{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:52:55Z","timestamp":1791395575324,"version":"4.3.3"},"reference-count":134,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Methamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences. Neuronal apoptosis plays a critical role in METH-induced neurotoxicity and may provide promising pharmacological targets for preventing and treating METH addiction. In recent years, accumulating evidence has revealed that natural products may possess significant potentials to inhibit METH-evoked neuronal apoptosis. In this review, we summarized and analyzed the improvement effect of natural products on METH-induced neuronal apoptosis and their potential molecular mechanisms on modulating dopamine release, oxidative stress, mitochondrial-dependent apoptotic pathway, endoplasmic reticulum stress-mediated apoptotic pathway, and neuroinflammation. Hopefully, this review may highlight the potential value of natural products in modulating METH-caused neuronal apoptosis and provide useful information for future research and developments of novel and efficacious pharmacotherapies in this field.<\/jats:p>","DOI":"10.3389\/fphar.2021.805991","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T06:25:44Z","timestamp":1641277544000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis"],"prefix":"10.3389","volume":"12","author":[{"given":"Yiwei","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhi","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/jcbfm.2012.158","article-title":"The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target","volume":"33","author":"Anne Stetler","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B2","unstructured":"National Drug Strategy Household Survey 20192020"},{"key":"B3","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1111\/dar.13126","article-title":"Characterising the Increasing Prevalence of crystal Methamphetamine Use in Vancouver, Canada, from 2006-2017: A Gender-Based Analysis","volume":"39","author":"Bach","year":"2020","journal-title":"Drug Alcohol. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3390\/ijms17091558","article-title":"ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players","volume":"17","author":"Bahar","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1039\/b602241n","article-title":"The Value of Natural Products to Future Pharmaceutical Discovery","volume":"24","author":"Baker","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e230288","DOI":"10.1136\/bcr-2019-230288","article-title":"Methamphetamine (N-Methylamphetamine)-Induced Renal Disease: Underevaluated Cause of End-Stage Renal Disease (ESRD)","volume":"12","author":"Baradhi","year":"2019","journal-title":"BMJ Case Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1007\/s00204-015-1478-9","article-title":"Mitochondria: Key Players in the Neurotoxic Effects of Amphetamines","volume":"89","author":"Barbosa","year":"2015","journal-title":"Arch. Toxicol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1002\/jcb.26398","article-title":"Intranasal Insulin Treatment Restores Cognitive Deficits and Insulin Signaling Impairment Induced by Repeated Methamphetamine Exposure","volume":"119","author":"Beirami","year":"2018","journal-title":"J. Cel Biochem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1242\/jcs.073643","article-title":"Regulation of the Apaf-1-Caspase-9 Apoptosome","volume":"123","author":"Bratton","year":"2010","journal-title":"J. Cel Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1096\/fj.03-0073rev","article-title":"Speed Kills: Cellular and Molecular Bases of Methamphetamine-Induced Nerve Terminal Degeneration and Neuronal Apoptosis","volume":"17","author":"Cadet","year":"2003","journal-title":"FASEB J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/s0300-9084(02)01376-7","article-title":"The Apaf-1 Apoptosome: a Large Caspase-Activating Complex","volume":"84","author":"Cain","year":"2002","journal-title":"Biochimie"},{"key":"B12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.13375\/j.cnki.wcjps.2016.02.013","article-title":"Effects of Psuedoginsenoside F11 on the Oxidation Material Levels in the Serum and Brain Tissue of Methamphetamine - Dependent Rats (China)","volume":"31","author":"Chen","year":"2016","journal-title":"West China J. Pharm. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3389\/fncel.2019.00366","article-title":"Role of C\/EBP-\u03b2 in Methamphetamine-Mediated Microglial Apoptosis","volume":"13","author":"Chen","year":"2019","journal-title":"Front. Cel Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"397408","DOI":"10.13418\/j.issn.1001-165x.2017.04.009","article-title":"The Protective Effect and its Mechanism of Antrodia Camphorata Enzyme on the Cytotoxicity Injury of PC12 Cells Induced by Amphetamine (China)","volume":"35","author":"Chi","year":"2017","journal-title":"Chin. J. Clin. Anat."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e2710","DOI":"10.1002\/hup.2710","article-title":"Methamphetamine-associated Psychosis: Clinical Presentation, Biological Basis, and Treatment Options","volume":"34","author":"Chiang","year":"2019","journal-title":"Hum. Psychopharmacol."},{"key":"B16","article-title":"National Drug Report","year":"2019"},{"key":"B17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/1742-2094-9-103","article-title":"Prevention of Methamphetamine-Induced Microglial Cell Death by TNF-\u03b1 and IL-6 through Activation of the JAK-STAT Pathway","volume":"9","author":"Coelho-Santos","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.drugalcdep.2014.08.003","article-title":"Methamphetamine: an Update on Epidemiology, Pharmacology, Clinical Phenomenology, and Treatment Literature","volume":"143","author":"Courtney","year":"2014","journal-title":"Drug Alcohol Depend."},{"key":"B19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12974-016-0478-x","article-title":"Apocynin Prevents Mitochondrial Burdens, Microglial Activation, and Pro-apoptosis Induced by a Toxic Dose of Methamphetamine in the Striatum of Mice via Inhibition of P47phox Activation by ERK","volume":"13","author":"Dang","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0165-0173(01)00054-6","article-title":"Methamphetamine Neurotoxicity: Necrotic and Apoptotic Mechanisms and Relevance to Human Abuse and Treatment","volume":"36","author":"Davidson","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1146\/annurev-pharmtox-010716-105001","article-title":"Mitochondrial Mechanisms of Neuronal Cell Death: Potential Therapeutics","volume":"57","author":"Dawson","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/npp.2012.179","article-title":"An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans","volume":"38","author":"Dean","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"5769","DOI":"10.3390\/molecules25235769","article-title":"Biological Activities of Natural Products","volume":"25","author":"Ekiert","year":"2020","journal-title":"Molecules"},{"key":"B24","volume-title":"National Survey on Drug Use and Health-2019","author":"Elinore","year":"2020"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1212\/wnl.54.6.1344","article-title":"Evidence for Long-Term Neurotoxicity Associated with Methamphetamine Abuse: A 1H MRS Study","volume":"54","author":"Ernst","year":"2000","journal-title":"Neurology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1124\/jpet.104.072264","article-title":"Lobeline Attenuates Methamphetamine-Induced Changes in Vesicular Monoamine Transporter 2 Immunoreactivity and Monoamine Depletions in the Striatum","volume":"312","author":"Eyerman","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e2736","DOI":"10.1002\/hup.2736","article-title":"The Association between Interleukin-8 Levels and the Development of Withdrawal Symptoms during Methamphetamine Abstinence","volume":"35","author":"Feng","year":"2020","journal-title":"Hum. Psychopharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neuropharm.2008.07.002","article-title":"Psychostimulant-induced Alterations in Vesicular Monoamine Transporter-2 Function: Neurotoxic and Therapeutic Implications","volume":"56","author":"Fleckenstein","year":"2009","journal-title":"Neuropharmacology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.neulet.2013.08.039","article-title":"A Role for D1 Dopamine Receptors in Striatal Methamphetamine-Induced Neurotoxicity","volume":"555","author":"Friend","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B30","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s00213-015-4159-8","article-title":"Pseudoginsenoside-F11 Inhibits Methamphetamine-Induced Behaviors by Regulating Dopaminergic and GABAergic Neurons in the Nucleus Accumbens","volume":"233","author":"Fu","year":"2016","journal-title":"Psychopharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"104642","DOI":"10.1016\/j.yrtph.2020.104642","article-title":"\"Natural\" Is Not Synonymous with \"Safe\": Toxicity of Natural Products Alone and in Combination with