{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:19:30Z","timestamp":1773235170328,"version":"3.50.1"},"reference-count":205,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>According to the World Health Organization, the neoplasm is one of the main reasons for morbidity and mortality worldwide. At the same time, application of cytostatic drugs like an independent type of cancer treatment and in combination with surgical methods, is often associated with the development of cardiovascular complications both in the early and in the delayed period of treatment. Doxorubicin (DOX) is the most commonly used cytotoxic anthracycline antibiotic. DOX can cause both acute and delayed side effects. The problem is still not solved, as evidenced by the continued activity of researchers in terms of developing approaches for the prevention and treatment of cardiovascular complications. It is known, the heart muscle consists of cardiomyocytes connected by intercalated discs (ID), which ensure the structural, electrical, metabolic unity of the heart. Various defects in the ID proteins can lead to the development of cardiovascular diseases of various etiologies, including DOX-induced cardiomyopathy. The search for ways to influence the functioning of ID proteins of the cardiac muscle can become the basis for the creation of new therapeutic approaches to the treatment and prevention of cardiac pathologies. SIRT1 may be an interesting cardioprotective variant due to its wide functional significance. SIRT1 activation triggers nuclear transcription programs that increase the efficiency of cellular, mitochondrial metabolism, increases resistance to oxidative stress, and promotes cell survival. It can be assumed that SIRT1 can not only provide a protective effect at the cardiomyocytes level, leading to an improvement in mitochondrial and metabolic functions, reducing the effects of oxidative stress and inflammatory processes, but also have a protective effect on the functioning of IDs structures of the cardiac muscle.<\/jats:p>","DOI":"10.3389\/fphar.2022.1035387","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T10:25:40Z","timestamp":1667557540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["SIRT1 activation and its effect on intercalated disc proteins as a way to reduce doxorubicin cardiotoxicity"],"prefix":"10.3389","volume":"13","author":[{"given":"Ekaterina","family":"Podyacheva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yana","family":"Toropova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3390\/ph14100970","article-title":"Anticancer drug-induced cardiotoxicity: Insights and pharmacogenetics","volume":"14","author":"Adhikari","year":"2021","journal-title":"Pharmaceuticals"},{"key":"B2","doi-asserted-by":"publisher","first-page":"32270","DOI":"10.18632\/oncotarget.15650","article-title":"Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis","volume":"8","author":"Aktary","year":"2017","journal-title":"Oncotarget"},{"key":"B3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1042\/BST0360181","article-title":"Structural studies on desmosomes","volume":"36","author":"Al-Amoudi","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1161\/01.RES.0000267723.65696.4a","article-title":"Sirt1 regulates aging and resistance to oxidative stress in the heart","volume":"100","author":"Alcendor","year":"2007","journal-title":"Circ. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"7619","DOI":"10.1074\/jbc.M110.158477","article-title":"N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: Implications for neurodegeneration in Alzheimer disease","volume":"286","author":"Ando","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S0092-8674(00)81878-4","article-title":"MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure","volume":"88","author":"Arber","year":"1997","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1128\/mcb.00758-14","article-title":"Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation","volume":"34","author":"Arimoto","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s43440-019-00034-9","article-title":"Bisoprolol and linagliptin ameliorated electrical and mechanical isometric myocardial contractions in doxorubicin-induced cardiomyopathy in rats","volume":"72","author":"Aykan","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.jnutbio.2015.06.006","article-title":"Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3","volume":"26","author":"Bagul","year":"2015","journal-title":"Elsevier B.V"},{"key":"B10","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.cmet.2012.06.016","article-title":"The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease","volume":"16","author":"Bai","year":"2012","journal-title":"Cell Metab."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/ki.2013.503","article-title":"Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation","volume":"85","author":"Bakker","year":"2014","journal-title":"Kidney Int."},{"key":"B12","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.ceb.2009.07.002","article-title":"Plakophilins: Multifunctional scaffolds for adhesion and signaling","volume":"21","author":"Bass-Zubek","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1007\/s00018-012-0925-5","article-title":"SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytes","volume":"69","author":"Becatti","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1091\/mbc.e05-12-1109","article-title":"The transitional junction: A new functional subcellular domain at the intercalated disc","volume":"17","author":"Bennett","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.110.223768","article-title":"WNT signaling in adult cardiac hypertrophy and remodeling: Lessons learned from cardiac development","volume":"107","author":"Bergmann","year":"2010","journal-title":"Circ. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a preiss-handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3921796","DOI":"10.1155\/2020\/3921796","article-title":"Sinapic acid ameliorates oxidative stress, inflammation, and apoptosis in acute doxorubicin-induced cardiotoxicity via the NF-\u03ba B-mediated pathway","volume":"2020","author":"Bin Jardan","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00395-019-0738-x","article-title":"P66shc and its role in ischemic cardiovascular diseases","volume":"114","author":"Boengler","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"Ca. Cancer J. Clin."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.freeradbiomed.2009.03.011","article-title":"Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway","volume":"46","author":"Brookins Danz","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/bjc.2016.67","article-title":"PARP inhibitors: The race is on","volume":"114","author":"Brown","year":"2016","journal-title":"Br. J. Cancer"},{"key":"B22","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s10741-016-9570-7","article-title":"Mitochondrial sirtuins in the heart","volume":"21","author":"Bugger","year":"2016","journal-title":"Heart fail. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.mam.2013.01.004","article-title":"Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes","volume":"34","author":"Cant\u00f3","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13046-014-0097-2","article-title":"Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer","volume":"33","author":"Cao","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijcard.2015.12.008","article-title":"SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy","volume":"205","author":"Cappetta","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.yjmcc.2010.01.022","article-title":"Cardiomyocyte-targeted overexpression of the coxsackie-adenovirus receptor causes a cardiomyopathy in association with \u03b2-catenin signaling","volume":"48","author":"Caruso","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/med.21280","article-title":"Doxorubicin-induced cardiotoxicity: From bioenergetic failure and cell death to cardiomyopathy","volume":"34","author":"Carvalho","year":"2014","journal-title":"Med. Res. Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"8130","DOI":"10.7150\/thno.47407","article-title":"Screening for in-vivo regional contractile defaults to predict the delayed doxorubicin cardiotoxicity in Juvenile Rat","volume":"10","author":"Chakouri","year":"2020","journal-title":"Theranostics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1161\/CIRCRESAHA.115.307604","article-title":"MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodeling","volume":"118","author":"Chan","year":"2016"},{"key":"B30","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"Chang","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"B31","doi-asserted-by":"publisher","first-page":"111215","DOI":"10.1016\/j.mad.2020.111215","article-title":"SIRT1 and aging related signaling pathways","volume":"187","author":"Chen","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"10794","DOI":"10.1073\/pnas.1934713100","article-title":"Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice","volume":"100","author":"Cheng","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2174\/138161209787185788","article-title":"CD38 as a regulator of cellular NAD: A novel potential pharmacological target for metabolic conditions","volume":"15","author":"Chini","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"B34","doi-asserted-by":"publisher","first-page":"31776","DOI":"10.1074\/jbc.M109.047928","article-title":"Interactions of plakoglobin and \u03b2-catenin with desmosomal cadherins: Basis of selective exclusion of \u03b1- and \u03b2-catenin from desmosomes","volume":"284","author":"Choi","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"44962","DOI":"10.1074\/jbc.M209427200","article-title":"Casein kinase 1 regulates connexin-43 gap junction assembly","volume":"277","author":"Cooper","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/1440-1681.13036","article-title":"Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity","volume":"46","author":"Corremans","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"E330","DOI":"10.3390\/biom10020330","article-title":"Nad+ metabolism and regulation: Lessons from yeast","volume":"10","author":"Croft","year":"2020","journal-title":"Biomolecules"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis","volume":"8","author":"de Martel","year":"2020","journal-title":"Lancet. Glob. Health"},{"key":"B40","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ejmg.2005.05.003","article-title":"Novel GJA1 mutations in patients with oculo-dento-digital dysplasia (ODDD)","volume":"48","author":"Debeer","year":"2005","journal-title":"Eur. J. Med. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12012-007-0024-2","article-title":"Genotyping the risk of anthracycline-induced cardiotoxicity","volume":"7","author":"Deng","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1089\/ars.2008.2128","article-title":"Connexin-caused genetic diseases and corresponding mouse models","volume":"11","author":"Dobrowolski","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"B43","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1515\/hsz-2016-0316","article-title":"The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction","volume":"398","author":"Dolinsky","year":"2017","journal-title":"Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1089\/ars.2017.7178","article-title":"SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection","volume":"28","author":"D\u2019Onofrio","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"B45","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"Du","year":"2011","journal-title":"Sci. (80-. )"},{"key":"B46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jdermsci.2006.10.006","article-title":"Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion","volume":"45","author":"Dusek","year":"2007","journal-title":"J. Dermatol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/jcp.29026","article-title":"SCD1 regulates the AMPK\/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle","volume":"235","author":"Dziewulska","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1083\/jcb.153.4.763","article-title":"Alterations at the intercalated disk associated with the absence of muscle LIM protein","volume":"153","author":"Ehler","year":"2001","journal-title":"J. Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1161\/01.RES.0000227572.45891.2c","article-title":"Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation","volume":"98","author":"Ek-Vitorin","year":"2006","journal-title":"Circ. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/jbcpp-2018-0212","article-title":"Effect of ghrelin on VEGF-B and connexin-43 in a rat model of doxorubicin-induced cardiomyopathy","volume":"31","author":"Elhadidy","year":"2020","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1242\/JCS.115.8.1623","article-title":"Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart","volume":"115","author":"Ferreira-Cornwell","year":"2002","journal-title":"J. Cell Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1161\/CIRCRESAHA.115.307604","article-title":"Chemical endoplasmic reticulum chaperone alleviates doxorubicin-induced cardiac dysfunction","volume":"118","author":"Fu","year":"2016","journal-title":"Circ. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1172\/JCI27751DS1","article-title":"Suppression of canonical Wnt\/b-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy","volume":"116","author":"Garcia-gras","year":"2006"},{"key":"B54","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.bbamem.2007.07.014","article-title":"Desmosome structure, composition and function","volume":"1778","author":"Garrod","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"B55","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/09687680210132476","article-title":"Desmosomal adhesion: Structural basis, molecular mechanism and regulation (review)","volume":"19","author":"Garrod","year":"2002","journal-title":"Mol. Membr. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1091\/mbc.E10-02-0131","article-title":"Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA","volume":"21","author":"Godsel","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/cvr\/cvs134","article-title":"Inhibition of AMPK signalling by doxorubicin: At the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress","volume":"95","author":"Gratia","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1159\/000356602","article-title":"Exogenous hydrogen sulfide protects against doxorubicin-induced inflammation and cytotoxicity by inhibiting p38MAPK\/NF\u03baB pathway in H9c2 cardiac cells","volume":"32","author":"Guo","year":"2013","journal-title":"Cell. Physiol. biochem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1152\/ajpheart.00806.2007","article-title":"Loss of mXin\u03b1, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects","volume":"293","author":"Gustafson-Wagner","year":"2007","journal-title":"Am. J. Physiology-Heart Circulatory Physiology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1093\/eurheartj\/ehu301","article-title":"Atlas of the clinical genetics of human dilated cardiomyopathy","volume":"36","author":"Haas","year":"2015","journal-title":"Eur. Heart J."},{"key":"B61","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12038-020-9997-9","article-title":"Resveratrol protects H9c2 cells against hypoxia-induced apoptosis through miR-30d-5p\/SIRT1\/NF-\u03baB axis","volume":"45","author":"Han","year":"2020","journal-title":"J. Biosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/0041-008X(85)90284-4","article-title":"Comparison of the severity of the chronic cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats","volume":"78","author":"Herman","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S1058-9813(98)00002-2","article-title":"Animal models of anthracycline cardiotoxicity: Basic mechanisms and cardioprotective activity","volume":"8","author":"Herman","year":"1997","journal-title":"Prog. Pediatr. Cardiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"Ampk: Guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0092-8674(92)90103-J","article-title":"Identification of a neural \u03b1-catenin as a key regulator of cadherin function and multicellular organization","volume":"70","author":"Hirano","year":"1992","journal-title":"Cell"},{"key":"B66","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0074-7696(07)64003-0","article-title":"Structure and function of desmosomes","volume":"264","author":"Holth\u00f6fer","year":"2007","journal-title":"Int. Rev. Cytol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-\u03b2\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1007\/s00018-003-3050-7","article-title":"Structure and function of desmosomal proteins and their role in development and disease","volume":"60","author":"Huber","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.1016\/s0021-9258(17)35666-1","article-title":"Transforming growth factor-\u03b2 stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix","volume":"261","author":"Ignotz","year":"1986","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-90502-1","article-title":"Disorganization of intercalated discs in dilated cardiomyopathy","volume":"11","author":"Ito","year":"2021","journal-title":"Sci. Rep."},{"key":"B72","first-page":"292","article-title":"An anthracycline antibiotic-induced cardiomyopathy in rabbits","volume":"30","author":"Jaenke","year":"1974","journal-title":"Lab. Invest."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1242\/JCS.114.17.3177","article-title":"alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion","volume":"114","author":"Janssens","year":"2001","journal-title":"J. Cell Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00439-002-0857-5","article-title":"Assessment of the CTNNA3 gene encoding human \u03b1T-catenin regarding its involvement in dilated cardiomyopathy","volume":"112","author":"Janssens","year":"2003","journal-title":"Hum. Genet."