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Omega-lycotoxin-Gsp2671e (OLG1e) is a P\/Q-type VGCC modulator with high affinity and selectivity. This bio-active small protein was purified and identified from the <jats:italic>Lycosa praegrandis<\/jats:italic> venom. The effect of this state-dependent low molecular weight P\/Q-type calcium modulator on rats was investigated <jats:italic>via<\/jats:italic> glutamate-induced excitotoxicity by N-Methyl-D-aspartate. Also, Electrophysiological amplitude of field excitatory postsynaptic potentials (fEPSPs) in the input\u2013output and Long-term potentiation (LTP) curves were recorded in mossy fiber and the amount of synaptophysin (SYN), synaptosomal-associated protein, 25\u00a0kDa (SNAP-25), and synaptotagmin 1(SYT1) genes expression were measured using Real-time PCR technique for synaptic quantification. The outcomes of the current study suggest that OLG1e as a P\/Q-type VGCC modulator has an ameliorative effect on excitotoxicity-induced memory defects and prevents the impairment of pyramidal neurons in the rat hippocampus.<\/jats:p>","DOI":"10.3389\/fphar.2022.1048563","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T05:43:06Z","timestamp":1671169386000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ameliorative effects of omega-lycotoxin-Gsp2671e purified from the spider venom of Lycosa praegrandis on memory deficits of glutamate-induced excitotoxicity rat model"],"prefix":"10.3389","volume":"13","author":[{"given":"Mohammad","family":"Keimasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kowsar","family":"Salehifard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Shahidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Esmaeili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noushin","family":"Mirshah Jafar Esfahani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Beheshti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Amirsadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh","family":"Naseri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadjavad","family":"Keimasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najmeh","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Mofid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Moradmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/s0143-4160(03)00141-6","article-title":"Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity","volume":"34","author":"Arundine","year":"2003","journal-title":"Cell. calcium"},{"key":"B2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.32598\/ppj.24.1.60","article-title":"Frankincense improves memory retrieval and down-regulates the hippocampal synaptophysin mRNA during the development of the rat brain","volume":"24","author":"Beheshti","year":"2020","journal-title":"Physiol. 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