{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:36Z","timestamp":1753891956787,"version":"3.41.2"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Previous studies have shown that matrine, a natural compound extracted from the herb <jats:italic>Sophora flavescens<\/jats:italic>, has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines, and matrine inhibited both transcription and translation of c-Myc. Ribosome biogenesis and nucleotide metabolism, the key downstream of c-Myc, were significantly suppressed after matrine treatment. Therefore, our results confirmed that matrine is a special c-Myc inhibitor which suppresses ribosome biogenesis and nucleotide metabolism by inhibiting c-Myc in myeloid leukemia. This study provides scientific basis for the development of matrine derivatives to c-Myc-driven cancers.<\/jats:p>","DOI":"10.3389\/fphar.2022.1027441","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T07:51:49Z","timestamp":1666338709000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia"],"prefix":"10.3389","volume":"13","author":[{"given":"Wang-Jing","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingdi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanfan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.canlet.2014.01.017","article-title":"Nucleotide metabolism, oncogene-induced senescence and cancer","volume":"356","author":"Aird","year":"2015","journal-title":"Cancer Lett."},{"key":"B2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/s0962-8924(98)01251-3","article-title":"Control of cell proliferation by Myc","volume":"8","author":"Bouchard","year":"1998","journal-title":"Trends Cell Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"12416","DOI":"10.1074\/jbc.M109.074211","article-title":"Chemotherapeutic drugs inhibit ribosome biogenesis at various levels","volume":"285","author":"Burger","year":"2010","journal-title":"J. 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