},{"key":"B75","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/BF00434396","article-title":"Doxorubicin pharmacokinetics after intravenous and intraperitoneal administration in the nude mouse","volume":"5","author":"Johansen","year":"1981","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1101\/gad.13.19.2570","article-title":"The SIR2\/3\/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms","volume":"13","author":"Kaeberlein","year":"1999","journal-title":"Genes Dev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1161\/CIRCRESAHA.118.312498","article-title":"Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases","volume":"123","author":"Kane","year":"2018","journal-title":"Circ. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/0006-2952(90)90438-Q","article-title":"Inhibition of mitochondrial carnitine palmitoyltransferases by adriamycin and adriamycin analogues","volume":"40","author":"Kashfi","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1091\/mbc.e07-12-1215","article-title":"Deficiency of zonula occludens-1 causes embryonic lethal phenotype Associated with defected yolk sac angiogenesis and apoptosis of embryonic cells","volume":"19","author":"Katsuno","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"B80","doi-asserted-by":"publisher","first-page":"4121","DOI":"10.1242\/JCS.113.22.4121","article-title":"The armadillo repeat region targets ARVCF to cadherin-based cellular junctions","volume":"113","author":"Kaufmann","year":"2000","journal-title":"J. Cell Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-\u03baB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell. Signal."},{"key":"B82","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1093\/cvr\/cvs282","article-title":"Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes","volume":"96","author":"Kawaguchi","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1161\/CIRCRESAHA.108.190454","article-title":"Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction","volume":"104","author":"Kieken","year":"2009","journal-title":"Circ. Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1042\/BJ20121284","article-title":"Wnt\/\u03b2-catenin signalling: From plasma membrane to nucleus","volume":"450","author":"Kim","year":"2013","journal-title":"Biochem. J."},{"key":"B85","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-04843-7","volume-title":"Current advances in osteosarcoma","author":"Kleinerman","year":"2014"},{"key":"B86","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/cco.0b013e32834d813b","article-title":"SIRT1, metabolism and cancer","volume":"24","author":"Knight","year":"2012","journal-title":"Curr. Opin. Oncol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1165\/rcmb.2016-0374OC","article-title":"p38 MAPK inhibition improves heart function in pressure-loaded right ventricular hypertrophy","volume":"57","author":"Kojonazarov","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1161\/01.RES.0000156274.72390.2c","article-title":"Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure","volume":"96","author":"Kostetskii","year":"2005","journal-title":"Circ. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0092-8674(00)81282-9","article-title":"The gap junction communication channel","volume":"84","author":"Kumar","year":"1996","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cmet.2014.12.001","article-title":"Physiological and pathological roles of the mitochondrial permeability transition pore in the heart","volume":"21","author":"Kwong","year":"2015","journal-title":"Cell Metab."},{"key":"B91","doi-asserted-by":"publisher","first-page":"4582","DOI":"10.1093\/hmg\/ddr392","article-title":"Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy","volume":"20","author":"Li","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B92","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1161\/CIRCRESAHA.116.304472","article-title":"Alpha-catenins control cardiomyocyte proliferation by regulating yap activity","volume":"116","author":"Li","year":"2015","journal-title":"Circ. Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3121\/cmr.4.1.42","article-title":"Dysregulation of cell adhesion proteins and cardiac arrhythmogenesis","volume":"4","author":"Li","year":"2006","journal-title":"Clin. Med. Res."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1172\/JCI34777","article-title":"Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart","volume":"118","author":"Lim","year":"2008","journal-title":"J. Clin. Invest."},{"key":"B95","doi-asserted-by":"publisher","first-page":"172490","DOI":"10.1016\/j.ejphar.2019.172490","article-title":"Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress","volume":"859","author":"Lin","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1084\/jem.20080897","article-title":"The tight junction protein CAR regulates cardiac conduction and cell-cell communication","volume":"205","author":"Lisewski","year":"2008","journal-title":"J. Exp. Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s00210-019-01641-2","article-title":"Aldosterone stimulation mediates cardiac metabolism remodeling via Sirt1\/AMPK signaling in canine model","volume":"392","author":"Liu","year":"2019","journal-title":"Naunyn. Schmiedeb. Arch. Pharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3892\/ijmm.2015.2291","article-title":"Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway","volume":"36","author":"Lou","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.jacbts.2018.06.005","article-title":"Role of endothelium in doxorubicin-induced cardiomyopathy","volume":"3","author":"Luu","year":"2018","journal-title":"JACC. Basic Transl. Sci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1161\/01.CIR.95.1.17","article-title":"Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin","volume":"95","author":"Maeda","year":"1997","journal-title":"Circulation"},{"key":"B101","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1096\/fj.05-5148com","article-title":"Estrogen receptor alpha up\u2010regulation and redistribution in human heart failure","volume":"20","author":"Mahmoodzadeh","year":"2006","journal-title":"FASEB J."