":"J. Pediatr. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.ajhg.2016.06.033","article-title":"Impaired Presynaptic High-Affinity Choline Transporter Causes a Congenital Myasthenic Syndrome with Episodic Apnea","volume":"99","author":"Bauch\u00e9","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"B13","volume-title":"Vincristine","author":"Below","year":"2021"},{"key":"B14","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/cpt1977224430","article-title":"The Pharmacokinetics of [3H]-Vincristine in Man","volume":"22","author":"Bender","year":"1977","journal-title":"Clin. Pharmacol. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0022-510x(70)90013-4","article-title":"The Neuromyopathy of Vincristine in Man. Clinical, Electrophysiological and Pathological Studies","volume":"10","author":"Bradley","year":"1970","journal-title":"J. Neurol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/s1470-2045(10)70206-0","article-title":"Mechanisms of Peripheral Neuropathy Associated with Bortezomib and Vincristine in Patients with Newly Diagnosed Multiple Myeloma: a Prospective Analysis of Data from the HOVON-65\/gmmg-HD4 Trial","volume":"11","author":"Broyl","year":"2010","journal-title":"Lancet Oncol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s00280-008-0689-7","article-title":"Interleukin-6 Protects against Paclitaxel, Cisplatin and Vincristine-Induced Neuropathies without Impairing Chemotherapeutic Activity","volume":"62","author":"Callizot","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1182\/blood.v21.5.640.640","article-title":"Clinical Studies with Vincristine","volume":"21","author":"Carbone","year":"1963","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fphys.2018.00095","article-title":"Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels","volume":"9","author":"Carrasco","year":"2018","journal-title":"Front. Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.semcdb.2013.12.010","article-title":"Nesprins in Health and Disease","volume":"29","author":"Cartwright","year":"2014","journal-title":"Semin. Cel Dev Biol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.2217\/pgs.14.68","article-title":"Polymorphisms of the Vincristine Pathway and Response to Treatment in Children with Childhood Acute Lymphoblastic Leukemia","volume":"15","author":"Ceppi","year":"2014","journal-title":"Pharmacogenomics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"110003","DOI":"10.1016\/j.biopha.2020.110003","article-title":"Mitoquinone Alleviates Vincristine-Induced Neuropathic Pain through Inhibiting Oxidative Stress and Apoptosis via the Improvement of Mitochondrial Dysfunction","volume":"125","author":"Chen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.pneurobio.2015.06.001","article-title":"Trends in the Design of Nerve Guidance Channels in Peripheral Nerve Tissue Engineering","volume":"131","author":"Chiono","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0092-8674(88)90568-5","article-title":"An Altered Pattern of Cross-Resistance in Multidrug-Resistant Human Cells Results from Spontaneous Mutations in the Mdr1 (P-Glycoprotein) Gene","volume":"53","author":"Choi","year":"1988","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00281-015-0526-0","article-title":"TRPs and Pain","volume":"38","author":"Dai","year":"2016","journal-title":"Semin. Immunopathol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1124\/jpet.106.118471","article-title":"Effect of CYP3A5 Expression on Vincristine Metabolism with Human Liver Microsomes","volume":"321","author":"Dennison","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1124\/dmd.106.009902","article-title":"Selective Metabolism of Vincristine In Vitro by CYP3A5","volume":"34","author":"Dennison","year":"2006","journal-title":"Drug Metab. Dispos"},{"key":"B28","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1001\/jama.2015.0894","article-title":"Association of an Inherited Genetic Variant with Vincristine-Related Peripheral Neuropathy in Children with Acute Lymphoblastic Leukemia","volume":"313","author":"Diouf","year":"2015","journal-title":"JAMA"},{"key":"B29","doi-asserted-by":"publisher","first-page":"100681","DOI":"10.1016\/j.drup.2020.100681","article-title":"Medicinal Chemistry Strategies to Discover P-Glycoprotein Inhibitors: An Update","volume":"49","author":"Dong","year":"2020","journal-title":"Drug Resist. Updat"},{"key":"B30","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3892\/ijo.30.1.139","article-title":"RALBP1\/RLIP76 