{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:21:51Z","timestamp":1782166911467,"version":"3.54.5"},"reference-count":176,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Podocyte is also called glomerular epithelial cell, which has been considered as the final gatekeeper of glomerular filtration barrier (GFB). As a major contributor to proteinuria, podocyte injury underlies a variety of glomerular diseases and becomes the challenge to patients and their families in general. At present, the therapeutic methods of podocyte injury mainly include angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, steroid and immunosuppressive medications. Nevertheless, the higher cost and side effects seriously disturb patients with podocyte injury. Promisingly, traditional Chinese medicine (TCM) has received an increasing amount of attention from different countries in the treatment of podocyte injury by invigorating spleen and kidney, clearing heat and eliminating dampness, as well enriching qi and activating blood. Therefore, we searched articles published in peer-reviewed English-language journals through Google Scholar, PubMed, Web of Science, and Science Direct. The protective effects of active ingredients, herbs, compound prescriptions, acupuncture and moxibustion for treatment of podocyte injury were further summarized and analyzed. Meanwhile, we discussed feasible directions for future development, and analyzed existing deficiencies and shortcomings of TCM in the treatment of podocyte injury. In conclusion, this paper shows that TCM treatments can serve as promising auxiliary therapeutic methods for the treatment of podocyte injury.<\/jats:p>","DOI":"10.3389\/fphar.2022.816025","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T09:36:00Z","timestamp":1645781760000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury"],"prefix":"10.3389","volume":"13","author":[{"given":"Tianwen","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105852","DOI":"10.1016\/j.phrs.2021.105852","article-title":"Deciphering Nutritional Interventions for Podocyte Structure and Function","volume":"172","author":"Afsar","year":"2021","journal-title":"Pharmacol. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"111268","DOI":"10.1016\/j.biopha.2021.111268","article-title":"Resveratrol Supplementation and Acute Pancreatitis: A Comprehensive Review","volume":"137","author":"Agah","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B3","first-page":"128","article-title":"Ethnobotanical Knowledge of Astragalus spp.: The World's Largest Genus of Vascular Plants","volume":"10","author":"Amiri","year":"2020","journal-title":"Avicenna. J. Phytomed."},{"key":"B4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.jep.2014.05.019","article-title":"\u201cQufeng Tongluo\u201d Acupuncture Prevents the Progression of Glomerulonephritis by Decreasing Renal Sympathetic Nerve Activity","volume":"155","author":"An","year":"2014","journal-title":"J. Ethnopharmacol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.1038\/s41598-017-06844-2","article-title":"Hyperoside Pre-treatment Prevents Glomerular Basement Membrane Damage in Diabetic Nephropathy by Inhibiting Podocyte Heparanase Expression","volume":"7","author":"An","year":"2017","journal-title":"Sci. Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1186\/s12935-020-01634-9","article-title":"Autophagy Regulation Using Luteolin: New Insight into its Anti-tumor Activity","volume":"20","author":"Ashrafizadeh","year":"2020","journal-title":"Cancer Cel. Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3390\/biom11020323","article-title":"Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and its Complications","volume":"11","author":"Bhattamisra","year":"2020","journal-title":"Biomolecules"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.3390\/molecules22111942","article-title":"Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-chemistry, Bioavailability, and Metabolism","volume":"22","author":"Bijak","year":"2017","journal-title":"Molecules"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e042686","DOI":"10.1136\/bmjopen-2020-042686","article-title":"Efficacy, Safety and Response Predictors of Adjuvant astragalus for Diabetic Kidney Disease (READY): Study Protocol of an Add-On, Assessor-Blind, Parallel, Pragmatic Randomised Controlled Trial","volume":"11","author":"Chan","year":"2021","journal-title":"BMJ. Open."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1080\/13880209.2021.1950192","article-title":"A Metabolomic Approach to Elucidate the Inhibitory Effects of Baicalin in Pulmonary Fibrosis","volume":"59","author":"Chang","year":"2021","journal-title":"Pharm. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"8336","DOI":"10.3390\/ijms21218336","article-title":"Anti-cancer Effect of Cordycepin on FGF9-Induced Testicular Tumorigenesis","volume":"21","author":"Chang","year":"2020","journal-title":"Ijms"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1159\/000373963","article-title":"Emodin Ameliorates High Glucose Induced-Podocyte Epithelial-Mesenchymal Transition Iin-Vvitro and Iin-Vvivo","volume":"35","author":"Chen","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/1440-1681.12528","article-title":"Treatment of Chronic Kidney Disease Using a Traditional Chinese Medicine, Flos Abelmoschus Manihot (Linnaeus) Medicus (Malvaceae)","volume":"43","author":"Chen","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cbi.2017.05.025","article-title":"Role of RAS\/Wnt\/\u03b2-catenin axis Activation in the Pathogenesis of Podocyte Injury and Tubulo-Interstitial Nephropathy","volume":"273","author":"Chen","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"B15","doi-asserted-by":"publisher","first-page":"88792","DOI":"10.18632\/oncotarget.21287","article-title":"Hyperoside Alleviates Adriamycin-Induced Podocyte Injury via Inhibiting Mitochondrial Fission","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"B16","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s12906-019-2656-8","article-title":"The Protective Effect and Mechanism of Catalpol on High Glucose-Induced Podocyte Injury","volume":"19","author":"Chen","year":"","journal-title":"BMC Complement. Altern. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3389\/fphar.2019.01477","article-title":"Catalpol Ameliorates Podocyte Injury by Stabilizing Cytoskeleton and Enhancing Autophagy in Diabetic Nephropathy","volume":"10","author":"Chen","year":"","journal-title":"Front. Pharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1028415X.2021.1901047","article-title":"Hyperoside Attenuates Neuroinflammation, Cognitive Impairment and Oxidative Stress via Suppressing TNF-\u0391\/nf-\u03baB\/caspase-3 Signaling in Type 2 Diabetes Rats","volume":"16","author":"Chen","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"153643","DOI":"10.1016\/j.phymed.2021.153643","article-title":"Atractylodis Rhizoma Water Extract Attenuates Fructose-Induced Glomerular Injury in Rats through Anti-oxidation to Inhibit TRPC6\/p-CaMK4 Signaling","volume":"91","author":"Chen","year":"2021","journal-title":"Phytomedicine"},{"key":"B20","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.intimp.2015.02.023","article-title":"Leonurine Ameliorates Kidney Fibrosis via Suppressing TGF-\u03b2 and NF-\u039ab Signaling Pathway in UUO Mice","volume":"25","author":"Cheng","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3704","DOI":"10.3892\/mmr.2016.5713","article-title":"Antiviral Activities of Atractylon from Atractylodis Rhizoma","volume":"14","author":"Cheng","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5957423","DOI":"10.1155\/2016\/5957423","article-title":"Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats","volume":"2016","author":"Cui","year":"2016","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"424193","DOI":"10.1155\/2015\/424193","article-title":"Effect of Tongxinluo on Nephrin Expression via Inhibition of Notch1\/Snail Pathway in Diabetic Rats","volume":"2015","author":"Cui","year":"2015","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2981705","DOI":"10.1155\/2019\/2981705","article-title":"Effect of Baoshenfang Formula on Podocyte Injury via Inhibiting the NOX-4\/ROS\/p38 Pathway in Diabetic Nephropathy","volume":"2019","author":"Cui","year":"","journal-title":"J. Diabetes Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"9512406","DOI":"10.1155\/2019\/9512406","article-title":"Effects of BSF on Podocyte Apoptosis via Regulating the ROS-Mediated PI3K\/AKT Pathway in DN","volume":"2019","author":"Cui","year":"","journal-title":"J. Diabetes Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000440851","article-title":"Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury","volume":"42","author":"Dai","year":"2015","journal-title":"Am. J. Nephrol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2615286","DOI":"10.1155\/2017\/2615286","article-title":"Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy","volume":"2017","author":"Dai","year":"2017","journal-title":"J. Diabetes Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"379291","DOI":"10.1155\/2013\/379291","article-title":"The Mechanism of Moxibustion: Ancient Theory and Modern Research","volume":"2013","author":"Deng","year":"2013","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ejmech.2017.03.004","article-title":"Therapeutic Potentials of Baicalin and its Aglycone, Baicalein against Inflammatory Disorders","volume":"131","author":"Dinda","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1002\/mnfr.201500370","article-title":"Curcumin Protects against Fructose-Induced Podocyte Insulin Signaling Impairment through Upregulation of miR-206","volume":"59","author":"Ding","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"118010","DOI":"10.1016\/j.lfs.2020.118010","article-title":"Baicalin Alleviates Adriamycin-Induced Focal Segmental Glomerulosclerosis and Proteinuria by Inhibiting the Notch1-Snail axis Mediated Podocyte EMT","volume":"257","author":"Dou","year":"2020","journal-title":"Life Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1159\/000516191","article-title":"Renovation of Intestinal Barrier by Polydatin in Experimentally Induced Ulcerative Colitis: Comparative Ultrastructural Study with L-Carnosine","volume":"210","author":"Ebrahim","year":"2021","journal-title":"Cells. Tissues. Organs"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1007\/s00394-021-02623-y","article-title":"Can Resveratrol Modulate Sirtuins in Obesity and Related Diseases? A Systematic Review of Randomized Controlled Trials","volume":"60","author":"Fraiz","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1080\/00498254.2018.1548718","article-title":"Evaluation of the Inhibition of Human Carboxylesterases (CESs) by the Active Ingredients from Schisandra Chinensis","volume":"49","author":"Fu","year":"2019","journal-title":"Xenobiotica"},{"key":"B35","doi-asserted-by":"publisher","first-page":"105882","DOI":"10.1016\/j.ejps.2021.105882","article-title":"Preparation and Evaluation of Lecithin\/zein Hybrid Nanoparticles for the Oral Delivery of Panax Notoginseng Saponins","volume":"164","author":"Fu","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"120004","DOI":"10.1016\/j.jns.2021.120004","article-title":"Glucocorticoids for Therapeutic Immunosuppression: Clinical Pearls for the Practicing Neurologist","volume":"430","author":"Galati","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.xkme.2020.10.005","article-title":"Diabetic Kidney Disease, Endothelial Damage, and Podocyte-Endothelial Crosstalk","volume":"3","author":"Gil","year":"2020","journal-title":"Kidney. