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In the nervous system, LXs exert an array of protective effects against neurological diseases, including ischemic or hemorrhagic stroke, neonatal hypoxia-ischemia encephalopathy, brain and spinal cord injury, Alzheimer\u2019s disease, multiple sclerosis, and neuropathic pain. Lipoxin administration is a potential therapeutic strategy in neurological diseases due to its notable efficiency and unique superiority regarding safety. Here, we provide an overview of LXs in terms of their synthesis, signaling pathways and neuroprotective evidence. Overall, we believe that, along with advances in lipoxin-related drug design, LXs will bring brighter prospects for neuroprotection.<\/jats:p>","DOI":"10.3389\/fphar.2022.781889","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T11:50:24Z","timestamp":1643197824000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Lipoxins in the Nervous System: Brighter Prospects for Neuroprotection"],"prefix":"10.3389","volume":"13","author":[{"given":"Jiayu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1139\/cjpp-2016-0060","article-title":"Aspirin and (Or) omega-3 Polyunsaturated Fatty Acids Protect against Corticohippocampal Neurodegeneration and Downregulate Lipoxin A4 Production and Formyl Peptide Receptor-like 1 Expression in Pentylenetetrazole-Kindled Rats","volume":"95","author":"Abd-Elghafour","year":"2017","journal-title":"Can. 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