{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:44:46Z","timestamp":1792201486868,"version":"4.4.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The growing interest in the development of drugs that target the endocannabinoid system has extended to conditions that affect the audiovestibular pathway. The expression of cannabinoid (CB) receptors in that pathway has been widely demonstrated, indicating a therapeutic potential for drug development at this level. These medications may be beneficial for conditions such as noise-induced hearing loss, ototoxicity, or various forms of vertigo of central or peripheral origin. The therapeutic targets of interest include natural or synthetic compounds that act as CB1\/CB2 receptor agonists\/antagonists, and inhibitors of the endocannabinoid-degrading enzymes FAAH and MAGL. Furthermore, genetic variations implicated in the response to treatment and the development of related disorders such as epilepsy or migraine have been identified. Direct methods of administering these medications should be examined beyond the systemic strategy.<\/jats:p>","DOI":"10.3389\/fphar.2022.1010296","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T06:57:47Z","timestamp":1671519467000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Potential effects of cannabinoids on audiovestibular function: A narrative review"],"prefix":"10.3389","volume":"13","author":[{"given":"Joaquin","family":"Guerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinogran","family":"Naidoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Cacabelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.brainres.2004.06.065","article-title":"Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation","volume":"1021","author":"Ashton","year":"2004","journal-title":"Brain Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.neulet.2010.10.050","article-title":"Cannabinoid CB1 receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation","volume":"487","author":"Baek","year":"2011","journal-title":"Neurosci. Lett."},{"key":"B3","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1080\/00016480701796944","article-title":"Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei","volume":"128","author":"Baek","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.nlm.2010.08.007","article-title":"Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent","volume":"94","author":"Baek","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/S0140-6736(13)60142-7","article-title":"Tinnitus","volume":"382","author":"Baguley","year":"2013","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10517-015-3098-z","article-title":"The use of release-active antibody-based preparations for vertigo prevention in adults","volume":"160","author":"Barchukov","year":"2015","journal-title":"Bull. Exp. Biol. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.heares.2017.10.012","article-title":"Effects of the cannabinoid CB 1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in Guinea pigs","volume":"356","author":"Berger","year":"2017","journal-title":"Hear. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1038\/s41467-021-22405-8","article-title":"Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling","volume":"12","author":"Bonnan","year":"2021","journal-title":"Nat. Commun."},{"key":"B9","volume-title":"World guide for drug use and pharmacogenomics","author":"Cacabelos","year":"2012"},{"key":"B10","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s40266-021-00877-z","article-title":"Current insights into treating vertigo in older adults","volume":"38","author":"Casani","year":"2021","journal-title":"Drugs Aging"},{"key":"B11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.drugalcdep.2014.08.005","article-title":"Synthetic cannabinoids: Epidemiology, pharmacodynamics, and clinical implications","volume":"144","author":"Castaneto","year":"2014","journal-title":"Drug Alcohol Depend."},{"key":"B12","doi-asserted-by":"publisher","first-page":"958","DOI":"10.3389\/fpls.2020.00958","article-title":"Propagation of cannabis for clinical research: An approach towards a modern herbal medicinal products development","volume":"11","author":"Chandra","year":"2020","journal-title":"Front. Plant Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neulet.2011.12.047","article-title":"Cannabinoid receptor expression at the MNTB-LSO synapse in developing rats","volume":"509","author":"Chi","year":"2012","journal-title":"Neurosci. Lett."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1365-2710.2010.01164.x","article-title":"An overview of the metabolic effects of rimonabant in randomized controlled trials: Potential for other cannabinoid 1 receptor blockers in obesity","volume":"36","author":"Christopoulou","year":"2011","journal-title":"J. Clin. Pharm. Ther."