Mediates Multidrug Resistance","volume":"30","author":"Drake","year":"2007","journal-title":"Int. J. Oncol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1158\/1535-7163.MCT-06-0086","article-title":"Expression Profiling of ATP-Binding Cassette Transporters in Childhood T-Cell Acute Lymphoblastic Leukemia","volume":"5","author":"Efferth","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"B32","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/pbc.22845","article-title":"Increased Risk of Vincristine Neurotoxicity Associated with Low CYP3A5 Expression Genotype in Children with Acute Lymphoblastic Leukemia","volume":"56","author":"Egbelakin","year":"2011","journal-title":"Pediatr. Blood Cancer"},{"key":"B33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1093\/brain\/awt339","article-title":"Molecular, Clinical and Peripheral Neuropathy Study of Tunisian Patients with Ataxia with Vitamin E Deficiency","volume":"137","author":"El Euch-Fayache","year":"2014","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1517\/14728222.2016.1162295","article-title":"Nav1.7 and Other Voltage-Gated Sodium Channels as Drug Targets for Pain Relief","volume":"20","author":"Emery","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1126\/science.1073774","article-title":"Predictive Identification of Exonic Splicing Enhancers in Human Genes","volume":"297","author":"Fairbrother","year":"2002","journal-title":"Science"},{"key":"B36","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/sj.cgt.7701082","article-title":"Reversal of Drug Resistance of Hepatocellular Carcinoma Cells by Adenoviral Delivery of Anti-ABCC2 Antisense Constructs","volume":"14","author":"Folmer","year":"2007","journal-title":"Cancer Gene Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/tpj.2015.83","article-title":"Pharmacogenetics and Induction\/consolidation Therapy Toxicities in Acute Lymphoblastic Leukemia Patients Treated with AIEOP-BFM ALL 2000 Protocol","volume":"17","author":"Franca","year":"2017","journal-title":"Pharmacogenomics J."},{"key":"B38","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/s1040-8428(98)00023-7","article-title":"Vincristine Revisited","volume":"29","author":"Gidding","year":"1999","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/humu.21641","article-title":"Genome-wide Identification of SNPs in microRNA Genes and the SNP Effects on microRNA Target Binding and Biogenesis","volume":"33","author":"Gong","year":"2012","journal-title":"Hum. Mutat."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s00280-010-1541-4","article-title":"Population Pharmacokinetics and Pharmacogenetics of Vincristine in Paediatric Patients Treated for Solid Tumour Diseases","volume":"68","author":"Guilhaumou","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5320","DOI":"10.1111\/j.1742-4658.2006.05525.x","article-title":"Dietary Antioxidant Curcumin Inhibits Microtubule Assembly through Tubulin Binding","volume":"273","author":"Gupta","year":"2006","journal-title":"FEBS J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"23857","DOI":"10.1038\/srep23857","article-title":"Prioritization of Anticancer Drugs against a Cancer Using Genomic Features of Cancer Cells: A Step towards Personalized Medicine","volume":"6","author":"Gupta","year":"2016","journal-title":"Sci. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/FPC.0000000000000191","article-title":"Lack of Association of the CEP72 Rs924607 TT Genotype with Vincristine-Related Peripheral Neuropathy during the Early Phase of Pediatric Acute Lymphoblastic Leukemia Treatment in a Spanish Population","volume":"26","author":"Gutierrez-Camino","year":"2016","journal-title":"Pharmacogenet Genomics"},{"key":"B44","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41397-017-0003-3","article-title":"Mir-pharmacogenetics of Vincristine and Peripheral Neurotoxicity in Childhood B-Cell Acute Lymphoblastic Leukemia","volume":"18","author":"Gutierrez-Camino","year":"2018","journal-title":"Pharmacogenomics J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.leukres.2009.04.027","article-title":"Polymorphisms in Genes Involved in Vincristine Pharmacokinetics or Pharmacodynamics Are Not Related to Impaired Motor Performance in Children with Leukemia","volume":"34","author":"Hartman","year":"2010","journal-title":"Leuk. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1200\/JCO.2015.66.2346","article-title":"Comorbidities and Risk of Chemotherapy-Induced Peripheral Neuropathy Among Participants 65 Years or Older in Southwest Oncology Group Clinical Trials","volume":"34","author":"Hershman","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1016\/j.bcp.2006.03.009","article-title":"Vincristine Transcriptional Regulation of Efflux Drug Transporters in Carcinoma Cell Lines","volume":"71","author":"Huang","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.bbrc.2009.01.064","article-title":"The Actin-Capping Protein CapG Localizes to Microtubule-dependent Organelles during the Cell Cycle","volume":"380","author":"Hubert","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.braindev.2011.08.007","article-title":"Long-term Effectiveness of Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy","volume":"34","author":"Hwang","year":"2012","journal-title":"Brain Dev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/cpt1978241101","article-title":"Biliary Excretion of Vincristine","volume":"24","author":"Jackson","year":"1978","journal-title":"Clin. Pharmacol. Ther."},{"key":"B51","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1177\/0883073813491829","article-title":"Vincristine-induced Neuropathy in Childhood ALL (Acute Lymphoblastic Leukemia) Survivors: Prevalence and Electrophysiological Characteristics","volume":"29","author":"Jain","year":"2014","journal-title":"J. Child. Neurol."},{"key":"B52","first-page":"882","article-title":"Multi-drug Transporter MDR1 Gene Polymorphism and Prognosis in Adult Acute Lymphoblastic Leukemia","volume":"57","author":"Jamroziak","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1600-0609.2004.00228.x","article-title":"Functional C3435T Polymorphism of MDR1 Gene: an Impact on Genetic Susceptibility and Clinical Outcome of Childhood Acute Lymphoblastic Leukemia","volume":"72","author":"Jamroziak","year":"2004","journal-title":"Eur. J. Haematol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.bcp.2014.03.015","article-title":"A Peripherally Acting, Selective T-type Calcium Channel Blocker, ABT-639, Effectively Reduces Nociceptive and Neuropathic Pain in Rats","volume":"89","author":"Jarvis","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e60733","DOI":"10.1371\/journal.pone.0060733","article-title":"Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model","volume":"8","author":"Ji","year":"2013","journal-title":"PLoS One"},{"key":"B56","first-page":"1390","article-title":"The Vinca Alkaloids: A New Class of Oncolytic Agents","volume":"23","author":"Johnson","year":"1963","journal-title":"Cancer Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1177\/1078155219882081","article-title":"Surveillance of Adverse Drug Reactions and Drug-Drug Interactions with Pediatric Oncology Patients in a South Indian Tertiary Care Hospital","volume":"26","author":"Joseph","year":"2020","journal-title":"J. Oncol. Pharm. Pract."},{"key":"B58","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.pain.2006.02.011","article-title":"Involvement of the TTX-Resistant Sodium Channel Nav 1.8 in Inflammatory and Neuropathic, but Not post-operative, Pain States","volume":"123","author":"Joshi","year":"2006","journal-title":"Pain"},{"key":"B59","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pain.2005.05.026","article-title":"Possible Involvement of the Spinal Nitric oxide\/cGMP Pathway in Vincristine-Induced Painful Neuropathy in Mice","volume":"117","author":"Kamei","year":"2005","journal-title":"Pain"},{"key":"B60","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.gpb.2016.11.005","article-title":"Exploitation of Gene Expression and Cancer Biomarkers in Paving the Path to Era of Personalized Medicine","volume":"15","author":"Kamel","year":"2017","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"B61","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/s0022-3476(76)80416-7","article-title":"Overdosage with Vincristine","volume":"89","author":"Kaufman","year":"1976","journal-title":"J. Pediatr."