{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:07:59Z","timestamp":1784250479975,"version":"3.55.0"},"reference-count":154,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:title>Graphical Abstract<\/jats:title><jats:p><jats:fig><jats:caption><jats:p>Pharmacological treatment and mechanisms of bariatric surgery for diabetic comorbidities.<\/jats:p><\/jats:caption><\/jats:fig><\/jats:p>","DOI":"10.3389\/fphar.2022.1016635","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:34:51Z","timestamp":1667208891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Bariatric surgery for diabetic comorbidities: A focus on hepatic, cardiac and renal fibrosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Huanxin","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.soard.2021.07.019","article-title":"Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects","volume":"17","author":"Abu El Haija","year":"2021","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1046\/j.1523-1755.2003.00712.x","article-title":"Development and progression of nephropathy in type 2 diabetes: The United Kingdom prospective diabetes study (UKPDS 64)","volume":"63","author":"Adler","year":"2003","journal-title":"Kidney Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1681\/asn.2012070718","article-title":"Kidney disease and increased mortality risk in type 2 diabetes","volume":"24","author":"Afkarian","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1186\/s12967-019-2096-8","article-title":"Metabolic signature of obesity-associated insulin resistance and type 2 diabetes","volume":"17","author":"Al-Sulaiti","year":"2019","journal-title":"J. Transl. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.soard.2019.03.021","article-title":"Impact of bariatric surgery on heart failure mortality","volume":"15","author":"Aleassa","year":"2019","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41581-018-0001-y","article-title":"CKD in diabetes: Diabetic kidney disease versus nondiabetic kidney disease","volume":"14","author":"Anders","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s0140-6736(15)00803-x","article-title":"Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study","volume":"387","author":"Armstrong","year":"","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jhep.2015.08.038","article-title":"Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis","volume":"64","author":"Armstrong","year":"","journal-title":"J. Hepatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/jama.2020.12567","article-title":"Benefits and risks of bariatric surgery in adults: A review","volume":"324","author":"Arterburn","year":"2020","journal-title":"Jama"},{"key":"B10","doi-asserted-by":"publisher","first-page":"S13-S27","DOI":"10.2337\/dc18-S002","article-title":"2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2018","volume":"41","year":"2018","journal-title":"Diabetes Care"},{"key":"B12","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1056\/NEJMoa030204","article-title":"Inhibition of food intake in obese subjects by peptide YY3-36","volume":"349","author":"Batterham","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s11695-015-1878-1","article-title":"Changes in bile acid profile After laparoscopic sleeve gastrectomy are associated with improvements in metabolic profile and fatty liver disease","volume":"26","author":"Belgaumkar","year":"2016","journal-title":"Obes. Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.21037\/cdt.2018.10.04","article-title":"Bariatric surgery and hypertension: Implications and perspectives after the GATEWAY randomized trial","volume":"9","author":"Benaiges","year":"2019","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"745045","DOI":"10.3389\/fendo.2021.745045","article-title":"Bariatric surgery induces a differential effect on plasma aldosterone in comparison to dietary advice alone","volume":"12","author":"Berney","year":"2021","journal-title":"Front. Endocrinol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","article-title":"Molecular pathways of nonalcoholic fatty liver disease development and progression","volume":"76","author":"Bessone","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1136\/gutjnl-2016-313654","article-title":"Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice","volume":"67","author":"Bijnen","year":"2018","journal-title":"Gut"},{"key":"B18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.soard.2018.09.488","article-title":"Laparoscopic sleeve gastrectomy versus roux-en-Y gastric bypass in cardiovascular risk reduction: A match control study","volume":"15","author":"Blanco","year":"2019","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2337\/diabetes.54.1.146","article-title":"Glucagon-like peptide 1 can directly protect the heart against ischemia\/reperfusion injury","volume":"54","author":"Bose","year":"2005","journal-title":"Diabetes"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1007\/s11695-015-1691-x","article-title":"Bariatric surgery and non-alcoholic fatty liver disease: A systematic review of liver biochemistry and histology","volume":"25","author":"Bower","year":"2015","journal-title":"Obes. Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1002\/bjs.7264","article-title":"Renal cytokines improve early after bariatric surgery","volume":"97","author":"Bueter","year":"2010","journal-title":"Br. J. Surg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.metabol.2019.07.002","article-title":"Laparoscopic sleeve gastrectomy reverses non-alcoholic fatty liver disease modulating oxidative stress and inflammation","volume":"99","author":"Cabr\u00e9","year":"2019","journal-title":"Metabolism."},{"key":"B23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1042\/bj20130609","article-title":"Diacylglycerol kinase \u03b8 couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes","volume":"454","author":"Cai","year":"2013","journal-title":"Biochem. J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1479164119879039","DOI":"10.1177\/1479164119879039","article-title":"Improvements in diabetic albuminuria and podocyte differentiation following Roux-en-Y gastric bypass surgery","volume":"17","author":"Canney","year":"2020","journal-title":"Diab. Vasc. Dis. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"567","DOI":"10.2337\/db19-0773","article-title":"Bariatric surgery rapidly decreases cardiac dietary fatty acid partitioning and hepatic insulin resistance through increased intra-abdominal adipose tissue storage and reduced spillover in type 2 diabetes","volume":"69","author":"Carreau","year":"2020","journal-title":"Diabetes"},{"key":"B26","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1053\/j.gastro.2015.10.009","article-title":"Differences in alimentary glucose absorption and intestinal disposal of blood glucose after roux-en-Y gastric bypass vs sleeve gastrectomy","volume":"150","author":"Cavin","year":"2016","journal-title":"Gastroenterology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1053\/j.gastro.2011.05.050","article-title":"Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats","volume":"141","author":"Chambers","year":"2011","journal-title":"Gastroenterology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"810","DOI":"10.2337\/db10-0566","article-title":"Diet and gastrointestinal bypass-induced weight loss: The roles of ghrelin and peptide YY","volume":"60","author":"Chandarana","year":"2011","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1007\/s00464-019-07017-0","article-title":"Impact of sleeve gastrectomy and Roux-en-Y gastric bypass on biopsy-proven non-alcoholic fatty liver disease","volume":"34","author":"Cherla","year":"2020","journal-title":"Surg. Endosc."},{"key":"B31","doi-asserted-by":"publisher","first-page":"G554-G573","DOI":"10.1152\/ajpgi.00223.2019","article-title":"Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy","volume":"318","author":"Chiang","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1007\/s11892-013-0423-7","article-title":"Impact of behavioral interventions in the management of adults with type 2 diabetes mellitus","volume":"13","author":"Cox","year":"2013","journal-title":"Curr. Diab. Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cmet.2013.03.013","article-title":"Pleiotropic roles of bile acids in metabolism","volume":"17","author":"de Aguiar Vallim","year":"2013","journal-title":"Cell. Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1007\/s11695-021-05412-y","article-title":"Gastric bypass compared with sleeve gastrectomy for nonalcoholic fatty liver disease: A systematic review and meta-analysis","volume":"31","author":"de Brito","year":"2021","journal-title":"Obes. Surg."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1007\/s00464-020-07555-y","article-title":"Clinical practice guidelines of the European association for endoscopic surgery (EAES) on bariatric surgery: Update 2020 endorsed by IFSO-ec, EASO and ESPCOP","volume":"34","author":"Di Lorenzo","year":"2020","journal-title":"Surg. Endosc."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1161\/circresaha.118.314665","article-title":"Diabetic cardiomyopathy","volume":"124","author":"Dillmann","year":"2019","journal-title":"Circ. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.cmet.2018.03.001","article-title":"Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1","volume":"27","author":"Drucker","year":"2018","journal-title":"Cell Metab."},{"key":"B38","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1053\/j.gastro.2015.05.044","article-title":"Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease","volume":"149","author":"du Plessis","year":"2015","journal-title":"Gastroenterology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1038\/s41366-020-0578-7","article-title":"Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy","volume":"44","author":"Eiken","year":"2020","journal-title":"Int. J. Obes."