{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:09:37Z","timestamp":1790690977615,"version":"4.1.0"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by <jats:italic>LMNA<\/jats:italic> and <jats:italic>LMNB<\/jats:italic> genes, respectively. Importantly, mutations in nuclear lamins not only participate in lipid disorders but also in the human diseases, such as lipodystrophy, metabolic-associated fatty liver disease, and dilated cardiomyopathy. Among those diseases, the mechanism of lamin has been widely discussed. Thereby, this review mainly focuses on the regulatory mechanism of the mutations in the lamin gene in lipid alterations and the human diseases. Considering the protean actions, targeting nuclear lamins may be a potent therapeutic avenue for lipid metabolic disorders and human diseases in the future.<\/jats:p>","DOI":"10.3389\/fphar.2022.820857","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T07:33:19Z","timestamp":1645774399000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Yue","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4161\/nucl.24089","article-title":"Disruption of Lamin B1 and Lamin B2 Processing and Localization by Farnesyltransferase Inhibitors","volume":"4","author":"Adam","year":"2013","journal-title":"Nucleus"},{"key":"B2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.atherosclerosis.2015.12.012","article-title":"LMNA Mutations Resulting in Lipodystrophy and HIV Protease Inhibitors Trigger Vascular Smooth Muscle Cell Senescence and Calcification: Role of ZMPSTE24 Downregulation","volume":"245","author":"Afonso","year":"2016","journal-title":"Atherosclerosis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.2174\/1574892811666151111142554","article-title":"Metreleptin Treatment in Patients with Non-HIV Associated Lipodystrophy","volume":"9","author":"Akinci","year":"2015","journal-title":"Recent Pat Endocr. Metab. Immune Drug Discov."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7280","DOI":"10.1073\/pnas.1200425109","article-title":"Tandem Mass Spectrometry Identifies many Mouse Brain O-GlcNAcylated Proteins Including EGF Domain-specific O-GlcNAc Transferase Targets","volume":"109","author":"Alfaro","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/ehjci\/jez188","article-title":"Dilated Cardiomyopathy and Arrhythmogenic Left Ventricular Cardiomyopathy: a Comprehensive Genotype-Imaging Phenotype Study","volume":"21","author":"Augusto","year":"2020","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.2147\/DMSO.S206053","article-title":"Familial Partial Lipodystrophy (FPLD): Recent Insights","volume":"13","author":"Bagias","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1161\/ATVBAHA.113.301933","article-title":"Lipodystrophy-linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction","volume":"33","author":"Bidault","year":"2013","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124506","article-title":"Nucleophagy-Implications for Microautophagy and Health","volume":"21","author":"Bo Otto","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1210\/jc.2009-1293","article-title":"LMNA Mutations, Skeletal Muscle Lipid Metabolism, and Insulin Resistance","volume":"95","author":"Boschmann","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1242\/jcs.112.11.1743","article-title":"Caspase-dependent Proteolysis of Integral and Peripheral Proteins of Nuclear Membranes and Nuclear Pore Complex Proteins during Apoptosis","volume":"112","author":"Buendia","year":"1999","journal-title":"J. Cel Sci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1093\/hmg\/ddi158","article-title":"Altered Pre-lamin A Processing Is a Common Mechanism Leading to Lipodystrophy","volume":"14","author":"Capanni","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40364-018-0144-9","article-title":"Overexpression and Cytoplasmic Localization of Caspase-6 Is Associated with Lamin A Degradation in Set of Ovarian Cancers","volume":"6","author":"Capo-Chichi","year":"2018","journal-title":"Biomark Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1136\/heartjnl-2017-312338","article-title":"Lamin and the Heart","volume":"104","author":"Captur","year":"2018","journal-title":"Heart"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2017.12.001","article-title":"Mandibuloacral Dysplasia: A Premature Ageing Disease with Aspects of Physiological Ageing","volume":"42","author":"Cenni","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"104070","DOI":"10.1016\/j.lpm.2021.104070","article-title":"Metreleptin Treatment of Non-HIV Lipodystrophy Syndromes","volume":"50","author":"Chevalier","year":"2021","journal-title":"Presse Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1194\/jlr.R009761","article-title":"Lipid Metabolism in Myelinating Glial Cells: Lessons from Human Inherited Disorders and Mouse Models","volume":"52","author":"Chrast","year":"2011","journal-title":"J. Lipid Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1111\/1346-8138.15570","article-title":"Evidence of Ongoing Complement Activation on Adipose Tissue from an 11-Year-Old Girl with Barraquer-Simons Syndrome","volume":"47","author":"Corvillo","year":"2020","journal-title":"J. Dermatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.tcb.2017.08.004","article-title":"Nuclear Lamins: Thin Filaments with Major Functions","volume":"28","author":"de Leeuw","year":"2018","journal-title":"Trends Cel Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/gb-2011-12-5-222","article-title":"The Lamin Protein Family","volume":"12","author":"Dittmer","year":"2011","journal-title":"Genome Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3904\/kjim.2009.24.1.68","article-title":"Novel LMNA Gene Mutation in a Patient with Atypical Werner's Syndrome","volume":"24","author":"Doh","year":"2009","journal-title":"Korean J. Intern. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature15548","article-title":"Autophagy Mediates Degradation of Nuclear Lamina","volume":"527","author":"Dou","year":"2015","journal-title":"Nature"},{"key":"B22","first-page":"33","article-title":"Familial Lipoatrophic Diabetes with Dominant Transmission. A New Syndrome","volume":"43","author":"Dunnigan","year":"1974","journal-title":"Q. J. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.str.2016.11.001","article-title":"Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms","volume":"25","author":"Eron","year":"2017","journal-title":"Structure"},{"key":"B24","doi-asserted-by":"publisher","first-page":"20422","DOI":"10.1016\/s0021-9258(19)47079-8","article-title":"Human Lamin B Contains a Farnesylated Cysteine Residue","volume":"264","author":"Farnsworth","year":"1989","journal-title":"J. Biol. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bbrc.2017.11.008","article-title":"FPLD2 LMNA Mutation R482W Dysregulates iPSC-Derived Adipocyte Function and Lipid Metabolism","volume":"495","author":"Friesen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.2174\/1389450119666180518112350","article-title":"Nucleophagy Plays a Major Role in Human Diseases","volume":"19","author":"Fu","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1093\/hmg\/ddv065","article-title":"A Large Genomic Deletion Leads to Enhancer Adoption by the Lamin B1 Gene: a Second Path to Autosomal Dominant Adult-Onset Demyelinating Leukodystrophy (ADLD)","volume":"24","author":"Giorgio","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1242\/jcs.022020","article-title":"Filaments Made from A- and B-type Lamins Differ in Structure and Organization","volume":"121","author":"Goldberg","year":"2008","journal-title":"J. Cel Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.arr.2016.06.007","article-title":"Hutchinson-Gilford Progeria Syndrome: A Premature Aging Disease Caused by LMNA Gene Mutations","volume":"33","author":"Gonzalo","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ceb.2014.09.009","article-title":"Lamins: the Structure and Protein Complexes","volume":"32","author":"Gruenbaum","year":"2015","journal-title":"Curr. Opin. Cel Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.semcdb.2013.12.015","article-title":"Nuclear Envelope-Related Lipodystrophies","volume":"29","author":"Gu\u00e9nantin","year":"2014","journal-title":"Semin. Cel Dev Biol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153657","article-title":"Adipogenesis: A Necessary but Harmful Strategy","volume":"20","author":"Hafidi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1210\/jcem.85.9.6768","article-title":"LMNA R482Q Mutation in Partial Lipodystrophy Associated with Reduced Plasma Leptin Concentration","volume":"85","author":"Hegele","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1086\/505885","article-title":"Sequencing of the Reannotated LMNB2 Gene Reveals Novel Mutations in Patients with Acquired Partial Lipodystrophy","volume":"79","author":"Hegele","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.102","article-title":"Clinical Utility Gene Card for: Familial Partial Lipodystrophy","volume":"25","author":"J\u00e9ru","year":"2017","journal-title":"Eur. J. Hum. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e13048","DOI":"10.1111\/acel.13048","article-title":"The Role of Lipid Metabolism in Aging, Lifespan Regulation, and Age-Related Disease","volume":"18","author":"Johnson","year":"2019","journal-title":"Aging Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"E1923","DOI":"10.1073\/pnas.1303916110","article-title":"Farnesylation of Lamin B1 Is Important for Retention of Nuclear Chromatin during Neuronal Migration","volume":"110","author":"Jung","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B38","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3390\/cells9040985","article-title":"Colocalization of MID1IP1 and C-Myc Is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2","volume":"9","author":"Jung","year":"2020","journal-title":"Cells"},{"key":"B39","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/s12276-020-0455-4","article-title":"Autophagy as a Decisive Process for Cell Death","volume":"52","author":"Jung","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"696","DOI":"10.3389\/fimmu.2018.00696","article-title":"Macrophage Lamin A\/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance","volume":"9","author":"Kim","year":"2018","journal-title":"Front. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6113","DOI":"10.3390\/ijms21176113","article-title":"Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases","volume":"21","author":"Kloska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/BF00430347","article-title":"Lipodystrophy of the Extremities. A Dominantly Inherited Syndrome Associated with Lipatrophic Diabetes","volume":"29","author":"K\u00f6bberling","year":"1975","journal-title":"Humangenetik"},{"key":"B43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12887-016-0581-2","article-title":"Fitting the Pieces of the Puzzle Together: a Case Report of the Dunnigan-type of Familial Partial Lipodystrophy in the Adolescent Girl","volume":"16","author":"Krawiec","year":"2016","journal-title":"BMC Pediatr."},{"key":"B44","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/s41594-019-0249-3","article-title":"GGTase3 Is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase","volume":"26","author":"Kuchay","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jcmgh.2017.06.005","article-title":"Hepatocyte-Specific Deletion of Mouse Lamin A\/C Leads to Male-Selective Steatohepatitis","volume":"4","author":"Kwan","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1210\/jc.2017-02662","article-title":"PLIN1 Haploinsufficiency Is Not Associated with Lipodystrophy","volume":"103","author":"Laver","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B47","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3892\/mmr.2015.4628","article-title":"Fructus Xanthii Improves Lipid Homeostasis in the Epididymal Adipose Tissue of Rats Fed a High-Fat Diet","volume":"13","author":"Li","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1523\/JNEUROSCI.5994-10.2011","article-title":"Adult-onset Autosomal Dominant Leukodystrophy: Linking Nuclear Envelope to Myelin","volume":"31","author":"Lin","year":"2011","journal-title":"J. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.150094","article-title":"Regulation of Lamin Properties and Functions: Does Phosphorylation Do it All?","volume":"5","author":"Machowska","year":"2015","journal-title":"Open Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e00375","DOI":"10.14309\/crj.0000000000000375","article-title":"Hepatic Steatosis Resulting from LMNA-Associated Familial Lipodystrophy","volume":"7","author":"Mahdi","year":"2020","journal-title":"ACG Case Rep. J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.dld.2020.09.013","article-title":"NAFLD, MAFLD and DAFLD","volume":"52","author":"Mantovani","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1002\/jcb.22992","article-title":"Laminopathies and Lamin-Associated Signaling Pathways","volume":"112","author":"Maraldi","year":"2011","journal-title":"J. Cel Biochem"},{"key":"B53","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1586\/17512433.2016.1096772","article-title":"Metreleptin for Injection to Treat the Complications of Leptin Deficiency in Patients with Congenital or Acquired Generalized Lipodystrophy","volume":"9","author":"Meehan","year":"2016","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"11473","DOI":"10.1074\/jbc.RA120.014129","article-title":"The Spo7 Sequence LLI Is Required for Nem1-Spo7\/Pah1 Phosphatase cascade Function in Yeast Lipid Metabolism","volume":"295","author":"Mirheydari","year":"2020","journal-title":"J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.yexcr.2016.02.016","article-title":"Lamin A Reassembly at the End of Mitosis Is Regulated by its SUMO-Interacting Motif","volume":"342","author":"Moriuchi","year":"2016","journal-title":"Exp. Cel Res"},{"key":"B56","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/s1471-4914(01)02128-1","article-title":"The Role of the Nuclear Envelope in Emery-Dreifuss Muscular Dystrophy","volume":"7","author":"Morris","year":"2001","journal-title":"Trends Mol. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/hmg\/9.9.1453","article-title":"Identification of Mutations in the Gene Encoding Lamins A\/C in Autosomal Dominant Limb Girdle Muscular Dystrophy with Atrioventricular Conduction Disturbances (LGMD1B)","volume":"9","author":"Muchir","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071598","article-title":"Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells","volume":"10","author":"Najdi","year":"2021","journal-title":"Cells"},{"key":"B59","first-page":"52","article-title":"Expression of Emerin and Lamins in Muscle of Patients with Different Forms of Emery-Dreifuss Muscular Dystrophy","volume":"22","author":"Niebroj-Dobosz","year":"2003","journal-title":"Acta Myol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1086\/341908","article-title":"Mandibuloacral Dysplasia Is Caused by a Mutation in LMNA-Encoding Lamin A\/C","volume":"71","author":"Novelli","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"B61","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13104-016-1975-9","article-title":"Barraquer-Simons Syndrome: a Rare Form of Acquired Lipodystrophy","volume":"9","author":"Oliveira","year":"2016","journal-title":"BMC Res. Notes"},{"key":"B62","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12944-017-0521-7","article-title":"Lipid Droplets in Health and Disease","volume":"16","author":"Onal","year":"2017","journal-title":"Lipids Health Dis."