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/ki.2015.300","article-title":"Chinese Herbal Medicines and Chronic Kidney Disease: a Positive Outcome in a Large Patient Study in Taiwan","volume":"88","author":"Gobe","year":"2015","journal-title":"Kidney IntInt"},{"key":"B39","doi-asserted-by":"publisher","first-page":"111079","DOI":"10.1016\/j.mce.2020.111079","article-title":"Polydatin Enhances Glomerular Podocyte Autophagy Homeostasis by Improving Nrf2-dependent Antioxidant Capacity in Fructose-Fed Rats","volume":"520","author":"Gu","year":"2021","journal-title":"Mol. Cel. Endocrinol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e39824","DOI":"10.1371\/journal.pone.0039824","article-title":"Astragaloside IV, a Novel Antioxidant, Prevents Glucose-Induced Podocyte Apoptosis In Vitro and In Vivo","volume":"7","author":"Gui","year":"2012","journal-title":"PLoS One"},{"key":"B41","doi-asserted-by":"publisher","first-page":"500","DOI":"10.3389\/fphar.2016.00500","article-title":"Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco\/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic Nephropathy","volume":"7","author":"Guo","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/abbs\/gmz145","article-title":"Cordycepin Protects Renal Ischemia\/reperfusion Injury through Regulating Inflammation, Apoptosis, and Oxidative Stress","volume":"52","author":"Han","year":"2020","journal-title":"Acta Biochim. Biophys. Sin (Shanghai)"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.3892\/etm.2014.1670","article-title":"Effect of Cordyceps Sinensis and Tripterygium Wilfordii Polyglycosidium on Podocytes in Rats with Diabetic Nephropathy","volume":"7","author":"Hao","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1166\/jbn.2021.3041","article-title":"Functional Exosome-Mediated Delivery of Triptolide Endowed with Targeting Properties as Chemotherapy Carriers for Ovarian Carcinoma","volume":"17","author":"He","year":"2021","journal-title":"J. Biomed. Nanotechnol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"716125","DOI":"10.3389\/fphar.2021.716125","article-title":"Research Progress on Catalpol as Treatment for Atherosclerosis","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B46","first-page":"173","article-title":"[Cordycepin Protects Podocytes from Injury Mediated by Complements Complex C5b-9]","volume":"46","author":"Hong","year":"2015","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.13703\/j.0255-2930.2017.09.031","article-title":"[Startup Mechanism of Moxibustion Warming and Dredging Function]","volume":"37","author":"Huang","year":"2017","journal-title":"Zhongguo Zhen Jiu"},{"key":"B48","doi-asserted-by":"publisher","first-page":"6624976","DOI":"10.1155\/2021\/6624976","article-title":"Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2\/ARE-Related Pathways in Alzheimer and Parkinson Diseases","volume":"2021","author":"Huang","year":"2021","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1111\/jcmm.14340","article-title":"Salidroside Ameliorates Adriamycin Nephropathy in Mice by Inhibiting \u03b2-catenin Activity","volume":"23","author":"Huang","year":"2019","journal-title":"J. Cel. Mol. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"692","DOI":"10.3892\/mmr.2021.12324","article-title":"Salidroside Inhibits Endothelial-mesenchymal T-ransition via the KLF4\/eNOS S-ignaling P-athway","volume":"24","author":"Huang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3390\/plants10040679","article-title":"MYC2 Transcription Factors TwMYC2a and TwMYC2b Negatively Regulate Triptolide Biosynthesis in Tripterygium Wilfordii Hairy Roots","volume":"10","author":"Huo","year":"2021","journal-title":"Plants (Basel)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"F398","DOI":"10.1152\/ajprenal.00136.2015","article-title":"Podocyte Endocytosis in the Regulation of the Glomerular Filtration Barrier","volume":"309","author":"Inoue","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"107814","DOI":"10.1155\/2015\/107814","article-title":"Triptolide Attenuates Podocyte Injury by Regulating Expression of miRNA-344b-3p and miRNA-30b-3p in Rats with Adriamycin-Induced Nephropathy","volume":"2015","author":"Jiang","year":"2015","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1097\/FJC.0000000000001021","article-title":"Recent Insights into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases","volume":"77","author":"Jiao","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"5691468","DOI":"10.1155\/2020\/5691468","article-title":"Efficacy and Safety of Acupuncture-Moxibustion Therapy on Chemotherapy-Induced Leukopenia: A Systematic Review and Meta-Analysis","volume":"2020","author":"Jin","year":"2020","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"F691","DOI":"10.1152\/ajprenal.00028.2013","article-title":"The Antioxidant Silybin Prevents High Glucose-Induced Oxidative Stress and Podocyte Injury In Vitro and In Vivo","volume":"305","author":"Khazim","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.3390\/nu10111703","article-title":"Supplementation of Abelmoschus Manihot Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice","volume":"10","author":"Kim","year":"2018","journal-title":"nutrients"},{"key":"B58","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4062\/biomolther.2019.130","article-title":"Catalpol and Mannitol, Two Components of Rehmannia Glutinosa, Exhibit Anticonvulsant Effects Probably via GABAA Receptor Regulation","volume":"28","author":"Kim","year":"2020","journal-title":"Biomol. Ther. (Seoul)"},{"key":"B59","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1186\/s12935-021-02179-1","article-title":"STAT3 Pathway as a Molecular Target for Resveratrol in Breast Cancer Treatment","volume":"21","author":"Kohandel","year":"2021","journal-title":"Cancer Cel. Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1039\/c5np00133a","article-title":"Artemisinin, a Miracle of Traditional Chinese Medicine","volume":"32","author":"Kong","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/17425255.2019.1650914","article-title":"Is Curcumin Bioavailability a Problem in Humans: Lessons from Clinical Trials","volume":"15","author":"Kunnumakkara","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"193","DOI":"10.17305\/bjbms.2016.887","article-title":"Huaiqihuang May Protect from Proteinuria by Resisting MPC5 Podocyte Damage via Targeting P-ERK\/CHOP Pathway","volume":"16","author":"Li","year":"2016","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/fcp.12232","article-title":"Research Review on the Pharmacological Effects of Astragaloside IV","volume":"31","author":"Li","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.3892\/mmr.2017.6753","article-title":"Beneficial Effects of Huaiqihuang on Hyperglycemia-Induced MPC5 Podocyte Dysfunction through the Suppression of