{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:10:37Z","timestamp":1791893437948,"version":"4.3.4"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Shenerjiangzhi formulation (SEJZ) is a new traditional Chinese medicine formulation (patent number: CN110680850A). SEJZ contains <jats:italic>Eleutherococcus senticosus<\/jats:italic> (<jats:italic>Rupr.<\/jats:italic> and <jats:italic>Maxim.<\/jats:italic>), <jats:italic>Maxim<\/jats:italic> (Araliaceae; <jats:italic>E. senticosus<\/jats:italic> radix and rhizome), <jats:italic>Lonicera japonica<\/jats:italic> Thunb (Caprifoliaceae; <jats:italic>Lonicera japonica<\/jats:italic> branch, stem), <jats:italic>Crataegus pinnatifida<\/jats:italic> Bunge (Rosaceae; Crataegus pinnatifida fruit), and <jats:italic>Auricularia auricula<\/jats:italic>. SEJZ has been designed to treat hyperlipidemia. Despite the therapeutic benefits of SEJZ, its underlying mechanism of action is not known. We explored the efficacy of SEJZ against hyperlipidemia by integrating network pharmacology and 16S rRNA gene sequencing and elucidated its mechanism of action. First, SEJZ targets were found through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and from the literature. Hyperlipidemia-related therapeutic targets were obtained from GeneCards, Online Mendelian Inheritance in Man, and DrugBank databases. Then, Search Tool for the Retrieval of Interacting Genes\/Proteins and Cytoscape were applied for the analyses and construction of a protein\u2013protein interaction (PPI) network. The Kyoto Encyclopedia of Genes and Genomes database was employed to identify signaling pathways that were enriched. Second, the therapeutic effects of SEJZ against hyperlipidemia induced by consumption of a high-fat diet in rats were evaluated by measuring body weight changes and biochemical tests. SEJZ treatment was found to alleviate obesity and hyperlipidemia in rats. Finally, 16S rRNA gene sequencing showed that SEJZ could significantly increase the abundance of short-chain fatty acid-producing bacteria, restore the intestinal barrier, and maintain intestinal-flora homeostasis. Using PICRUSt2, six metabolic pathways were found to be consistent with the results of network pharmacology: \u201cAfrican trypanosomiasis\u201d, \u201camoebiasis\u201d, \u201carginine and proline metabolism\u201d, \u201ccalcium signaling pathway\u201d, \u201cNOD-like receptor signaling pathway\u201d, and \u201ctryptophan metabolism\u201d. These pathways might represent how SEJZ works against hyperlipidemia. Moreover, the \u201cAfrican trypanosomiasis pathway\u201d had the highest association with core genes. These results aid understanding of how SEJZ works against dyslipidemia and provide a reference for further studies.<\/jats:p>","DOI":"10.3389\/fphar.2022.745074","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T12:31:35Z","timestamp":1649161895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Mechanism of Action of Shenerjiangzhi Formulation on Hyperlipidemia Induced by Consumption of a High-Fat Diet in Rats Using Network Pharmacology and Analyses of the Gut Microbiota"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi A. D.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.clnu.2017.06.009","article-title":"Dynapenic Obesity as an Associated Factor to Lipid and Glucose Metabolism Disorders and Metabolic Syndrome in Older Adults - Findings from SABE Study","volume":"37","author":"Alexandre","year":"2018","journal-title":"Clin. Nutr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.13386\/j.issn1002-0306.2016.04.068","article-title":"Research advance on Acanthopanax Structure and the Content of Active Ingredient","volume":"37","author":"Bai","year":"2016","journal-title":"Sci. Tech. Food Industry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"12403","DOI":"10.1111\/hel.12403","article-title":"Epidemiology of Helicobacter pylori Infection","author":"Burucoa","year":"2017","journal-title":"Helicobacter"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4130","DOI":"10.1210\/jc.2012-2285","article-title":"Insulin-mediated FFA Suppression Is Associated with Triglyceridemia and Insulin Sensitivity Independent of Adiposity","volume":"97","author":"Bush","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"B6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1365-2672.1992.tb01858.x","article-title":"Cyanobacteria