},{"key":"B62","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nrc2803","article-title":"Microtubules and Resistance to Tubulin-Binding Agents","volume":"10","author":"Kavallaris","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"B63","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/MPH.0000000000000825","article-title":"Electrophysiological Studies to Detect Peripheral Neuropathy in Children Treated with Vincristine","volume":"39","author":"Kavcic","year":"2017","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1055\/a-1213-5995","article-title":"Association of CEP72 Rs924607 TT Genotype with Vincristine-Induced Peripheral Neuropathy Measured by Motor Nerve Conduction Studies","volume":"232","author":"Kav\u010di\u010d","year":"2020","journal-title":"Klin Padiatr"},{"key":"B65","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1006\/geno.2001.6622","article-title":"The Human Mitochondrial Ribosomal Protein Genes: Mapping of 54 Genes to the Chromosomes and Implications for Human Disorders","volume":"77","author":"Kenmochi","year":"2001","journal-title":"Genomics"},{"key":"B66","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1517\/14622416.2.1.51","article-title":"ABC Drug Transporters: Hereditary Polymorphisms and Pharmacological Impact in MDR1, MRP1 and MRP2","volume":"2","author":"Kerb","year":"2001","journal-title":"Pharmacogenomics"},{"key":"B67","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neulet.2008.09.009","article-title":"Up-regulation of Tumor Necrosis Factor-Alpha in Spinal Cord Contributes to Vincristine-Induced Mechanical Allodynia in Mice","volume":"445","author":"Kiguchi","year":"2008","journal-title":"Neurosci. Lett."},{"key":"B68","doi-asserted-by":"publisher","first-page":"11074","DOI":"10.1523\/JNEUROSCI.3708-15.2016","article-title":"CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain","volume":"36","author":"Krukowski","year":"2016","journal-title":"J. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1177\/1073858414567884","article-title":"ThermoTRPs and Pain","volume":"22","author":"Laing","year":"2016","journal-title":"Neuroscientist"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e1005898","DOI":"10.1371\/journal.pgen.1005898","article-title":"Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism","volume":"12","author":"Lakisic","year":"2016","journal-title":"Plos Genet."},{"key":"B71","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00424-009-0779-3","article-title":"Sodium Channelopathies and Pain","volume":"460","author":"Lampert","year":"2010","journal-title":"Pflugers Arch."},{"key":"B72","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/jns.12114","article-title":"Patterns and Severity of Vincristine-Induced Peripheral Neuropathy in Children with Acute Lymphoblastic Leukemia","volume":"20","author":"Lavoie Smith","year":"2015","journal-title":"J. Peripher. Nerv Syst."},{"key":"B73","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/psp4.12453","article-title":"Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition","volume":"8","author":"Lee","year":"2019","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-021-09631-y","article-title":"CaMKII and CaV3.2 T-type Calcium Channel Mediate Connexin-43-dependent Inflammation by Activating Astrocytes in Vincristine-Induced Neuropathic Pain","author":"Li","year":"2021","journal-title":"Cell Biol Toxicol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/cpt.1324","article-title":"Genetic Variants Associated with Vincristine-Induced Peripheral Neuropathy in Two Populations of Children with Acute Lymphoblastic Leukemia","volume":"105","author":"Li","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"m798","DOI":"10.1107\/S1600536812022155","article-title":"Aqua-(2,6-dihy-droxy-benzoato-\u03baO(1))bis-(1,10-phenanthroline-\u03ba(2)N,N')Manganese(II) 2,6-Dihy-Droxy-Benzoate Hemihydrate","volume":"68","author":"Li","year":"2012","journal-title":"Acta Crystallogr. Sect E Struct. Rep. Online"},{"key":"B77","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3389\/fgene.2015.00339","article-title":"Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome","volume":"6","author":"Libertini","year":"2015","journal-title":"Front. Genet."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1038\/cr.2014.106","article-title":"Nociceptive Neurons Regulate Innate and Adaptive Immunity and Neuropathic Pain through MyD88 Adapter","volume":"24","author":"Liu","year":"2014","journal-title":"Cell Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"731","DOI":"10.2217\/pgs-2016-0001","article-title":"Vincristine Pharmacokinetics Pathway and Neurotoxicity during Early Phases of Treatment in Pediatric Acute Lymphoblastic Leukemia","volume":"17","author":"Lopez-Lopez","year":"2016","journal-title":"Pharmacogenomics"},{"key":"B80","doi-asserted-by":"publisher","first-page":"270","DOI":"10.5114\/fn.2015.54428","article-title":"Emery-dreifuss Muscular Dystrophy Type 2 Associated (?) with Mild Peripheral Polyneuropathy","volume":"53","author":"Madej-Pilarczyk","year":"2015","journal-title":"Folia Neuropathol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/s41397-019-0081-5","article-title":"Variants in Vincristine Pharmacodynamic Genes Involved in Neurotoxicity at Induction Phase in the Therapy of Pediatric Acute Lymphoblastic Leukemia","volume":"19","author":"Martin-Guerrero","year":"2019","journal-title":"Pharmacogenomics J."