},{"key":"B15","author":"Chu","year":"2022"},{"key":"B16","doi-asserted-by":"publisher","first-page":"11152","DOI":"10.1038\/s41598-017-11606-1","article-title":"The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity","volume":"7","author":"Colangeli","year":"2017","journal-title":"Sci. Rep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1468-1331.2006.01639.x","article-title":"Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis","volume":"14","author":"Collin","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.jpain.2019.11.001","article-title":"Short- and long-term effects of cannabis on headache and migraine","volume":"21","author":"Cuttler","year":"2020","journal-title":"J. Pain"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/ph3092930","article-title":"Mechanisms of broad-spectrum antiemetic efficacy of cannabinoids against chemotherapy-induced acute and delayed vomiting","volume":"3","author":"Darmani","year":"2010","journal-title":"Pharmaceuticals"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/cpt.2408","article-title":"Pharmacogenetic predictors of cannabidiol response and tolerability in treatment\u2010resistant epilepsy","volume":"110","author":"Davis","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"key":"B21","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S1474-4422(15)00379-8","article-title":"Cannabidiol in patients with treatment-resistant epilepsy: An open-label interventional trial","volume":"15","author":"Devinsky","year":"2016","journal-title":"Lancet. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"8116","DOI":"10.1038\/s41598-021-87387-5","article-title":"Regulator of G protein signaling 17 represents a novel target for treating cisplatin induced hearing loss","volume":"11","author":"Dhukhwa","year":"2021","journal-title":"Sci. Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/antiox7070093","article-title":"Modulation of the oxidative stress and lipid peroxidation by endocannabinoids and their lipid analogues","volume":"7","author":"Gallelli","year":"2018","journal-title":"Antioxidants"},{"key":"B24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fncel.2018.00271","article-title":"The endocannabinoid\/cannabinoid receptor 2 system protects against cisplatin-induced hearing loss","volume":"12","author":"Ghosh","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainres.2005.11.035","article-title":"Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain","volume":"1071","author":"Gong","year":"2006","journal-title":"Brain Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.3390\/cells10102543","article-title":"Dual inhibition of FAAH and MAGL counteracts migraine-like pain and behavior in an animal model of migraine","volume":"10","author":"Greco","year":"","journal-title":"Cells"},{"key":"B27","doi-asserted-by":"publisher","first-page":"105157","DOI":"10.1016\/j.nbd.2020.105157","article-title":"Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine","volume":"147","author":"Greco","year":"","journal-title":"Neurobiol. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"104624","DOI":"10.1016\/j.nbd.2019.104624","article-title":"FAAH inhibition as a preventive treatment for migraine: A pre-clinical study","volume":"134","author":"Greco","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/B978-0-12-813939-4.00028-0","article-title":"Pharmacoepigenetics of vertigo and related vestibular syndromes","volume":"10","author":"Guerra","year":"2019","journal-title":"Pharmacoepigenetics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2165\/00023210-200317020-00002","article-title":"Pharmacological treatment of vertigo","volume":"17","author":"Hain","year":"2003","journal-title":"CNS Drugs"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.jagp.2019.05.002","article-title":"Randomized placebo-controlled trial of nabilone for agitation in Alzheimer's disease","volume":"27","author":"Herrmann","year":"2019","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fnint.2013.00073","article-title":"Epilepsy and the cortical vestibular system: Tales of dizziness and recent concepts","volume":"7","author":"Hewett","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"B33","first-page":"1","article-title":"Pharmacogenetics of cannabinoids","volume-title":"Eur. J. Drug Metab. Pharmacokinet.","author":"Hryhorowicz","year":"2018"},{"key":"B34","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s13311-015-0377-3","article-title":"Molecular targets of cannabidiol in neurological disorders","volume":"12","author":"Ibeas Bih","year":"2015","journal-title":"Neurotherapeutics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"10365","DOI":"10.1038\/s41598-018-23793-6","article-title":"Targeting TRPV1 to relieve motion sickness symptoms in mice by electroacupuncture and gene deletion","volume":"8","author":"Inprasit","year":"2018","journal-title":"Sci. Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neulet.2009.06.021","article-title":"Variations in the cannabinoid receptor 1 gene predispose to migraine","volume":"461","author":"Juhasz","year":"2009","journal-title":"Neurosci. Lett."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1124\/jpet.107.120147","article-title":"Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage","volume":"322","author":"Karanian","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40429-022-00438-3","article-title":"Review: Cannabinoids as medicinals","volume":"7","author":"Khalsa","year":"2022","journal-title":"Curr. Addict. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1042\/EBC20190086","article-title":"The endocannabinoid system","volume":"64","author":"Kilaru","year":"2020","journal-title":"Essays Biochem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.heares.2004.09.007","article-title":"Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge","volume":"201","author":"Kitahara","year":"2005","journal-title":"Hear. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/bcp.12071","article-title":"Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits \u03949-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans","volume":"76","author":"Klumpers","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"413","DOI":"10.31887\/DCNS.2007.9.4\/nkogan","article-title":"Cannabinoids in health and disease","volume":"9","author":"Kogan","year":"2007","journal-title":"Dialogues Clin. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3389\/fphar.2018.00420","article-title":"Emerging role of (Endo)Cannabinoids in migraine","volume":"9","author":"Leimuranta","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3233\/VES-2012-0453","article-title":"Vestibular migraine: Diagnostic criteria","volume":"22","author":"Lempert","year":"2012","journal-title":"J. Vestib. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e94","DOI":"10.1038\/tp.2012.15","article-title":"Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia","volume":"2","author":"Leweke","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An introduction to the endogenous cannabinoid system","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e0161954","DOI":"10.1371\/journal.pone.0161954","article-title":"Spontaneous cannabinoid receptor 2 (CB2) expression in the cochlea of adult albino rat and its up-regulation after cisplatin treatment","volume":"11","author":"Mart\u00edn-Salda\u00f1a","year":"2016","journal-title":"PLOS ONE"},{"key":"B48","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1176\/appi.ajp.2017.17030325","article-title":"Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: A multicenter randomized controlled trial","volume":"175","author":"McGuire","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11916-020-00931-2","article-title":"Cannabis and migraine: It\u2019s complicated","volume":"25","author":"Mechtler","year":"2021","journal-title":"Curr. Pain Headache Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"381","DOI":"10.2147\/NDT.S203782","article-title":"Cannabinoids in the treatment of epilepsy: Current status and future prospects","volume":"16","author":"Morano","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/lio2.479","article-title":"Does cannabis alleviate tinnitus? A review of the current literature","volume":"5","author":"Narwani","year":"2020","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/ajad.12529","article-title":"Long lasting effects of chronic heavy cannabis abuse","volume":"26","author":"Nestoros","year":"2017","journal-title":"Am. J. Addict."},{"key":"B53","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1016\/s0014-2999(98)00237-4","article-title":"Potent effects of a selective cannabinoid receptor agonist on some Guinea pig medial vestibular nucleus neurons","volume":"348","author":"Newsham-West","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.physbeh.2009.02.014","article-title":"The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew)","volume":"97","author":"Parker","year":"2009","journal-title":"Physiol. Behav."},{"key":"B55","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.tins.2016.05.001","article-title":"The neural consequences of age-related hearing loss","volume":"39","author":"Peelle","year":"2016","journal-title":"Trends Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"505995","DOI":"10.3389\/fneur.2020.505995","article-title":"Cannabinoids, inner ear, hearing, and tinnitus: A neuroimmunological perspective","volume":"11","author":"Perin","year":"2020","journal-title":"Front. Neurol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3389\/fnmol.2018.00067","article-title":"Antiepileptogenic effect of SubchronicPalmitoylethanolamide treatment in a mouse model of acute epilepsy","volume":"11","author":"Post","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e17407","DOI":"10.7759\/cureus.17407","article-title":"Medical cannabis, headaches, and migraines: A review of the current literature","volume":"13","author":"Poudel","year":"2021","journal-title":"Cureus"},{"key":"B59","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/09273970701821063","article-title":"Reduction of congenital nystagmus in a patient after smoking cannabis","volume":"16","author":"Pradeep","year":"2008","journal-title":"Strabismus"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1089\/ars.2021.0191","article-title":"Transient receptor potential channels and auditory functions","volume":"36","author":"Ramkumar","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"B61","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1089\/can.2016.0009","article-title":"Clinical endocannabinoid deficiency reconsidered: Current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes. Syndromes","volume":"1","author":"Russo","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1111\/epi.17036","article-title":"Add\u2010on cannabidiol in patients with Dravet syndrome: Results of a long\u2010term open\u2010label extension