Pharmaceutical Agents","volume":"113","author":"Gaston","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s40263-014-0209-8","article-title":"Methamphetamine Psychosis: Epidemiology and Management","volume":"28","author":"Glasner-Edwards","year":"2014","journal-title":"CNS Drugs"},{"key":"B33","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1007\/s12035-016-9969-0","article-title":"Psychostimulant-Induced Endoplasmic Reticulum Stress and Neurodegeneration","volume":"54","author":"Go","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"112300","DOI":"10.1016\/j.bbr.2019.112300","article-title":"Methamphetamine Administration Impairs Behavior, Memory and Underlying Signaling Pathways in the hippocampus","volume":"379","author":"Golsorkhdan","year":"2020","journal-title":"Behav. Brain Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1196\/annals.1432.043","article-title":"Methamphetamine-induced Early Increase of IL-6 and TNF-Alpha mRNA Expression in the Mouse Brain","volume":"1139","author":"Gon\u00e7alves","year":"2008","journal-title":"Ann. N. Y Acad. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1460-9568.2009.07059.x","article-title":"Methamphetamine-induced Neuroinflammation and Neuronal Dysfunction in the Mice hippocampus: Preventive Effect of Indomethacin","volume":"31","author":"Gon\u00e7alves","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.neuro.2021.03.011","article-title":"Curcumin Attenuates Spatial Memory Impairment by Anti-oxidative, Anti-apoptosis, and Anti-inflammatory Mechanism against Methamphetamine Neurotoxicity in Male Wistar Rats: Histological and Biochemical Changes","volume":"84","author":"Hadizadeh-Bazaz","year":"2021","journal-title":"Neurotoxicology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.lfs.2013.07.014","article-title":"Neurotoxicity of Methamphetamine and 3,4-methylenedioxymethamphetamine","volume":"97","author":"Halpin","year":"","journal-title":"Life Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/npp.2013.306","article-title":"Ammonia Mediates Methamphetamine-Induced Increases in Glutamate and Excitotoxicity","volume":"39","author":"Halpin","year":"","journal-title":"Neuropsychopharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"112230","DOI":"10.1016\/j.jep.2019.112230","article-title":"Best Practice in Research - Overcoming Common Challenges in Phytopharmacological Research","volume":"246","author":"Heinrich","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neuint.2003.11.018","article-title":"Autoxidation and MAO-Mediated Metabolism of Dopamine as a Potential Cause of Oxidative Stress: Role of Ferrous and Ferric Ions","volume":"45","author":"Hermida-Ameijeiras","year":"2004","journal-title":"Neurochem. Int."},{"key":"B42","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1037\/0033-2909.134.2.301","article-title":"Methamphetamine Abuse and Impairment of Social Functioning: a Review of the Underlying Neurophysiological Causes and Behavioral Implications","volume":"134","author":"Homer","year":"2008","journal-title":"Psychol. Bull."},{"key":"B43","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small Molecule Activators of Sirtuins Extend Saccharomyces cerevisiae Lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.3389\/fimmu.2018.03083","article-title":"The C\/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.taap.2012.08.036","article-title":"L-ascorbate Attenuates Methamphetamine Neurotoxicity through Enhancing the Induction of Endogenous Heme Oxygenase-1","volume":"265","author":"Huang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/pcn.12025","article-title":"Oxidative Stress Status in Recently Abstinent Methamphetamine Abusers","volume":"67","author":"Huang","year":"2013","journal-title":"Psychiatry Clin. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"S82","DOI":"10.1038\/sj.bjp.0706428","article-title":"Neurotransmitter Transporters and Their Impact on the Development of Psychopharmacology","volume":"147","author":"Iversen","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1096\/fj.01-0025com","article-title":"Methamphetamine Causes Differential Regulation of Pro-death and Anti-death Bcl-2 Genes in the Mouse Neocortex","volume":"15","author":"Jayanthi","year":"2001","journal-title":"FASEB J."