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Pharmacol."],"abstract":"<jats:p><jats:italic>Berberidis radix<\/jats:italic> polysaccharide (BRP) extracted as capping agents was applied to prepare BRP-selenium nanoparticles (BRP-SeNPs) in the redox reaction system of sodium selenite and ascorbic acid. The stability and characterization of BRP-SeNPs were investigated by physical analysis method. The results revealed that BRP were tightly wrapped on the surface of SeNPs by forming C-O\u22efSe bonds or hydrogen bonding interaction (O-H\u22efSe). BRP-SeNPs presented irregular, fragmented and smooth surface morphology and polycrystalline nanoring structure, and its particle size was 89.4\u00a0nm in the optimal preparation condition. The pharmacologic functions of BRP-SeNPs were explored <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. The results showed that BRP-SeNPs could heighten the cell viabilities and the enzyme activity of GSH-Px and decrease the content of MDA on H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced AML-12 cells injury model. <jats:italic>In vivo<\/jats:italic> tests, the results displayed that BRP-SeNPs could increase the body weight of mice, promote the enzyme activity like SOD and GSH-Px, decrease the liver organ index and the hepatic function index such as ALT, AST, CYP2E1, reduce the content of MDA, and relieve the proinflammation factors of NO, IL-1\u03b2 and TNF-\u03b1 in CCl<jats:sub>4<\/jats:sub>-induced mice injury model. Liver tissue histopathological studies corroborated the improvement of BRP-SeNPs on liver of CCl<jats:sub>4<\/jats:sub>-induced mice. The results of Western blot showed that BRP-SeNPs could attenuate oxidant stress by the Nrf2\/Keap1\/MKP1\/JNK pathways, and downregulate the proinflammatory factors by TLR4\/MAPK pathway. These findings suggested that BRP-SeNPs possess the hepatoprotection and have the potential to be a green liver-protecting and auxiliary liver inflammation drugs.<\/jats:p>","DOI":"10.3389\/fphar.2022.1058480","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T06:55:17Z","timestamp":1667976917000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Ameliorative effect of Berberidis radix polysaccharide selenium nanoparticles against carbon tetrachloride induced oxidative stress and inflammation"],"prefix":"10.3389","volume":"13","author":[{"given":"Fei","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranran","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.ijbiomac.2022.03.087","article-title":"Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio cholerae LPS: a novel delivery system candidate for nanovaccine","volume":"208","author":"Bagheri-Josheghani","year":"2022","journal-title":"Int. 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