Secondary Metabolites-Tthe Cyanotoxins","volume":"72","author":"Carmichael","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1055\/s-0031-1279992","article-title":"Kaempferol Regulates the Lipid-Profile in High-Fat Diet-Fed Rats through an Increase in Hepatic PPAR\u03b1 Levels","volume":"77","author":"Chang","year":"2011","journal-title":"Planta Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1080\/14786419.2015.1101105","article-title":"Flavonoid Derivative Exerts an Antidiabetic Effect via AMPK Activation in Diet-Induced Obesity Mice","volume":"30","author":"Chen","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jep.2015.03.047","article-title":"Use of Traditional Chinese Medicine in Patients with Hyperlipidemia: A Population-Based Study in Taiwan","volume":"168","author":"Chu","year":"2015","journal-title":"J. Ethnopharmacol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"7767","DOI":"10.1128\/AEM.01477-07","article-title":"Intestinal Integrity and Akkermansia Muciniphila, a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly","volume":"73","author":"Collado","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s40168-016-0202-1","article-title":"Unusual Sub-genus Associations of Faecal Prevotella and Bacteroides with Specific Dietary Patterns","volume":"4","author":"De Filippis","year":"2016","journal-title":"Microbiome"},{"key":"B12","doi-asserted-by":"publisher","first-page":"104353","DOI":"10.1016\/j.micpath.2020.104353","article-title":"Diverse Effects of Different Akkermansia Muciniphila Genotypes on Brown Adipose Tissue Inflammation and Whitening in a High-Fat-Diet Murine Model","volume":"147","author":"Deng","year":"2020","journal-title":"Microb. Pathog."},{"key":"B13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.micpath.2016.02.005","article-title":"Akkermansia Muciniphila and its Role in Regulating Host Functions","volume":"106","author":"Derrien","year":"2017","journal-title":"Microb. Pathog."},{"key":"B14","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.tim.2015.03.002","article-title":"Fate, Activity, and Impact of Ingested Bacteria within the Human Gut Microbiota","volume":"23","author":"Derrien","year":"2015","journal-title":"Trends Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s10482-013-9898-0","article-title":"Cyanobacteria: Potential Candidates for Drug Discovery","volume":"103","author":"Dixit","year":"2013","journal-title":"Antonie Van Leeuwenhoek"},{"key":"B16","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for Prediction of Metagenome Functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-3-030-45328-2_3","article-title":"Amino Acids in Circulatory Function and Health","volume":"1265","author":"Durante","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1089\/152308603764816505","article-title":"Free Fatty Acid Overload Attenuates Ca2+ Signaling and NO Production in Endothelial Cells","volume":"5","author":"Esenabhalu","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"B19","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.virol.2007.12.002","article-title":"Characterization of 1706, a Virulent Phage from Lactococcus Lactis with Similarities to Prophages from Other Firmicutes","volume":"373","author":"Garneau","year":"2008","journal-title":"Virology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1038\/s41598-019-38874-3","article-title":"Faecal Bacterial and Short-Chain Fatty Acids Signature in Hypercholesterolemia","volume":"9","author":"Granado-Serrano","year":"2019","journal-title":"Sci. Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/5584_2018_319","article-title":"Probiotics in the Treatment of Inflammatory Bowel Disease","volume":"1125","author":"Guandalini","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s00394-020-02414-x","article-title":"Inulin Supplementation Ameliorates Hyperuricemia and Modulates Gut Microbiota in Uox-Knockout Mice","volume":"60","author":"Guo","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/15384047.2018.1507255","article-title":"Intestinal Microorganisms Involved in Colorectal Cancer Complicated with Dyslipidosis","volume":"20","author":"Han","year":"2019","journal-title":"Cancer Biol. Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1254\/fpj.118.389","article-title":"Lipid-lowering Drugs","volume":"118","author":"Hirakawa","year":"2001","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.3389\/fmicb.2017.02663","article-title":"Exogenous Fecal Microbiota Transplantation from Local Adult Pigs to Crossbred Newborn Piglets","volume":"8","author":"Hu","year":"2017","journal-title":"Front. Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/md17080455","article-title":"Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota","volume":"17","author":"Hu","year":"2019","journal-title":"Mar. Drugs"},{"key":"B27","doi-asserted-by":"publisher","first-page":"15555","DOI":"10.1038\/s41598-020-72601-7","article-title":"Higher Visit-To-Visit Total Cholesterol Variability Is Associated with Lower Cognitive Function Among Middle-Aged and Elderly Chinese Men","volume":"10","author":"Hua","year":"2020","journal-title":"Sci. Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"7312","DOI":"10.12659\/MSM.915984","article-title":"Proteobacteria Acts as a Pathogenic Risk-Factor for Chronic Abdominal Pain and Diarrhea in Post-Cholecystectomy Syndrome Patients: A Gut Microbiome Metabolomics Study","volume":"25","author":"Kang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/s41564-018-0272-x","article-title":"Interactions between Roseburia Intestinalis and Diet Modulate Atherogenesis in a Murine Model","volume":"3","author":"Kasahara","year":"2018","journal-title":"Nat. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.nut.2018.10.002","article-title":"Probiotics Improve Gut Microbiota Dysbiosis in Obese Mice Fed a High-Fat or High-Sucrose Diet","volume":"60","author":"Kong","year":"2019","journal-title":"Nutrition"},{"key":"B31","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.tim.2016.02.015","article-title":"Oscillospira: a Central, Enigmatic Component of the Human Gut Microbiota","volume":"24","author":"Konikoff","year":"2016","journal-title":"Trends Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.biopha.2016.07.006","article-title":"Anti-diabetic and Anti-obesitic Effects of Aqueous Extracts of Yangkyuksanhwa-Tang and its Two Major Compositions on Db\/db Mice","volume":"83","author":"Lee","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"B33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3389\/fmicb.2020.610173","article-title":"Research Progress in Functional Components and Drying Technology of Auricularia Auricula","volume":"20","author":"Li","year":"","journal-title":"Storage and Process"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2000746","DOI":"10.1002\/mnfr.202000746","article-title":"Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Galectin\u20103\u2010NLRP3 Signaling Pathway","volume":"65","author":"Li","year":"","journal-title":"Mol. Nutr. Food Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.freeradbiomed.2021.05.028","article-title":"Vitexin Alleviates High-Fat Diet Induced Brain Oxidative Stress and Inflammation via Anti-oxidant, Anti-inflammatory and Gut Microbiota Modulating Properties","volume":"171","author":"Li","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"7599","DOI":"10.1021\/jf400283w","article-title":"Effects of Pectin Pentaoligosaccharide from Hawthorn (Crataegus Pinnatifida Bunge. Var. Major) on the Activity and mRNA Levels of Enzymes Involved in Fatty Acid Oxidation in the Liver of Mice Fed a High-Fat Diet","volume":"61","author":"Li","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.3390\/molecules26082215","article-title":"Acanthopanax Henryi: Review of Botany, Phytochemistry and Pharmacology","volume":"26","author":"Li","year":"","journal-title":"Molecules"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e00313","DOI":"10.1128\/mSystems.00313-20","article-title":"The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin","volume":"5","author":"Li","year":"","journal-title":"mSystems"},{"key":"B39","doi-asserted-by":"publisher","first-page":"skaa070","DOI":"10.1093\/jas\/skaa070","article-title":"Combined Signature of Rumen Microbiome and Metabolome in Dairy Cows with Different Feed Intake Levels","volume":"98","author":"Li","year":"","journal-title":"J. Anim. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s00248-016-0888-4","article-title":"Age-Related Response of Rumen Microbiota to Mineral Salt and Effects of Their Interactions on Enteric Methane Emissions in Cattle","volume":"73","author":"Liu","year":"2017","journal-title":"Microb. Ecol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e1700729","DOI":"10.1002\/mnfr.201700729","article-title":"Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in Their Liver and Pancreas","volume":"62","author":"Mbikay","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s40618-013-0044-7","article-title":"Increased Amino Acids Levels and the Risk of Developing of Hypertriglyceridemia in a 7-year Follow-Up","volume":"37","author":"Mook-Kanamori","year":"2014","journal-title":"J. Endocrinol. Invest."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1002\/jsfa.7557","article-title":"Antihyperlipidemic effect of Acanthopanax senticosus (Rupr. et Maxim) Harms leaves in high-fat-diet fed mice","volume":"96","author":"Nishida","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"B44","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.intimp.2014.12.041","article-title":"Protective Effects of Isofraxidin against Lipopolysaccharide-Induced Acute Lung Injury in Mice","volume":"24","author":"Niu","year":"2015","journal-title":"Int. Immunopharmacol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jnutbio.2015.12.003","article-title":"Milk Sphingomyelin Improves Lipid Metabolism and Alters Gut Microbiota in High Fat Diet-Fed Mice","volume":"30","author":"Norris","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e12572","DOI":"10.1111\/hel.12572","article-title":"First Nationwide Seroepidemiology and Risk Factors Report of Helicobater Pylori in Jordan","volume":"24","author":"Obaidat","year":"2019","journal-title":"Helicobacter"},{"key":"B47","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1615\/IntJMedMushrooms.v19.i2.90","article-title":"Evaluation and Characterization of Nutritive Properties of the Jelly Ear Culinary-Medicinal Mushroom Auricularia Auricula-Judae (Agaricomycetes) from Nigeria","volume":"19","author":"Ohiri","year":"2017","journal-title":"Int. J. Med. Mushrooms"},{"key":"B48","doi-asserted-by":"publisher","first-page":"353","DOI":"10.13386\/j.issn1002-0306.2019.23.058","article-title":"Research Progress on Chemical Constituents and Pharmacological Activities of Acanthopanax Senticosus","volume":"40","author":"Pan","year":"2019","journal-title":"Sci. Tech. Food Industry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1056\/NEJMoa1315665","article-title":"Application of New Cholesterol Guidelines to a Population-Based Sample","volume":"370","author":"Pencina","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/j.1469-7793.1998.819bs.x","article-title":"The Characterization of Butyrate Transport across Pig and Human Colonic Luminal Membrane","volume":"507","author":"Ritzhaupt","year":"1998","journal-title":"J. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s10557-017-6727-0","article-title":"Identification and Management of Statin-Associated Symptoms in Clinical Practice: Extension of a Clinician Survey to 12 Further Countries","volume":"31","author":"Rosenson","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0166-6851(80)90046-8","article-title":"Hypertriglyceridemia Associated with Trypanosoma Brucei Brucei Infection in Rabbits: Role of Defective Triglyceride Removal","volume":"2","author":"Rouzer","year":"1980","journal-title":"Mol. Biochem. Parasitol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/gut.47.3.397","article-title":"Butyrate Inhibits Inflammatory Responses through NFkappaB Inhibition: Implications for Crohn's Disease","volume":"47","author":"Segain","year":"2000","journal-title":"Gut"},{"key":"B54","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10787-015-0237-0","article-title":"Novel Quercetin-3-O-Glucoside Eicosapentaenoic Acid Ester Ameliorates Inflammation and Hyperlipidemia","volume":"23","author":"Sekhon-Loodu","year":"2015","journal-title":"Inflammopharmacology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1805418","DOI":"10.1155\/2020\/1805418","article-title":"An Integrated Fecal Microbiome and Metabolomics in T2DM Rats Reveal Antidiabetes Effects from Host-Microbial Metabolic Axis of EtOAc Extract from Sophora Flavescens","volume":"2020","author":"Shao","year":"2020","journal-title":"Oxid Med. Cel Longev"},{"key":"B56","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1111\/j.1463-1326.2007.00837.x","article-title":"Metabolomic Profiling of Dietary-Induced Insulin Resistance in the High Fat-Fed C57BL\/6J Mouse","volume":"10","author":"Shearer","year":"2008","journal-title":"Diabetes Obes. Metab."