},{"key":"B49","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1096\/fj.03-0295com","article-title":"Methamphetamine Induces Neuronal Apoptosis via Cross-Talks between Endoplasmic Reticulum and Mitochondria-dependent Death Cascades","volume":"18","author":"Jayanthi","year":"2004","journal-title":"FASEB J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.semnephrol.2008.04.010","article-title":"Natural Medicines Causing Acute Kidney Injury","volume":"28","author":"Jha","year":"2008","journal-title":"Semin. Nephrol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"31199","DOI":"10.1074\/jbc.C000405200","article-title":"Cytochrome C Promotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"317","DOI":"10.15585\/mmwr.mm6912a1","article-title":"Patterns and Characteristics of Methamphetamine Use Among Adults - United States, 2015-2018","volume":"69","author":"Jones","year":"2020","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"145","DOI":"10.4062\/biomolther.2018.092","article-title":"Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress","volume":"27","author":"Kang","year":"2019","journal-title":"Biomol. Ther. (Seoul)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1089\/152308603770310275","article-title":"Role of Proteolytic Activation of Protein Kinase Cdelta in Oxidative Stress-Induced Apoptosis","volume":"5","author":"Kanthasamy","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"B55","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2174\/157015911795017353","article-title":"Neuroprotective Effect of Resveratrol against Methamphetamine-Induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity","volume":"9","author":"Kanthasamy","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1046\/j.1460-9568.2003.02864.x","article-title":"Caspase-3 Dependent Proteolytic Activation of Protein Kinase C delta Mediates and Regulates 1-Methyl-4-Phenylpyridinium (MPP+)-induced Apoptotic Cell Death in Dopaminergic Cells: Relevance to Oxidative Stress in Dopaminergic Degeneration","volume":"18","author":"Kaul","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1161\/ATVBAHA.119.312461","article-title":"Methamphetamine Use and Cardiovascular Disease","volume":"39","author":"Kevil","year":"2019","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3390\/nu10081021","article-title":"Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review","volume":"10","author":"Kim","year":"2018","journal-title":"Nutrients"},{"key":"B59","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1055\/s-2006-957991","article-title":"Blockade by Ginseng Total Saponin of the Development of Methamphetamine Reverse Tolerance and Dopamine Receptor Supersensitivity in Mice","volume":"61","author":"Kim","year":"1995","journal-title":"Planta Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0306-3623(95)02023-3","article-title":"Blockade by Ginseng Total Saponin of Methamphetamine-Induced Hyperactivity and Conditioned Place Preference in Mice","volume":"27","author":"Kim","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"381","DOI":"10.4062\/biomolther.2020.044","article-title":"Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation","volume":"28","author":"Kim","year":"2020","journal-title":"Biomol. Ther. (Seoul)"},{"key":"B62","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.brainresrev.2009.03.002","article-title":"Methamphetamine Toxicity and Messengers of Death","volume":"60","author":"Krasnova","year":"2009","journal-title":"Brain Res. Rev."},{"key":"B63","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial Membrane Permeabilization in Cell Death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.drugalcdep.2018.02.032","article-title":"Methamphetamine Use and Future Risk for Parkinson's Disease: Evidence and Clinical Implications","volume":"187","author":"Lappin","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.3390\/ijms22052274","article-title":"Aromadendrin Protects Neuronal Cells from Methamphetamine-Induced Neurotoxicity by Regulating Endoplasmic Reticulum Stress and PI3K\/Akt\/mTOR Signaling Pathway","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/s0091-3057(00)00260-4","article-title":"Antagonistic Effect of Pseudoginsenoside-F11 on the Behavioral Actions of Morphine in Mice","volume":"66","author":"Li","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.3390\/molecules24152687","article-title":"Ginsenoside Re Inhibits ROS\/ASK-1 Dependent Mitochondrial Apoptosis Pathway and Activation of Nrf2-Antioxidant Response in Beta-Amyloid-Challenged SH-SY5Y Cells","volume":"24","author":"Liu","year":"2019","journal-title":"Molecules"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00952990802455469","article-title":"Traditional Medicine in the Treatment of Drug Addiction","volume":"35","author":"Lu","year":"2009","journal-title":"Am. J. Drug Alcohol. Abuse"},{"key":"B69","doi-asserted-by":"publisher","first-page":"505","DOI":"10.19845\/j.cnki.zfysjjbzz.2015.06.007","article-title":"Caspase-3 and Bcl-2 Expression in Methamphetamine-dependent Rat Brain Interfered with Astragaloside IV (China)","volume":"32","author":"Lu","year":"2015","journal-title":"J. Apoplexy Nervous Dis."