},{"key":"B102","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/cvr\/cvn203","article-title":"Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant","volume":"80","author":"Manias","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s12551-018-0430-7","article-title":"At the heart of inter- and intracellular signaling: The intercalated disc","volume":"10","author":"Manring","year":"2018","journal-title":"Biophys. Rev."},{"key":"B104","first-page":"903","article-title":"[Toxicologic study and experimental antitumor activity of rubidomycin (13, 057 R.P.)]","volume":"15","author":"Maral","year":"1967","journal-title":"Pathol. Biol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1200\/JCO.19.03141","article-title":"Clinical cancer advances 2020: Annual report on progress against cancer from the American society of clinical oncology","volume":"38","author":"Markham","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1111\/bph.12901","article-title":"P38 MAPK in cardioprotection - are we there yet?","volume":"172","author":"Martin","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.cell.2014.06.050","article-title":"Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism","volume":"158","author":"Masri","year":"2014","journal-title":"Cell"},{"key":"B108","doi-asserted-by":"publisher","first-page":"H1375","DOI":"10.1152\/ajpheart.00053.2015","article-title":"The role of sirtuins in cardiac disease","volume":"309","author":"Matsushima","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/0014-2964(80)90189-9","article-title":"Solution chemistry studies of adriamycin-iron complexes present in vivo","volume":"16","author":"May","year":"1980","journal-title":"Eur. J. Cancer"},{"key":"B110","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.yjmcc.2008.04.005","article-title":"Claudin-5 levels are reduced in human end-stage cardiomyopathy","volume":"45","author":"Mays","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline chemotherapy and cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B112","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10571-016-0355-2","article-title":"Sirt1: Role under the condition of ischemia\/hypoxia","volume":"37","author":"Meng","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1517\/14740338.2011.589834","article-title":"Anthracycline cardiotoxicity","volume":"11","author":"Menna","year":"2012","journal-title":"Expert Opin. Drug Saf."},{"key":"B114","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0092-8674(00)81662-1","article-title":"Chronic phospholamban-sarcoplasmic reticulum calcium atpase interaction is the critical calcium cycling defect in dilated cardiomyopathy","volume":"99","author":"Minamisawa","year":"1999","journal-title":"Cell"},{"key":"B115","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"B116","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1096\/fasebj.12.7.541","article-title":"The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase\/iron regulatory protein\u20101 in cytosolic fractions from human myocardium","volume":"12","author":"Minotti","year":"1998","journal-title":"FASEB J."},{"key":"B117","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijcha.2015.11.004","article-title":"Doxorubicin induced heart failure: Phenotype and molecular mechanisms","volume":"10","author":"Mitry","year":"2016","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"B118","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.bcp.2011.12.014","article-title":"Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress","volume":"83","author":"M\u00f3dis","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.cell.2013.06.016","article-title":"The NAD(+)\/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling","volume":"154","author":"Mouchiroud","year":"2013","journal-title":"Cell"},{"key":"B120","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1083\/jcb.3.2.193","article-title":"An electron microscope study of the embryology of the intercalated disc in the heart of the rabbit","volume":"3","author":"Muir","year":"1956","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"02219400","DOI":"10.1371\/journal.pone.0221940","article-title":"Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways","volume":"14","author":"Narikawa","year":"2019","journal-title":"PLoS One"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, \u03b2-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1038\/sj.jid.5700865","article-title":"Tight junctions\/adherens junctions: Basic structure and function","volume":"127","author":"Niessen","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1016\/j.cellsig.2012.07.007","article-title":"ERK5: Structure, regulation and function","volume":"24","author":"Nithianandarajah-Jones","year":"2012","journal-title":"Cell. Signal."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.yjmcc.2012.03.006","article-title":"Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies","volume":"52","author":"Octavia","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1254\/jjp.88.183","article-title":"Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters","volume":"88","author":"Okumura","year":"2002","journal-title":"Jpn. J. Pharmacol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1161\/hc0402.102930","article-title":"Metavinculin mutations alter actin interaction in dilated cardiomyopathy","volume":"105","author":"Olson","year":"2002","journal-title":"Circulation"},{"key":"B128","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41419-019-1901-x","article-title":"miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b\/P53 pathway in doxorubicin-induced cardiotoxicity","volume":"10","author":"Pan","year":"2019","journal-title":"Cell Death Dis."