{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:44:14Z","timestamp":1776210254614,"version":"3.50.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Accumulating evidence shows that DNA methylation plays a role in antipsychotic response. However, the mechanisms by which DNA methylation changes are associated with antipsychotic responses remain largely unknown.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We performed a methylome-wide association study (MWAS) to evaluate the association between DNA methylation and the response to risperidone in schizophrenia. Genomic DNA methylation patterns were assessed using the Agilent Human DNA Methylation Microarray.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We identified numerous differentially methylated positions (DMPs) and regions (DMRs) associated with antipsychotic response. <jats:italic>CYP46A1<\/jats:italic>, <jats:italic>SPATS2<\/jats:italic>, and <jats:italic>ATP6V1E1<\/jats:italic> had the most significant DMPs, with <jats:italic>p<\/jats:italic> values of 2.50 \u00d7 10<jats:sup>\u20136<\/jats:sup>, 3.53 \u00d7 10<jats:sup>\u20136<\/jats:sup>, and 5.71 \u00d7 10<jats:sup>\u20136<\/jats:sup>, respectively. The top-ranked DMR was located on chromosome 7, corresponding to the <jats:italic>PTPRN2<\/jats:italic> gene with a \u0160id\u00e1k-corrected <jats:italic>p<\/jats:italic>-value of 9.04 \u00d7 10<jats:sup>\u201313<\/jats:sup>. Additionally, a significant enrichment of synaptic function and neurotransmitters was found in the differentially methylated genes after gene ontology and pathway analysis.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The identified DMP- and DMR-overlapping genes associated with antipsychotic response are related to synaptic function and neurotransmitters. These findings may improve understanding of the mechanisms underlying antipsychotic response and guide the choice of antipsychotic in schizophrenia.<\/jats:p>","DOI":"10.3389\/fphar.2022.1078464","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T13:50:31Z","timestamp":1671717031000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Methylome-wide association study of different responses to risperidone in schizophrenia"],"prefix":"10.3389","volume":"13","author":[{"given":"Huihui","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingsong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Huai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songyin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengying","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.schres.2013.12.007","article-title":"DNA hypermethylation of serotonin transporter gene promoter in drug na\u00efve patients with schizophrenia","volume":"152","author":"Abdolmaleky","year":"2014","journal-title":"Schizophr. 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