trial","volume":"62","author":"Scheffer","year":"2021","journal-title":"Epilepsia"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1212\/wnl.53.9.2209-a","article-title":"Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis","volume":"53","author":"Schon","year":"1999","journal-title":"Neurology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/13543784.2017.1269171","article-title":"Emerging therapeutic interventions against noise-induced hearing loss","volume":"26","author":"Sha","year":"2016","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e0187926","DOI":"10.1371\/journal.pone.0187926","article-title":"Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans","volume":"12","author":"Smith","year":"2017","journal-title":"PLOS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s13181-016-0595-z","article-title":"Cannabinoid hyperemesis syndrome: Diagnosis, pathophysiology, and treatment\u2014A systematic review","volume":"13","author":"Sorensen","year":"2016","journal-title":"J. Med. Toxicol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s00415-011-5999-8","article-title":"Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus","volume":"258","author":"Strupp","year":"2011","journal-title":"J. Neurol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1002\/cne.21774","article-title":"Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei","volume":"509","author":"Su\u00e1rez","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.heares.2015.09.013","article-title":"Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice","volume":"332","author":"Toal","year":"2016","journal-title":"Hear. Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/jnc.12369","article-title":"Depolarization-induced suppression of a glycinergic synapse in the superior olivary complex by endocannabinoids","volume":"127","author":"Trattner","year":"2013","journal-title":"J. Neurochem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1097\/j.pain.0000000000001464","article-title":"An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia","volume":"160","author":"Van de Donk","year":"2018","journal-title":"Pain"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3902740","DOI":"10.1155\/2020\/3902740","article-title":"Potential pharmacokinetic drug-drug interactions between cannabinoids and drugs used for chronic pain","volume":"2020","author":"V\u00e1zquez","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1136\/jnnp.2009.200642","article-title":"Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: A randomised, double-blind crossover trial","volume":"81","author":"Weber","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e1396","DOI":"10.1097\/MAO.0000000000003280","article-title":"Cannabinoid receptor 2 agonism is capable of preventing lipopolysaccharide induced decreases of cochlear microcirculation \u2013 a potential approach for inner ear pathologies","volume":"42","author":"Weiss","year":"2021","journal-title":"Otol. Neurotol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e1285","DOI":"10.1212\/WNL.0000000000006293","article-title":"Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity","volume":"91","author":"Weizman","year":"2018","journal-title":"Neurology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1001\/jama.2015.6358","article-title":"Cannabinoids for medical use: A systematic review and meta-analysis","volume":"313","author":"Whiting","year":"2015","journal-title":"JAMA"},{"key":"B78","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: A major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1136\/jnnp-2012-302468","article-title":"MUltiple sclerosis and extract of cannabis: Results of the MUSEC trial","volume":"83","author":"Zajicek","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B80","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fneur.2015.00060","article-title":"Cannabinoid CB1 receptor agonists do not decrease, but may increase acoustic trauma-induced tinnitus in rats","volume":"6","author":"Zheng","year":"2015","journal-title":"Front. Neurol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.heares.2010.05.015","article-title":"The effects of the synthetic cannabinoid receptor agonists, WIN55, 212-2 and CP55, 940, on salicylate-induced tinnitus in rats","volume":"268","author":"Zheng","year":"2010","journal-title":"Hear. Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/fcp.12008","article-title":"The role of endocannabinoids in pain modulation","volume":"27","author":"Zogopoulos","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3390\/ijms19030833","article-title":"Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system","volume":"19","author":"Zou","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/WCO.0000000000000769","article-title":"Vertigo and dizziness in the emergency room","volume":"33","author":"Zwergal","year":"2020","journal-title":"Curr. Opin. Neurol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.1010296\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T06:57:54Z","timestamp":1671519474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.1010296\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":83,"alternative-id":["10.3389\/fphar.2022.1010296"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.1010296","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"article-number":"1010296"}}