{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:42:34Z","timestamp":1792802554637,"version":"4.5.0"},"reference-count":365,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role in cancer progression and as a suitable therapeutic target. The use of small molecule RTK inhibitors however, has been crippled by the emergence of resistance, highlighting the need for a pleiotropic anti-cancer agent that can replace or be used in combination with existing pharmacological agents to enhance treatment efficacy. Curcumin is an attractive therapeutic agent mainly due to its potent anti-cancer effects, extensive range of targets and minimal toxicity. Out of the numerous documented targets of curcumin, RTKs appear to be one of the main nodes of curcumin-mediated inhibition. Many studies have found that curcumin influences RTK activation and their downstream signaling pathways resulting in increased apoptosis, decreased proliferation and decreased migration in cancer both<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. This review focused on how curcumin exhibits anti-cancer effects through inhibition of RTKs and downstream signaling pathways like the MAPK, PI3K\/Akt, JAK\/STAT, and NF-\u03baB pathways. Combination studies of curcumin and RTK inhibitors were also analysed with emphasis on their common molecular targets.<\/jats:p>","DOI":"10.3389\/fphar.2021.772510","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T06:19:07Z","timestamp":1636957147000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":137,"title":["Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer"],"prefix":"10.3389","volume":"12","author":[{"given":"Sareshma","family":"Sudhesh Dev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syafiq Asnawi","family":"Zainal Abidin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhaneh","family":"Farghadani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iekhsan","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Naidu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1001\/archoto.2011.63","article-title":"Sensitization of Head and Neck Cancer to Cisplatin through the Use of a Novel Curcumin Analog","volume":"137","author":"Abuzeid","year":"2011","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3390\/ph13070153","article-title":"Curcumin, a Natural Antimicrobial Agent with Strain-specific Activity","volume":"13","author":"Adamczak","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.humpath.2018.01.025","article-title":"Autocrine Activation of Platelet-Derived Growth Factor Receptor \u03b1 in Metastatic Papillary Thyroid Cancer","volume":"75","author":"Adewuyi","year":"2018","journal-title":"Hum. Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1038\/bjc.2017.337","article-title":"IGF-1R Associates with Adverse Outcomes after Radical Radiotherapy for Prostate Cancer","volume":"117","author":"Aleksic","year":"2017","journal-title":"Br. J. Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/CEJ.0b013e32834ef194","article-title":"Curcumin: a Novel Stat3 Pathway Inhibitor for Chemoprevention of Lung Cancer","volume":"21","author":"Alexandrow","year":"2012","journal-title":"Eur. J. Cancer Prev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"G1227","DOI":"10.1152\/ajpgi.00253.2004","article-title":"EGFR-induced Cell Migration Is Mediated Predominantly by the JAK-STAT Pathway in Primary Esophageal Keratinocytes","volume":"287","author":"Andl","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.critrevonc.2016.11.008","article-title":"Platelet-derived Growth Factor Receptors (PDGFRs) Fusion Genes Involvement in Hematological Malignancies","volume":"109","author":"Appiah-Kubi","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1084\/jem.20011481","article-title":"c-Jun NH(2)-terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8(+) T Cell-Mediated Antiviral Immunity","volume":"195","author":"Arbour","year":"2002","journal-title":"J. Exp. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1158\/1078-0432.Ccr-14-2821","article-title":"Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer","volume":"21","author":"Arena","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1124\/jpet.105.084145","article-title":"Role of Tyrosine Kinase Inhibitors in Cancer Therapy","volume":"315","author":"Arora","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e1423170","DOI":"10.1080\/2162402x.2017.1423170","article-title":"PD-L1 Expression Is Regulated by Both DNA Methylation and NF-kB during EMT Signaling in Non-small Cell Lung Carcinoma","volume":"7","author":"Asgarova","year":"2018","journal-title":"Oncoimmunology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1200\/jco.2015.63.4600","article-title":"MET Exon 14 Mutations in Non-small-cell Lung Cancer Are Associated with Advanced Age and Stage-dependent MET Genomic Amplification and C-Met Overexpression","volume":"34","author":"Awad","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1097\/JTO.0b013e3181f38f57","article-title":"Increased Insulin-like Growth Factor 1 Receptor Protein Expression and Gene Copy Number in Small Cell Lung Cancer","volume":"5","author":"Badzio","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"B14","first-page":"1208","article-title":"Effect of the Combination of Imatinib Mesylate (Glivec) and Curcumin in Chronic Myeloid Leukemia Cell Line","volume":"65","author":"Bae","year":"2005","journal-title":"Cancer Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3892\/ijmm.2018.3725","article-title":"Sequence-dependent E-ffect of S-orafenib in C-ombination with N-atural P-henolic C-ompounds on H-epatic C-ancer C-ells and the P-ossible M-echanism of A-ction","volume":"42","author":"Bahman","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2741\/e798","article-title":"Combinatorial Effect of Curcumin with Docetaxel Modulates Apoptotic and Cell Survival Molecules in Prostate Cancer","volume":"9","author":"Banerjee","year":"2017","journal-title":"Front. Biosci. (Elite Ed."},{"key":"B17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jnutbio.2016.01.003","article-title":"Small Molecule Tolfenamic Acid and Dietary Spice Curcumin Treatment Enhances Antiproliferative Effect in Pancreatic Cancer Cells via Suppressing Sp1, Disrupting NF-kB Translocation to Nucleus and Cell Cycle Phase Distribution","volume":"31","author":"Basha","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.3390\/molecules16064567","article-title":"Curcumin: an Anti-inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment","volume":"16","author":"Basnet","year":"2011","journal-title":"Molecules"},{"key":"B19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0090-8258(02)00073-2","article-title":"Overexpression of the C-Met\/HGF Receptor and its Prognostic Significance in Uterine Cervix Carcinomas","volume":"88","author":"Baykal","year":"2003","journal-title":"Gynecol. Oncol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2147\/DDDT.S238955","article-title":"Targeted Therapy for Hepatocellular Carcinoma: Co-delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles","volume":"14","author":"Bian","year":"2020","journal-title":"Drug Des. Devel Ther."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1136\/gut.2008.152496","article-title":"Curcumin Inhibits VEGF-Mediated Angiogenesis in Human Intestinal Microvascular Endothelial Cells through COX-2 and MAPK Inhibition","volume":"57","author":"Binion","year":"2008","journal-title":"Gut"},{"key":"B22","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1634\/theoncologist.2020-0502","article-title":"Tepotinib Efficacy in a Patient with Non-small Cell Lung Cancer with Brain Metastasis Harboring an HLA-DRB1-MET Gene Fusion","volume":"25","author":"Blanc-Durand","year":"2020","journal-title":"Oncologist"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.bcp.2006.07.029","article-title":"Curcumin Regulates Signal Transducer and Activator of Transcription (STAT) Expression in K562 Cells","volume":"72","author":"Blasius","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s11060-009-0014-2","article-title":"Amplification and Overexpression of KIT, PDGFRA, and VEGFR2 in Medulloblastomas and Primitive Neuroectodermal Tumors","volume":"97","author":"Blom","year":"2010","journal-title":"J. Neurooncol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/34657","article-title":"Induction of Epithelial Tubules by Growth Factor HGF Depends on the STAT Pathway","volume":"391","author":"Boccaccio","year":"1998","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"185102","DOI":"10.1088\/1361-6528\/ab6d20","article-title":"GANT61 and Curcumin-Loaded PLGA Nanoparticles for GLI1 and PI3K\/Akt-Mediated Inhibition in Breast Adenocarcinoma","volume":"31","author":"Borah","year":"2020","journal-title":"Nanotechnology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1002\/ptr.6780","article-title":"Curcumin Downregulates the PI3K-AKT-mTOR Pathway and Inhibits Growth and Progression in Head and Neck Cancer Cells","volume":"34","author":"Borges","year":"2020","journal-title":"Phytother Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"211","DOI":"10.15171\/jhp.2018.33","article-title":"Immunomodulatory, Anti-inflammatory, and Antioxidant Effects of Curcumin","volume":"7","author":"Boroumand","year":"2018","journal-title":"J. Herbmed Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1158\/0008-5472.Can-07-1588","article-title":"Enhanced Activation of Epidermal Growth Factor Receptor Caused by Tumor-Derived E-Cadherin Mutations","volume":"68","author":"Bremm","year":"2008","journal-title":"Cancer Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"80","DOI":"10.5306\/wjco.v2.i2.80","article-title":"Tyrosine Kinase Inhibitors: Multi-Targeted or Single-Targeted?","volume":"2","author":"Broekman","year":"2011","journal-title":"World J. Clin. Oncol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1080\/10428194.2017.1318437","article-title":"Identification of a Novel Fusion TBL1XR1-PDGFRB in a Patient with Acute Myeloid Leukemia Harboring the DEK-Nup214 Fusion and Clinical Response to Dasatinib","volume":"58","author":"Campregher","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"B32","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/s41580-020-00322-w","article-title":"Diversity and Versatility of P38 Kinase Signalling in Health and Disease","volume":"22","author":"Canovas","year":"2021","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1158\/1535-7163.Mct-10-0799","article-title":"BRAFV600E: Implications for Carcinogenesis and Molecular Therapy","volume":"10","author":"Cantwell-Dorris","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"B34","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1021\/mp500755j","article-title":"Codelivery of Sorafenib and Curcumin by Directed Self-Assembled Nanoparticles Enhances Therapeutic Effect on Hepatocellular Carcinoma","volume":"12","author":"Cao","year":"2015","journal-title":"Mol. Pharm."},{"key":"B35","doi-asserted-by":"publisher","first-page":"6551","DOI":"10.1158\/1078-0432.Ccr-14-1337","article-title":"Identification of Recurrent FGFR3-TACC3 Fusion Oncogenes from Lung Adenocarcinoma","volume":"20","author":"Capelletti","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.gore.2015.06.005","article-title":"FGFR3-TACC3: A Novel Gene Fusion in Cervical Cancer","volume":"13","author":"Carneiro","year":"2015","journal-title":"Gynecol. Oncol. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrc3277","article-title":"Spatial Regulation of Receptor Tyrosine Kinases in Development and Cancer","volume":"12","author":"Casaletto","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"7342","DOI":"10.1038\/sj.onc.1204926","article-title":"Transcriptional Regulation of Bcl-2 by Nuclear Factor Kappa B and its Significance in Prostate Cancer","volume":"20","author":"Catz","year":"2001","journal-title":"Oncogene"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7580","DOI":"10.1158\/0008-5472.Can-10-0436","article-title":"MET and KRAS Gene Amplification Mediates Acquired Resistance to MET Tyrosine Kinase Inhibitors","volume":"70","author":"Cepero","year":"2010","journal-title":"Cancer Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3892\/mmr_00000005","article-title":"Curcumin Suppresses Breast Tumor Angiogenesis by Abrogating Osteopontin-Induced VEGF Expression","volume":"1","author":"Chakraborty","year":"2008","journal-title":"Mol. Med. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3978\/j.issn.2218-6751.2014.05.01","article-title":"Targeted Therapy for Non-small Cell Lung Cancer: Current Standards and the Promise of the Future","volume":"4","author":"Chan","year":"2014","journal-title":"Transl Lung Cancer Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e105524","DOI":"10.1371\/journal.pone.0105524","article-title":"Prognostic Value of FGFR Gene Amplification in Patients with Different Types of Cancer: a Systematic Review and Meta-Analysis","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/ijc.25220","article-title":"Curcumin Upregulates Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) and C\/EBPalpha during Oral Cancer Suppression","volume":"127","author":"Chang","year":"2010","journal-title":"Int. J. Cancer"},{"key":"B44","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1476-4598-8-64","article-title":"JNK1 Activation Predicts the Prognostic Outcome of the Human Hepatocellular Carcinoma","volume":"8","author":"Chang","year":"2009","journal-title":"Mol. Cancer"},{"key":"B45","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3324\/haematol.2009.010785","article-title":"Autocrine IGF-1\/IGF-1R Signaling Is Responsible for Constitutive PI3K\/Akt Activation in Acute Myeloid Leukemia: Therapeutic Value of Neutralizing Anti-IGF-1r Antibody","volume":"95","author":"Chapuis","year":"2010","journal-title":"Haematologica"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1172\/jci65385","article-title":"Tumor VEGF:VEGFR2 Autocrine Feed-Forward Loop Triggers Angiogenesis in Lung Cancer","volume":"123","author":"Chatterjee","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B47","doi-asserted-by":"publisher","first-page":"7336","DOI":"10.1073\/pnas.90.15.7336","article-title":"Substitution of the erbB-2 Oncoprotein Transmembrane Domain Activates the Insulin Receptor and Modulates the Action of Insulin and Insulin-Receptor Substrate 1","volume":"90","author":"Cheatham","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B48","doi-asserted-by":"publisher","first-page":"G447","DOI":"10.1152\/ajpgi.00209.2004","article-title":"Activation of PPAR{gamma} by Curcumin Inhibits Moser Cell Growth and Mediates Suppression of Gene Expression of Cyclin D1 and EGFR","volume":"288","author":"Chen","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/sj.onc.1209019","article-title":"Curcumin Inhibits Human colon Cancer Cell Growth by Suppressing Gene Expression of Epidermal Growth Factor Receptor through Reducing the Activity of the Transcription Factor Egr-1","volume":"25","author":"Chen","year":"2006","journal-title":"Oncogene"},{"key":"B50","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3389\/fonc.2020.00867","article-title":"A Novel Oncogenic Driver in a Lung Adenocarcinoma Patient Harboring an EGFR-KDD and Response to Afatinib","volume":"10","author":"Chen","year":"2020","journal-title":"Front. Oncol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"242","DOI":"10.5732\/cjc.012.10263","article-title":"IGF-1R as an Anti-cancer Target-Ttrials and Tribulations","volume":"32","author":"Chen","year":"2013","journal-title":"Chin. J. Cancer"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15419060490471739","article-title":"Metastatic Properties of Prostate Cancer Cells Are Controlled by VEGF","volume":"11","author":"Chen","year":"2004","journal-title":"Cell Commun Adhes"},{"key":"B53","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s13046-019-1234-8","article-title":"Curcumin Overcome Primary Gefitinib Resistance in Non-small-cell Lung Cancer Cells through Inducing Autophagy-Related Cell Death","volume":"38","author":"Chen","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5302","DOI":"10.4049\/jimmunol.170.10.5302","article-title":"Akt Phosphorylates P47phox and Mediates Respiratory Burst Activity in Human Neutrophils","volume":"170","author":"Chen","year":"2003","journal-title":"J. Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.1039\/C7TB00040E","article-title":"Curcumin\/sunitinib Co-loaded BSA-Stabilized SPIOs for Synergistic Combination Therapy for Breast Cancer","volume":"5","author":"Chen","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"B56","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s11705-016-1574-2","article-title":"Curcumin Based Combination Therapy for Anti-breast Cancer: from In Vitro Drug Screening to In Vivo Efficacy Evaluation","volume":"10","author":"Chen","year":"2016","journal-title":"Front. Chem. Sci. Eng."},{"key":"B57","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s11010-010-0562-y","article-title":"Vascular Endothelial Growth Factor-C Promotes the Growth and Invasion of Gallbladder Cancer via an Autocrine Mechanism","volume":"345","author":"Chen","year":"2010","journal-title":"Mol. Cel Biochem"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.3892\/etm.2018.5783","article-title":"Effect of Curcumin on Vascular Endothelial Growth Factor in Hypoxic HepG2 Cells via the Insulin-like Growth Factor 1 Receptor Signaling Pathway","volume":"15","author":"Chen","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/sj.onc.1201941","article-title":"Inhibition of the C-Jun N-Terminal Kinase (JNK) Signaling Pathway by Curcumin","volume":"17","author":"Chen","year":"1998","journal-title":"Oncogene"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e2001128","DOI":"10.1002\/adhm.202001128","article-title":"Carrier-Free Nanoassembly of Curcumin-Erlotinib Conjugate for Cancer Targeted Therapy","volume":"9","author":"Cheng","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.2147\/OTT.S96197","article-title":"HER2 Induces Cell Proliferation and Invasion of Non-small-cell Lung Cancer by Upregulating COX-2 Expression via MEK\/ERK Signaling Pathway","volume":"9","author":"Chi","year":"2016","journal-title":"Onco Targets Ther."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1002\/ijc.30848","article-title":"Mutation in the FGFR1 Tyrosine Kinase Domain or Inactivation of PTEN Is Associated with Acquired Resistance to FGFR Inhibitors in FGFR1-Driven Leukemia\/lymphomas","volume":"141","author":"Cowell","year":"2017","journal-title":"Int. J. Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1097\/JTO.0b013e3182a46fe9","article-title":"Prognostic Value of Fibroblast Growth Factor Receptor 1 Gene Locus Amplification in Resected Lung Squamous Cell Carcinoma","volume":"8","author":"Craddock","year":"2013","journal-title":"J. Thorac. Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.canlet.2011.07.029","article-title":"Spectrum of KIT\/PDGFRA\/BRAF Mutations and Phosphatidylinositol-3-Kinase Pathway Gene Alterations in Gastrointestinal Stromal Tumors (GIST)","volume":"312","author":"Daniels","year":"2011","journal-title":"Cancer Lett."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/po.17.00117","article-title":"Dramatic Response to Crizotinib in a Patient with Lung Cancer Positive for anHLA-DRB1-METGene Fusion","volume":"2017","author":"Davies","year":"2017","journal-title":"JCO Precision Oncol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/s0092-8674(00)00116-1","article-title":"Signal Transduction by the JNK Group of MAP Kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"9680","DOI":"10.1073\/pnas.1511794112","article-title":"Erlotinib Protects against LPS-Induced Endotoxicity Because TLR4 Needs EGFR to Signal","volume":"112","author":"De","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.2174\/18715206113139990093","article-title":"Curcumin Potentiates the Ability of Sunitinib to Eliminate the VHL-Lacking Renal Cancer Cells 786-O: Rapid Inhibition of Rb Phosphorylation as a Preamble to Cyclin D1 Inhibition","volume":"13","author":"Debata","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ctim.2016.06.009","article-title":"Successful Treatment of C-Kit-Positive Metastatic Adenoid Cystic Carcinoma (ACC) with a Combination of Curcumin Plus Imatinib: A Case Report","volume":"27","author":"Demiray","year":"2016","journal-title":"Complement. Ther. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.21873\/anticanres.11147","article-title":"Molecular Mechanisms of Anti-metastatic Activity of Curcumin","volume":"36","author":"Deng","year":"2016","journal-title":"Anticancer Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","article-title":"MAP Kinase Signalling Pathways in Cancer","volume":"26","author":"Dhillon","year":"2007","journal-title":"Oncogene"},{"key":"B73","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2165\/11593320-000000000-00000","article-title":"Clinical Pharmacokinetics of Tyrosine Kinase Inhibitors: Focus on Pyrimidines, Pyridines and Pyrroles","volume":"50","author":"Di Gion","year":"2011","journal-title":"Clin. Pharmacokinet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.mpsur.2017.12.002","article-title":"Principles of Cancer Treatment by Chemotherapy","volume":"36","author":"Dickens","year":"2018","journal-title":"Surgery (Oxford)"},{"key":"B75","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00428-005-1264-9","article-title":"NF-kB in Development and Progression of Human Cancer","volume":"446","author":"Dolcet","year":"2005","journal-title":"Virchows Arch."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1038\/s41467-021-21613-6","article-title":"Structure-function Analysis of Oncogenic EGFR Kinase Domain Duplication Reveals Insights into Activation and a Potential Approach for Therapeutic Targeting","volume":"12","author":"Du","year":"2021","journal-title":"Nat. Commun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12943-018-0782-4","article-title":"Mechanisms of Receptor Tyrosine Kinase Activation in Cancer","volume":"17","author":"Du","year":"2018","journal-title":"Mol. Cancer"},{"key":"B78","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1158\/0008-5472.Can-03-2904","article-title":"Akt Stimulates Aerobic Glycolysis in Cancer Cells","volume":"64","author":"Elstrom","year":"2004","journal-title":"Cancer Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"9719","DOI":"10.1158\/0008-5472.Can-05-1683","article-title":"Mutations of C-RAF Are Rare in Human Cancer Because C-RAF Has a Low Basal Kinase Activity Compared with B-RAF","volume":"65","author":"Emuss","year":"2005","journal-title":"Cancer Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"100023","DOI":"10.1016\/j.jtocrr.2020.100023","article-title":"Oncogenic Fusions May Be Frequently Present at Resistance of EGFR Tyrosine Kinase Inhibitors in Patients with NSCLC: A Brief Report","volume":"1","author":"Enrico","year":"2020","journal-title":"JTO Clin. Res. Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"e20611","DOI":"10.1200\/JCO.2019.37.15_suppl.e20611","article-title":"A Phase I Open Prospective Cohort Trial of Curcumin Plus Tyrosine Kinase Inhibitors for EGFR-Mutant Advanced Non-small Cell Lung Cancer","volume":"37","author":"Esfahani","year":"2019","journal-title":"Jco"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.3390\/cancers13143427","article-title":"Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-independent Breast Cancer","volume":"13","author":"Farghadani","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B83","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1002\/jcp.27442","article-title":"Curcumin as an Anti-inflammatory Agent: Implications to Radiotherapy and Chemotherapy","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cel Physiol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"E964","DOI":"10.1152\/ajpendo.00239.2003","article-title":"Akt Promotes Increased Mammalian Cell Size by Stimulating Protein Synthesis and Inhibiting Protein Degradation","volume":"285","author":"Faridi","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B85","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/cbf.3120","article-title":"Platelet-derived Growth Factor (PDGF) Signalling in Cancer: Rapidly Emerging Signalling Landscape","volume":"33","author":"Farooqi","year":"2015","journal-title":"Cell Biochem Funct"},{"key":"B86","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer Statistics for the Year 2020: An Overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"B87","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/cas.12891","article-title":"Elevated Hepatocyte Growth Factor Expression as an Autocrine C-Met Activation Mechanism in Acquired Resistance to Sorafenib in Hepatocellular Carcinoma Cells","volume":"107","author":"Firtina Karagonlar","year":"2016","journal-title":"Cancer Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cytogfr.2004.03.007","article-title":"The PDGF Family: Four Gene Products Form Five Dimeric Isoforms","volume":"15","author":"Fredriksson","year":"2004","journal-title":"Cytokine Growth Factor. Rev."},{"key":"B89","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K Pathway in Human Disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"19469","DOI":"10.18632\/oncotarget.3625","article-title":"Curcumin Inhibits Angiogenesis and Improves Defective Hematopoiesis Induced by Tumor-Derived VEGF in Tumor Model through Modulating VEGF-VEGFR2 Signaling Pathway","volume":"6","author":"Fu","year":"2015","journal-title":"Oncotarget"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1093\/nar\/gkr006","article-title":"NF-kB and C-Jun Induce the Expression of the Oncogenic miR-221 and miR-222 in Prostate Carcinoma and Glioblastoma Cells","volume":"39","author":"Galardi","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1158\/2159-8290.Cd-15-0654","article-title":"EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer that Is Clinically Responsive to Afatinib","volume":"5","author":"Gallant","year":"2015","journal-title":"Cancer Discov."