},{"key":"B57","doi-asserted-by":"publisher","first-page":"12041","DOI":"10.1038\/s41598-017-12245-2","article-title":"Mulberry Leaf Alleviates Streptozotocin-Induced Diabetic Rats by Attenuating NEFA Signaling and Modulating Intestinal Microflora","volume":"7","author":"Sheng","year":"2017","journal-title":"Sci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3389\/fphar.2020.01295","article-title":"An Integrated Pharmacokinetic Study of an Acanthopanax Senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"116","DOI":"10.13863\/j.issn1001-4454.2019.01.025","article-title":"Concent Determinations of Seven Bioactive Components in Crateagus Pinnatifida Var. Major by QAMS","volume":"42","author":"Shi","year":"2019","journal-title":"J. Chin. Med. Mater."},{"key":"B60","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: Microbial Signature of Dysbiosis in Gut Microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.fsi.2017.09.006","article-title":"Suppressor of Cytokine Signaling 3 (SOCS3) Is Related to Pro-inflammatory Cytokine Production and Triglyceride Deposition in Turbot (Scophthalmus maximus)","volume":"70","author":"Tan","year":"2017","journal-title":"Fish. Shellfish Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3390\/toxins12090569","article-title":"The Effects of Deoxynivalenol on the Ultrastructure of the Sacculus Rotundus and Vermiform Appendix, as Well as the Intestinal Microbiota of Weaned Rabbits","volume":"12","author":"Wang","year":"","journal-title":"Toxins (Basel)"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1265324","DOI":"10.1080\/16546628.2017.1265324","article-title":"Antioxidant Activities of Aqueous Extracts from 12 Chinese Edible Flowers In Vitro and In Vivo","volume":"61","author":"Wang","year":"2017","journal-title":"Food Nutr. Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3390\/toxins11020077","article-title":"Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids","volume":"11","author":"Wang","year":"2019","journal-title":"Toxins (Basel)"},{"key":"B65","doi-asserted-by":"publisher","first-page":"4532482","DOI":"10.1155\/2020\/4532482","article-title":"Preventive Effects of Kaempferol on High-Fat Diet-Induced Obesity Complications in C57BL\/6 Mice","volume":"2020","author":"Wang","year":"","journal-title":"Biomed. Res. Int."},{"key":"B66","doi-asserted-by":"publisher","first-page":"16117","DOI":"10.1096\/fj.201902900RR","article-title":"The Intestinal Microbial Metabolite Desaminotyrosine Is an Anti-inflammatory Molecule that Modulates Local and Systemic Immune Homeostasis","volume":"34","author":"Wei","year":"2020","journal-title":"FASEB J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3748","DOI":"10.3390\/jcm9113748","article-title":"Statin Treatment in Specific Patient Groups: Role for Improved Cardiovascular Risk Markers","volume":"9","author":"White","year":"2020","journal-title":"J. Clin. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"152863","DOI":"10.1016\/j.phymed.2019.152863","article-title":"The Pandanus Tectorius Fruit Extract (PTF) Modulates the Gut Microbiota and Exerts Anti-hyperlipidaemic Effects","volume":"58","author":"Wu","year":"","journal-title":"Phytomedicine"},{"key":"B69","doi-asserted-by":"publisher","first-page":"225","DOI":"10.13422\/j.cnki.syfjx.20190408","article-title":"Chemical Constituents and Pharmacological Effect of Lonicerae Japonicae Flos","volume":"25","author":"Wu","year":"","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B70","doi-asserted-by":"publisher","first-page":"344","DOI":"10.12998\/wjcc.v6.i10.344","article-title":"Gastrointestinal Toxicity Induced by Microcystins","volume":"6","author":"Wu","year":"2018","journal-title":"World J. Clin. Cases"},{"key":"B71","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1124\/jpet.120.000162","article-title":"Apigenin Ameliorates Insulin Resistance and Lipid Accumulation by Endoplasmic Reticulum Stress and SREBP-1c\/SREBP-2 Pathway in Palmitate-Induced HepG2 Cells and High-Fat Diet-Fed Mice","volume":"377","author":"Wu","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B72","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1142\/s0192415x09007119","article-title":"Analysis