},{"key":"B40","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pcad.2018.07.003","article-title":"An overview and update on obesity and the obesity paradox in cardiovascular diseases","volume":"61","author":"Elagizi","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.pcad.2018.06.003","article-title":"Metabolic and bariatric surgery: An effective treatment option for obesity and cardiovascular disease","volume":"61","author":"English","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.soard.2018.12.002","article-title":"Bariatric surgery improves nonalcoholic fatty liver disease: A contemporary systematic review and meta-analysis","volume":"15","author":"Fakhry","year":"2019","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.soard.2012.03.009","article-title":"Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: A 12-month prospective study","volume":"9","author":"Fenske","year":"2013","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1001\/jama.2018.14619","article-title":"Association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity","volume":"320","author":"Fisher","year":"2018","journal-title":"Jama"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1210\/en.2011-0281","article-title":"Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo","volume":"152","author":"Fisher","year":"2011","journal-title":"Endocrinology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jhep.2022.02.003","article-title":"Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis","volume":"77","author":"Fondevila","year":"2022","journal-title":"J. Hepatol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jhep.2015.02.019","article-title":"PPAR\u03b1 gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis","volume":"63","author":"Francque","year":"2015","journal-title":"J. Hepatol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"528","DOI":"10.2215\/cjn.07670715","article-title":"Is bariatric surgery an effective treatment for type II diabetic kidney disease?","volume":"11","author":"Friedman","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1007\/s11695-012-0617-0","article-title":"Changes in renal function following roux-en-Y gastric bypass: A prospective study","volume":"22","author":"Getty","year":"2012","journal-title":"Obes. Surg."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/circresaha.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.tem.2017.04.005","article-title":"The role of PYY in pancreatic islet physiology and surgical control of diabetes","volume":"28","author":"Guida","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-med-053117-123246","article-title":"Bariatric surgery as a long-term treatment for type 2 diabetes\/metabolic syndrome","volume":"71","author":"Hanipah","year":"2020","journal-title":"Annu. Rev. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1210\/jc.2017-01295","article-title":"Roux-en-Y gastric bypass surgery has unique effects on postprandial FGF21 but not FGF19 secretion","volume":"102","author":"Harris","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B55","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s12192-015-0577-0","article-title":"TLR4 mutation and HSP60-induced cell death in adult mouse cardiac myocytes","volume":"20","author":"Heiserman","year":"2015","journal-title":"Cell. Stress Chaperones"},{"key":"B56","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1161\/atv.0000615456.97862.30","article-title":"Endothelial GLP-1 (Glucagon-Like peptide-1) receptor mediates cardiovascular protection by liraglutide in mice with experimental arterial hypertension","volume":"40","author":"Helmst\u00e4dter","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: From mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: One function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am. J. Pathol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"E815","DOI":"10.3390\/jcm8060815","article-title":"Bile acid and fibroblast growth factor 19 regulation in obese diabetics, and non-alcoholic fatty liver disease after sleeve gastrectomy","volume":"8","author":"Huang","year":"2019","journal-title":"J. Clin. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"H1258-H1268","DOI":"10.1152\/ajpheart.00274.2018","article-title":"Facilitated Ca(2+) homeostasis and attenuated myocardial autophagy contribute to alleviation of diabetic cardiomyopathy after bariatric surgery","volume":"315","author":"Huang","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1381\/096089291765560962","article-title":"Gastrointestinal surgery for severe obesity","volume":"1","author":"Hubbard","year":"1991","journal-title":"Obes. Surg."},{"key":"B61","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s11695-012-0643-y","article-title":"Obesity and inflammation: Change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery","volume":"22","author":"Ill\u00e1n-G\u00f3mez","year":"2012","journal-title":"Obes. Surg."