},{"key":"B93","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cytogfr.2015.03.003","article-title":"Functions of Fibroblast Growth Factor Receptors in Cancer Defined by Novel Translocations and Mutations","volume":"26","author":"Gallo","year":"2015","journal-title":"Cytokine Growth Factor. Rev."},{"key":"B94","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1038\/onc.2009.198","article-title":"Activating and Resistance Mutations of EGFR in Non-small-cell Lung Cancer: Role in Clinical Response to EGFR Tyrosine Kinase Inhibitors","volume":"28","author":"Gazdar","year":"2009","journal-title":"Oncogene"},{"key":"B95","doi-asserted-by":"publisher","first-page":"152556","DOI":"10.1016\/j.prp.2019.152556","article-title":"Curcumin Inhibits NF-kB and Wnt\/\u03b2-Catenin Pathways in Cervical Cancer Cells","volume":"215","author":"Ghasemi","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.3390\/nu11102376","article-title":"Curcumin and Cancer","volume":"11","author":"Giordano","year":"2019","journal-title":"Nutrients"},{"key":"B97","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1186\/1471-2407-10-626","article-title":"COX-2 Activation Is Associated with Akt Phosphorylation and Poor Survival in ER-Negative, HER2-Positive Breast Cancer","volume":"10","author":"Glynn","year":"2010","journal-title":"BMC Cancer"},{"key":"B98","doi-asserted-by":"publisher","first-page":"7079","DOI":"10.1158\/0008-5472.Can-14-2073","article-title":"ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors","volume":"74","author":"Goetz","year":"2014","journal-title":"Cancer Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1634\/theoncologist.2013-0168","article-title":"Chemotherapy with Erlotinib or Chemotherapy Alone in Advanced Non-small Cell Lung Cancer with Acquired Resistance to EGFR Tyrosine Kinase Inhibitors","volume":"18","author":"Goldberg","year":"2013","journal-title":"Oncologist"},{"key":"B100","doi-asserted-by":"publisher","first-page":"111512","DOI":"10.1016\/j.ejmech.2019.07.015","article-title":"Curcumin as Tyrosine Kinase Inhibitor in Cancer Treatment","volume":"181","author":"Golonko","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"e7273","DOI":"10.1371\/journal.pone.0007273","article-title":"High Expression Levels of Total IGF-1R and Sensitivity of NSCLC Cells In Vitro to an Anti-IGF-1r Antibody (R1507)","volume":"4","author":"Gong","year":"2009","journal-title":"PLoS One"},{"key":"B102","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1182\/blood.V120.21.3559.3559","article-title":"Curcumin Potentiates Antitumor Activity of Imatinib via Inhibition of the AKT\/mTOR Signaling Pathway and Down-Regulation of Bcr-Abl Gene in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia","volume":"120","author":"Gong","year":"2012","journal-title":"Blood"},{"key":"B103","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.neo.2018.06.007","article-title":"Oncogenic Function of a KIF5B-MET Fusion Variant in Non-small Cell Lung Cancer","volume":"20","author":"Gow","year":"2018","journal-title":"Neoplasia"},{"key":"B104","doi-asserted-by":"publisher","first-page":"63","DOI":"10.5173\/ceju.2016.726","article-title":"Microvascular Density and Immunohistochemical Expression of VEGF, VEGFR-1 and VEGFR-2 in Benign Prostatic Hyperplasia, High-Grade Prostate Intraepithelial Neoplasia and Prostate Cancer","volume":"69","author":"Grivas","year":"2016","journal-title":"Cent. Eur. J Urol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s12253-011-9430-7","article-title":"HGF\/c-Met Overexpressions, but Not Met Mutation, Correlates with Progression of Non-small Cell Lung Cancer","volume":"18","author":"Gumustekin","year":"2012","journal-title":"Pathol. Oncol. Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biocel.2015.05.003","article-title":"Curcumin Potentiates the Anti-leukemia Effects of Imatinib by Downregulation of the AKT\/mTOR Pathway and BCR\/ABL Gene Expression in Ph+ Acute Lymphoblastic Leukemia","volume":"65","author":"Guo","year":"2015","journal-title":"Int. J. Biochem. Cel Biol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1038\/modpathol.2013.108","article-title":"MET Overexpression Assessed by New Interpretation Method Predicts Gene Amplification and Poor Survival in Advanced Gastric Carcinomas","volume":"26","author":"Ha","year":"2013","journal-title":"Mod. Pathol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1023\/a:1026122421369","article-title":"Coexpression of IGF-1R and C-Src Proteins in Human Pancreatic Ductal Adenocarcinoma","volume":"48","author":"Hakam","year":"2003","journal-title":"Dig. Dis. Sci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3390\/biomedicines8090316","article-title":"Involvement of STAT5 in Oncogenesis","volume":"8","author":"Halim","year":"2020","journal-title":"Biomedicines"},{"key":"B110","first-page":"127","article-title":"Colorectal Cancer and NF-\u039ab Signaling Pathway","volume":"4","author":"Hassanzadeh","year":"2011","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"B111","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1126\/science.1079666","article-title":"PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors","volume":"299","author":"Heinrich","year":"2003","journal-title":"Science"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1097\/JTO.0b013e31826aed28","article-title":"FGFR1 Amplification in Squamous Cell Carcinoma of the Lung","volume":"7","author":"Heist","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1038\/sj.onc.1205248","article-title":"Hepatocyte Growth Factor Promotes Hepatocarcinogenesis through C-Met Autocrine Activation and Enhanced Angiogenesis in Transgenic Mice Treated with Diethylnitrosamine","volume":"21","author":"Horiguchi","year":"2002","journal-title":"Oncogene"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.22038\/ijbms.2019.35808.8530","article-title":"The Effect of Nanomicelle Curcumin, Sorafenib, and Combination of the Two on the Cyclin D1 Gene Expression of the Hepatocellular Carcinoma Cell Line (HUH7)","volume":"22","author":"Hosseini","year":"2019","journal-title":"Iran J. Basic Med. Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT Network at the Interface of Oncogenic Signalling and Cancer Metabolism","volume":"20","author":"Hoxhaj","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"B116","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/tox.22568","article-title":"Curcuminoids Combined with Gefitinib Mediated Apoptosis and Autophagy of Human Oral Cancer SAS Cellsin Vitroand Reduced Tumor of SAS Cell Xenograft Micein Vivo","volume":"33","author":"Hsiao","year":"2018","journal-title":"Environ. Toxicol."},{"key":"B117","first-page":"278","article-title":"Curcumin Suppresses Invasiveness and Vasculogenic Mimicry of Squamous Cell Carcinoma of the Larynx through the Inhibition of JAK-2\/STAT-3 Signaling Pathway","volume":"5","author":"Hu","year":"2014","journal-title":"Am. J. Cancer Res."},{"key":"B118","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.bbrc.2015.10.031","article-title":"A Polymeric Nanoparticle Formulation of Curcumin in Combination with Sorafenib Synergistically Inhibits Tumor Growth and Metastasis in an Orthotopic Model of Human Hepatocellular Carcinoma","volume":"468","author":"Hu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3892\/ol.2015.4063","article-title":"Curcumin Mediates Reversion of HGF-Induced Epithelial-Mesenchymal Transition via Inhibition of C-Met Expression in DU145 Cells","volume":"11","author":"Hu","year":"2016","journal-title":"Oncol. Lett."},{"key":"B120","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/leu.2010.272","article-title":"PDGFRA Rearrangement Leading to Hyper-Eosinophilia, T-Lymphoblastic Lymphoma, Myeloproliferative Neoplasm and Precursor B-Cell Acute Lymphoblastic Leukemia","volume":"25","author":"Huang","year":"2011","journal-title":"Leukemia"},{"key":"B121","doi-asserted-by":"publisher","first-page":"9691","DOI":"10.1074\/jbc.M211360200","article-title":"Differentiation Status-dependent Regulation of Cyclooxygenase-2 Expression and Prostaglandin E2 Production by Epidermal Growth Factor via Mitogen-Activated Protein Kinase in Articular Chondrocytes","volume":"278","author":"Huh","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B122","doi-asserted-by":"publisher","first-page":"152878","DOI":"10.1016\/j.prp.2020.152878","article-title":"High-level FGFR2 Amplification Is Associated with Poor Prognosis and Lower Response to Chemotherapy in Gastric Cancers","volume":"216","author":"Hur","year":"2020","journal-title":"Pathol. Res. Pract."},{"key":"B123","first-page":"3169","article-title":"Dietary Turmeric Potentially Reduces the Risk of Cancer","volume":"12","author":"Hutchins-Wolfbrandt","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B124","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1365-2990.2008.00977.x","article-title":"Epidermal Growth Factor Receptor Extracellular Domain Mutations in Primary Glioblastoma","volume":"35","author":"Idbaih","year":"2009","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.3390\/cancers11101428","article-title":"STAT3 and STAT5 Activation in Solid Cancers","volume":"11","author":"Igelmann","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B126","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/(sici)1097-0215(20000101)85:1<27:aid-ijc5>3.0.co;2-8","article-title":"Concomitant Over-expression of Vascular Endothelial Growth Factor and its Receptors in Pancreatic Cancer","volume":"85","author":"Itakura","year":"2000","journal-title":"Int. J. Cancer"},{"key":"B127","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1002\/cncr.11425","article-title":"Involvement of the P38 Mitogen-Activated Protein Kinase cascade in Hepatocellular Carcinoma","volume":"97","author":"Iyoda","year":"2003","journal-title":"Cancer"},{"key":"B128","first-page":"854","article-title":"A Potential Autocrine Role for Vascular Endothelial Growth Factor in Prostate Cancer","volume":"62","author":"Jackson","year":"2002","journal-title":"Cancer Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/ptr.5984","article-title":"Curcumin Mediated Down-Regulation of \u03b1V \u03b23 Integrin and Up-Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) in Erlotinib Resistant SW480 colon Cancer Cells","volume":"32","author":"Javadi","year":"2018","journal-title":"Phytother Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1172\/jci24652","article-title":"Autocrine PDGFR Signaling Promotes Mammary Cancer Metastasis","volume":"116","author":"Jechlinger","year":"2006","journal-title":"J. Clin. Invest."},{"key":"B131","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1158\/1078-0432.Ccr-07-4839","article-title":"Somatic Mutations of JAK1 and JAK3 in Acute Leukemias and Solid Cancers","volume":"14","author":"Jeong","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"B132","doi-asserted-by":"publisher","first-page":"15118","DOI":"10.18632\/oncotarget.7701","article-title":"FGFR1 Promotes the Stem Cell-like Phenotype of FGFR1-Amplified Non-small Cell Lung Cancer Cells through the Hedgehog Pathway","volume":"7","author":"Ji","year":"2016","journal-title":"Oncotarget"},{"key":"B133","doi-asserted-by":"publisher","first-page":"9453","DOI":"10.1073\/pnas.1821068116","article-title":"Inflammatory Regulatory Network Mediated by the Joint Action of NF-kB, STAT3, and AP-1 Factors Is Involved in many Human Cancers","volume":"116","author":"Ji","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B134","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jnutbio.2013.11.001","article-title":"Down-regulation of Epidermal Growth Factor Receptor by Curcumin-Induced UBE1L in Human Bronchial Epithelial Cells","volume":"25","author":"Jiang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.3892\/ol.2020.11274","article-title":"Expression and Clinical Significance of MAPK and EGFR in Triple-Negative Breast Cancer","volume":"19","author":"Jiang","year":"2020","journal-title":"Oncol. Lett."