},{"key":"B70","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial Activation and Chronic Neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1177\/0960327120911438","article-title":"Neuroprotective Effect of Gastrodin in Methamphetamine-Induced Apoptosis through Regulating cAMP\/PKA\/CREB Pathway in Cortical Neuron","volume":"39","author":"Ma","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"11449","DOI":"10.1523\/JNEUROSCI.3597-04.2004","article-title":"High-dose Methamphetamine Acutely Activates the Striatonigral Pathway to Increase Striatal Glutamate and Mediate Long-Term Dopamine Toxicity","volume":"24","author":"Mark","year":"2004","journal-title":"J. Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1007\/s10495-010-0526-4","article-title":"Calpain and Caspase Processing of Caspase-12 Contribute to the ER Stress-Induced Cell Death Pathway in Differentiated PC12 Cells","volume":"15","author":"Martinez","year":"2010","journal-title":"Apoptosis"},{"key":"B74","doi-asserted-by":"publisher","first-page":"300","DOI":"10.2174\/1570159x14666160428110329","article-title":"The Role of Oxidative Stress in Methamphetamine-Induced Toxicity and Sources of Variation in the Design of Animal Studies","volume":"15","author":"McDonnell-Dowling","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/syn.21506","article-title":"Methamphetamine Self-Administration Acutely Decreases Monoaminergic Transporter Function","volume":"66","author":"McFadden","year":"2012","journal-title":"Synapse"},{"key":"B76","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1093\/ijnp\/pyy044","article-title":"Behavioral and Serotonergic Changes in the Frontal Cortex Following Methamphetamine Self-Administration","volume":"21","author":"McFadden","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1002\/jcp.23021","article-title":"Crosstalk between Mitochondrial (Dys)function and Mitochondrial Abundance","volume":"227","author":"Michel","year":"2012","journal-title":"J. Cel Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.lfs.2013.12.031","article-title":"Subchronic Apocynin Treatment Attenuates Methamphetamine-Induced Dopamine Release and Hyperactivity in Rats","volume":"98","author":"Miller","year":"2014","journal-title":"Life Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neuint.2018.12.019","article-title":"Methamphetamine Use Causes Cognitive Impairment and Altered Decision-Making","volume":"124","author":"Mizoguchi","year":"2019","journal-title":"Neurochem. Int."},{"key":"B80","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.pneurobio.2015.09.011","article-title":"Amphetamine-related Drugs Neurotoxicity in Humans and in Experimental Animals: Main Mechanisms","volume":"155","author":"Moratalla","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1124\/jpet.116.238501","article-title":"Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment","volume":"362","author":"Moszczynska","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B82","doi-asserted-by":"publisher","first-page":"745","DOI":"10.22037\/ijpr.2019.2393","article-title":"Crocin Acting as a Neuroprotective Agent against Methamphetamine-Induced Neurodegeneration via CREB-BDNF Signaling Pathway","volume":"18","author":"Mozaffari","year":"2019","journal-title":"Iran J. Pharm. Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1083\/jcb.150.4.887","article-title":"Cross-talk between Two Cysteine Protease Families. Activation of Caspase-12 by Calpain in Apoptosis","volume":"150","author":"Nakagawa","year":"2000","journal-title":"J. Cel Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jat.3093","article-title":"Ginsenoside Re Protects Methamphetamine-Induced Mitochondrial Burdens and Proapoptosis via Genetic Inhibition of Protein Kinase C \u03b4 in Human Neuroblastoma Dopaminergic SH-SY5Y Cell Lines","volume":"35","author":"Nam","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000441268","article-title":"Nephrotoxicity of Natural Products","volume":"41","author":"Nauffal","year":"2016","journal-title":"Blood Purif."