{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:50:43Z","timestamp":1790700643150,"version":"4.1.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Diabetes mellitus is a fast-growing disease with a major influence on people\u2019s quality of life. Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment of diabetes, but chronic consumption of these drugs has certain side effects. Polysaccharides, saponins, flavonoids, and phenolics are the primary secondary metabolites isolated from the rhizomes of\n                    <jats:italic>Polygonatum sibiricum<\/jats:italic>\n                    Redout\u00e9 [Asparagaceae],\n                    <jats:italic>Polygonatum kingianum<\/jats:italic>\n                    Collett &amp;amp; Hemsl [Asparagaceae], or\n                    <jats:italic>Polygonatum cyrtonema<\/jats:italic>\n                    Hua [Asparagaceae], which have attracted much more attention owing to their unique therapeutic role in the treatment and prevention of diabetes. However, the research on the mechanism of these three\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    spp. in diabetes has not been reviewed. This review provides a summary of the research progress of three\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    spp. on diabetes and its complications, reveals the potential antidiabetic mechanism of three\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    spp., and discusses the effect of different processed products of three\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    spp. in treating diabetes, for the sake of a thorough understanding of its effects on the prevention and treatment of diabetes and diabetes complications.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2022.758501","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T01:48:41Z","timestamp":1644284921000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Advances in Mechanism Research on Polygonatum in Prevention and Treatment of Diabetes"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Jun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Hui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-e","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-Suo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e22254","DOI":"10.1002\/jbt.22254","article-title":"Candesartan and Epigallocatechin-3-Gallate Ameliorate Gentamicin-Induced Renal Damage in Rats through P38-MAPK and NF-\u039ab Pathways","volume":"33","author":"Ahmed","year":"2018","journal-title":"J. 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