},{"key":"B136","doi-asserted-by":"publisher","first-page":"16018","DOI":"10.1038\/mto.2016.18","article-title":"Curcumin Inhibited HGF-Induced EMT and Angiogenesis through Regulating C-Met Dependent PI3K\/Akt\/mTOR Signaling Pathways in Lung Cancer","volume":"3","author":"Jiao","year":"2016","journal-title":"Mol. Ther. Oncolytics"},{"key":"B137","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12943-018-0801-5","article-title":"Advances in Studies of Tyrosine Kinase Inhibitors and Their Acquired Resistance","volume":"17","author":"Jiao","year":"2018","journal-title":"Mol. Cancer"},{"key":"B138","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1200\/JCO.2014.57.4970","article-title":"KIT and PDGFRA Mutations and the Risk of GI Stromal Tumor Recurrence","volume":"33","author":"Joensuu","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1038\/sj.onc.1209955","article-title":"Transgenic Overexpression of IGF-IR Disrupts Mammary Ductal Morphogenesis and Induces Tumor Formation","volume":"26","author":"Jones","year":"2007","journal-title":"Oncogene"},{"key":"B140","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0145-2126(94)90003-5","article-title":"The Met\/hepatocyte Growth Factor Receptor (HGFR) Gene Is Overexpressed in Some Cases of Human Leukemia and Lymphoma","volume":"18","author":"J\u00fccker","year":"1994","journal-title":"Leuk. Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1124\/mol.114.096065","article-title":"The C-Met\/pi3k Signaling Is Associated with Cancer Resistance to Doxorubicin and Photodynamic Therapy by Elevating BCRP\/ABCG2 Expression","volume":"87","author":"Jung","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.bbamcr.2007.01.002","article-title":"Regulation of MAPKs by Growth Factors and Receptor Tyrosine Kinases","volume":"1773","author":"Katz","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/nm.2819","article-title":"Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia","volume":"18","author":"Kentsis","year":"2012","journal-title":"Nat. Med."},{"key":"B144","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3390\/ijms21020438","article-title":"Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-like Cells through Targeting of the JAK\/STAT3 Signaling Pathway","volume":"21","author":"Khan","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.3389\/fonc.2020.01246","article-title":"Impact of Tyrosine Kinase Inhibitors (TKIs) Combined with Radiation Therapy for the Management of Brain Metastases from Renal Cell Carcinoma","volume":"10","author":"Khan","year":"","journal-title":"Front. Oncol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s11626-014-9791-9","article-title":"Chemopreventive Effects of Curcumin on Chemically Induced Mouse Skin Carcinogenesis in BK5.Insulin-like Growth Factor-1 Transgenic Mice","volume":"50","author":"Kim","year":"2014","journal-title":"In Vitro"},{"key":"B147","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3892\/ol.2011.531","article-title":"Cancer Stem-like Cells Persist in Established Cell Lines through Autocrine Activation of EGFR Signaling","volume":"3","author":"Kim","year":"2012","journal-title":"Oncol. Lett."},{"key":"B148","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1093\/carcin\/bgi272","article-title":"Inhibition of EGFR Signaling in Human Prostate Cancer PC-3 Cells by Combination Treatment with Beta-Phenylethyl Isothiocyanate and Curcumin","volume":"27","author":"Kim","year":"2005","journal-title":"Carcinogenesis"},{"key":"B149","first-page":"31","article-title":"Clinical Significance of VEGFR-2 and VEGFR-3 Expression in Ovarian Cancer Patients","volume":"62","author":"Klasa-Mazurkiewicz","year":"2011","journal-title":"Pol. J. Pathol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1056\/NEJMoa044238","article-title":"EGFR Mutation and Resistance of Non-small-cell Lung Cancer to Gefitinib","volume":"352","author":"Kobayashi","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B151","doi-asserted-by":"publisher","first-page":"7205","DOI":"10.1158\/1078-0432.CCR-08-0818","article-title":"Vascular Endothelial Growth Factor C Stimulates Progression of Human Gastric Cancer via Both Autocrine and Paracrine Mechanisms","volume":"14","author":"Kodama","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"B152","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1158\/2159-8290.CD-16-0075","article-title":"EGFR Fusions as Novel Therapeutic Targets in Lung Cancer","volume":"6","author":"Konduri","year":"2016","journal-title":"Cancer Discov."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1038\/sj.onc.1203437","article-title":"M6P\/IGF2R Is Mutated in Squamous Cell Carcinoma of the Lung","volume":"19","author":"Kong","year":"2000","journal-title":"Oncogene"},{"key":"B154","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1128\/MCB.21.12.3964-3973.2001","article-title":"NF-kappaB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling","volume":"21","author":"Kreuz","year":"2001","journal-title":"Mol. Cel Biol"},{"key":"B155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-13-1486-5_1","article-title":"HGFR and FGR2: Their Roles in Progression and Metastasis of Esophageal Cancer","volume-title":"Role of Tyrosine Kinases in Gastrointestinal Malignancies","author":"Kumar","year":"2018"},{"key":"B156","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1152\/physrev.2001.81.2.807","article-title":"Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation","volume":"81","author":"Kyriakis","year":"2001","journal-title":"Physiol. Rev."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/486568","article-title":"The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: AnIn VitroandIn VivoComparison Study with Herceptin","volume":"2012","author":"Lai","year":"2012","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B158","doi-asserted-by":"publisher","first-page":"114734","DOI":"10.1016\/j.taap.2019.114734","article-title":"Gefitinib and Curcumin-Loaded Nanoparticles Enhance Cell Apoptosis in Human Oral Cancer SAS Cells In Vitro and Inhibit SAS Cell Xenografted Tumor In Vivo","volume":"382","author":"Lai","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s10585-018-9919-5","article-title":"The Therapeutic Targeting of the FGFR1\/Src\/NF-\u039ab Signaling axis Inhibits Pancreatic Ductal Adenocarcinoma Stemness and Oncogenicity","volume":"35","author":"Lai","year":"2018","journal-title":"Clin. Exp. Metastasis"},{"key":"B160","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1053\/j.semdp.2006.08.006","article-title":"KIT and PDGFRA Mutations in Gastrointestinal Stromal Tumors (GISTs)","volume":"23","author":"Lasota","year":"2006","journal-title":"Semin. Diagn. Pathol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00109-006-0054-4","article-title":"Gene Amplification, Mutation, and Protein Expression of EGFR and Mutations of ERBB2 in Serous Ovarian Carcinoma","volume":"84","author":"Lassus","year":"2006","journal-title":"J. Mol. Med. (Berl)"},{"key":"B162","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1038\/sj.bjc.6602252","article-title":"Genetic Alterations and Protein Expression of KIT and PDGFRA in Serous Ovarian Carcinoma","volume":"91","author":"Lassus","year":"2004","journal-title":"Br. J. Cancer"},{"key":"B163","first-page":"4783","article-title":"Synergistic Antitumor Activity of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib and Curcumin in Non-small-cell Lung Cancer","volume":"67","author":"Lee","year":"2007","journal-title":"Cancer Res."},{"key":"B164","doi-asserted-by":"publisher","first-page":"e23756","DOI":"10.1371\/journal.pone.0023756","article-title":"Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates P38 Activation in Intestine: the Versatile Adjuvant for Gefitinib Therapy","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"B165","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.clcc.2018.02.013","article-title":"c-MET Overexpression in Colorectal Cancer: A Poor Prognostic Factor for Survival","volume":"17","author":"Lee","year":"2018","journal-title":"Clin. Colorectal Cancer"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell Signaling by Receptor Tyrosine Kinases","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1038\/sj.bjc.6603143","article-title":"Vascular Endothelial Growth Factor Receptor-1 Mediates Migration of Human Colorectal Carcinoma Cells by Activation of Src Family Kinases","volume":"94","author":"Lesslie","year":"2006","journal-title":"Br. J. Cancer"},{"key":"B168","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.jnutbio.2014.03.014","article-title":"Curcumin Induces Apoptosis and Inhibits Growth of Orthotopic Human Non-small Cell Lung Cancer Xenografts","volume":"25","author":"Lev-Ari","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"B169","first-page":"4423","article-title":"Inhibition of Pancreatic and Lung Adenocarcinoma Cell Survival by Curcumin Is Associated with Increased Apoptosis, Down-Regulation of COX-2 and EGFR and Inhibition of Erk1\/2 Activity","volume":"26","author":"Lev-Ari","year":"2006","journal-title":"Anticancer Res."},{"key":"B170","doi-asserted-by":"publisher","first-page":"6241","DOI":"10.1021\/bi060609y","article-title":"Role of Receptor Tyrosine Kinase Transmembrane Domains in Cell Signaling and Human Pathologies","volume":"45","author":"Li","year":"2006","journal-title":"Biochemistry"},{"key":"B171","doi-asserted-by":"publisher","first-page":"e21816","DOI":"10.1371\/journal.pone.0021816","article-title":"Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"B172","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.4049\/jimmunol.1801199","article-title":"FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK\/STAT3 Signaling Pathway","volume":"202","author":"Li","year":"","journal-title":"J. Immunol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3727\/096504013x13832473330032","article-title":"Curcumin Lowers Erlotinib Resistance in Non-small Cell Lung Carcinoma Cells with Mutated EGF Receptor","volume":"21","author":"Li","year":"2013","journal-title":"Oncol. Res."},{"key":"B174","doi-asserted-by":"publisher","first-page":"80579","DOI":"10.18632\/oncotarget.13013","article-title":"Sphk1 Promotes Breast Epithelial Cell Proliferation via NF-\u039ab-P65-Mediated Cyclin D1 Expression","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"B175","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3892\/or.2018.6833","article-title":"Curcumin Attenuates Hyperglycemia-Driven EGF-Induced Invasive and Migratory Abilities of Pancreatic Cancer via Suppression of the ERK and AKT Pathways","volume":"41","author":"Li","year":"","journal-title":"Oncol. Rep."},{"key":"B176","doi-asserted-by":"publisher","first-page":"6756","DOI":"10.3892\/ol.2018.9488","article-title":"Anticancer Effects of Curcumin on Nude Mice Bearing Lung Cancer A549 Cell Subsets SP and NSP Cells","volume":"16","author":"Li","year":"","journal-title":"Oncol. Lett."},{"key":"B177","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1186\/s12885-018-5130-y","article-title":"Curcumin Inhibits Proliferation, Migration, Invasion and Promotes Apoptosis of Retinoblastoma Cell Lines through Modulation of miR-99a and JAK\/STAT Pathway","volume":"18","author":"Li","year":"","journal-title":"BMC Cancer"},{"key":"B178","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12885-019-5322-0","article-title":"VEGFR2 Promotes Tumorigenesis and Metastasis in a Pro-angiogenic-independent Way in Gastric Cancer","volume":"19","author":"Lian","year":"2019","journal-title":"BMC Cancer"},{"key":"B179","doi-asserted-by":"publisher","first-page":"6189","DOI":"10.2147\/OTT.S178497","article-title":"Immunotherapy Combined with Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-small-cell Lung Cancer Treatment","volume":"11","author":"Liang","year":"2018","journal-title":"Onco Targets Ther."},{"key":"B180","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/1476-4598-9-217","article-title":"A Novel Small Molecule Inhibits STAT3 Phosphorylation and DNA Binding Activity and Exhibits Potent Growth Suppressive Activity in Human Cancer Cells","volume":"9","author":"Lin","year":"","journal-title":"Mol. Cancer"},{"key":"B181","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1158\/0008-5472.CAN-09-2468","article-title":"Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells","volume":"70","author":"Lin","year":"","journal-title":"Cancer Res."},{"key":"B182","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.canlet.2009.04.037","article-title":"Curcumin Inhibits the Migration and Invasion of Human A549 Lung Cancer Cells through the Inhibition of Matrix Metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)","volume":"285","author":"Lin","year":"2009","journal-title":"Cancer Lett."},{"key":"B183","first-page":"411","article-title":"EGFR-TKI Resistance in NSCLC Patients: Mechanisms and Strategies","volume":"4","author":"Lin","year":"2014","journal-title":"Am. J. Cancer Res."