},{"key":"B86","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/jpi.12195","article-title":"Liposomal Melatonin Rescues Methamphetamine-Elicited Mitochondrial Burdens, Pro-apoptosis, and Dopaminergic Degeneration through the Inhibition PKC\u03b4 Gene","volume":"58","author":"Nguyen","year":"2015","journal-title":"J. Pineal Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1176\/jnp.15.3.317","article-title":"Neuropsychological Effects of Chronic Methamphetamine Use on Neurotransmitters and Cognition: a Review","volume":"15","author":"Nordahl","year":"2003","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1007\/BF02973952","article-title":"Inhibitory Effects of Ginseng Total Saponin on Methamphetamine-Induced Striatal Dopamine Increase in Mice","volume":"20","author":"Oh","year":"","journal-title":"Arch. Pharm. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1055\/s-2006-957610","article-title":"Ginseng Total Saponin Inhibits the Dopaminergic Depletions Induced by Methamphetamine","volume":"63","author":"Oh","year":"","journal-title":"Planta Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s12640-020-00177-1","article-title":"Epigallocatechin Gallate Mitigates the Methamphetamine-Induced Striatal Dopamine Terminal Toxicity by Preventing Oxidative Stress in the Mouse Brain","volume":"37","author":"Pan","year":"2020","journal-title":"Neurotox Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.drugalcdep.2012.11.016","article-title":"Methamphetamine Use: a Comprehensive Review of Molecular, Preclinical and Clinical Findings","volume":"129","author":"Panenka","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"B92","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s12974-017-1009-0","article-title":"Asiatic Acid Attenuates Methamphetamine-Induced Neuroinflammation and Neurotoxicity through Blocking of NF-kB\/STAT3\/ERK and Mitochondria-Mediated Apoptosis Pathway","volume":"14","author":"Park","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"B93","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1089\/ars.2006.8.144","article-title":"The Role of Oxidative Stress in the Dysregulation of Gene Expression and Protein Metabolism in Neurodegenerative Disease","volume":"8","author":"Potashkin","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1021\/ci700452r","article-title":"Optimal Drug Cocktail Design: Methods for Targeting Molecular Ensembles and Insights from Theoretical Model Systems","volume":"48","author":"Radhakrishnan","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"B95","doi-asserted-by":"publisher","first-page":"E413","DOI":"10.1007\/BF02854914","article-title":"Mechanisms of Methamphetamine-Induced Dopaminergic Neurotoxicity","volume":"8","author":"Riddle","year":"2006","journal-title":"AAPS J."},{"key":"B96","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1055\/s-0042-107081","article-title":"Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs","volume":"82","author":"R\u00edos","year":"2016","journal-title":"Planta Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/mrdd.1036","article-title":"Apoptosis and Brain Development","volume":"7","author":"Roth","year":"2001","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"B98","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.psc.2013.02.005","article-title":"Neurologic Manifestations of Chronic Methamphetamine Abuse","volume":"36","author":"Rusyniak","year":"2013","journal-title":"Psychiatr. Clin. North. Am."},{"key":"B99","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/mdc3.12649","article-title":"Bilateral Basal Ganglia Necrosis Secondary to Methamphetamine","volume":"5","author":"Sanchez","year":"2018","journal-title":"Mov Disord. Clin. Pract."},{"key":"B100","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","article-title":"ER Stress-Induced Cell Death Mechanisms","volume":"1833","author":"Sano","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B101","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3109\/15563650.2010.516752","article-title":"The Clinical Toxicology of Metamfetamine","volume":"48","author":"Schep","year":"2010","journal-title":"Clin. Toxicol. (Phila)"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s00702-005-0383-4","article-title":"The Effect of Psychostimulants on [3H]dopamine Uptake and Release in Rat Brain Synaptic Vesicles","volume":"113","author":"Schwartz","year":"2006","journal-title":"J. Neural Transm. (Vienna)"},{"key":"B103","doi-asserted-by":"publisher","first-page":"5756","DOI":"10.1523\/JNEUROSCI.1179-08.2008","article-title":"Methamphetamine