},{"key":"B82","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1001\/jama.2015.1086","article-title":"Precision Medicine to Improve the Risk and Benefit of Cancer Care: Genetic Factors in Vincristine-Related Neuropathy","volume":"313","author":"McLeod","year":"2015","journal-title":"JAMA"},{"key":"B83","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/j.1440-1754.2011.02103.x","article-title":"Vincristine Pharmacodynamics and Pharmacogenetics in Children with Cancer: a Limited-Sampling, Population Modelling Approach","volume":"47","author":"Moore","year":"2011","journal-title":"J. Paediatr. Child. Health"},{"key":"B84","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1439-0507.2011.02158.x","article-title":"Adverse Interactions between Antifungal Azoles and Vincristine: Review and Analysis of Cases","volume":"55","author":"Moriyama","year":"2012","journal-title":"Mycoses"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26677","article-title":"Vincristine-induced Neuropathy in Pediatric Patients with Acute Lymphoblastic Leukemia in Oman: Frequent Autonomic and More Severe Cranial Nerve Involvement","volume":"64","author":"Nazir","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.apmr.2013.03.009","article-title":"Chemotherapy-related Neuropathic Symptoms and Functional Impairment in Adult Survivors of Extracranial Solid Tumors of Childhood: Results from the St. Jude Lifetime Cohort Study","volume":"94","author":"Ness","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.jpain.2017.06.007","article-title":"Synergistic Interaction between Dexmedetomidine and Ulinastatin against Vincristine-Induced Neuropathic Pain in Rats","volume":"18","author":"Nie","year":"2017","journal-title":"J. Pain"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e11786","DOI":"10.1097\/MD.0000000000011786","article-title":"Clinical Analysis of Neoadjuvant Chemotherapy in Patients with Advanced Vulvar Cancer: A STROBE-Compliant Article","volume":"97","author":"Niu","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0378-1119(01)00808-3","article-title":"Evolution of a Protein-Rich Mitochondrial Ribosome: Implications for Human Genetic Disease","volume":"286","author":"O'Brien","year":"2002","journal-title":"Gene"},{"key":"B90","doi-asserted-by":"publisher","first-page":"252","DOI":"10.14740\/jocmr1856w","article-title":"Risk Factors for Early-Onset Peripheral Neuropathy Caused by Vincristine in Patients with a First Administration of R-CHOP or R-CHOP-like Chemotherapy","volume":"6","author":"Okada","year":"2014","journal-title":"J. Clin. Med. Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1172\/JCI71389","article-title":"Monocytes Expressing CX3CR1 Orchestrate the Development of Vincristine-Induced Pain","volume":"124","author":"Old","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1038\/emboj.2009.161","article-title":"Cep72 Regulates the Localization of Key Centrosomal Proteins and Proper Bipolar Spindle Formation","volume":"28","author":"Oshimori","year":"2009","journal-title":"EMBO J."},{"key":"B150","doi-asserted-by":"publisher","first-page":"216-224","DOI":"10.1038\/srep12227","article-title":"Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample","volume":"49","author":"Ou","year":"2017","journal-title":"Cancer Epidemiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/cpt.1675","article-title":"Precision Medicine 2030","volume":"107","author":"Pacanowski","year":"2020","journal-title":"Clin. Pharmacol. Ther."},{"key":"B94","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.clpt.2004.05.007","article-title":"Influence of Functional Polymorphisms of the MDR1 Gene on Vincristine Pharmacokinetics in Childhood Acute Lymphoblastic Leukemia","volume":"76","author":"Plasschaert","year":"2004","journal-title":"Clin. Pharmacol. Ther."