{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:57:19Z","timestamp":1790737039539,"version":"4.1.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008009","name":"Environment and Health Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Polychlorinated biphenyls (PCBs) are persistent organic pollutants banned for use worldwide. Due to their biodegradation resistance, they accumulate along the food chain and in the environment. Maternal exposure to PCBs may affect the fetus and the infant. PCBs are immunotoxic and may damage the developing immune system. PCBs are associated with elevated IgE antibodies in cord blood and are considered to be predictive of atopic reactions. Several studies on the association between prenatal exposure to PCBs and atopic reactions were previously published, albeit with conflicting results.<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold> To examine the association between maternal PCBs levels and atopic reactions in their offspring.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> During the years 2013\u20132015, a prospective birth cohort was recruited at the delivery rooms of Shamir Medical Center (Assaf Harofeh) and \u201cDana Dwek\u201d Children\u2019s Hospital. Four PCBs congeners were investigated: PCBs 118, 138, 153, and 180. In 2019, when children reached the age of 4\u20136\u00a0years, mothers were interviewed using the ISAAC questionnaire to assess symptoms of atopic reactions, including asthma, allergic rhinitis, and atopic dermatitis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> One hundred and fifty mother-child dyads were analyzed. No significant differences were found in the median serum PCBs concentrations of each studied congener or total PCBs for asthma, allergic rhinitis, atopic dermatitis diagnosis, or parent-reported symptoms. No association was found between exposure to total PCBs and the risk for asthma symptoms or diagnosis, adjusted to maternal age and family member with atopic condition: aOR = 0.94, 95%CI: (0.88; 0.99). No association was observed between each studied PCB congener and asthma symptoms or diagnosis. The same results were found also for other studied outcomes\u2014allergic rhinitis and atopic dermatitis.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our study joins a series of previous studies that attempt to shed light on environmental exposures <jats:italic>in utero<\/jats:italic> as influencing factors for atopic conditions in children. Our results reflect the complexity of the pathophysiology of these phenomena. No relationship between maternal serum PCBs levels was demonstrated for asthma, allergic rhinitis, or atopic dermatitis. However, additional multi-participant studies, with longer, spanning into later pediatric age follow up are needed.<\/jats:p>","DOI":"10.3389\/fphar.2022.802974","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T05:33:48Z","timestamp":1649223228000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort"],"prefix":"10.3389","volume":"13","author":[{"given":"Maya","family":"Berlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar","family":"Flor-Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elkana","family":"Kohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimona","family":"Keidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Livne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronella","family":"Marom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Ovental","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Lubetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Factor-Litvak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Tovbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Betser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Moskovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela","family":"Hazan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malka","family":"Britzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itai","family":"Gueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matitiahu","family":"Berkovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Matok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Hamiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1164\/rccm.201804-0682CI","article-title":"Underdiagnosis and Overdiagnosis of Asthma","volume":"198","author":"Aaron","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B2","volume-title":"Toxicological Profile for Polychlorinated Biphenyls (PCBS) - Update","year":"2000"},{"key":"B3","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"International Study of Asthma and Allergies in Childhood (ISAAC): Rationale and Methods","volume":"8","author":"Asher","year":"1995","journal-title":"Eur. Respir. J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/152873902753396794","article-title":"Cord Blood Lymphocyte Functions in Newborns from A Remote Maritime Population Exposed to Organochlorines and Methylmercury","volume":"65","author":"Belles-Isles","year":"2002","journal-title":"J. Toxicol. Environ. Health A."},{"key":"B5","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.toxlet.2012.03.020","article-title":"State-of-the-science of Endocrine Disrupting Chemicals","volume":"211","author":"Bergman","year":"2012","journal-title":"Toxicol. Lett."