Causes Microglial Activation in the Brains of Human Abusers","volume":"28","author":"Sekine","year":"2008","journal-title":"J. Neurosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1186\/s12974-018-1385-0","article-title":"Methamphetamine Neurotoxicity, Microglia, and Neuroinflammation","volume":"15","author":"Shaerzadeh","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1007\/s11064-018-2644-2","article-title":"Crocin Inhibits Apoptosis and Astrogliosis of Hippocampus Neurons against Methamphetamine Neurotoxicity via Antioxidant and Anti-inflammatory Mechanisms","volume":"43","author":"Shafahi","year":"2018","journal-title":"Neurochem. Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1742-2094-9-52","article-title":"Involvement of Metabotropic Glutamate Receptor 5, AKT\/PI3K Signaling and NF-\u03baB Pathway in Methamphetamine-Mediated Increase in IL-6 and IL-8 Expression in Astrocytes","volume":"9","author":"Shah","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B107","doi-asserted-by":"publisher","first-page":"857","DOI":"10.2174\/1871527315666160518122816","article-title":"Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine","volume":"15","author":"Shen","year":"2016","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B108","doi-asserted-by":"publisher","first-page":"118","DOI":"10.2174\/157015911795016967","article-title":"Gastrodia Elata Bl Attenuates Methamphetamine-Induced Dopaminergic Toxicity via Inhibiting Oxidative Burdens","volume":"9","author":"Shin","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1007\/s12035-013-8617-1","article-title":"Ginsenoside Re Rescues Methamphetamine-Induced Oxidative Damage, Mitochondrial Dysfunction, Microglial Activation, and Dopaminergic Degeneration by Inhibiting the Protein Kinase C\u03b4 Gene","volume":"49","author":"Shin","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s12272-017-0897-y","article-title":"Current Understanding of Methamphetamine-Associated Dopaminergic Neurodegeneration and Psychotoxic Behaviors","volume":"40","author":"Shin","year":"2017","journal-title":"Arch. Pharm. Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s11064-017-2318-5","article-title":"Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis-A Review","volume":"43","author":"Shin","year":"2018","journal-title":"Neurochem. Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"101062","DOI":"10.1016\/j.arr.2020.101062","article-title":"The Multi-Faceted Impact of Methamphetamine on Alzheimer's Disease: From a Triggering Role to a Possible Therapeutic Use","volume":"60","author":"Shukla","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"B113","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2174\/1389200217666160709204826","article-title":"Natural Products Combating Neurodegeneration: Parkinson's Disease","volume":"18","author":"Solayman","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"B114","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13722-020-00209-3","article-title":"A Novel Brief Treatment for Methamphetamine Use Disorders in South Africa: a Randomised Feasibility Trial","volume":"16","author":"Sorsdahl","year":"2021","journal-title":"Addict. Sci. Clin. Pract."},{"key":"B115","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/syn.890170310","article-title":"Methamphetamine-induced Neurotoxicity: Roles for Glutamate and Dopamine Efflux","volume":"17","author":"Stephans","year":"1994","journal-title":"Synapse"},{"key":"B116","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/biof.1221","article-title":"Neuroprotection of Resveratrol against Neurotoxicity Induced by Methamphetamine in Mouse Mesencephalic Dopaminergic Neurons","volume":"41","author":"Sun","year":"2015","journal-title":"Biofactors"},{"key":"B117","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1360-0443.2007.01770.x","article-title":"Interactions between Methamphetamine and Environmental Stress: Role of Oxidative Stress, Glutamate and Mitochondrial Dysfunction","volume":"102","author":"Tata","year":"2007","journal-title":"Addiction"},{"key":"B118","unstructured":"World Drug Report 20212020"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1002\/jcb.25795","article-title":"Escalating Methamphetamine Regimen Induces Compensatory Mechanisms, Mitochondrial Biogenesis, and GDNF Expression, in Substantia Nigra","volume":"118","author":"Valian","year":"2017","journal-title":"J. Cel