{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:51:12Z","timestamp":1774954272372,"version":"3.50.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202201ZYTS139"],"award-info":[{"award-number":["YDZJ202201ZYTS139"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> Stroke patients with high intracranial pressure (ICP) may have poor prognosis. Non-invasive ultrasonic optic nerve sheath diameter (ONSD) could evaluate increased ICP. To investigate whether ONSD is valuable for prognosis of patients with acute ischemic stroke (AIS).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> AIS receiving intensive care were recruited with the Glasgow Coma Scale (GCS) score. Patients in group A underwent ultrasonic ONSD to assess ICP voluntarily, whereas group B without ONSD. Patients were followed up at discharge and once a week for 3 months with Glasgow Outcome Scale (GOS) score (four to five scores indicated good prognosis and one to three scores indicated poor prognosis).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Forty-nine patients were included. GCS scores did not differ significantly between groups A (26 patients) and B (8 \u00b1 3 vs. 7 \u00b1 3, <jats:italic>p<\/jats:italic> &amp;lt; 0.05). In group A, ONSD was 5.01 \u00b1 0.48\u00a0mm, which correlated with GCS score (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). At discharge, the GOS score was higher in group A than in group B (3.35 \u00b1 1.35 vs. 2.57 \u00b1 1.121, <jats:italic>p<\/jats:italic> = 0.034). The proportion of patients with a good prognosis was higher in group A than in group B (46.2% vs. 13.0%, <jats:italic>p<\/jats:italic> = 0.006). At discharge and after 3\u00a0months of follow-up, ONSD at admission was correlated with the GOS score in group A (r = -0.648 [<jats:italic>p<\/jats:italic> &amp;lt; 0.05] and -0.731 [<jats:italic>p<\/jats:italic> &amp;lt; 0.05], respectively). After 3\u00a0months of follow-up, the GOS score was higher in group A than group B (3.00 \u00b1 1.673 vs. 2.04 \u00b1 1.430, <jats:italic>p<\/jats:italic> &amp;lt; 0.05). The proportion of patients with a good prognosis was higher in group A than in group B (46.2% vs. 21.2%, <jats:italic>p<\/jats:italic> = 0.039). The Kaplan-Meier curve showed a higher rate of good prognosis in group A than in group B. ONSD (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) was an independent predictor of poor prognosis.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Non-invasive ultrasonic ONSD could be useful in improving the prognosis of patients with AIS receiving intensive care.<\/jats:p>","DOI":"10.3389\/fphar.2022.1077131","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T05:35:49Z","timestamp":1671773749000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Ultrasonic optic nerve sheath diameter could improve the prognosis of acute ischemic stroke in the intensive care unit"],"prefix":"10.3389","volume":"13","author":[{"given":"Cong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui-Cui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1227\/NEU.0b013e31821a45ba","article-title":"Meta-analysis of hemorrhagic complications from ventriculostomy placement by neurosurgeons","volume":"69","author":"Bauer","year":"2011","journal-title":"Neurosurgery"},{"key":"B2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/1471-2377-13-187","article-title":"Reproducibility and accuracy of optic nerve sheath diameter assessment using ultrasound compared to magnetic resonance imaging","volume":"13","author":"B\u00e4uerle","year":"2013","journal-title":"BMC Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1007\/s00415-008-0059-8","article-title":"Nosocomial ventriculitis and meningitis in neurocritical care patients","volume":"255","author":"Beer","year":"2008","journal-title":"J. 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