Mitochondrial Dysfunction and Endoplasmic Reticulum Stress","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"7169547","DOI":"10.1155\/2017\/7169547","article-title":"Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model","volume":"2017","author":"Li","year":"2017","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"117277","DOI":"10.1016\/j.lfs.2020.117277","article-title":"Berberine Mitigates High Glucose-Induced Podocyte Apoptosis by Modulating Autophagy via the mTOR\/P70S6K\/4EBP1 Pathway","volume":"243","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3892\/etm.2019.8178","article-title":"Resveratrol Alleviates Obesity-Associated Podocyte Injury in Ovariectomized Obese Rats","volume":"19","author":"Li","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.brainresbull.2020.08.016","article-title":"Anti-inflammatory and Immunomodulatory Effects of Baicalin in Cerebrovascular and Neurological Disorders","volume":"164","author":"Li","year":"2020","journal-title":"Brain Res. Bull."},{"key":"B69","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3892\/etm.2020.8701","article-title":"Baicalin Serves a Protective Role in Diabetic Nephropathy through Preventing High Glucose-Induced Podocyte Apoptosis","volume":"20","author":"Li","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3892\/etm.2021.10504","article-title":"A Steroid-Induced Osteonecrosis Model Established Using an Organ-On-A-Chip Platform","volume":"22","author":"Li","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/jre.12914","article-title":"Curcumin: A Review of Experimental Studies and Mechanisms Related to Periodontitis Treatment","volume":"56","author":"Li","year":"2021","journal-title":"J. Periodontal Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"8891093","DOI":"10.1155\/2021\/8891093","article-title":"Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps Sinensis on the Treatment of Diabetic Nephropathy","volume":"2021","author":"Li","year":"2021","journal-title":"J. Diabetes Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"131604","DOI":"10.1155\/2014\/131604","article-title":"Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage","volume":"2014","author":"Liang","year":"20142014","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.3390\/jcm10061184","article-title":"Podocyte Autophagy in Homeostasis and Disease","volume":"10","author":"Lin","year":"2021","journal-title":"J. Clin. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11655-015-2293-0","article-title":"Huaiqihuang Granules () Reduce Proteinuria by Enhancing Nephrin Expression and Regulating Necrosis Factor \u03baB Signaling Pathway in Adriamycin-Induced Nephropathy","volume":"23","author":"Liu","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1080\/10715762.2018.1500021","article-title":"Leonurine Ameliorates Adriamycin-Induced Podocyte Injury via Suppression of Oxidative Stress","volume":"52","author":"Liu","year":"2018","journal-title":"Free Radic. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.biopha.2018.02.127","article-title":"Zhen-Wu-tang Protects against Podocyte Injury in Rats with IgA Nephropathy via PPAR\u03b3\/NF-\u039ab Pathway","volume":"101","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B78","doi-asserted-by":"publisher","first-page":"152913","DOI":"10.1016\/j.phymed.2019.152913","article-title":"Zhen-Wu-tang Ameliorates Membranous Nephropathy Rats through Inhibiting NF-\u039ab Pathway and NLRP3 Inflammasome","volume":"59","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"B79","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1080\/10286020.2019.1621851","article-title":"Cytotoxic Monoterpenoid Indole Alkaloids from the Aerial Parts of Kopsia Officinalis","volume":"22","author":"Liu","year":"2020","journal-title":"J. Asian Nat. Prod. Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"5917","DOI":"10.1021\/acs.jafc.1c01557","article-title":"De Novo biosynthesis of Polydatin in saccharomyces Cerevisiae","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.2147\/DMSO.S299375","article-title":"Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK\/mTOR-mediated Autophagy Signaling Pathway","volume":"14","author":"Liu","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"B82","doi-asserted-by":"publisher","first-page":"667644","DOI":"10.3389\/fphar.2021.667644","article-title":"Total Flavones of Abelmoschus Manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN\/PI3K\/Akt Signaling","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000448223","article-title":"Antioxidative Stress Effects of Salvia Przewalskii Extract in Experimentally Injured Podocytes","volume":"134","author":"Liu","year":"2016","journal-title":"Nephron"},{"key":"B84","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/978-981-13-8871-2_10","article-title":"Role of Podocyte Injury in Glomerulosclerosis","volume":"1165","author":"Lu","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.12659\/msm.902806","article-title":"Salidroside Reduces High-Glucose-Induced Podocyte Apoptosis and Oxidative Stress via Upregulating Heme Oxygenase-1 (HO-1) Expression","volume":"23","author":"Lu","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"B86","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biopha.2017.09.105","article-title":"Paeoniflorin Ameliorates Adriamycin-Induced Nephrotic Syndrome through the PPAR\u03b3\/ANGPTL4 Pathway In Vivo and Vitro","volume":"96","author":"Lu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.3389\/fphar.2020.01068","article-title":"Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus Manihot L.: A Comprehensive Review","volume":"11","author":"Luan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1007\/s11684-018-0649-5","article-title":"Immunoregulatory Effects of Tripterygium Wilfordii Hook F and its Extracts in Clinical Practice","volume":"13","author":"Luo","year":"2019","journal-title":"Front. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e0145130","DOI":"10.1371\/journal.pone.0145130","article-title":"Tongxinluo Protects against Hypertensive Kidney Injury in Spontaneously-Hypertensive Rats by Inhibiting Oxidative Stress and Activating Forkhead Box O1 Signaling","volume":"10","author":"Luo","year":"2016","journal-title":"PLoS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"108767","DOI":"10.1016\/j.biopha.2019.108767","article-title":"Tongxinluo May Stabilize Atherosclerotic Plaque via Multiple Mechanisms Scanning by Genechip","volume":"113","author":"Ma","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B91","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3892\/etm.2013.1226","article-title":"Triptolide Markedly Attenuates Albuminuria and Podocyte Injury in an Animal Model of Diabetic Nephropathy","volume":"6","author":"Ma","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"e12974","DOI":"10.1111\/jfbc.12974","article-title":"Novel Extraction Techniques and Pharmaceutical Activities of Luteolin and its Derivatives","volume":"43","author":"Manzoor","year":"2019","journal-title":"J. Food Biochem."},{"key":"B93","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1002\/cbin.10634","article-title":"Ginsenoside Rg1 Inhibits Angiotensin II-Induced Podocyte Autophagy via AMPK\/mTOR\/PI3K Pathway","volume":"40","author":"Mao","year":"2016","journal-title":"Cell. Biol Int."},{"key":"B94","first-page":"3651","article-title":"[Overview Research of Uremic Ulearance Granule Treating Chronic Renal Failure]","volume":"38","author":"Meng","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.kint.2016.01.012","article-title":"Podocyte Injury and its Consequences","volume":"89","author":"Nagata","year":"2016","journal-title":"Kidney. Int."},{"key":"B96","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/jdi.13119","article-title":"Berberine Ameliorates Renal Impairment and Inhibits Podocyte Dysfunction by Targeting the Phosphatidylinositol 3-Kinase-Protein Kinase B Pathway in Diabetic Rats","volume":"11","author":"Ni","year":"2020","journal-title":"J. Diabetes Investig."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1002\/jcp.25943","article-title":"Polydatin Impairs Mitochondria Fitness and Ameliorates Podocyte Injury by Suppressing Drp1 Expression","volume":"232","author":"Ni","year":"2017","journal-title":"J. Cel. Physiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1515\/med-2021-0335","article-title":"Baicalin Improves Podocyte Injury in Rats with Diabetic Nephropathy by Inhibiting PI3K\/Akt\/mTOR Signaling Pathway","volume":"16","author":"Ou","year":"2021","journal-title":"Open Med. (Wars)"},{"key":"B99","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijbiomac.2017.08.130","article-title":"Characterization and Immunomodulatory Activity of Polysaccharides from the Stems and Leaves of Abelmoschus Manihot and a Sulfated Derivative","volume":"107","author":"Pan","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.3390\/molecules26144350","article-title":"Cytotoxic and Proapoptotic Effects of Resveratrol in In Vitro Studies on Selected Types of Gastrointestinal Cancers","volume":"26","author":"Ratajczak","year":"2021","journal-title":"Molecules"},{"key":"B101","doi-asserted-by":"publisher","first-page":"114","DOI":"10.12688\/f1000research.7255.1","article-title":"Podocytes","volume":"5","author":"Reiser","year":"2016","journal-title":"F1000Res"},{"key":"B102","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/0886022X.2018.1456460","article-title":"Salvia Przewalskii Extract of Total Phenolic Acids Inhibit TLR4 Signaling Activation in Podocyte Injury Induced by Puromycin Aminonucleoside In Vitro","volume":"40","author":"Ren","year":"2018","journal-title":"Ren. Fail."},{"key":"B103","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/jmwh.12752","article-title":"Moxibustion for Cephalic Version of Breech Presentation","volume":"63","author":"Schlaeger","year":"2018","journal-title":"J. Midwifery Womens Health"},{"key":"B104","doi-asserted-by":"publisher","first-page":"112854","DOI":"10.1016\/j.phytochem.2021.112854","article-title":"Emodin - A Natural Anthraquinone Derivative with Diverse Pharmacological Activities","volume":"190","author":"Semwal","year":"2021","journal-title":"Phytochemistry"},{"key":"B105","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.nephro.2018.04.002","article-title":"Intracellular Organelles in Health and Kidney Disease","volume":"15","author":"Shamekhi Amiri","year":"2019","journal-title":"Nephrol. Ther."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.4268\/cjcmm20161308","article-title":"[Pathomechanisms of Podocyte Injury in Diabetic Nephropathy and Interventional Effects of Chinese Herbal Medicine]","volume":"41","author":"Shi","year":"2016","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"B107","doi-asserted-by":"publisher","first-page":"e13757","DOI":"10.1111\/jfbc.13757","article-title":"Astragaloside IV Prevents Acute Myocardial Infarction by Inhibiting the TLR4\/MyD88\/NF-\u039ab Signaling Pathway","volume":"45","author":"Shi","year":"2021","journal-title":"J. Food Biochem."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1903627","DOI":"10.1155\/2020\/1903627","article-title":"Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKT\/GSK3 \u03b2\/\u03b2-Catenin Pathway by Restoring Autophagic Activity","volume":"2020","author":"Shi","year":"2020","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B109","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.3390\/molecules20033549","article-title":"Anti-glycation Activities of Phenolic Constituents from Silybum marianum (Milk Thistle) Flower In Vitro and on Human Explants","volume":"20","author":"Shin","year":"2015","journal-title":"Molecules"},{"key":"B110","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.3892\/mmr.2015.4214","article-title":"Extract of Rhizoma Polygonum Cuspidatum Reduces Early Renal Podocyte Injury in Streptozotocin-induced D-iabetic R-ats and its A-ctive C-ompound E-modin I-nhibits M-ethylglyoxal-mediated G-lycation of P-roteins","volume":"12","author":"Sohn","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"B111","doi-asserted-by":"publisher","first-page":"111949","DOI":"10.1016\/j.biopha.2021.111949","article-title":"Salidroside Attenuates Acute Lung Injury via Inhibition of Inflammatory Cytokine Production","volume":"142","author":"Song","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/ibd\/izy371","article-title":"Acupuncture in Inflammatory Bowel Disease","volume":"25","author":"Song","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"B113","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.gtc.2017.08.015","article-title":"Massage Acupuncture, Moxibustion, and Other Forms of Complementary and Alternative Medicine in Inflammatory Bowel Disease","volume":"46","author":"Stein","year":"2017","journal-title":"Gastroenterol. Clin. North. Am."