Biochem"},{"key":"B120","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.neuropharm.2014.01.022","article-title":"Pseudoginsenoside-F11 (PF11) Exerts Anti-neuroinflammatory Effects on LPS-Activated Microglial Cells by Inhibiting TLR4-Mediated TAK1\/IKK\/NF-\u03baB, MAPKs and Akt Signaling Pathways","volume":"79","author":"Wang","year":"2014","journal-title":"Neuropharmacology"},{"key":"B121","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nature14431","article-title":"Neurotransmitter and Psychostimulant Recognition by the Dopamine Transporter","volume":"521","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"B122","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/s0091-3057(03)00215-6","article-title":"Protective Effects of Pseudoginsenoside-F11 on Methamphetamine-Induced Neurotoxicity in Mice","volume":"76","author":"Wu","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B123","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.taap.2007.01.011","article-title":"Enhanced Oxidative Stress and Aberrant Mitochondrial Biogenesis in Human Neuroblastoma SH-SY5Y Cells during Methamphetamine Induced Apoptosis","volume":"220","author":"Wu","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"607412","DOI":"10.3389\/fphar.2021.607412","article-title":"Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review","volume":"12","author":"Xie","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B125","first-page":"84","article-title":"Role of Microglia in Methamphetamine-Induced Neurotoxicity","volume":"9","author":"Xu","year":"2017","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"e98981","DOI":"10.1371\/journal.pone.0098981","article-title":"Luteolin Inhibits Behavioral Sensitization by Blocking Methamphetamine-Induced MAPK Pathway Activation in the Caudate Putamen in Mice","volume":"9","author":"Yan","year":"2014","journal-title":"PLoS One"},{"key":"B127","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3389\/fnmol.2018.00186","article-title":"The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment","volume":"11","author":"Yang","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3969\/j.issn.1001-1978.2020.02.017","article-title":"Protective Effect of Gastrodin for Methamphetamine-Induced Neurotoxicity (China)","volume":"36","author":"Yang","year":"2020","journal-title":"Chinses Pharmacol. Bull."},{"key":"B129","doi-asserted-by":"publisher","first-page":"103969","DOI":"10.1155\/2015\/103969","article-title":"Recent Advances in Methamphetamine Neurotoxicity Mechanisms and its Molecular Pathophysiology","volume":"2015","author":"Yu","year":"2015","journal-title":"Behav. Neurol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.phymed.2013.12.004","article-title":"Limonene Inhibits Methamphetamine-Induced Locomotor Activity via Regulation of 5-HT Neuronal Function and Dopamine Release","volume":"21","author":"Yun","year":"2014","journal-title":"Phytomedicine"},{"key":"B131","doi-asserted-by":"publisher","first-page":"299","DOI":"10.13386\/j.issn1002-0306.2020.05.049","article-title":"Protective Effect and Mechanism of Terminalia Chebula Polyphenol Extract on Methamphetamine-Induced Injury in PC12 Cells","volume":"41","author":"Zeng","year":"2020","journal-title":"Sci. Techn. Food Industry"},{"key":"B132","doi-asserted-by":"publisher","first-page":"e13622","DOI":"10.1111\/jfbc.13622","article-title":"Resveratrol Attenuates Methamphetamine-Induced Memory Impairment via Inhibition of Oxidative Stress and Apoptosis in Mice","volume":"45","author":"Zeng","year":"2021","journal-title":"J. Food Biochem."},{"key":"B133","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.intimp.2018.11.026","article-title":"Pseudoginsenoside-F11 Attenuates Cognitive Impairment by Ameliorating Oxidative Stress and Neuroinflammation in D-galactose-T-reated M-ice","volume":"67","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11011-018-0319-y","article-title":"Role of PUMA in the Methamphetamine-Induced Migration of Microglia","volume":"34","author":"Zhao","year":"2019","journal-title":"Metab. Brain Dis."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.805991\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T06:25:55Z","timestamp":1641277555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.805991\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":134,"alternative-id":["10.3389\/fphar.2021.805991"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2021.805991","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"article-number":"805991"}}