},{"key":"B184","doi-asserted-by":"publisher","first-page":"11990","DOI":"10.18632\/oncotarget.14467","article-title":"Autocrine VEGF Signaling Promotes Cell Proliferation through a PLC-dependent Pathway and Modulates Apatinib Treatment Efficacy in Gastric Cancer","volume":"8","author":"Lin","year":"2017","journal-title":"Oncotarget"},{"key":"B185","doi-asserted-by":"publisher","first-page":"e13009","DOI":"10.1111\/cpr.13009","article-title":"Inhibition of FGF-FGFR and VEGF-VEGFR Signalling in Cancer Treatment","volume":"54","author":"Liu","year":"2021","journal-title":"Cell Prolif"},{"key":"B186","doi-asserted-by":"publisher","first-page":"10844","DOI":"10.1128\/MCB.24.24.10844-10856.2004","article-title":"c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced C-Jun Kinase Activation and Apoptosis","volume":"24","author":"Liu","year":"2004","journal-title":"Mol. Cel Biol"},{"key":"B187","doi-asserted-by":"publisher","first-page":"e11594","DOI":"10.1200\/jco.2015.33.15_suppl.e11594","article-title":"Effect of Curcumin on Lapatinib Sensitivity and Lapatinib Resistance Associated EMT and Stem-like Phenotype in HER2 Positive Breast Cancer","volume":"33","author":"Liu","year":"2015","journal-title":"Jco"},{"key":"B188","first-page":"3729","article-title":"Platelet-derived Growth Factor (PDGF) Autocrine Signaling Regulates Survival and Mitogenic Pathways in Glioblastoma Cells: Evidence that the Novel PDGF-C and PDGF-D Ligands May Play a Role in the Development of Brain Tumors","volume":"62","author":"Lokker","year":"2002","journal-title":"Cancer Res."},{"key":"B189","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.prp.2004.11.008","article-title":"VEGFR-3 Expression in Breast Cancer Tissue Is Not Restricted to Lymphatic Vessels","volume":"201","author":"Longatto Filho","year":"2005","journal-title":"Pathol. Res. Pract."},{"key":"B190","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/molecules26010030","article-title":"Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells' Migration and Invasion in Culture by Inhibition of uPA via the JAK\/STAT Signaling Pathway","volume":"26","author":"Lu","year":"2020","journal-title":"Molecules"},{"key":"B191","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1172\/JCI26322","article-title":"IKK\/NF-kappaB Signaling: Balancing Life and Death-Aa New Approach to Cancer Therapy","volume":"115","author":"Luo","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B192","doi-asserted-by":"publisher","first-page":"6422","DOI":"10.1039\/c9fo01901d","article-title":"Curcumin-enhanced Antitumor Effects of Sorafenib via Regulating the Metabolism and Tumor Microenvironment","volume":"11","author":"Man","year":"2020","journal-title":"Food Funct."},{"key":"B193","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1186\/s12885-020-07256-8","article-title":"Clinical Effects of Curcumin in Enhancing Cancer Therapy: A Systematic Review","volume":"20","author":"Mansouri","year":"2020","journal-title":"BMC Cancer"},{"key":"B194","doi-asserted-by":"publisher","first-page":"5974","DOI":"10.1158\/1078-0432.Ccr-19-3958","article-title":"Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer","volume":"26","author":"Mao","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"B195","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.3748\/wjg.v11.i22.3385","article-title":"Activation of JAK-STAT Pathway Is Required for Platelet-Derived Growth Factor-Induced Proliferation of Pancreatic Stellate Cells","volume":"11","author":"Masamune","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1038\/sj.onc.1209232","article-title":"Autocrine Activation of PDGFRalpha Promotes the Progression of Ovarian Cancer","volume":"25","author":"Matei","year":"2006","journal-title":"Oncogene"},{"key":"B197","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/bjc.2011.603","article-title":"FGFR2 Gene Amplification and Clinicopathological Features in Gastric Cancer","volume":"106","author":"Matsumoto","year":"2012","journal-title":"Br. J. Cancer"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.2353\/ajpath.2009.081139","article-title":"Autocrine Loop between Vascular Endothelial Growth Factor (VEGF)-C and VEGF Receptor-3 Positively Regulates Tumor-Associated Lymphangiogenesis in Oral Squamoid Cancer Cells","volume":"175","author":"Matsuura","year":"2009","journal-title":"Am. J. Pathol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12094-012-0889-9","article-title":"EGFR Expression Is Linked to Osteopontin and Nf-\u039ab Signaling in clear Cell Renal Cell Carcinoma","volume":"15","author":"Matu\u0161an-Ilija\u0161","year":"2013","journal-title":"Clin. Transl Oncol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"179","DOI":"10.7314\/apjcp.2014.15.1.179","article-title":"Curcumin and its Analogues (PGV-0 and PGV-1) Enhance Sensitivity of Resistant MCF-7 Cells to Doxorubicin through Inhibition of HER2 and NF-kB Activation","volume":"15","author":"Meiyanto","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B201","first-page":"327","article-title":"In Vivo antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Receptors: Determination of a Pharmacokinetic\/pharmacodynamic Relationship","volume":"9","author":"Mendel","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"B202","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1002\/cber.191004302168","article-title":"Zur Kenntnis des Curcumins","volume":"43","author":"Mi\u0142ob\u0229dzka","year":"1910","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"B203","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3332\/ecancer.2015.525","article-title":"Curcumin Modulates Cellular AP-1, NF-kB, and HPV16 E6 Proteins in Oral Cancer","volume":"9","author":"Mishra","year":"2015","journal-title":"Ecancermedicalscience"},{"key":"B204","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1210\/me.2009-0387","article-title":"Mixed Lineage Kinase-3\/JNK1 Axis Promotes Migration of Human Gastric Cancer Cells Following Gastrin Stimulation","volume":"24","author":"Mishra","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/S0006-291X(03)00281-X","article-title":"Overexpression of Hepatocyte Growth Factor Receptor in Renal Carcinoma Cells Indirectly Stimulates Tumor Growth In Vivo","volume":"302","author":"Miyata","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B206","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/s0092-8674(00)80131-2","article-title":"Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism","volume":"86","author":"Mohammadi","year":"1996","journal-title":"Cell"},{"key":"B207","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/ajcp\/aqv013","article-title":"FGFR1 Amplification in Squamous Cell Carcinoma of the Lung with Correlation of Primary and Metastatic Tumor Status","volume":"145","author":"Monaco","year":"2015","journal-title":"Am. J. Clin. Pathol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1111\/j.1349-7006.2008.00962.x","article-title":"Association of Epidermal Growth Factor Receptor (EGFR) Gene Mutations with EGFR Amplification in Advanced Non-small Cell Lung Cancer","volume":"99","author":"Morinaga","year":"2008","journal-title":"Cancer Sci."},{"key":"B209","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.canlet.2014.12.007","article-title":"Antiangiogenic Effects of a Novel Synthetic Curcumin Analogue in Pancreatic Cancer","volume":"357","author":"Nagaraju","year":"2015","journal-title":"Cancer Lett."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/po.18.00013","article-title":"Enrichment of FGFR3-TACC3 Fusions in Patients with Bladder Cancer Who Are Young, Asian, or Have Never Smoked","volume":"2","author":"Nassar","year":"2018","journal-title":"JCO Precision Oncol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"462","DOI":"10.2174\/156800910791517208","article-title":"Tyrosine Kinase Inhibitors","volume":"10","author":"Natoli","year":"2010","journal-title":"Curr. Cancer Drug Targets"},{"key":"B212","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/ijc.25410","article-title":"Curcumin Enhances Dasatinib-Induced Inhibition of Growth and Transformation of colon Cancer Cells","volume":"128","author":"Nautiyal","year":"","journal-title":"Int. J. Cancer"},{"key":"B213","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1750-2187-6-7","article-title":"Combination of Dasatinib and Curcumin Eliminates Chemo-Resistant colon Cancer Cells","volume":"6","author":"Nautiyal","year":"","journal-title":"J. Mol. Signal."},{"key":"B214","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1158\/1541-7786.Mcr-15-0497","article-title":"Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation","volume":"14","author":"Nelson","year":"2016","journal-title":"Mol. Cancer Res."},{"key":"B215","doi-asserted-by":"publisher","first-page":"31768","DOI":"10.1074\/jbc.M203995200","article-title":"Deletion of the Carboxyl Terminus of Tie2 Enhances Kinase Activity, Signaling, and Function. Evidence for an Autoinhibitory Mechanism","volume":"277","author":"Niu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B216","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.canlet.2004.10.051","article-title":"Antitumor Effects of Curcumin, Alone or in Combination with Cisplatin or Doxorubicin, on Human Hepatic Cancer Cells. Analysis of Their Possible Relationship to Changes in NF-kB Activation Levels and in IAP Gene Expression","volume":"224","author":"Notarbartolo","year":"2005","journal-title":"Cancer Lett."},{"key":"B217","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.immuni.2018.03.003","article-title":"Loss of NF-\u039ab1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-dependent Manner","volume":"48","author":"O'Reilly","year":"2018","journal-title":"Immunity"},{"key":"B218","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention","volume":"66","author":"O'Shea","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"B219","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.3892\/ol.2020.11523","article-title":"Curcumin Inhibits Epithelial-Mesenchymal Transition in Oral Cancer Cells via C-Met Blockade","volume":"19","author":"Ohnishi","year":"2020","journal-title":"Oncol. Lett."},{"key":"B220","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.intimp.2011.12.009","article-title":"Inhibition of the NF-\u039ab Signaling Pathway by the Curcumin Analog, 3,5-Bis(2-Pyridinylmethylidene)-4-Piperidone (EF31): Anti-inflammatory and Anti-cancer Properties","volume":"12","author":"Olivera","year":"2012","journal-title":"Int. Immunopharmacol"},{"key":"B221","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/jop.12571","article-title":"PDGFRA mRNA Is Overexpressed in Oral Cancer Patients as Compared to normal Subjects with a Significant Trend of Overexpression Among Tobacco Users","volume":"46","author":"Ong","year":"2017","journal-title":"J. Oral Pathol. Med."},{"key":"B222","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/jop.12713","article-title":"PDGFRA mRNA Overexpression Is Associated with Regional Metastasis and Reduced Survival in Oral Squamous Cell Carcinoma","volume":"47","author":"Ong","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"B223","doi-asserted-by":"publisher","first-page":"35119","DOI":"10.18632\/oncotarget.9046","article-title":"JNK2 Downregulation Promotes Tumorigenesis and Chemoresistance by Decreasing P53 Stability in Bladder Cancer","volume":"7","author":"Pan","year":"2016","journal-title":"Oncotarget"},{"key":"B224","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.3892\/ol.2018.7988","article-title":"Curcumin Inhibits Hepatocellular Carcinoma Growth by Targeting VEGF Expression","volume":"15","author":"Pan","year":"2018","journal-title":"Oncol. Lett."},{"key":"B225","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/modpathol.2013.251","article-title":"High EGFR Gene Copy Number Predicts Poor Outcome in Triple-Negative Breast Cancer","volume":"27","author":"Park","year":"2014","journal-title":"Mod. Pathol."},{"key":"B226","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.molonc.2008.09.006","article-title":"Curcumin in Combination with Bortezomib Synergistically Induced Apoptosis in Human Multiple Myeloma U266 Cells","volume":"2","author":"Park","year":"2008","journal-title":"Mol. Oncol."},{"key":"B227","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1172\/jci67144","article-title":"The Tumorigenic FGFR3-TACC3 Gene Fusion Escapes miR-99a Regulation in Glioblastoma","volume":"123","author":"Parker","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B228","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/path.4297","article-title":"Emergence of FGFR Family Gene Fusions as Therapeutic Targets in a Wide Spectrum of Solid Tumours","volume":"232","author":"Parker","year":"2014","journal-title":"J. Pathol."},{"key":"B229","first-page":"319","article-title":"Curcumin Targets FOLFOX-Surviving colon Cancer Cells via Inhibition of EGFRs and IGF-1R","volume":"30","author":"Patel","year":"2010","journal-title":"Anticancer Res."},{"key":"B230","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/ijc.23097","article-title":"Curcumin Enhances the Effects of 5-fluorouracil and Oxaliplatin in Mediating Growth Inhibition of colon Cancer Cells by Modulating EGFR and IGF-1R","volume":"122","author":"Patel","year":"2008","journal-title":"Int. J. Cancer"},{"key":"B231","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.ygyno.2007.02.012","article-title":"Insulin-like Growth Factor 2 and its Receptors (IGF 1R and IGF 2R\/mannose 6-phosphate) in Endometrial Adenocarcinoma","volume":"105","author":"Paveli\u0107","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/path.1465","article-title":"Gastric Cancer: the Role of Insulin-like Growth Factor 2 (IGF 2) and its Receptors (IGF 1R and M6-P\/IGF 2R)","volume":"201","author":"Paveli\u0107","year":"2003","journal-title":"J. Pathol."