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s00420-009-0426-5","article-title":"Evaluation of Different Methods to Determine Total Serum Lipids for Normalization of Circulating Organochlorine Compounds","volume":"82","author":"Bergonzi","year":"2009","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"B7","doi-asserted-by":"publisher","first-page":"705395","DOI":"10.3389\/fped.2021.705395","article-title":"Maternal and Newborn Thyroid Hormone, and the Association with Polychlorinated Biphenyls (PCBs) Burden: The EHF (Environmental Health Fund) Birth Cohort","volume":"9","author":"Berlin","year":"2021","journal-title":"Front. Pediatr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.chemosphere.2007.02.043","article-title":"Calculation of Serum \u201cTotal Lipid\u201d Concentrations for the Adjustment of Persistent Organohalogen Toxicant Measurements in Human Samples","volume":"68","author":"Bernert","year":"2007","journal-title":"Chemosphere"},{"key":"B9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1399-3038.2007.00601.x","article-title":"Worldwide Time Trends for Symptoms of Rhinitis and Conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood","volume":"19","author":"Bj\u00f6rkst\u00e9n","year":"2008","journal-title":"Pediatr. Allergy Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/s0300-483x(00)00368-1","article-title":"Effect of Highly Bioaccumulated Polychlorinated Biphenyl Congeners on Estrogen and Androgen Receptor Activity","volume":"158","author":"Bonefeld-J\u00f8rgensen","year":"2001","journal-title":"Toxicology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"900","DOI":"10.2478\/s13382-013-0162-7","article-title":"Underdiagnosis of Childhood Asthma: A Comparison of Survey Estimates to Clinical Evaluation","volume":"26","author":"Bro\u017cek","year":"2013","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"B12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1289\/ehp.0900916","article-title":"Effect of Early Life Exposure to Air Pollution on Development of Childhood Asthma","volume":"118","author":"Clark","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1289\/ehp.7255","article-title":"Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik","volume":"112","author":"Dallaire","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"B14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ijgo.2015.09.002","article-title":"International Federation of Gynecology and Obstetrics Opinion on Reproductive Health Impacts of Exposure to Toxic Environmental Chemicals","volume":"131","author":"Di Renzo","year":"2015","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"B15","first-page":"311","article-title":"Birthweight Standards in the Live-Born Population in Israel","volume":"7","author":"Dollberg","year":"2005","journal-title":"Isr. Med. Assoc. J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.fct.2011.11.004","article-title":"Polybrominated Diphenyl Ethers in Food and Human Dietary Exposure: A Review of the Recent Scientific Literature","volume":"50","author":"Domingo","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1089\/ped.2014.0344","article-title":"Underdiagnosed and Undertreated Allergic Rhinitis in Urban School-Aged Children with Asthma","volume":"27","author":"Esteban","year":"2014","journal-title":"Pediatr. Allergy Immunol. Pulmonol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1177\/0748233715587849","article-title":"Polychlorinated Biphenyls: New Evidence from the Last Decade","volume":"32","author":"Faroon","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1080\/10408398.2012.710279","article-title":"A Critical Review about Human Exposure to Polychlorinated Dibenzo-P-Dioxins (PCDDs), Polychlorinated Dibenzofurans (PCDFs) and Polychlorinated Biphenyls (PCBs) through Foods","volume":"55","author":"Fern\u00e1ndez-Gonz\u00e1lez","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.chemosphere.2007.04.087","article-title":"Congener Profiles of Occupational PCB Exposure versus PCB Exposure from Fish Consumption","volume":"69","author":"Freels","year":"2007","journal-title":"Chemosphere"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1289\/ehp.1002289","article-title":"Allergy and Sensitization during Childhood Associated with Prenatal and Lactational Exposure to marine Pollutants","volume":"118","author":"Grandjean","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"B22","first-page":"445","article-title":"Air Pollution and Respiratory Morbidity in Israel: A Review of Accumulated Empiric Evidence","volume":"17","author":"Greenberg","year":"2015","journal-title":"Isr. Med. Assoc. J."