},{"key":"B95","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1200\/JCO.2000.18.4.813","article-title":"Racial Differences in the Survival of Childhood B-Precursor Acute Lymphoblastic Leukemia: a Pediatric Oncology Group Study","volume":"18","author":"Pollock","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/17425255.2021.1855141","article-title":"Genetic Factors Influencing the Development of Vincristine-Induced Neurotoxicity","volume":"17","author":"Pozzi","year":"2021","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of Acute Lymphoblastic Leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/s0140-6736(08)60457-2","article-title":"Acute Lymphoblastic Leukaemia","volume":"371","author":"Pui","year":"2008","journal-title":"Lancet"},{"key":"B99","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3171\/spi.2007.6.3.280","article-title":"Inadvertent Intrathecal Vincristine Administration: a Neurosurgical Emergency. Case Report","volume":"6","author":"Qweider","year":"2007","journal-title":"J. Neurosurg. Spine"},{"key":"B100","doi-asserted-by":"publisher","first-page":"e40098","DOI":"10.1371\/journal.pone.0040098","article-title":"Multiple Novel Nesprin-1 and Nesprin-2 Variants Act as Versatile Tissue-specific Intracellular Scaffolds","volume":"7","author":"Rajgor","year":"2012","journal-title":"PLoS One"},{"key":"B101","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1017\/erm.2013.6","article-title":"Nesprins: from the Nuclear Envelope and beyond","volume":"15","author":"Rajgor","year":"2013","journal-title":"Expert Rev. Mol. Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1097\/PRS.0b013e3181b5a3c3","article-title":"Tibial Nerve Decompression in Patients with Tarsal Tunnel Syndrome: Pressures in the Tarsal, Medial Plantar, and Lateral Plantar Tunnels","volume":"124","author":"Rosson","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"B103","doi-asserted-by":"publisher","first-page":"7225","DOI":"10.1073\/pnas.87.18.7225","article-title":"Molecular Basis of Preferential Resistance to Colchicine in Multidrug-Resistant Human Cells Conferred by Gly-185----Val-185 substitution in P-glycoprotein","volume":"87","author":"Safa","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B104","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1517\/17425255.2014.885016","article-title":"Pharmacokinetic evaluation of vincristine for the treatment of lymphoid malignancies","volume":"10","author":"Said","year":"2014","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"e637","DOI":"10.1097\/MPH.0000000000001604","article-title":"Obesity as a Potential Risk Factor for Vincristine-induced Peripheral Neuropathy","volume":"42","author":"Sajdyk","year":"2020","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.3390\/ijms20102488","article-title":"Nociceptor Signalling through ion Channel Regulation via GPCRs","volume":"20","author":"Salzer","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s12185-020-02832-x","article-title":"Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy","volume":"111","author":"Sawaki","year":"2020","journal-title":"Int. J. Hematol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"14","DOI":"10.4331\/wjbc.v7.i1.14","article-title":"Complexity of vitamin E metabolism","volume":"7","author":"Schm\u00f6lz","year":"2016","journal-title":"World J. Biol. Chem."},{"key":"B109","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1007\/s00520-019-05106-3","article-title":"Measuring vincristine-induced peripheral neuropathy in children with cancer: validation of the Dutch pediatric-modified Total Neuropathy Score","volume":"28","author":"Schouten","year":"2020","journal-title":"Support Care Cancer"},{"key":"B110","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1042\/CBI20110264","article-title":"ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia","volume":"36","author":"Semsei","year":"2012","journal-title":"Cell Biol Int"},{"key":"B111","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1523\/JNEUROSCI.22-08-03052.2002","article-title":"The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta","volume":"22","author":"Shamash","year":"2002","journal-title":"J. Neurosci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/fcp.12519","article-title":"Pain attenuating actions of vincristinet-preconditioning in chemotherapeutic agent-induced neuropathic pain: key involvement of T-type calcium channels","volume":"34","author":"Sharma","year":"2020","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1242\/jcs.179994","article-title":"Regulators of actin filament barbed ends at a glance","volume":"129","author":"Shekhar","year":"2016","journal-title":"J. Cel