{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:06Z","timestamp":1787026986966,"version":"build-2736575974"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-108-122"],"award-info":[{"award-number":["DMR-108-122"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    It has been reported that antroquinonol extracted from Golden-\n                    <jats:italic>Antrodia camphorate<\/jats:italic>\n                    exerts protective effects on liver function both\n                    <jats:italic>in vitro and in vivo<\/jats:italic>\n                    . However, the protective effects of Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    on liver function have not been fully investigated in human clinical studies. Therefore, the present study aimed to evaluate the beneficial effects of Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    on hepatic function after alcohol consumption in human subjects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 80 participants with increased \u03b3-glutamyl transferase levels (60\u2013180 U\/L) were enrolled in the current study and were randomly divided into two groups. Participants in the first group were orally administrated with 300\u00a0mg\/day Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    (tablets), while those in the second group received placebo tablets for 12\u00a0weeks. Biochemical routine blood tests were performed at 6 and 12\u00a0weeks following the first administration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    At 12\u00a0weeks post the first Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    administration, the serum levels of aspartate aminotransferase (AST;\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.0001), alanine aminotransferase (ALT;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0002) and triglyceride (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0158) were notably declined in the Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    treatment group compared with the placebo group. No clinically significant differences were observed between the Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    treatment and placebo groups in terms of general safety parameters.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    A statistically significant difference was obtained in the serum levels of AST, ALT and triglycerides between the Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    and placebo groups. However, no clinical significance was observed in any of the safety parameters examined. Overall, these findings indicated that treatment with Golden-\n                    <jats:italic>Antrodia camphorata<\/jats:italic>\n                    exerted protective effects on liver function.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2022.757494","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:53:49Z","timestamp":1655772829000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Benefits of Golden-Antrodia Camphorata Containing Antroquinonol in Liver Protection and Liver Fat Reduction After Alcoholic Hepatitis"],"prefix":"10.3389","volume":"13","author":[{"given":"Yu-Ting","family":"Yen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Today","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Che","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Shiou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ling","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cbi.2018.10.009","article-title":"Pharmacological Activities of Antroquinonol- Mini Review","volume":"297","author":"Angamuthu","year":"2019","journal-title":"Chem. 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