},{"key":"B129","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0006-2952(98)00305-0","article-title":"Structural and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice: Suppression of cytochrome c oxidase II gene expression","volume":"57","author":"Papadopoulou","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.devcel.2005.04.010","article-title":"Kaiso\/p120-catenin and TCF\/beta-catenin complexes coordinately regulate canonical Wnt gene targets","volume":"8","author":"Park","year":"2005","journal-title":"Dev. Cell"},{"key":"B131","doi-asserted-by":"publisher","first-page":"E757","DOI":"10.3390\/ijms19030757","article-title":"Diazoxide improves mitochondrial connexin 43 expression in a mouse model of doxorubicin-induced cardiotoxicity","volume":"19","author":"Pecoraro","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3892\/ijmm.2020.4669","article-title":"Doxorubicin-induced oxidative and nitrosative stress: Mitochondrial connexin 43 is at the crossroads","volume":"46","author":"Pecoraro","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s12012-014-9305-8","article-title":"Doxorubicin-mediated cardiotoxicity: Role of mitochondrial connexin 43","volume":"15","author":"Pecoraro","year":"2015","journal-title":"Cardiovasc. Toxicol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S1050-1738(02)00209-8","article-title":"Dilated cardiomyopathy: A disease of the intercalated disc?","volume":"13","author":"Perriard","year":"2003","journal-title":"Trends cardiovasc. Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction: Experimental observations and clinical implications","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"B136","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.3390\/cells9020426","article-title":"SIRT1 protects the heart from ER stress-induced injury by promoting eEF2K\/eEF2-Dependent autophagy","volume":"9","author":"Pires Da Silva","year":"2020","journal-title":"Cells"},{"key":"B137","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.3390\/nu13103435","article-title":"Nicotinamide riboside for the prevention and treatment of doxorubicin cardiomyopathy. Opportunities and prospects","volume":"13","author":"Podyacheva","year":"2021","journal-title":"Nutrients"},{"key":"B138","doi-asserted-by":"publisher","first-page":"670479","DOI":"10.3389\/fphar.2021.670479","article-title":"Analysis of models of doxorubicin-induced cardiomyopathy in rats and mice. A modern view from the perspective of the pathophysiologist and the clinician","volume":"12","author":"Podyacheva","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/j.ajpath.2017.05.011","article-title":"HIV-associated cardiovascular disease: Role of connexin 43","volume":"187","author":"Prevedel","year":"2017","journal-title":"Am. J. Pathol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"E1304","DOI":"10.3390\/nu10091304","article-title":"Cardioprotective effects of nanoemulsions loaded with anti-inflammatory nutraceuticals against doxorubicin-induced cardiotoxicity","volume":"10","author":"Quagliariello","year":"2018","journal-title":"Nutrients"},{"key":"B141","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1128\/mcb.00121-09","article-title":"SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1","volume":"29","author":"Rajamohan","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.cmet.2018.02.011","article-title":"Therapeutic potential of NAD-boosting molecules: The in vivo evidence","volume":"27","author":"Rajman","year":"2018","journal-title":"Cell Metab."},{"key":"B143","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1152\/ajpheart.00749.2013","article-title":"Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes","volume":"306","author":"Ram","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"4128","DOI":"10.1074\/jbc.M115.689620","article-title":"Myozap deficiency promotes adverse cardiac remodeling via differential regulation of mitogen-activated protein kinase\/serum-response factor and \u03b2-catenin\/GSK-3\u03b2 protein signaling","volume":"291","author":"Rangrez","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B145","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/fcp.12054","article-title":"Protective effect of a direct renin inhibitor in acute murine model of cardiotoxicity and nephrotoxicity","volume":"28","author":"Rashikh","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1083\/jcb.42.1.322","article-title":"Ultrastructure of desmosomes in mammalian intercalated disc; appearances after lanthanum treatment","volume":"42","author":"Rayns","year":"1969","journal-title":"J. Cell Biol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ejphar.2017.10.043","article-title":"Molecular mechanism of doxorubicin-induced cardiomyopathy \u2013 an update","volume":"818","author":"Renu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"key":"B149","doi-asserted-by":"publisher","first-page":"a029207","DOI":"10.1101\/cshperspect.a029207","article-title":"Adherens junctions and desmosomes coordinate mechanics and signaling to orchestrate tissue morphogenesis and function: An evolutionary perspective","volume":"10","author":"R\u00fcbsam","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5772\/intechopen.79588","article-title":"\u00abDoxorubicin-Induced cardiotoxicity: From mechanisms to development of efficient therapy\u00bb, \u0432 cardiotoxicity","author":"Santos","year":"2018","journal-title":"InTech"},{"key":"B151","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1161\/CIRCRESAHA.111.247023","article-title":"Interactions between ankyrin-G, plakophilin-2, and connexin43 at the cardiac intercalated disc","volume":"109","author":"Sato","year":"2011","journal-title":"Circ. Res."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.4161\/cbt.11.12.15540","article-title":"Doxorubicin and daunorubicin induce processing and release of interleukin-1\u03b2 through activation of the NLRP3 inflammasome","volume":"11","author":"Sauter","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"B153","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jdermsci.2003.12.006","article-title":"TGF-\u03b2-induced SMAD signaling and gene regulation: Consequences for extracellular matrix remodeling and wound healing","volume":"35","author":"Schiller","year":"2004","journal-title":"J. Dermatol. Sci."