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1161\/01.cir.103.22.2668","article-title":"Glycemic control and heart failure among adult patients with diabetes","volume":"103","author":"Iribarren","year":"2001","journal-title":"Circulation"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00441-010-1024-2","article-title":"Hormone-like (endocrine) fgfs: Their evolutionary history and roles in development, metabolism, and disease","volume":"342","author":"Itoh","year":"2010","journal-title":"Cell. Tissue Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","article-title":"Diabetic cardiomyopathy: A hyperglycaemia- and insulin-resistance-induced heart disease","volume":"61","author":"Jia","year":"2018","journal-title":"Diabetologia"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.2337\/dc12-1535","article-title":"GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery","volume":"36","author":"Jim\u00e9nez","year":"2013","journal-title":"Diabetes Care"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3372","DOI":"10.2337\/db14-0357","article-title":"GLP-1 and glucose tolerance after sleeve gastrectomy in morbidly obese subjects with type 2 diabetes","volume":"63","author":"Jim\u00e9nez","year":"2014","journal-title":"Diabetes"},{"key":"B67","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.bbadis.2013.02.010","article-title":"Renal epithelial injury and fibrosis","volume":"1832","author":"Kaissling","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B68","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1097\/sla.0000000000002397","article-title":"Liver function in patients with nonalcoholic fatty liver disease randomized to roux-en-Y gastric bypass versus sleeve gastrectomy: A secondary analysis of a randomized clinical trial","volume":"266","author":"Kalinowski","year":"2017","journal-title":"Ann. Surg."},{"key":"B69","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/jgh.12690","article-title":"Duodenal-jejunal bypass improves diabetes and liver steatosis via enhanced glucagon-like peptide-1 elicited by bile acids","volume":"30","author":"Kashihara","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.soard.2017.09.534","article-title":"Bariatric surgery as a treatment for heart failure: Review of the literature and potential mechanisms","volume":"14","author":"Kindel","year":"2018","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1172\/jci88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Investig."},{"key":"B72","doi-asserted-by":"publisher","first-page":"E105","DOI":"10.1152\/ajpendo.00070.2021","article-title":"Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity","volume":"321","author":"Kunz","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B73","doi-asserted-by":"publisher","first-page":"E8178","DOI":"10.3390\/ijms21218178","article-title":"Prevention of diabetes and cardiovascular disease in obesity","volume":"21","author":"La Sala","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.2337\/db11-1805","article-title":"Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humans","volume":"61","author":"Labb\u00e9","year":"2012","journal-title":"Diabetes"},{"key":"B75","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrneph.2012.281","article-title":"Improving the efficacy of RAAS blockade in patients with chronic kidney disease","volume":"9","author":"Lambers Heerspink","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1053\/j.gastro.2020.06.006","article-title":"Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis","volume":"159","author":"Lassailly","year":"2020","journal-title":"Gastroenterology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1079\/pns2005427","article-title":"Peptide YY, appetite and food intake","volume":"64","author":"le Roux","year":"2005","journal-title":"Proc Nutr Soc"},{"key":"B78","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1002\/ptr.7055","article-title":"Isotschimgine alleviates nonalcoholic steatohepatitis and fibrosis via FXR agonism in mice","volume":"35","author":"Li","year":"2021","journal-title":"Phytother. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"12839","DOI":"10.1002\/jcp.27940","article-title":"Farnesoid X receptor interacts with cAMP response element binding protein to modulate glucagon-like peptide-1 (7-36) amide secretion by intestinal L cell","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"837798","DOI":"10.3389\/fphys.2022.837798","article-title":"Sleeve gastrectomy-induced AMPK activation attenuates diabetic cardiomyopathy by maintaining mitochondrial homeostasis via NR4A1 suppression in rats","volume":"13","author":"Li","year":"2022","journal-title":"Front. Physiol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"E182","DOI":"10.1002\/oby.20030","article-title":"Visceral fat resection in humans: Effect on insulin sensitivity, beta-cell function, adipokines, and inflammatory markers","volume":"21","author":"Lima","year":"2013","journal-title":"Obes. (Silver Spring)"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1038\/oby.2011.186","article-title":"Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight loss","volume":"19","author":"Lin","year":"2011","journal-title":"Obes. (Silver Spring)"},{"key":"B83","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.addr.2021.03.021","article-title":"Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies","volume":"173","author":"Liu","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3389\/fendo.2019.00566","article-title":"Improved FGF21 sensitivity and restored FGF21 signaling pathway in high-fat diet\/streptozotocin-induced diabetic rats after duodenal-jejunal bypass and sleeve gastrectomy","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Endocrinol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1002\/hep.30975","article-title":"Probiotic lactobacillus rhamnosus GG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice","volume":"71","author":"Liu","year":"2020","journal-title":"Hepatology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.matbio.2017.11.010","article-title":"Inflammation and fibrosis","author":"Mack","year":"2018","journal-title":"Matrix Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s11695-017-2595-8","article-title":"Impact of bariatric surgery on metabolic and gut microbiota profile: A systematic review and meta-analysis","volume":"27","author":"Magouliotis","year":"2017","journal-title":"Obes. Surg."