{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:12:43Z","timestamp":1790431963781,"version":"4.1.0"},"reference-count":121,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:italic>Ocimum basilicum<\/jats:italic>L. (<jats:italic>O. basilicum<\/jats:italic>) and its constituents show anti-inflammatory, immunomodulatory, and antioxidant effects. The plant has been mainly utilized in traditional medicine for the treatment of respiratory disorders. In the present article, effects of<jats:italic>O. basilicum<\/jats:italic>and its main constituents on respiratory disorders, assessed by experimental and clinical studies, were reviewed. Relevant studies were searched in PubMed, Science Direct, Medline, and Embase databases using relevant keywords including \u201cOcimum basilicum,\u201d \u201cbasilicums,\u201d \u201clinalool,\u201d \u201crespiratory disease,\u201d \u201casthma,\u201d \u201cobstructive pulmonary disease,\u201d \u201cbronchodilatory,\u201d \u201cbronchitis,\u201d \u201clung cancer,\u201d and \u201c<jats:ext-link>pulmonary fibrosis,\u201d and other related keywords.<\/jats:ext-link>The reviewed articles showed both relieving and preventing effects of the plant and its ingredients on obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory disorders such as bronchitis, aspergillosis tuberculosis, and lung cancer. The results of the reviewed articles suggest the therapeutic potential of<jats:italic>O. basilicum<\/jats:italic>and its constituent, linalool, on respiratory disorders.<\/jats:p>","DOI":"10.3389\/fphar.2021.805391","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T08:38:17Z","timestamp":1641199097000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review"],"prefix":"10.3389","volume":"12","author":[{"given":"Ahmad Reza","family":"Aminian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Mohebbati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Boskabady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"131170","DOI":"10.1016\/j.foodchem.2021.131170","article-title":"Effects of Sweet Basil Leaves (Ocimum Basilicum L) Addition on the Chemical, Antioxidant, and Storage Stability of roselle Calyces (Hibiscus sabdariffa) Drink","volume":"371","author":"Abidoye","year":"2022","journal-title":"Food Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/1465-9921-11-122","article-title":"Characterisation of COPD Heterogeneity in the ECLIPSE Cohort","volume":"11","author":"Agusti","year":"2010","journal-title":"Respir. 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