},{"key":"B154","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.116.309631","volume-title":"Adrenergic signaling strengthens cardiac myocyte cohesion","author":"Schinner","year":"2017"},{"key":"B155","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0163-7827(00)00005-9","article-title":"The biosynthesis and functional role of cardiolipin","volume":"39","author":"Schlame","year":"2000","journal-title":"Prog. Lipid Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1084\/jem.20070145","article-title":"Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy","volume":"204","author":"Schroen","year":"2007","journal-title":"J. Exp. Med."},{"key":"B157","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1161\/CIRCRESAHA.109.213256","article-title":"Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo","volume":"106","author":"Seeger","year":"2010","journal-title":"Circ. Res."},{"key":"B158","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/cvr\/cvn133","article-title":"Remodelling of gap junctions and connexin expression in diseased myocardium","volume":"80","author":"Severs","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"e03803","DOI":"10.1016\/j.heliyon.2020.e03803","article-title":"Modulation of Nrf2 by quercetin in doxorubicin-treated rats","volume":"6","author":"Sharma","year":"2020","journal-title":"Heliyon"},{"key":"B160","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.cell.2006.12.037","article-title":"Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions","volume":"128","author":"Shaw","year":"2007","journal-title":"Cell"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1161\/CIRCULATIONAHA.106.634469","article-title":"alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture","volume":"114","author":"Sheikh","year":"2006","journal-title":"Circulation"},{"key":"B162","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1172\/JCI39740","article-title":"Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium","volume":"120","author":"Smyth","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B163","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10741-020-09977-1","article-title":"Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system\u2014From molecular mechanisms to therapeutic applications","volume":"27","author":"Sobczuk","year":"2020","journal-title":"Heart fail. Rev."},{"key":"B164","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cardiores.2003.11.013","article-title":"Gap junctions and the connexin protein family","volume":"62","author":"S\u00f6hl","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.semcdb.2015.12.010","article-title":"Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair","volume":"50","author":"Solan","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","article-title":"Oxidative stress injury in doxorubicin-induced cardiotoxicity","volume":"307","author":"Songbo","year":"2019","journal-title":"Toxicol. Lett."},{"key":"B167","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1074\/jbc.275.4.2399","article-title":"Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription","volume":"275","author":"Strovel","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B168","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1172\/JCI1167","article-title":"Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice","volume":"101","author":"Sussman","year":"1998","journal-title":"J. Clin. Invest."},{"key":"B169","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.carpath.2014.10.006.Claudin-5","article-title":"Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin- B1","volume":"176","author":"Swager","year":"2016","journal-title":"Cardiovasc Pathol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1002\/cncr.11407","article-title":"Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials","volume":"97","author":"Swain","year":"2003","journal-title":"Cancer"},{"key":"B171","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1016\/j.yexcr.2008.07.030","article-title":"Heterocellular interaction enhances recruitment of \u03b1 and \u03b2-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells","volume":"314","author":"Talhouk","year":"2008","journal-title":"Exp. Cell Res."},{"key":"B173","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1126\/SCIENCE.6093249","article-title":"Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II","volume":"226","author":"Tewey","year":"1984","journal-title":"Science"},{"key":"B174","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1006\/jmcc.1997.0446","article-title":"Null mutation in the desmin gene gives rise to a cardiomyopathy","volume":"29","author":"Thornell","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1291\/hypres.25.597","article-title":"Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy","volume":"25","author":"Toko","year":"2002","journal-title":"Hypertens. Res."},{"key":"B176","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1016\/j.jacc.2008.02.056","article-title":"Defective intercellular adhesion complex in myocardium predisposes to infarct rupture in humans","volume":"51","author":"van den Borne","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1152\/ajpheart.01047.2009","article-title":"Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice","volume":"298","author":"Vedam","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.jacc.2014.06.1167","article-title":"Prevention of anthracycline-induced cardiotoxicity: Challenges and opportunities","volume":"64","author":"Vejpongsa","year":"","journal-title":"J. Am. Coll. Cardiol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/clpt.2013.201","article-title":"Topoisomerase 2\u03b2: A promising molecular target for primary prevention of anthracycline-induced cardiotoxicity","volume":"95","author":"Vejpongsa","year":"","journal-title":"Clin. Pharmacol. Ther."},{"key":"B180","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvw259","volume-title":"Refining the molecular organization of the cardiac intercalated disc","author":"Vermij","year":"2017"},{"key":"B181","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3109\/15419061.2014.908853","article-title":"N-cadherin\/Catenin complex as a master regulator of intercalated disc function","volume":"21","author":"Vite","year":"2014","journal-title":"Cell Commun. Adhes."