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In this respect, repurposing drugs that are already available and might exhibit anti-inflammatory effects have received significant attention. With the <jats:italic>in vitro<\/jats:italic> and clinical investigation of several studies on the effect of antidepressants on COVID-19 prognosis, previous data suggest that selective serotonin reuptake inhibitors (SSRIs) might be the new hope for the early treatment of severely afflicted patients. SSRIs\u2019 low cost and availability make them potentially eligible for COVID-19 repurposing. 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