},{"key":"B89","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3389\/fendo.2020.00289","article-title":"Metabolic surgery to treat obesity in diabetic kidney disease, chronic kidney disease, and end-stage kidney disease; what are the unanswered questions?","volume":"11","author":"Martin","year":"2020","journal-title":"Front. Endocrinol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1111\/j.1540-8167.2010.01736.x","article-title":"Diminished cardiac fibrosis in heart failure is associated with altered ventricular arrhythmia phenotype","volume":"21","author":"Massare","year":"2010","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11605-018-3938-z","article-title":"Concomitant PPAR\u03b1 and FXR activation as a putative mechanism of NASH improvement after gastric bypass surgery: A GEO datasets analysis","volume":"23","author":"Mazzini","year":"2019","journal-title":"J. Gastrointest. Surg."},{"key":"B92","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1042\/cs20030186","article-title":"C-reactive protein, cardiovascular risk, and renal disease in a remote Australian Aboriginal community","volume":"106","author":"McDonald","year":"2004","journal-title":"Clin. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3389\/fphys.2018.00259","article-title":"Functional changes induced by orexin A and adiponectin on the sympathetic\/parasympathetic balance","volume":"9","author":"Messina","year":"2018","journal-title":"Front. Physiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1161\/hy09t1.094234","article-title":"Angiotensin II and renal fibrosis","volume":"38","author":"Mezzano","year":"2001","journal-title":"Hypertension"},{"key":"B95","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.surg.2011.09.038","article-title":"Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus","volume":"151","author":"Monte","year":"2012","journal-title":"Surgery"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1172\/jci74783","article-title":"Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis","volume":"124","author":"Moore-Morris","year":"2014","journal-title":"J. Clin. Investig."},{"key":"B97","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s11695-009-0026-1","article-title":"Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery","volume":"20","author":"Navaneethan","year":"2010","journal-title":"Obes. Surg."},{"key":"B98","doi-asserted-by":"publisher","first-page":"S213","DOI":"10.1681\/asn.2006080917","article-title":"Effect of drastic weight loss after bariatric surgery on renal parameters in extremely obese patients: Long-term follow-up","volume":"17","author":"Navarro-D\u00edaz","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.2337\/diacare.27.8.1879","article-title":"The incidence of congestive heart failure in type 2 diabetes: An update","volume":"27","author":"Nichols","year":"2004","journal-title":"Diabetes Care"},{"key":"B100","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1007\/s00464-013-3125-y","article-title":"Bariatric surgery rapidly improves mitochondrial respiration in morbidly obese patients","volume":"27","author":"Nijhawan","year":"2013","journal-title":"Surg. Endosc."},{"key":"B101","doi-asserted-by":"publisher","first-page":"300","DOI":"10.7326\/m17-2383","article-title":"Microvascular outcomes in patients with diabetes after bariatric surgery versus usual care: A matched cohort study","volume":"169","author":"O'Brien","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1161\/circulationaha.114.011791","article-title":"Rapid and body weight-independent improvement of endothelial and high-density lipoprotein function after roux-en-Y gastric bypass: Role of glucagon-like peptide-1","volume":"131","author":"Osto","year":"2015","journal-title":"Circulation"},{"key":"B103","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","article-title":"Cardiac fibroblasts: At the heart of myocardial remodeling","volume":"123","author":"Porter","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"B105","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/s0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"B106","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000358343","article-title":"Protein PYY and its role in metabolism","volume":"42","author":"Price","year":"2014","journal-title":"Front. Horm. Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1210\/en.2013-2011","article-title":"Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy","volume":"155","author":"Qi","year":"2014","journal-title":"Endocrinology"},{"key":"B108","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00011-012-0473-3","article-title":"Inflammatory markers and bariatric surgery: A meta-analysis","volume":"61","author":"Rao","year":"2012","journal-title":"Inflamm. Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1172\/jci108843","article-title":"Evidence for cardiomyopathy in familial diabetes mellitus","volume":"60","author":"Regan","year":"1977","journal-title":"J. Clin. Investig."},{"key":"B110","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1172\/jci72271","article-title":"Molecular mechanisms of diabetic kidney disease","volume":"124","author":"Reidy","year":"2014","journal-title":"J. Clin. Investig."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/j.soard.2017.05.024","article-title":"Bile acid profiles over 5 years after gastric bypass and duodenal switch: Results from a randomized clinical trial","volume":"13","author":"Risstad","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B112","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1053\/j.ajkd.2009.08.001","article-title":"KDOQI in the era of global guidelines","volume":"54","author":"Rocco","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis--a common pathway to organ injury and failure","volume":"372","author":"Rockey","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1172\/jci116769","article-title":"Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo","volume":"92","author":"Rockey","year":"1993","journal-title":"J. Clin. Investig."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.jhep.2019.06.031","article-title":"Crosstalk between adipose tissue insulin resistance and liver macrophages in non-alcoholic fatty liver disease","volume":"71","author":"Rosso","year":"2019","journal-title":"J. Hepatol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/s13679-020-00389-8","article-title":"Outcomes in bariatric and metabolic surgery: An updated 5-year review","volume":"9","author":"Roth","year":"2020","journal-title":"Curr. Obes. Rep."},{"key":"B117","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nature13135","article-title":"FXR is a molecular target for the effects of vertical sleeve gastrectomy","volume":"509","author":"Ryan","year":"2014","journal-title":"Nature"},{"key":"B118","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11892-017-0841-z","article-title":"Intestinal microbiota in type 2 diabetes and chronic kidney disease","volume":"17","author":"Sabatino","year":"2017","journal-title":"Curr. Diab. Rep."},{"key":"B119","doi-asserted-by":"publisher","first-page":"110885","DOI":"10.1016\/j.nut.2020.110885","article-title":"Intestinal expression of toll-like receptor gene changes early after gastric bypass surgery and association with type 2 diabetes remission","author":"Sala","year":"2020","journal-title":"Nutrition"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"key":"B122","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1002\/oby.22014","article-title":"Heat shock protein 60 in obesity: Effect of bariatric surgery and its relation to inflammation and cardiovascular risk","volume":"25","author":"Sell","year":"2017","journal-title":"Obes. (Silver Spring)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1136\/jcp.46.1.32","article-title":"Collagen remodelling in myocardia of patients with diabetes","volume":"46","author":"Shimizu","year":"1993","journal-title":"J. Clin. Pathol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1056\/NEJMra1011035","article-title":"Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease","volume":"371","author":"Shulman","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.jhep.2019.06.017","article-title":"FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis","volume":"71","author":"Sorribas","year":"2019","journal-title":"J. Hepatol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1152\/physrev.00012.2007","article-title":"Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function","volume":"87","author":"Spinale","year":"2007","journal-title":"Physiol. Rev."},{"key":"B127","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.diff.2016.05.008","article-title":"The origin of renal fibroblasts\/myofibroblasts and the signals that trigger fibrosis","volume":"92","author":"Sun","year":"2016","journal-title":"Differentiation."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1002\/hep.510290632","article-title":"Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways","volume":"29","author":"Svegliati-Baroni","year":"1999","journal-title":"Hepatology"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2337\/dc12-1805","article-title":"Type 2 diabetes: Etiology and reversibility","volume":"36","author":"Taylor","year":"2013","journal-title":"Diabetes Care"},{"key":"B130","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1681\/asn.2010010010","article-title":"Pathologic classification of diabetic nephropathy","volume":"21","author":"Tervaert","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"F697","DOI":"10.1152\/ajprenal.00016.2008","article-title":"MCP-1\/CCL2: A new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy","volume":"294","author":"Tesch","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1083\/jcb.201802095","article-title":"The cell biology of systemic insulin function","volume":"217","author":"Tokarz","year":"2018","journal-title":"J. Cell. Biol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"7629","DOI":"10.1038\/ncomms8629","article-title":"Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells","volume":"6","author":"Trabelsi","year":"2015","journal-title":"Nat. Commun."