{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:06:35Z","timestamp":1778796395608,"version":"3.51.4"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772476 31861143050 31911530077"],"award-info":[{"award-number":["31772476 31861143050 31911530077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Acne vulgaris is a common adolescent skin condition which is mainly caused by <jats:italic>Propionibacterium acnes<\/jats:italic> overcolonization and subsequent inflammation. Our previous studies have demonstrated that Cath-MH, an antimicrobial peptide from the skin of the frog <jats:italic>Microhyla heymonsivogt<\/jats:italic>, possesses potential antimicrobial, LPS-binding, and anti-septicemic properties. However, its protective effects and potential mechanisms against acne vulgaris are still unclear. In the present study, its anti-<jats:italic>P. acnes<\/jats:italic> effects were measured by two-fold broth dilution method, agglutination assay, scanning electron microscopy and confocal laser scanning microscopy experiments. Its treatment potential for acne vulgaris was further evaluated in mice ear inoculated by <jats:italic>P. acnes<\/jats:italic>. In addition, the binding ability between Cath-MH and LTA was measured by the Circular Dichroism and antibacterial assay. Moreover, the anti-inflammatory efficiency of Cath-MH was evaluated in LTA- and LPS-induced RAW 264.7 macrophage cells. Cath-MH was found to kill <jats:italic>P. acnes<\/jats:italic> with a MIC value of about 1.56\u00a0\u03bcM by membrane disruption mechanism. It also exhibited agglutination activity against <jats:italic>P. acnes<\/jats:italic>. Cath-MH was able to bind LTA as well as LPS, inhibit LTA\/LPS-stimulated TLR2\/4 expression, and subsequently decreased the inflammatory response in RAW 264.7 cells. As expected, Cath-MH alleviated the formation of edema and the infiltration of inflammatory cells in acne mouse model with concurrent suppression of <jats:italic>P. acnes<\/jats:italic> growth and inflammatory cytokines expression <jats:italic>in vivo<\/jats:italic>. The potent <jats:italic>P. acnes<\/jats:italic> inhibition activity combined with powerful anti-inflammatory effect of Cath-MH indicates its potential as a novel therapeutic option for acne vulgaris.<\/jats:p>","DOI":"10.3389\/fphar.2021.788358","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T13:16:59Z","timestamp":1639055819000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["The Protective Effects of Cath-MH With Anti-Propionibacterium Acnes and Anti-Inflammation Functions on Acne Vulgaris"],"prefix":"10.3389","volume":"12","author":[{"given":"Jiena","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiyin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwei","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weichen","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maolin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wancheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1042\/BJ20041270","article-title":"Enhancement of Endotoxin Neutralization by Coupling of a C12-Alkyl Chain to a Lactoferricin-Derived Peptide","volume":"385","author":"Andr\u00e4","year":"2005","journal-title":"Biochem. 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