},{"key":"B23","first-page":"785","article-title":"Prevalence of Asthma Among Young Men Residing in Urban Areas with Different Sources of Air Pollution","volume":"21","author":"Greenberg","year":"2019","journal-title":"Isr. Med. Assoc. J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/cea.12631","article-title":"Prenatal Exposure to Persistent Organic Pollutants and Offspring Allergic Sensitization and Lung Function at 20 Years of Age","volume":"46","author":"Hansen","year":"2016","journal-title":"Clin. Exp. Allergy"},{"key":"B25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1289\/ehp.1206397","article-title":"Maternal Concentrations of Persistent Organochlorine Pollutants and the Risk of Asthma in Offspring: Results from a Prospective Cohort with 20 Years of Follow-Up","volume":"122","author":"Hansen","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e311","DOI":"10.1371\/journal.pmed.0030311","article-title":"Reduced Antibody Responses to Vaccinations in Children Exposed to Polychlorinated Biphenyls","volume":"3","author":"Heilmann","year":"2006","journal-title":"Plos Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1742-7843.2007.00190.x","article-title":"Prenatal Exposures to Persistent and Non-persistent Organic Compounds and Effects on Immune System Development","volume":"102","author":"Hertz-Picciotto","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ni.3614","article-title":"The Aryl Hydrocarbon Receptor AhR Links Atopic Dermatitis and Air Pollution via Induction of the Neurotrophic Factor Artemin","volume":"18","author":"Hidaka","year":"2017","journal-title":"Nat. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.jaci.2014.03.028","article-title":"Underdiagnosis of Allergic Rhinitis in Underserved Children","volume":"134","author":"Jacobs","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12940-020-00586-x","article-title":"Maternal Phthalate Exposure and Asthma, Rhinitis and Eczema in 552 Children Aged 5 years; a Prospective Cohort Study","volume":"19","author":"J\u00f8hnk","year":"2020","journal-title":"Environ. Heal"},{"key":"B31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/crj.12110","article-title":"Gene-environment Interaction in Atopic Diseases: a Population-Based Twin Study of Early-Life Exposures","volume":"9","author":"Kahr","year":"2015","journal-title":"Clin. Respir. J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"198","DOI":"10.2500\/ajra.2016.30.4369","article-title":"Local Allergic Rhinitis to Pollens Is Underdiagnosed in Young Patients","volume":"30","author":"Krajewska-Wojtys","year":"2016","journal-title":"Am. J. Rhinol Allergy"},{"key":"B33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/000992289203100411","article-title":"Natural History of Atopic Disease in Early Childhood: Is Cord Blood IgE a Prognostic Factor? A Preliminary Report","volume":"31","author":"Liptay","year":"1992","journal-title":"Clin. Pediatr. (Phila)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1183\/16000617.00006114","article-title":"Environmental Exposure to Pesticides and Respiratory Health","volume":"24","author":"Mamane","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"The Global burden of Asthma: Executive Summary of the GINA Dissemination Committee Report","volume":"59","author":"Masoli","year":"2004","journal-title":"Allergy"},{"key":"B36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3389\/fped.2019.00499","article-title":"Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma","volume":"7","author":"Morales","year":"2019","journal-title":"Front. Pediatr."},{"key":"B37","doi-asserted-by":"publisher","first-page":"375","DOI":"10.33549\/physiolres.931022","article-title":"White Adipose Tissue: Storage and Effector Site for Environmental Pollutants","volume":"56","author":"M\u00fcllerov\u00e1","year":"2007","journal-title":"Physiol. Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00420-012-0819-8","article-title":"Association between Blood Levels of PCDDs\/PCDFs\/dioxin-like PCBs and History of Allergic and Other Diseases in the Japanese Population","volume":"86","author":"Nakamoto","year":"2013","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"B39","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s11882-020-00971-z","article-title":"The Role of Environmental Exposures in Atopic Dermatitis","volume":"20","author":"Narla","year":"2020","journal-title":"Curr. Allergy Asthma Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.chemosphere.2013.09.009","article-title":"A Pilot Study for Foetal Exposure to Multiple Persistent Organic Pollutants and the Development of Infant Atopic Dermatitis in Modern Japanese Society","volume":"94","author":"Ochiai","year":"2014","journal-title":"Chemosphere"},{"key":"B41","doi-asserted-by":"publisher","first-page":"9383","DOI":"10.1038\/s41598-017-09774-1","article-title":"Relationships between Serum-Induced AhR Bioactivity or Mitochondrial Inhibition and Circulating Polychlorinated Biphenyls (PCBs)","volume":"7","author":"Park","year":"2017","journal-title":"Sci. Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1080\/02770903.2017.1396470","article-title":"Prenatal Exposure to Polychlorinated Biphenyls and Asthma, Eczema\/hay Fever, and Frequent Ear Infections","volume":"55","author":"Parker-Lalomio","year":"2017","journal-title":"J. Asthma"},{"key":"B43","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1080\/10473289.2006.10464485","article-title":"Health Effects of Fine Particulate Air Pollution: Lines that Connect","volume":"56","author":"Pope","year":"2006","journal-title":"J. Air Waste Manag. Assoc."