},{"key":"B114","doi-asserted-by":"publisher","first-page":"107438","DOI":"10.1016\/j.intimp.2021.107438","article-title":"Hyperoside Attenuates Non-alcoholic Fatty Liver Disease through Targeting Nr4A1 in Macrophages","volume":"94","author":"Sun","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"103485","DOI":"10.1016\/j.bioorg.2019.103485","article-title":"Protective Effects of Polydatin on Multiple Organ Ischemia-Reperfusion Injury","volume":"94","author":"Sun","year":"2020","journal-title":"Bioorg. Chem."},{"key":"B116","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/biof.1720","article-title":"Analytical Determinations of Luteolin","volume":"47","author":"Tesio","year":"2021","journal-title":"Biofactors"},{"key":"B117","doi-asserted-by":"publisher","first-page":"6708061","DOI":"10.1155\/2020\/6708061","article-title":"Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation","volume":"2020","author":"Tian","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B118","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jep.2013.03.006","article-title":"Huangkui Capsule, an Extract from Abelmoschus Manihot (L.) Medic, Ameliorates Adriamycin-Induced Renal Inflammation and Glomerular Injury via Inhibiting p38MAPK Signaling Pathway Activity in Rats","volume":"147","author":"Tu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"105142","DOI":"10.1016\/j.tiv.2021.105142","article-title":"Emodin: A Metabolite that Exhibits Anti-neoplastic Activities by Modulating Multiple Oncogenic Targets","volume":"73","author":"Tuli","year":"2021","journal-title":"Toxicol. Vitro"},{"key":"B120","first-page":"1233","article-title":"TET2 Mediated Demethylation Is Involved in the Protective Effect of Triptolide on Podocytes","volume":"13","author":"Wan","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"B121","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12860-020-0248-6","article-title":"Triptolide Ameliorates fine Particulate Matter-Induced Podocytes Injury via Regulating NF-\u039ab Signaling Pathway","volume":"21","author":"Wan","year":"2020","journal-title":"BMC. Mol. Cel. Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000445618","article-title":"Berberine Improved Aldo-Induced Podocyte Injury via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress Pathways Both In Vivo and In Vitro","volume":"39","author":"Wang","year":"2016","journal-title":"Cel. Physiol. Biochem."},{"key":"B123","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.2147\/DDDT.S170840","article-title":"Astragaloside IV Improves Renal Function and Fibrosis via Inhibition of miR-21-Induced Podocyte Dedifferentiation and Mesangial Cell Activation in Diabetic Mice","volume":"12","author":"Wang","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"B124","doi-asserted-by":"publisher","first-page":"10843","DOI":"10.1038\/s41598-018-29203-1","article-title":"Triptolide Attenuates Proteinuria and Podocyte Apoptosis via Inhibition of NF-\u039ab\/gadd45b","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1390418","DOI":"10.1155\/2018\/1390418","article-title":"Artificially Cultivated Ophiocordyceps Sinensis Alleviates Diabetic Nephropathy and its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation","volume":"2018","author":"Wang","year":"2018","journal-title":"J. Diabetes Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"2735714","DOI":"10.1155\/2020\/2735714","article-title":"Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR\/NF-\u039ab\/nlrp3 Axis","volume":"2020","author":"Wang","year":"2020","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B127","doi-asserted-by":"publisher","first-page":"153669","DOI":"10.1016\/j.phymed.2021.153669","article-title":"Paeoniflorin: A Neuroprotective Monoterpenoid Glycoside with Promising Anti-depressive Properties","volume":"90","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"key":"B128","doi-asserted-by":"publisher","first-page":"104258","DOI":"10.1016\/j.fitote.2019.104258","article-title":"Chemical Constituents of Kopsia Officinalis and Their Antagonizing High Glucose-Evoked Podocyte Injury Activity","volume":"137","author":"Wang","year":"2019","journal-title":"Fitoterapia"},{"key":"B129","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.fitote.2017.01.017","article-title":"Three Novel Indole Alkaloids from Kopsia Officinalis","volume":"119","author":"Wang","year":"2017","journal-title":"Fitoterapia"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s11010-020-03997-z","article-title":"The Roles of NLRP3 Inflammasome-Mediated Signaling Pathways in Hyperuricemic Nephropathy","volume":"476","author":"Wen","year":"2021","journal-title":"Mol. Cel. Biochem."},{"key":"B131","doi-asserted-by":"publisher","first-page":"119824","DOI":"10.1016\/j.lfs.2021.119824","article-title":"Functional Effects of Berberine in Modulating Mitochondrial Dysfunction and Inflammatory Response in the Respective Amyloidogenic Cells and Activated Microglial Cells - In Vitro Models Simulating Alzheimer's Disease Pathology","volume":"282","author":"Wong","year":"2021","journal-title":"Life Sci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1080\/10715762.2019.1623883","article-title":"Protective Effect of Hyperoside against Renal Ischemia-Reperfusion Injury via Modulating Mitochondrial Fission, Oxidative Stress, and Apoptosis","volume":"53","author":"Wu","year":"2019","journal-title":"Free Radic. Res."