Sci"},{"key":"B114","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.nbd.2015.04.012","article-title":"Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice","volume":"79","author":"Shen","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B115","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1113\/jphysiol.2006.118620","article-title":"Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse","volume":"581","author":"Sikand","year":"2007","journal-title":"J. Physiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1177\/1078155214553143","article-title":"The effect of race on the CYP3A-mediated metabolism of vincristine in pediatric patients with acute lymphoblastic leukemia","volume":"22","author":"Sims","year":"2016","journal-title":"J. Oncol. Pharm. Pract."},{"key":"B117","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1021\/acschemneuro.9b00206","article-title":"Bergapten Ameliorates Vincristine-Induced Peripheral Neuropathy by Inhibition of Inflammatory Cytokines and NF\u03baB Signaling","volume":"10","author":"Singh","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1158\/0008-5472.CAN-05-3534","article-title":"Regression of melanoma in a murine model by RLIP76 depletion","volume":"66","author":"Singhal","year":"2006","journal-title":"Cancer Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/pbc.26854","article-title":"CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer","volume":"65","author":"Skiles","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"B120","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1532\/ijh97.e0418","article-title":"GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia","volume":"81","author":"Stanulla","year":"2005","journal-title":"Int. J. Hematol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/clpt.2008.154","article-title":"Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia","volume":"85","author":"Stocco","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"B122","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/cpt.506","article-title":"An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine-Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia","volume":"101","author":"Stock","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"B123","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s00439-002-0798-z","article-title":"Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency","volume":"111","author":"Sumi","year":"2002","journal-title":"Hum. Genet."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.2174\/1381612824666180829101836","article-title":"Individualized Tacrolimus Therapy for Pediatric Nephrotic Syndrome: Considerations for Ontogeny and Pharmacogenetics of CYP3A","volume":"24","author":"Sun","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.4161\/epi.29676","article-title":"Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E","volume":"9","author":"Sun","year":"2014","journal-title":"Epigenetics"},{"key":"B126","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1744-8069-7-5","article-title":"Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain","volume":"7","author":"Takeda","year":"2011","journal-title":"Mol. Pain"},{"key":"B127","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3969\/j.issn","article-title":"Progress in the diagnosis and treatment of common tumors in children","volume":"25","author":"Tang","year":"2020","journal-title":"China Pediatr. Blood Cancer"},{"key":"B128","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/1096-9861(20000904)424:4<563:aid-cne1>3.0.co;2-u","article-title":"Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat","volume":"424","author":"Topp","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/jnr.20873","article-title":"Heterozygous P0 deficiency protects mice from vincristine-induced polyneuropathy","volume":"84","author":"U\u00e7eyler","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/0887-8994(95)00191-3","article-title":"Vincristine Therapy for Children With Acute Lymphoblastic Leukemia Impairs Conduction in the Entire Peripheral Nerve","volume":"13","author":"Vainionp\u00e4\u00e4","year":"1995","journal-title":"Pediatr. Neurol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.critrevonc.2017.04.004","article-title":"Vincristine-induced peripheral neuropathy in children with cancer: A systematic review","volume":"114","author":"van de Velde","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1002\/pmic.200500417","article-title":"Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia--an In Vivo study","volume":"6","author":"Verrills","year":"","journal-title":"Proteomics"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/jnci\/djj372","article-title":"Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia","volume":"98","author":"Verrills","year":"","journal-title":"J. Natl. Cancer Inst."