},{"key":"B182","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1161\/CIRCRESAHA.119.314681","article-title":"Mitochondrial determinants of doxorubicin- induced cardiomyopathy","volume":"126","author":"Wallace","year":"2020","journal-title":"Circ. Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1007\/s00018-020-03729-y","article-title":"Molecular mechanisms of doxorubicin-induced cardiotoxicity: Novel roles of sirtuin 1-mediated signaling pathways","volume":"78","author":"Wang","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"B184","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nrm831","article-title":"Cellular roles of DNA topoisomerases: A molecular perspective","volume":"3","author":"Wang","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1093\/cvr\/cvy033","article-title":"Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury","volume":"114","author":"Wang","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"B186","volume-title":"Xin proteins and intercalated disc maturation, signaling and diseases","author":"Wang","year":"2011"},{"key":"B187","doi-asserted-by":"publisher","first-page":"30188","DOI":"10.1038\/cddis.2017.410","article-title":"Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the sirt1\/lkb1\/ampk pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"key":"B188","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.yjmcc.2011.12.009","article-title":"Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress","volume":"52","author":"Wang","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B189","volume-title":"World cancer report: Cancer research for cancer prevention","author":"Wild","year":"2020"},{"key":"B190","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1242\/bio.020362","article-title":"Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability","volume":"5","author":"Wilkinson","year":"2016","journal-title":"Biol. Open"},{"key":"B191","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/jcp.26064","article-title":"Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells","volume":"233","author":"Wilkinson","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"B192","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.bbrc.2019.10.140","article-title":"MicroRNA-22 inhibition prevents doxorubicin-induced cardiotoxicity via upregulating SIRT1","volume":"521","author":"Xu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B193","doi-asserted-by":"publisher","first-page":"36588","DOI":"10.3390\/ijms19113658","article-title":"Ginsenoside Rg1 prevents doxorubicin-induced cardiotoxicity through the inhibition of autophagy and endoplasmic reticulum stress in mice","volume":"19","author":"Xu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B194","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.cell.2007.07.035","article-title":"Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival","volume":"130","author":"Yang","year":"2007","journal-title":"Cell"},{"key":"B195","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"B196","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.1158\/0008-5472.CAN-07-1649","article-title":"Topoisomerase IIbeta mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane","volume":"67","author":"Yi","year":"2007","journal-title":"Cancer Res."},{"key":"B197","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD + intermediates: The biology and therapeutic potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab."},{"key":"B198","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.yjmcc.2017.10.008","article-title":"CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1","volume":"114","author":"Yuan","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"7522","DOI":"10.1128\/mcb.00728-07","article-title":"Cardiac-Myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy","volume":"27","author":"Zemljic-Harpf","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"264411","DOI":"10.1371\/journal.pone.0026441","article-title":"S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"},{"key":"B201","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1038\/nm.919","article-title":"Identification of the molecular basis of doxorubicin-induced cardiotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."},{"key":"B202","doi-asserted-by":"publisher","first-page":"7898","DOI":"10.12659\/MSM.919861","article-title":"MD-1 deficiency accelerates myocardial inflammation and apoptosis in doxorubicin-induced cardiotoxicity by activating the TLR4\/MAPKs\/nuclear factor kappa B (NF-\u03baB) signaling pathway","volume":"25","author":"Zhang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"B203","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10741-018-9743-7","article-title":"Intercalated discs: Cellular adhesion and signaling in heart health and diseases","volume":"24","author":"Zhao","year":"2019","journal-title":"Heart fail. Rev."},{"key":"B204","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1152\/ajpheart.00576.2006","article-title":"Upregulation of \u03b3-catenin compensates for the loss of \u03b2-catenin in adult cardiomyocytes","volume":"292","author":"Zhou","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"15983","DOI":"10.1073\/pnas.252625599","article-title":"AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation","volume":"99","author":"Zong","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"updated-by":[{"DOI":"10.3389\/fphar.2023.1154384","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000}}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.1035387\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:39:17Z","timestamp":1676385557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.1035387\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":205,"alternative-id":["10.3389\/fphar.2022.1035387"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.1035387","relation":{"erratum":[{"id-type":"doi","id":"10.3389\/fphar.2023.1154384","asserted-by":"object"}]},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"article-number":"1035387"}}