of Trace Elements in Chinese Therapeutic Foods and Herbs","volume":"37","author":"Xu","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e2100049","DOI":"10.1002\/cbdv.202100049","article-title":"Effects of Apigenin on the Expression of LOX\u20101, Bcl\u20102, and Bax in Hyperlipidemia Rats","volume":"18","author":"Xu","year":"2021","journal-title":"Chem. Biodiversity"},{"key":"B74","doi-asserted-by":"publisher","first-page":"5283","DOI":"10.3748\/wjg.v20.i18.5283","article-title":"Treatment of Helicobacter pylori Infection: Current Status and Future Concepts","volume":"20","author":"Yang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/fphar.2019.00158","article-title":"Emerging Applications of Metabolomics in Traditional Chinese Medicine Treating Hypertension: Biomarkers, Pathways and More","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1080\/14786419.2019.1587430","article-title":"A New Anti-inflammatory Lignan from Lonicerae Japonicae Flos","volume":"35","author":"Yang","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"62","DOI":"10.13386\/j.issn1002-0306.2017.10.004","article-title":"Determination of Nine Phenolic Components in the Leaves of Chinese Hawthorn by HPLC","volume":"38","author":"Yang","year":"","journal-title":"Sci. Tech. Food Industry"},{"key":"B78","doi-asserted-by":"publisher","first-page":"48863","DOI":"10.18632\/oncotarget.16458","article-title":"Gut Microbiota Drives the Attenuation of Dextran Sulphate Sodium-Induced Colitis by Huangqin Decoction","volume":"8","author":"Yang","year":"","journal-title":"Oncotarget"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/1751-7915.13410","article-title":"Akkermansia Muciniphila Is a Promising Probiotic","volume":"12","author":"Zhang","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"14405","DOI":"10.1038\/srep14405","article-title":"Modulation of Gut Microbiota by Berberine and Metformin during the Treatment of High-Fat Diet-Induced Obesity in Rats","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"109323","DOI":"10.1016\/j.cbi.2020.109323","article-title":"Antioxidation, Anti-hyperlipidaemia and Hepatoprotection of Polysaccharides from Auricularia Auricular Residue","volume":"333","author":"Zhang","year":"2021","journal-title":"Chem. Biol. Interact"},{"key":"B82","doi-asserted-by":"publisher","first-page":"145","DOI":"10.4103\/0973-1296.177902","article-title":"Application of Ultra-performance Liquid Chromatography with Time-Of-Flight Mass Spectrometry for the Rapid Analysis of Constituents and Metabolites from the Extracts of Acanthopanax Senticosus Harms Leaf","volume":"12","author":"Zhang","year":"2016","journal-title":"Pharmacogn Mag."},{"key":"B83","doi-asserted-by":"publisher","first-page":"7836","DOI":"10.1039\/d1fo00727k","article-title":"The Interaction between Gut Microbiota and Flavonoid Extract from Smilax Glabra Roxb. And its Potent Alleviation of Fatty Liver","volume":"12","author":"Zhao","year":"2021","journal-title":"Food Funct."},{"key":"B84","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.biopha.2020.110426","article-title":"Progress of Research on Animal Model of Hyperlipidemia","volume":"24","author":"Zhao","year":"2018","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B85","doi-asserted-by":"publisher","first-page":"586350","DOI":"10.3389\/fphar.2020.586350","article-title":"Integrating Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Citri Reticulatae Pericarpium against Reserpine-Induced Spleen Deficiency in Rats","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"412","DOI":"10.13386\/j.issn1002-0306.2020070411","article-title":"Research Progress in Functional Components and Bioactivity of Honeysuckle","volume":"42","author":"Zhu","year":"2021","journal-title":"Sci. Tech. Food Industry"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.745074\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T12:31:44Z","timestamp":1649161904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.745074\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":86,"alternative-id":["10.3389\/fphar.2022.745074"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.745074","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"article-number":"745074"}}