},{"key":"B233","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1158\/2159-8290.Cd-15-1246","article-title":"High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial","volume":"6","author":"Pearson","year":"2016","journal-title":"Cancer Discov."},{"key":"B234","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1002\/hep.27236","article-title":"Autocrine Vascular Endothelial Growth Factor Signaling Promotes Cell Proliferation and Modulates Sorafenib Treatment Efficacy in Hepatocellular Carcinoma","volume":"60","author":"Peng","year":"2014","journal-title":"Hepatology"},{"key":"B235","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1136\/jcp.2004.021766","article-title":"The Location of KIT and PDGFRA Gene Mutations in Gastrointestinal Stromal Tumours Is Site and Phenotype Associated","volume":"58","author":"Penzel","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"B236","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1667\/0033-7587(2002)158[0174:irepam]2.0.co;2","article-title":"IGF1 Receptor Expression Protects against Microenvironmental Stress Found in the Solid Tumor","volume":"158","author":"Peretz","year":"2002","journal-title":"Radiat. Res."},{"key":"B237","doi-asserted-by":"publisher","first-page":"4349","DOI":"10.1111\/jcmm.14326","article-title":"Curcumin Induces Apoptosis in JAK2-Mutated Cells by the Inhibition of JAK2\/STAT and mTORC1 Pathways","volume":"23","author":"Petiti","year":"2019","journal-title":"J. Cel Mol Med"},{"key":"B238","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/sj.onc.1201590","article-title":"Oncogenic Activation of the PDGF Beta Receptor by the Transmembrane Domain of P185neu*","volume":"16","author":"Petti","year":"1998","journal-title":"Oncogene"},{"key":"B239","doi-asserted-by":"publisher","first-page":"6465","DOI":"10.1038\/sj.onc.1208802","article-title":"PKB\/Akt Induces Transcription of Enzymes Involved in Cholesterol and Fatty Acid Biosynthesis via Activation of SREBP","volume":"24","author":"Porstmann","year":"2005","journal-title":"Oncogene"},{"key":"B240","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.critrevonc.2017.02.018","article-title":"FGFR a Promising Druggable Target in Cancer: Molecular Biology and New Drugs","volume":"113","author":"Porta","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030731","article-title":"Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy","volume":"12","author":"Pottier","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B242","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1158\/0008-5472.Can-19-3682","article-title":"The Frequency of Ras Mutations in Cancer","volume":"80","author":"Prior","year":"2020","journal-title":"Cancer Res."},{"key":"B243","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1080\/07357900801941852","article-title":"TLR4 Signaling Induces B7-H1 Expression through MAPK Pathways in Bladder Cancer Cells","volume":"26","author":"Qian","year":"2008","journal-title":"Cancer Invest."},{"key":"B244","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.yexmp.2013.10.005","article-title":"B-raf Mutation: A Key Player in Molecular Biology of Cancer","volume":"95","author":"Rahman","year":"2013","journal-title":"Exp. Mol. Pathol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"761608","DOI":"10.1155\/2014\/761608","article-title":"Curcumin: a Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways","volume":"2014","author":"Rahmani","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"B246","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.bbrc.2005.12.014","article-title":"Curcumin Induces Growth-Arrest and Apoptosis in Association with the Inhibition of Constitutively Active JAK-STAT Pathway in T Cell Leukemia","volume":"340","author":"Rajasingh","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B247","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/mc.22492","article-title":"Novel Synthetic Curcumin Analogs as Potent Antiangiogenic Agents in Colorectal Cancer","volume":"56","author":"Rajitha","year":"2017","journal-title":"Mol. Carcinog"},{"key":"B248","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/B978-0-12-386503-8.00006-5","article-title":"Role of the VEGF\/VEGFR axis in Cancer Biology and Therapy","volume":"114","author":"Rapisarda","year":"2012","journal-title":"Adv. Cancer Res."},{"key":"B249","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1023\/a:1005903000777","article-title":"Paracrine\/autocrine Regulation of Breast Cancer by the Insulin-like Growth Factors","volume":"47","author":"Rasmussen","year":"1998","journal-title":"Breast Cancer Res. Treat."},{"key":"B250","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/sj.onc.1209859","article-title":"A Positive Feedback Loop between Hepatocyte Growth Factor Receptor and Beta-Catenin Sustains Colorectal Cancer Cell Invasive Growth","volume":"26","author":"Rasola","year":"2007","journal-title":"Oncogene"},{"key":"B251","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1207\/s15327914nc5502_10","article-title":"Mechanisms of Curcumin- and EGF-Receptor Related Protein (ERRP)-dependent Growth Inhibition of colon Cancer Cells","volume":"55","author":"Reddy","year":"2006","journal-title":"Nutr. Cancer"},{"key":"B252","first-page":"2463","article-title":"The Insulin-like Growth Factor I Receptor Protects Tumor Cells from Apoptosis In Vivo","volume":"55","author":"Resnicoff","year":"1995","journal-title":"Cancer Res."},{"key":"B253","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.phrs.2019.03.006","article-title":"Properties of FDA-Approved Small Molecule Protein Kinase Inhibitors","volume":"144","author":"Roskoski","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B254","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1158\/1541-7786.Mcr-18-0429","article-title":"The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT","volume":"17","author":"Ryan","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"B255","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.molcel.2014.05.028","article-title":"Akt Phosphorylation and Regulation of Transketolase Is a Nodal point for Amino Acid Control of Purine Synthesis","volume":"55","author":"Saha","year":"2014","journal-title":"Mol. Cel"},{"key":"B256","doi-asserted-by":"publisher","first-page":"603235","DOI":"10.3389\/fphar.2020.603235","article-title":"Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K\/AKT and JAK\/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA","volume":"11","author":"Sandhiutami","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B257","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1158\/0008-5472.Can-06-1147","article-title":"c-Met Overexpression Is a Prognostic Factor in Ovarian Cancer and an Effective Target for Inhibition of Peritoneal Dissemination and Invasion","volume":"67","author":"Sawada","year":"2007","journal-title":"Cancer Res."},{"key":"B258","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.nutres.2020.05.007","article-title":"Lower Concentrations of Curcumin Inhibit Her2-Akt Pathway Components in Human Breast Cancer Cells, and Other Dietary Botanicals Potentiate This and Lapatinib Inhibition","volume":"78","author":"Saxena","year":"2020","journal-title":"Nutr. Res."},{"key":"B259","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/jcb.22558","article-title":"Curcumin Suppresses Constitutive Activation of STAT-3 by Up-Regulating Protein Inhibitor of Activated STAT-3 (PIAS-3) in Ovarian and Endometrial Cancer Cells","volume":"110","author":"Saydmohammed","year":"2010","journal-title":"J. Cel Biochem"},{"key":"B260","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/s0092-8674(00)00114-8","article-title":"Cell Signaling by Receptor Tyrosine Kinases","volume":"103","author":"Schlessinger","year":"2000","journal-title":"Cell"},{"key":"B261","doi-asserted-by":"publisher","first-page":"6579","DOI":"10.1158\/1078-0432.Ccr-07-1257","article-title":"Clinical Significance of Epidermal Growth Factor Receptor Protein Overexpression and Gene Copy Number Gains in Prostate Cancer","volume":"13","author":"Schlomm","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"B262","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/sj.leu.2404154","article-title":"Identification of a Novel Imatinib Responsive KIF5B-PDGFRA Fusion Gene Following Screening for PDGFRA Overexpression in Patients with Hypereosinophilia","volume":"20","author":"Score","year":"2006","journal-title":"Leukemia"},{"key":"B263","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbo.2015.01.001","article-title":"Receptor Tyrosine Kinases: Characterisation, Mechanism of Action and Therapeutic Interests for Bone Cancers","volume":"4","author":"S\u00e9galiny","year":"2015","journal-title":"J. Bone Oncol."},{"key":"B264","doi-asserted-by":"publisher","first-page":"37","DOI":"10.22037\/ipa.v1i1.19945","article-title":"Co-delivery of Curcumin and Imatinib by Nanostructured Lipid Carriers in the Treatment of Lymphoma","volume":"1","author":"Setareh","year":"2018","journal-title":"Int. Pharm. Acta"},{"key":"B265","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.lungcan.2006.02.009","article-title":"Prognostic Value of Expression of Vascular Endothelial Growth Factor and its Flt-1 and KDR Receptors in Stage I Non-small-cell Lung Cancer","volume":"53","author":"Seto","year":"2006","journal-title":"Lung Cancer"},{"key":"B266","doi-asserted-by":"publisher","first-page":"262","DOI":"10.2174\/1570161116666180209113014","article-title":"Anti-angiogenic Activity of Curcumin in Cancer Therapy: a Narrative Review","volume":"17","author":"Shakeri","year":"2019","journal-title":"Curr. Vasc. Pharmacol."},{"key":"B267","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/j.1365-2559.2011.03921.x","article-title":"Epidermal Growth Factor Receptor Gene Amplification and Protein Overexpression in Basal-like Carcinoma of the Breast","volume":"59","author":"Shao","year":"2011","journal-title":"Histopathology"},{"key":"B268","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13039-017-0306-8","article-title":"Multiple MYO18A-PDGFRB Fusion Transcripts in a Myeloproliferative Neoplasm Patient with T(5;17)(q32;q11)","volume":"10","author":"Sheng","year":"2017","journal-title":"Mol. Cytogenet."},{"key":"B269","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/ijc.21496","article-title":"Somatic Mutations of Epidermal Growth Factor Receptor Signaling Pathway in Lung Cancers","volume":"118","author":"Shigematsu","year":"2006","journal-title":"Int. J. Cancer"},{"key":"B270","first-page":"2541","article-title":"Expression of IGF-1 and IGF-1R and Their Relation to Clinicopathological Factors in Colorectal Cancer","volume":"31","author":"Shiratsuchi","year":"2011","journal-title":"Anticancer Res."},{"key":"B271","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/ijc.25441","article-title":"VEGFR-2 Expression in Carcinoid Cancer Cells and its Role in Tumor Growth and Metastasis","volume":"128","author":"Silva","year":"2011","journal-title":"Int. J. Cancer"},{"key":"B272","first-page":"2841","article-title":"Primary and Secondary Resistance to Tyrosine Kinase Inhibitors in Lung Cancer","volume":"34","author":"Simasi","year":"2014","journal-title":"Anticancer Res."},{"key":"B273","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1126\/science.1220834","article-title":"Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma","volume":"337","author":"Singh","year":"2012","journal-title":"Science"},{"key":"B274","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ebiom.2019.02.051","article-title":"OVA66 Promotes Tumour Angiogenesis and Progression through Enhancing Autocrine VEGF-VEGFR2 Signalling","volume":"41","author":"Song","year":"2019","journal-title":"EBioMedicine"},{"key":"B275","doi-asserted-by":"publisher","first-page":"703","DOI":"10.2147\/CMAR.S225376","article-title":"EGFR Promotes the Development of Triple Negative Breast Cancer through JAK\/STAT3 Signaling","volume":"12","author":"Song","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"B276","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/ijc.24028","article-title":"Functional Significance of VEGFR-2 on Ovarian Cancer Cells","volume":"124","author":"Spannuth","year":"2009","journal-title":"Int. J. Cancer"},{"key":"B277","doi-asserted-by":"publisher","first-page":"372","DOI":"10.7868\/s0026898417020197","article-title":"Transcription Factors NF-kB, HIF-1, HIF-2, Growth Factor VEGF, VEGFR2 and Carboanhydrase IX mRNA and Protein Level in the Development of Kidney Cancer Metastasis","volume":"51","author":"Spirina","year":"2017","journal-title":"Mol. Biol. (Mosk)"},{"key":"B278","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0006-2952(02)01517-4","article-title":"Relevance of Mitogen Activated Protein Kinase (MAPK) and Phosphotidylinositol-3-Kinase\/protein Kinase B (PI3K\/PKB) Pathways to Induction of Apoptosis by Curcumin in Breast Cells","volume":"65","author":"Squires","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"B279","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3892\/ijo.24.5.1311","article-title":"Akt Regulates COX-2 mRNA and Protein Expression in Mutated-PTEN Human Endometrial Cancer Cells","volume":"24","author":"St-Germain","year":"2004","journal-title":"Int. J. Oncol."