},{"key":"B133","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bcp.2017.12.004","article-title":"Ginsenoside Rh4 Induces Apoptosis and Autophagic Cell Death through Activation of the ROS\/JNK\/p53 Pathway in Colorectal Cancer Cells","volume":"148","author":"Wu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"107755","DOI":"10.1016\/j.diabres.2019.05.034","article-title":"Protective Effect of Umbilical Cord Mesenchymal Stem Cells Combined with Resveratrol against Renal Podocyte Damage in NOD Mice","volume":"156","author":"Xian","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B135","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/mmr.2020.11641","article-title":"Berberine Alleviates Palmitic Acid-induced P-odocyte A-poptosis by R-educing R-eactive O-xygen S-pecies-mediated E-ndoplasmic R-eticulum S-tress","volume":"23","author":"Xiang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"B136","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/cells7120270","article-title":"Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies","volume":"7","author":"Xie","year":"2018","journal-title":"Cells"},{"key":"B137","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3390\/molecules23040940","article-title":"Panax Notoginseng Saponins: A Review of its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology","volume":"23","author":"Xie","year":"2018","journal-title":"Molecules"},{"key":"B138","doi-asserted-by":"publisher","first-page":"104547","DOI":"10.1016\/j.fitote.2020.104547","article-title":"Monoterpenoid Indole Alkaloids from the Stems of Kopsia Officinalis","volume":"143","author":"Xie","year":"2020","journal-title":"Fitoterapia"},{"key":"B139","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2147\/DDDT.S235491","article-title":"Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt\/\u03b2-Catenin Signaling Pathway in STZ-Induced Diabetic Rats","volume":"14","author":"Xie","year":"2020","journal-title":"Drug Des. Devel Ther."},{"key":"B140","doi-asserted-by":"publisher","first-page":"119068","DOI":"10.1016\/j.lfs.2021.119068","article-title":"Astragaloside IV Protects against Podocyte Apoptosis by Inhibiting Oxidative Stress via Activating PPAR\u03b3-Klotho-FoxO1 axis in Diabetic Nephropathy","volume":"269","author":"Xing","year":"2021","journal-title":"Life Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.fitote.2014.06.005","article-title":"Leonurine Ameliorates LPS-Induced Acute Kidney Injury via Suppressing ROS-Mediated NF-\u039ab Signaling Pathway","volume":"97","author":"Xu","year":"2014","journal-title":"Fitoterapia"},{"key":"B142","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.3390\/molecules23123234","article-title":"UPLC-MS\/MS of Atractylenolide I, Atractylenolide II, Atractylenolide III, and Atractyloside A in Rat Plasma after Oral Administration of Raw and Wheat Bran-Processed Atractylodis Rhizoma","volume":"23","author":"Xu","year":"2018","journal-title":"Molecules"},{"key":"B143","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/tox.23081","article-title":"Ginsenoside Rg1 Ameliorates Reproductive Function Injury in C57BL\/6J Mice Induced by Di-N-butyl-phthalate","volume":"36","author":"Xu","year":"2021","journal-title":"Environ. Toxicol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jchromb.2010.12.016","article-title":"Identification of the Potential Active Components of Abelmoschus Manihot in Rat Blood and Kidney Tissue by Microdialysis Combined with Ultra-performance Liquid Chromatography\/quadrupole Time-Of-Flight Mass Spectrometry","volume":"879","author":"Xue","year":"2011","journal-title":"J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.phymed.2018.10.031","article-title":"Salidroside Stimulates the Sirt1\/PGC-1\u03b1 axis and Ameliorates Diabetic Nephropathy in Mice","volume":"54","author":"Xue","year":"2019","journal-title":"Phytomedicine"},{"key":"B146","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1016\/j.apsb.2020.12.020","article-title":"Clinical Efficacies, Underlying Mechanisms and Molecular Targets of Chinese Medicines for Diabetic Nephropathy Treatment and Management","volume":"11","author":"Tang","year":"2021","journal-title":"Acta Pharm. Sin. B."},{"key":"B147","doi-asserted-by":"publisher","first-page":"114187","DOI":"10.1016\/j.jep.2021.114187","article-title":"The Role and Mechanism of Hyperoside against Myocardial Infarction in Mice by Regulating Autophagy via NLRP1 Inflammation Pathway","volume":"276","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1080\/13880209.2017.1383486","article-title":"The Effects of Salvia Przewalskii Total Phenolic Acid Extract on Immune Complex Glomerulonephritis","volume":"55","author":"Yang","year":"2017","journal-title":"Pharm. Biol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1007\/s00253-019-09778-z","article-title":"Screening and Evaluation of Adventitious Root Lines of Panax Notoginseng by Morphology, Gene Expression, and Metabolite Profiles","volume":"103","author":"Yao","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"5149","DOI":"10.3892\/mmr.2016.5167","article-title":"Astragaloside IV Prevents High Glucose-Induced Podocyte Apoptosis via Downregulation of TRPC6","volume":"13","author":"Yao","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s00210-021-02072-8","article-title":"Protective Effects of Curcumin on Chemical and Drug-Induced Cardiotoxicity: a Review","volume":"394","author":"Yarmohammadi","year":"2021","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1080\/0886022X.2017.1313164","article-title":"Molecular Mechanisms Involved in Podocyte EMT and Concomitant Diabetic Kidney Diseases: an Update","volume":"39","author":"Ying","year":"2017","journal-title":"Ren. Fail."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.kint.2019.04.044","article-title":"Podocyte Development, Disease, and Stem Cell Research","volume":"96","author":"Yoshimura","year":"2019","journal-title":"Kidney. Int."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1002\/2211-5463.12946","article-title":"Curcumin Attenuates Angiotensin II-Induced Podocyte Injury and Apoptosis by Inhibiting Endoplasmic Reticulum Stress","volume":"10","author":"Yu","year":"2020","journal-title":"FEBS. Open Bio"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2019.03.073","article-title":"Luteolin Attenuates High Glucose-Induced Podocyte Injury via Suppressing NLRP3 Inflammasome Pathway","volume":"225","author":"Yu","year":"2019","journal-title":"Life Sci."