},{"key":"B134","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1089\/met.2012.0042","article-title":"Postprandial adiponectin levels are associated with improvements in postprandial triglycerides after Roux-en-Y gastric bypass in type 2 diabetic patients","volume":"11","author":"Umeda","year":"2013","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"B136","doi-asserted-by":"publisher","first-page":"E3327","DOI":"10.3390\/jcm9103327","article-title":"The metabolic rearrangements of bariatric surgery: Focus on orexin-A and the adiponectin system","volume":"9","author":"Valenzano","year":"2020","journal-title":"J. Clin. Med."},{"key":"B137","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1161\/01.cir.82.3.848","article-title":"A comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease","volume":"82","author":"van Hoeven","year":"1990","journal-title":"Circulation"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.soard.2020.04.017","article-title":"Effects of gastric bypass surgery on expression of glucose transporters and fibrotic biomarkers in kidney of diabetic fatty rats","volume":"16","author":"Vangoitsenhoven","year":"2020","journal-title":"Surg. Obes. Relat. Dis."},{"key":"B139","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/liv.12531","article-title":"Hepatic toll-like receptor 4 expression is associated with portal inflammation and fibrosis in patients with NAFLD","volume":"35","author":"Vespasiani-Gentilucci","year":"2015","journal-title":"Liver Int."},{"key":"B140","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1053\/j.gastro.2015.04.005","article-title":"Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis","volume":"149","author":"Vilar-Gomez","year":"2015","journal-title":"Gastroenterology"},{"key":"B141","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1007\/s11695-017-2714-6","article-title":"Effects of sleeve gastrectomy on serum 12\u03b1-hydroxylated bile acids in a diabetic rat model","volume":"27","author":"Wang","year":"2017","journal-title":"Obes. Surg."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.2337\/db09-0287","article-title":"Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity","volume":"59","author":"Wentworth","year":"2010","journal-title":"Diabetes"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1161\/circresaha.116.307591","article-title":"Treatment of obesity: Weight loss and bariatric surgery","volume":"118","author":"Wolfe","year":"2016","journal-title":"Circ. Res."},{"key":"B144","doi-asserted-by":"publisher","first-page":"e90883","DOI":"10.1371\/journal.pone.0090883","article-title":"Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"B145","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1172\/jci31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J. Clin. Investig."},{"key":"B146","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ebiom.2018.10.030","article-title":"Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure","volume":"66","author":"Xie","year":"2021","journal-title":"EBioMedicine"},{"key":"B148","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1007\/s11695-020-04611-3","article-title":"Sleeve gastrectomy attenuates diabetic nephropathy by upregulating nephrin expressions in diabetic obese rats","volume":"30","author":"Xiong","year":"2020","journal-title":"Obes. Surg."},{"key":"B149","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.7150\/ijbs.62929","article-title":"Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy","volume":"17","author":"You","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1007\/s00464-018-6458-8","article-title":"Long-term impact of bariatric surgery in diabetic nephropathy","volume":"33","author":"Young","year":"2019","journal-title":"Surg. Endosc."},{"key":"B151","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.molmet.2017.12.008","article-title":"Hepatic regulation of VLDL receptor by PPAR\u03b2\/\u03b4 and FGF21 modulates non-alcoholic fatty liver disease","volume":"8","author":"Zarei","year":"2018","journal-title":"Mol. Metab."},{"key":"B153","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"B154","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ebiom.2018.05.026","article-title":"Takeda G protein-coupled receptor 5-mechanistic target of rapamycin complex 1 signaling contributes to the increment of glucagon-like peptide-1 production after roux-en-Y gastric bypass","volume":"32","author":"Zhai","year":"2018","journal-title":"EBioMedicine"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.1016635\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:34:57Z","timestamp":1667208897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.1016635\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":154,"alternative-id":["10.3389\/fphar.2022.1016635"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.1016635","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"article-number":"1016635"}}