},{"key":"B280","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s13402-017-0367-z","article-title":"Fibroblast Growth Factor Receptor 1 and 3 Expression Is Associated with Regulatory PI3K\/AKT Kinase Activity, as Well as Invasion and Prognosis, in Human Laryngeal Cancer","volume":"41","author":"Starska","year":"2018","journal-title":"Cel Oncol (Dordr)"},{"key":"B281","doi-asserted-by":"publisher","first-page":"39885","DOI":"10.18632\/oncotarget.9414","article-title":"Microsatellite Instability Derived JAK1 Frameshift Mutations Are Associated with Tumor Immune Evasion in Endometrioid Endometrial Cancer","volume":"7","author":"Stelloo","year":"2016","journal-title":"Oncotarget"},{"key":"B282","doi-asserted-by":"publisher","first-page":"8078","DOI":"10.1073\/pnas.0601192103","article-title":"Activation of FIP1L1-PDGFRalpha Requires Disruption of the Juxtamembrane Domain of PDGFRalpha and Is FIP1L1-independent","volume":"103","author":"Stover","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B283","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1517\/13543784.2012.684752","article-title":"Regorafenib for Cancer","volume":"21","author":"Strumberg","year":"2012","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B284","doi-asserted-by":"publisher","first-page":"7000","DOI":"10.3892\/ol.2018.8234","article-title":"IGF-1-induced MMP-11 Expression Promotes the Proliferation and Invasion of Gastric Cancer Cells through the JAK1\/STAT3 Signaling Pathway","volume":"15","author":"Su","year":"2018","journal-title":"Oncol. Lett."},{"key":"B285","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1096\/fasebj.31.1_supplement.646.30","article-title":"Synthetic Lethality of K-Ras Mutant Human Colorectal Cancer Cells by Phytochemical Curcumin and FDA-Approved Targeted Drug Regorafenib","volume":"31","author":"Su","year":"2017","journal-title":"FASEB J."},{"key":"B286","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/bjc.2013.802","article-title":"FGFR2 Amplification Has Prognostic Significance in Gastric Cancer: Results from a Large International Multicentre Study","volume":"110","author":"Su","year":"2014","journal-title":"Br. J. Cancer"},{"key":"B287","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.3892\/mmr.2012.1103","article-title":"Curcumin Induces Apoptosis of Triple-Negative Breast Cancer Cells by Inhibition of EGFR Expression","volume":"6","author":"Sun","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"B288","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.2147\/OTT.S172909","article-title":"Curcumin Inhibits the Proliferation and Invasion of MG-63 Cells through Inactivation of the P-JAK2\/p-STAT3 Pathway","volume":"12","author":"Sun","year":"2019","journal-title":"Onco Targets Ther."},{"key":"B289","first-page":"11652","article-title":"IGF-1R Promotes the Expression of Cyclin D1 Protein and Accelerates the G1\/S Transition by Activating Ras\/Raf\/MEK\/ERK Signaling Pathway","volume":"10","author":"Tang","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B290","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.lungcan.2004.03.006","article-title":"Human Small Cell Lung Cancer Cells Express Functional VEGF Receptors, VEGFR-2 and VEGFR-3","volume":"46","author":"Tanno","year":"2004","journal-title":"Lung Cancer"},{"key":"B291","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1749-6632.2009.04890.x","article-title":"Gene Expression Profiling Related to Anti-inflammatory Properties of Curcumin in K562 Leukemia Cells","volume":"1171","author":"Teiten","year":"2009","journal-title":"Ann. N. Y Acad. Sci."},{"key":"B292","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3892\/ijo.2011.905","article-title":"Anti-proliferative Potential of Curcumin in Androgen-dependent Prostate Cancer Cells Occurs through Modulation of the Wingless Signaling Pathway","volume":"38","author":"Teiten","year":"2011","journal-title":"Int. J. Oncol."},{"key":"B293","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13058-017-0802-0","article-title":"Insulin-like Growth Factor 1 Receptor Activation Promotes Mammary Gland Tumor Development by Increasing Glycolysis and Promoting Biomass Production","volume":"19","author":"Ter Braak","year":"2017","journal-title":"Breast Cancer Res."},{"key":"B294","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1158\/1541-7786.Mcr-12-0652","article-title":"Activation of the FGF2-FGFR1 Autocrine Pathway: a Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC","volume":"11","author":"Terai","year":"2013","journal-title":"Mol. Cancer Res."},{"key":"B295","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1080\/1061186x.2017.1306535","article-title":"Curcumin Inhibits Urothelial Tumor Development by Suppressing IGF2 and IGF2-Mediated PI3K\/AKT\/mTOR Signaling Pathway","volume":"25","author":"Tian","year":"2017","journal-title":"J. Drug Target."},{"key":"B296","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41417-020-00290-5","article-title":"c-Jun N-Terminal Kinase 2 Suppresses Pancreatic Cancer Growth and Invasion and Is Opposed by C-Jun N-Terminal Kinase 1","author":"Tian","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"B297","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.critrevonc.2017.11.001","article-title":"The Role of Nuclear Factor-Kappa B Signaling in Human Cervical Cancer","volume":"120","author":"Tilborghs","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B298","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/s0969-2126(02)00814-6","article-title":"Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation","volume":"10","author":"Till","year":"2002","journal-title":"Structure"},{"key":"B299","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cllc.2011.02.002","article-title":"Immunohistochemical Overexpression of Platelet-Derived Growth Factor Receptor-Beta (PDGFR-\u03b2) Is Associated with PDGFRB Gene Copy Number Gain in Sarcomatoid Non-small-cell Lung Cancer","volume":"12","author":"Tsao","year":"2011","journal-title":"Clin. Lung Cancer"},{"key":"B300","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s00210-016-1235-5","article-title":"Curcumin Downregulates P38 MAPK-dependent X-ray Repair Cross-Complement Group 1 (XRCC1) Expression to Enhance Cisplatin-Induced Cytotoxicity in Human Lung Cancer Cells","volume":"389","author":"Tung","year":"2016","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B301","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1002\/mnfr.201000654","article-title":"Curcumin Reduces Pulmonary Tumorigenesis in Vascular Endothelial Growth Factor (VEGF)-overexpressing Transgenic Mice","volume":"55","author":"Tung","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"B302","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1158\/0008-5472.CAN-09-3746","article-title":"FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer","volume":"70","author":"Turner","year":"2010","journal-title":"Cancer Res."},{"key":"B303","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1182\/blood.V110.11.1177.1177","article-title":"Curcumin Downregulates NF-kB and Related Genes in Patients with Multiple Myeloma: Results of a Phase I\/II Study","volume":"110","author":"Vadhan-Raj","year":"2007","journal-title":"Blood"},{"key":"B304","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1006\/bbrc.1996.1034","article-title":"The IGF-I Receptor Protects Tumor Cells from Apoptosis Induced by High Concentrations of Serum","volume":"224","author":"Valentinis","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B305","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1477-3163-3-8","article-title":"Time- and Dose-dependent Effects of Curcumin on Gene Expression in Human colon Cancer Cells","volume":"3","author":"Van Erk","year":"2004","journal-title":"J. Carcinog"},{"key":"B306","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/path.1467","article-title":"Expression of Vascular Endothelial Growth Factor (VEGF)-C and VEGF-D, and Their Receptor VEGFR-3, during Different Stages of Cervical Carcinogenesis","volume":"201","author":"Van Trappen","year":"2003","journal-title":"J. Pathol."},{"key":"B307","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.virol.2011.12.023","article-title":"Human Papillomavirus Type 16 E6 and E 7 Proteins Alter NF-kB in Cultured Cervical Epithelial Cells and Inhibition of NF-kB Promotes Cell Growth and Immortalization","volume":"425","author":"Vandermark","year":"2012","journal-title":"Virology"},{"key":"B308","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1080\/08982104.2020.1720718","article-title":"Co-delivery of Rituximab Targeted Curcumin and Imatinib Nanostructured Lipid Carriers in Non-hodgkin Lymphoma Cells","volume":"31","author":"Varshosaz","year":"2021","journal-title":"J. Liposome Res."},{"key":"B309","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1038\/onc.2013.218","article-title":"PDGFRA Alterations in Cancer: Characterization of a Gain-Of-Function V536E Transmembrane Mutant as Well as Loss-Of-Function and Passenger Mutations","volume":"33","author":"Velghe","year":"2014","journal-title":"Oncogene"},{"key":"B310","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-230X(08)00001-8","article-title":"Met-related Receptor Tyrosine Kinase Ron in Tumor Growth and Metastasis","volume":"100","author":"Wagh","year":"2008","journal-title":"Adv. Cancer Res."},{"key":"B311","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ccr.2006.06.002","article-title":"Activating Alleles of JAK3 in Acute Megakaryoblastic Leukemia","volume":"10","author":"Walters","year":"2006","journal-title":"Cancer Cell"},{"key":"B312","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/gcc.20359","article-title":"Transient Response to Imatinib in a Chronic Eosinophilic Leukemia Associated with Ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA Fusion Gene","volume":"45","author":"Walz","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"B313","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1126\/science.281.5383.1680","article-title":"NF-kappaB Antiapoptosis: Induction of TRAF1 and TRAF2 and C-IAP1 and C-IAP2 to Suppress Caspase-8 Activation","volume":"281","author":"Wang","year":"1998","journal-title":"Science"},{"key":"B314","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.canlet.2011.12.040","article-title":"c-Met Upregulates Aquaporin 3 Expression in Human Gastric Carcinoma Cells via the ERK Signalling Pathway","volume":"319","author":"Wang","year":"2012","journal-title":"Cancer Lett."},{"key":"B315","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/ijc.31895","article-title":"Clinical Outcomes of EGFR Kinase Domain Duplication to Targeted Therapies in NSCLC","volume":"144","author":"Wang","year":"2019","journal-title":"Int. J. Cancer"},{"key":"B316","doi-asserted-by":"publisher","first-page":"4107","DOI":"10.1158\/1078-0432.Ccr-14-0284","article-title":"FGFR1\/3 Tyrosine Kinase Fusions Define a Unique Molecular Subtype of Non-small Cell Lung Cancer","volume":"20","author":"Wang","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"B317","doi-asserted-by":"publisher","first-page":"e000793","DOI":"10.1136\/jitc-2020-000793","article-title":"Hyperprogression to Camrelizumab in a Patient with Esophageal Squamous Cell Carcinoma Harboring EGFR Kinase Domain Duplication","volume":"8","author":"Wang","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"B318","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.lfs.2013.01.013","article-title":"Curcumin Induces FasL-Related Apoptosis through P38 Activation in Human Hepatocellular Carcinoma Huh7 Cells","volume":"92","author":"Wang","year":"2013","journal-title":"Life Sci."