},{"key":"B134","doi-asserted-by":"publisher","first-page":"45082","DOI":"10.1074\/jbc.M303378200","article-title":"Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations","volume":"278","author":"Verrills","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B135","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1365-2710.2011.01272.x","article-title":"Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine","volume":"37","author":"Wan Rosalina","year":"2012","journal-title":"J. Clin. Pharm. Ther."},{"key":"B136","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1016\/j.jacc.2013.02.058","article-title":"The P-glycoprotein transport system and cardiovascular drugs","volume":"61","author":"Wessler","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1242\/dev.114769","article-title":"Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells","volume":"142","author":"Wilson","year":"2015","journal-title":"Development"},{"key":"B138","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4236\/health.2013.55A005","article-title":"ATP Binding Cassette C1 (ABCC1\/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia","volume":"5","author":"Winter","year":"2013","journal-title":"Health (Irvine Calif)"},{"key":"B139","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/tpj.2011.16","article-title":"An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics","volume":"11","author":"Wolf","year":"2011","journal-title":"Pharmacogenomics J."},{"key":"B140","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00280-008-0906-4","article-title":"MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents","volume":"64","author":"Woodahl","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/cpt.1179","article-title":"Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes","volume":"105","author":"Wright","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"B142","first-page":"B01","volume-title":"Sixty Percent of Childhood Tumors in Our Country Are Leukemia","author":"Yi","year":"2021"},{"key":"B143","doi-asserted-by":"publisher","first-page":"FSO582","DOI":"10.2144\/fsoa-2020-0044","article-title":"Centrosomal protein72 rs924607 and vincristine-induced neuropathy in pediatric acute lymphocytic leukemia: meta-analysis","volume":"6","author":"Ze\u010dkanovi\u0107","year":"2020","journal-title":"Future Sci. OA"},{"key":"B144","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/FPC.0000000000000345","article-title":"Genetic polymorphisms in candidate genes are Not associated with increased vincristine-related peripheral neuropathy in Arab children treated for acute childhood leukemia: a single institution study","volume":"28","author":"Zgheib","year":"2018","journal-title":"Pharmacogenet Genomics"},{"key":"B145","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neuron.2009.08.018","article-title":"SUN1\/2 and Syne\/Nesprin-1\/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice","volume":"64","author":"Zhang","year":"2009","journal-title":"Neuron"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1161\/ATVBAHA.108.165753","article-title":"CD44 expressed on Both bone marrow-derived and non-bone marrow-derived cells promotes atherogenesis in ApoE-deficient mice","volume":"28","author":"Zhao","year":"2008","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuropharm.2018.03.004","article-title":"Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1\/CXCR2 signaling pathway","volume":"135","author":"Zhou","year":"2018","journal-title":"Neuropharmacology"},{"key":"B148","doi-asserted-by":"publisher","first-page":"12227","DOI":"10.1038\/srep12227","article-title":"Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis","volume":"5","author":"Zhu","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.771487\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T13:30:34Z","timestamp":1639056634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.771487\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,9]]},"references-count":149,"alternative-id":["10.3389\/fphar.2021.771487"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.771487","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,9]]},"article-number":"771487"}}