{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T04:55:59Z","timestamp":1773464159016,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Evaluate the data on the psychotropic drugs dispensed by private community pharmacies before and during the SARS-CoV-2 pandemic.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This cross-sectional study compared the quarterly and annual consumption of psychotropic drugs per Defined Daily Dose per 1000 inhabitants-day (DHD). Interrupted time series were also constructed to expose changes in the consumption pattern in the periods before and after March 2020.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among the 20 most consumed psychoactive drugs, 12 were antidepressants, for example, escitalopram (DHD 7.996 and 10.626; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), and sertraline (DHD 6.321 and 8.484; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), in addition to the hypnotic zolpidem (DHD 6.202 and 8.526; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). The time series reveals (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> value) a variation in drug dispensing, in DHD values, during the pandemic.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Despite the higher variance, a significant increase is clearly seen in the consumption trends of psychoactive drugs, particularly antidepressants, consistent with the pandemic\u2019s influence on the general population\u2019s mental health.<\/jats:p>","DOI":"10.3389\/fphar.2022.1028233","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T10:15:20Z","timestamp":1671790520000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Dispensing of psychotropic drugs in the Brazilian capital city before and during the COVID-19 pandemic (2018\u20132020)"],"prefix":"10.3389","volume":"13","author":[{"given":"Pamela Alejandra","family":"Escalante Saavedra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayani","family":"Galato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calliandra Maria","family":"de Souza Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabel Cristina","family":"Rodrigues da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Em\u00edlia Vitoria","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"B1","first-page":"e154","article-title":"Emerging mental health challenges, strategies, and opportunities in the context of the COVID-19 pandemic: Perspectives from South American decision-makers","volume":"44","author":"Antiporta","year":"2020","journal-title":"Rev Panam Salud Publica Ser. 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