},{"key":"B156","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fmed.2018.00221","article-title":"Proteinuric Kidney Diseases: a Podocyte's Slit Diaphragm and Cytoskeleton Approach","volume":"5","author":"Yu","year":"2018","journal-title":"Front. Med. (Lausanne)."},{"key":"B157","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1021\/acs.jnatprod.6b00697","article-title":"Monoterpenoid Indole Alkaloids from Kopsia Officinalis and the Immunosuppressive Activity of Rhazinilam","volume":"80","author":"Zeng","year":"2017","journal-title":"J. Nat. Prod."},{"key":"B158","first-page":"3512","article-title":"Astragaloside IV Alleviates Puromycin Aminonucleoside-Induced Podocyte Cytoskeleton Injury through the Wnt\/PCP Pathway","volume":"12","author":"Zeng","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1602892","DOI":"10.1155\/2019\/1602892","article-title":"Astragalus Membranaceus and Panax Notoginseng, the Novel Renoprotective Compound, Synergistically Protect against Podocyte Injury in Streptozotocin-Induced Diabetic Rats","volume":"2019","author":"Zhai","year":"2019","journal-title":"J. Diabetes Res."},{"key":"B160","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s11418-016-1007-z","article-title":"Hyperoside Reduces Albuminuria in Diabetic Nephropathy at the Early Stage through Ameliorating Renal Damage and Podocyte Injury","volume":"70","author":"Zhang","year":"2016","journal-title":"J. Nat. Med."},{"key":"B161","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jep.2012.02.007","article-title":"Schisandra Chinensis Fruit Extract Attenuates Albuminuria and Protects Podocyte Integrity in a Mouse Model of Streptozotocin-Induced Diabetic Nephropathy","volume":"141","author":"Zhang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.3390\/ijms19071970","article-title":"Schisandra Chinensis Fructus and its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases","volume":"19","author":"Zhang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1913691","DOI":"10.1155\/2018\/1913691","article-title":"Tiaolipiwei Acupuncture Reduces Albuminuria by Alleviating Podocyte Lesions in a Rat Model of Diabetic Nephropathy","volume":"2018","author":"Zhang","year":"2018","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B164","doi-asserted-by":"publisher","first-page":"641","DOI":"10.2147\/DMSO.S237451","article-title":"Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1\/UVRAG\/Bcl2","volume":"13","author":"Zhang","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"B165","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1111\/bph.14822","article-title":"Catalpol Alleviates Adriamycin-Induced Nephropathy by Activating the SIRT1 Signalling Pathway In Vivo and In Vitro","volume":"176","author":"Zhang","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.1002\/jcp.27306","article-title":"Resveratrol Ameliorates Podocyte Damage in Diabetic Mice via SIRT1\/PGC-1\u03b1 Mediated Attenuation of Mitochondrial Oxidative Stress","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cel. Physiol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"114249","DOI":"10.1016\/j.jep.2021.114249","article-title":"Berberine for Bone Regeneration: Therapeutic Potential and Molecular Mechanisms","volume":"277","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1124\/dmd.121.000438","article-title":"Silybin Restored CYP3A Expression through the Sirtuin 2\/Nuclear Factor \u03ba-B Pathway in Mouse Nonalcoholic Fatty Liver Disease","volume":"49","author":"Zhang","year":"2021","journal-title":"Drug Metab. Dispos."},{"key":"B169","doi-asserted-by":"publisher","first-page":"113415","DOI":"10.1016\/j.jep.2020.113415","article-title":"Atractylodis Rhizoma: A Review of its Traditional Uses, Phytochemistry, Pharmacology, Toxicology and Quality Control","volume":"266","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"8878428","DOI":"10.1155\/2021\/8878428","article-title":"The RIG-I Signal Pathway Mediated Panax Notoginseng Saponin Anti-inflammatory Effect in Ischemia Stroke","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"B171","doi-asserted-by":"publisher","first-page":"110082","DOI":"10.1016\/j.cellsig.2021.110082","article-title":"IL-6\/STAT3 Signaling Activation Exacerbates High Fructose-Induced Podocyte Hypertrophy by Ketohexokinase-A-Mediated Tristetraprolin Down-Regulation","volume":"86","author":"Zhou","year":"2020","journal-title":"Cell. Signal."},{"key":"B172","doi-asserted-by":"publisher","first-page":"173655","DOI":"10.1016\/j.ejphar.2020.173655","article-title":"The Pharmacological Activity of Berberine, a Review for Liver protection","volume":"890","author":"Zhou","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"173796","DOI":"10.1016\/j.ejphar.2020.173796","article-title":"Pharmacodynamic Effects and Molecular Mechanisms of Lignans from Schisandra Chinensis Turcz. (Baill.), a Current Review","volume":"892","author":"Zhou","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00467-011-1808-y","article-title":"Protective Effects of Huangqihuai Granules on Adriamycin Nephrosis in Rats","volume":"26","author":"Zhu","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3892\/mmr.2021.12076","article-title":"Astragaloside IV Alleviates Liver Injury in Type 2 Diabetes Due to Promotion of AMPK\/mTOR-mediated Autophagy","volume":"23","author":"Zhu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"B176","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1159\/000495205","article-title":"Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage","volume":"51","author":"Zuo","year":"2018","journal-title":"Cel. Physiol. Biochem."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.816025\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T09:36:10Z","timestamp":1645781770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.816025\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":176,"alternative-id":["10.3389\/fphar.2022.816025"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.816025","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"article-number":"816025"}}