},{"key":"B44","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/09603123.2011.634387","article-title":"High Prevalence of Childhood Asthma in Northern Israel Is Linked to Air Pollution by Particulate Matter: Evidence from GIS Analysis and Bayesian Model Averaging","volume":"22","author":"Portnov","year":"2012","journal-title":"Int. J. Environ. Health Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.envres.2018.11.002","article-title":"Pesticides Exposure by Air in Vineyard Rural Area and Respiratory Health in Children: A Pilot Study","volume":"169","author":"Raherison","year":"2019","journal-title":"Environ. Res."},{"key":"B46","first-page":"895","article-title":"Cord Serum Immunoglobulin E Related to the Environmental Contamination of Human Placentas with Organochlorine Compounds","volume":"107","author":"Reichrtov\u00e1","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"B47","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/02770900701363983","article-title":"Trends in the Prevalence of Asthma Symptoms and Allergic Diseases in Israeli Adolescents: Results from a National Survey 2003 and Comparison with 1997","volume":"44","author":"Romano-Zelekha","year":"2007","journal-title":"J. Asthma"},{"key":"B48","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1289\/ehp.7640","article-title":"Lipid Adjustment in the Analysis of Environmental Contaminants and Human Health Risks","volume":"113","author":"Schisterman","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"B49","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/rr179","article-title":"Interactions between Genes and Environmental Factors in Asthma and Atopy: New Developments","volume":"3","author":"Sengler","year":"2002","journal-title":"Respir. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1136\/bmj.328.7437.447","article-title":"How strong Is the Evidence of a Link between Environmental Chemicals and Adverse Effects on Human Reproductive Health?","volume":"328","author":"Sharpe","year":"2004","journal-title":"BMJ"},{"key":"B51","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.reprotox.2020.06.005","article-title":"Associations between Intrauterine Exposure to Polychlorinated Biphenyls on Neonatal Ano-Genital Distance","volume":"96","author":"Sheinberg","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1196\/annals.1454.017","article-title":"Susceptibility of Children to Environmental Pollutants","volume":"1140","author":"Sly","year":"2008","journal-title":"Ann. N. Y Acad. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/all.12605","article-title":"Prenatal Exposure to Environmental Chemical Contaminants and Asthma and Eczema in School-Age Children","volume":"70","author":"Smit","year":"2015","journal-title":"Allergy"},{"key":"B54","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.fct.2012.09.027","article-title":"Prenatal Exposure to Polychlorinated Biphenyls and Dioxins from the Maternal Diet May Be Associated with Immunosuppressive Effects that Persist into Early Childhood","volume":"51","author":"St\u00f8levik","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3390\/ijerph16030366","article-title":"Identification and Prioritization of Environmental Reproductive Hazards: A First Step in Establishing Environmental Perinatal Care","volume":"16","author":"Teysseire","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B56","unstructured":"WMA Declaration of Helsinki \u2013 Ethical Principles for Medical Research Involving Human Subjects2018"},{"key":"B57","volume-title":"Stockholm Convention on Persistent Organic Pollutants (POPs)","year":"2018"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1289\/ehp.001081203","article-title":"Immunologic Effects of Background Exposure to Polychlorinated Biphenyls and Dioxins in Dutch Preschool Children","volume":"108","author":"Weisglas-Kuperus","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"B59","volume-title":"Review of Evidence on Health Aspects of Air Pollution \u2013 REVIHAAP Project: Final Technical Report","year":"2013"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1289\/ehp.11191","article-title":"Effects of Maternal Exposure to Di-(2-ethylhexyl) Phthalate during Fetal And\/or Neonatal Periods on Atopic Dermatitis in Male Offspring","volume":"116","author":"Yanagisawa","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"B61","doi-asserted-by":"publisher","first-page":"100003","DOI":"10.1016\/j.waojou.2018.11.003","article-title":"Under-diagnosis of Atopic Dermatitis in Puerto Rican Children","volume":"12","author":"Yang","year":"2019","journal-title":"World Allergy Organ. J."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.3389\/fimmu.2020.01907","article-title":"Research Progress in Atopic March","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.802974\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T05:33:58Z","timestamp":1649223238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.802974\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":62,"alternative-id":["10.3389\/fphar.2022.802974"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.802974","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]},"article-number":"802974"}}