},{"key":"B319","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1038\/nsmb.2168","article-title":"Mechanistic Insights into the Activation of Oncogenic Forms of EGF Receptor","volume":"18","author":"Wang","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B320","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/mc.20571","article-title":"Curcumin-induced Apoptosis in Ovarian Carcinoma Cells Is P53-independent and Involves P38 Mitogen-Activated Protein Kinase Activation and Downregulation of Bcl-2 and Survivin Expression and Akt Signaling","volume":"49","author":"Watson","year":"2010","journal-title":"Mol. Carcinog"},{"key":"B321","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s10456-005-9010-0","article-title":"Autocrine Vascular Endothelial Growth Factor Signalling in Breast Cancer. Evidence from Cell Lines and Primary Breast Cancer Cultures In Vitro","volume":"8","author":"Weigand","year":"2005","journal-title":"Angiogenesis"},{"key":"B322","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-11888-8","volume-title":"Receptor Tyrosine Kinases: Family and Subfamilies","author":"Wheeler","year":"2015"},{"key":"B323","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1091\/mbc.e06-07-0593","article-title":"Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 kinase\/Akt Regulation of Glut1 Activity and Trafficking","volume":"18","author":"Wieman","year":"2007","journal-title":"Mol. Biol. Cel"},{"key":"B324","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.1158\/0008-5472.Can-04-1443","article-title":"BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF\/MEK\/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis","volume":"64","author":"Wilhelm","year":"2004","journal-title":"Cancer Res."},{"key":"B325","doi-asserted-by":"publisher","first-page":"108227","DOI":"10.1016\/j.jnutbio.2019.108227","article-title":"Curcumin Functions as a MEK Inhibitor to Induce a Synthetic Lethal Effect on KRAS Mutant Colorectal Cancer Cells Receiving Targeted Drug Regorafenib","volume":"74","author":"Wu","year":"","journal-title":"J. Nutr. Biochem."},{"key":"B326","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1002\/med.21574","article-title":"JNK Signaling in Cancer Cell Survival","volume":"39","author":"Wu","year":"","journal-title":"Med. Res. Rev."},{"key":"B327","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1158\/1535-7163.Mct-06-0759","article-title":"Expression of Epidermal Growth Factor (EGF)\/transforming Growth Factor-Alpha by Human Lung Cancer Cells Determines Their Response to EGF Receptor Tyrosine Kinase Inhibition in the Lungs of Mice","volume":"6","author":"Wu","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"B328","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/ijc.21865","article-title":"The Vascular Endothelial Growth Factor Receptor (VEGFR-1) Supports Growth and Survival of Human Breast Carcinoma","volume":"119","author":"Wu","year":"2006","journal-title":"Int. J. Cancer"},{"key":"B329","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1158\/2159-8290.Cd-13-0050","article-title":"Identification of Targetable FGFR Gene Fusions in Diverse Cancers","volume":"3","author":"Wu","year":"2013","journal-title":"Cancer Discov."},{"key":"B330","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1158\/2326-6066.Cir-14-0112","article-title":"NF-\u03baB, an Active Player in Human Cancers","volume":"2","author":"Xia","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"B331","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1158\/1078-0432.Ccr-12-3898","article-title":"FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547","volume":"19","author":"Xie","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"B332","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3748\/wjg.v7.i6.816","article-title":"SF\/HGF-c-Met Autocrine and Paracrine Promote Metastasis of Hepatocellular Carcinoma","volume":"7","author":"Xie","year":"2001","journal-title":"World J. Gastroenterol."},{"key":"B333","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0254-6272(17)30071-7","article-title":"Curcumin Co-treatment Ameliorates Resistance to Gefitinib in Drug-Resistant NCI-H1975 Lung Cancer Cells","volume":"37","author":"Xin","year":"2017","journal-title":"J. Traditional Chin. Med."},{"key":"B334","doi-asserted-by":"publisher","first-page":"8317","DOI":"10.2147\/OTT.S263994","article-title":"KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma","volume":"13","author":"Xu","year":"2020","journal-title":"Onco Targets Ther."},{"key":"B335","doi-asserted-by":"publisher","first-page":"889","DOI":"10.4143\/crt.2020.1272","article-title":"Identification of a Novel CSNK2A1-PDGFRB Fusion Gene in a Patient with Myeloid Neoplasm with Eosinophilia","volume":"53","author":"Xu","year":"2021","journal-title":"Cancer Res. Treat."},{"key":"B336","doi-asserted-by":"publisher","first-page":"1010428317711140","DOI":"10.1177\/1010428317711140","article-title":"JAK2 Variations and Functions in Lung Adenocarcinoma","volume":"39","author":"Xu","year":"2017","journal-title":"Tumour Biol."},{"key":"B337","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/ptr.5056","article-title":"Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability in Lung Cancer Cells","volume":"28","author":"Yamauchi","year":"2014","journal-title":"Phytother Res."},{"key":"B338","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.prp.2015.04.003","article-title":"Expression and Prognostic Significance of VEGFR-2 in Breast Cancer","volume":"211","author":"Yan","year":"2015","journal-title":"Pathol. Res. Pract."},{"key":"B339","doi-asserted-by":"publisher","first-page":"e37960","DOI":"10.1371\/journal.pone.0037960","article-title":"Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"B340","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cancergen.2015.04.007","article-title":"BCR-PDGFRA Fusion in a T Lymphoblastic Leukemia\/lymphoma","volume":"208","author":"Yigit","year":"2015","journal-title":"Cancer Genet."},{"key":"B341","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/S0959-8049(01)00015-6","article-title":"Lymphangiogenesis and the Vascular Endothelial Growth Factor Receptor (VEGFR)-3 in Gastric Cancer","volume":"37","author":"Yonemura","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"B342","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3109\/10428194.2014.938330","article-title":"Imatinib Non-responsive Chronic Eosinophilic Leukemia with ETV6-PDGFRA Fusion Gene","volume":"56","author":"Yoshida","year":"2015","journal-title":"Leuk. Lymphoma"},{"key":"B343","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.2147\/OTT.S131999","article-title":"The Non-small Cell Lung Cancer EGFR Extracellular Domain Mutation, M277E, Is Oncogenic and Drug-Sensitive","volume":"10","author":"Yu","year":"2017","journal-title":"Onco Targets Ther."},{"key":"B344","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.4161\/15384047.2014.961874","article-title":"Recurrent FGFR3-TACC3 Fusion Gene in Nasopharyngeal Carcinoma","volume":"15","author":"Yuan","year":"2014","journal-title":"Cancer Biol. Ther."},{"key":"B345","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1172\/jci28984","article-title":"PDGFRs Are Critical for PI3K\/Akt Activation and Negatively Regulated by mTOR","volume":"117","author":"Zhang","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B346","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.3390\/cancers6031408","article-title":"STAT3 in Cancer-Friend or Foe?","volume":"6","author":"Zhang","year":"2014","journal-title":"Cancers (Basel)"},{"key":"B347","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/mc.22718","article-title":"Metformin Incombination with Curcumin Inhibits the Growth, Metastasis, and Angiogenesis of Hepatocellular Carcinoma In Vitro and In Vivo","volume":"57","author":"Zhang","year":"2018","journal-title":"Mol. Carcinog"},{"key":"B348","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1080\/14786419.2015.1074229","article-title":"Combinatorial Anticancer Effects of Curcumin and Sorafenib towards Thyroid Cancer Cells via PI3K\/Akt and ERK Pathways","volume":"30","author":"Zhang","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"B349","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.3892\/or.2019.7278","article-title":"Curcumin Inhibits Cell Proliferation and Migration in NSCLC through a Synergistic Effect on the TLR4\/MyD88 and EGFR Pathways","volume":"42","author":"Zhang","year":"2019","journal-title":"Oncol. Rep."},{"key":"B350","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK Signal Pathways in the Regulation of Cell Proliferation in Mammalian Cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res"},{"key":"B351","doi-asserted-by":"publisher","first-page":"e335","DOI":"10.1002\/ctm2.335","article-title":"Arsenic Trioxide Induces Differentiation of Cancer Stem Cells in Hepatocellular Carcinoma through Inhibition of LIF\/JAK1\/STAT3 and NF-kB Signaling Pathways Synergistically","volume":"11","author":"Zhang","year":"2021","journal-title":"Clin. Transl Med."},{"key":"B352","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1038\/onc.2014.257","article-title":"VEGF Drives Cancer-Initiating Stem Cells through VEGFR-2\/Stat3 Signaling to Upregulate Myc and Sox2","volume":"34","author":"Zhao","year":"","journal-title":"Oncogene"},{"key":"B353","doi-asserted-by":"publisher","first-page":"5486","DOI":"10.1038\/onc.2008.244","article-title":"Class I PI3K in Oncogenic Cellular Transformation","volume":"27","author":"Zhao","year":"2008","journal-title":"Oncogene"},{"key":"B354","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/1759-7714.12222","article-title":"Potential Anti-cancer Effect of Curcumin in Human Lung Squamous Cell Carcinoma","volume":"6","author":"Zhao","year":"","journal-title":"Thorac. Cancer"},{"key":"B355","doi-asserted-by":"publisher","first-page":"56758","DOI":"10.18632\/oncotarget.18142","article-title":"Clinicopathological and Prognostic Significance of C-Met Overexpression in Breast Cancer","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"B356","doi-asserted-by":"publisher","first-page":"312","DOI":"10.31989\/ffhd.v4i7.1","article-title":"Turmeric and Chinese Goldthread Synergistically Inhibit Prostate Cancer Cell Proliferation and NF-kB Signaling","volume":"4","author":"Zhao","year":"2014","journal-title":"Ffhd"},{"key":"B357","first-page":"6438","article-title":"Curcumin Inhibits Oral Squamous Cell Carcinoma Proliferation and Invasion via EGFR Signaling Pathways","volume":"7","author":"Zhen","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B358","doi-asserted-by":"publisher","first-page":"551","DOI":"10.26355\/eurrev_201801_14209","article-title":"The Effect of Curcumin on Cell Adhesion of Human Esophageal Cancer Cell","volume":"22","author":"Zheng","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B359","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.7150\/ijbs.31999","article-title":"An Autocrine IL-6\/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer","volume":"15","author":"Zheng","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"B360","doi-asserted-by":"publisher","first-page":"332","DOI":"10.2174\/138945011794815356","article-title":"The Targets of Curcumin","volume":"12","author":"Zhou","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"B361","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/labinvest.3700532","article-title":"The Interruption of the PDGF and EGF Signaling Pathways by Curcumin Stimulates Gene Expression of PPARgamma in Rat Activated Hepatic Stellate Cell In Vitro","volume":"87","author":"Zhou","year":"2007","journal-title":"Lab. Invest."},{"key":"B362","doi-asserted-by":"publisher","first-page":"e181","DOI":"10.1016\/j.jtho.2019.03.031","article-title":"Identification of a Novel Icotinib-Sensitive EGFR-SEPTIN14 Fusion Variant in Lung Adenocarcinoma by Next-Generation Sequencing","volume":"14","author":"Zhu","year":"2019","journal-title":"J. Thorac. Oncol."},{"key":"B363","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1016\/j.jtho.2018.05.009","article-title":"MET-UBE2H Fusion as a Novel Mechanism of Acquired EGFR Resistance in Lung Adenocarcinoma","volume":"13","author":"Zhu","year":"","journal-title":"J. Thorac. Oncol."},{"key":"B364","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1093\/annonc\/mdy455","article-title":"Identification of a Novel Crizotinib-Sensitive MET-Atxn7l1 Gene Fusion Variant in Lung Adenocarcinoma by Next Generation Sequencing","volume":"29","author":"Zhu","year":"","journal-title":"Ann. Oncol."},{"key":"B365","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.gendis.2020.06.005","article-title":"The Nuclear Factor Kappa B (NF-kB) Signaling in Cancer Development and Immune Diseases","volume":"8","author":"Zinatizadeh","year":"2021","journal-title":"Genes Dis."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.772510\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T04:03:43Z","timestamp":1726113823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.772510\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":365,"alternative-id":["10.3389\/fphar.2021.772510"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.772510","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,15]]},"article-number":"772510"}}