},{"key":"B63","first-page":"140","article-title":"The First Japanese Case of Autosomal Dominant Emery-Dreifuss Muscular Dystrophy with a Novel Mutation in the Lamin A\/C Gene","volume":"42","author":"Onishi","year":"2002","journal-title":"Rinsho Shinkeigaku"},{"key":"B64","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s12020-019-01862-8","article-title":"Long-term Effectiveness and Safety of Metreleptin in the Treatment of Patients with Partial Lipodystrophy","volume":"64","author":"Oral","year":"2019","journal-title":"Endocrine"},{"key":"B65","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3390\/biology9100338","article-title":"The Nuclear Envelope in Lipid Metabolism and Pathogenesis of NAFLD","volume":"9","author":"\u00d6stlund","year":"2020","journal-title":"Biology (Basel)"},{"key":"B66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4274\/jcrpe.galenos.2019.2019.0124","article-title":"Current Diagnosis, Treatment and Clinical Challenges in the Management of Lipodystrophy Syndromes in Children and Young People","volume":"12","author":"\u00d6zen","year":"2020","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fcell.2019.00041","article-title":"Autosomal Dominant Leukodystrophy: A Disease of the Nuclear Lamina","volume":"7","author":"Padiath","year":"2019","journal-title":"Front Cel Dev Biol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0091-679X(10)98014-X","article-title":"Autosomal Dominant Leukodystrophy Caused by Lamin B1 Duplications a Clinical and Molecular Case Study of Altered Nuclear Function and Disease","volume":"98","author":"Padiath","year":"2010","journal-title":"Methods Cel Biol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"795","DOI":"10.4161\/auto.8901","article-title":"Autophagic Degradation of Nuclear Components in Mammalian Cells","volume":"5","author":"Park","year":"2009","journal-title":"Autophagy"},{"key":"B70","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1515\/bmc-2016-0030","article-title":"SUMO Conjugation - a Mechanistic View","volume":"8","author":"Pichler","year":"2017","journal-title":"Biomol. Concepts"},{"key":"B71","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2459\/JCM.0000000000001060","article-title":"A Very Long-Term Observation of a Family with Dilated Cardiomyopathy and Overlapping Phenotype from Lamin A\/C Mutation","volume":"22","author":"Porcu","year":"2021","journal-title":"J. Cardiovasc. Med. (Hagerstown)"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ncb2579","article-title":"Systems-wide Analysis of Ubiquitylation Dynamics Reveals a Key Role for PAF15 Ubiquitylation in DNA-Damage Bypass","volume":"14","author":"Povlsen","year":"2012","journal-title":"Nat. Cel Biol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1111\/febs.14448","article-title":"The Nem1\/Spo7-Pah1\/lipin axis Is Required for Autophagy Induction after TORC1 Inactivation","volume":"285","author":"Rahman","year":"2018","journal-title":"FEBS J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"100486","DOI":"10.1016\/j.jaim.2021.07.002","article-title":"Ayurvedic Management in Limb Girdle Muscular Dystrophy - A Case Report","volume":"13","author":"Rajoria","year":"2021","journal-title":"J. Ayurveda Integr. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e43260","DOI":"10.15252\/embr.201643260","article-title":"KMT1 Family Methyltransferases Regulate Heterochromatin-Nuclear Periphery Tethering via Histone and Non-histone Protein Methylation","volume":"20","author":"Rao","year":"2019","journal-title":"EMBO Rep."},{"key":"B76","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2121-5-12","article-title":"Expression and Localization of Nuclear Proteins in Autosomal-Dominant Emery-Dreifuss Muscular Dystrophy with LMNA R377H Mutation","volume":"5","author":"Reichart","year":"2004","journal-title":"BMC Cel Biol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"12002","DOI":"10.1523\/JNEUROSCI.1668-15.2015","article-title":"Defects of Lipid Synthesis Are Linked to the Age-dependent Demyelination Caused by Lamin B1 Overexpression","volume":"35","author":"Rolyan","year":"2015","journal-title":"J. Neurosci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.dnarep.2009.12.011","article-title":"Roles of Werner Syndrome Protein in protection of Genome Integrity","volume":"9","author":"Rossi","year":"2010","journal-title":"DNA Repair (Amst)"},{"key":"B79","doi-asserted-by":"publisher","first-page":"309","DOI":"10.5966\/sctm.2011-0010","article-title":"Sp1 Transcription Factor Interaction with Accumulated Prelamin a Impairs Adipose Lineage Differentiation in Human Mesenchymal Stem Cells: Essential Role of Sp1 in the Integrity of Lipid Vesicles","volume":"1","author":"Ruiz de Eguino","year":"2012","journal-title":"Stem Cell Transl Med"},{"key":"B80","doi-asserted-by":"publisher","first-page":"eaax9276","DOI":"10.1126\/scitranslmed.aax9276","article-title":"Clinical Trial in a Dish Using iPSCs Shows Lovastatin Improves Endothelial Dysfunction and Cellular Cross-Talk in LMNA Cardiomyopathy","volume":"12","author":"Sayed","year":"2020","journal-title":"Sci. Transl Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1194\/jlr.E069880","article-title":"Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death: Introduction to a Thematic Review Series","volume":"57","author":"Schaffer","year":"2016","journal-title":"J. Lipid Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"686","DOI":"10.14348\/molcells.2020.0046","article-title":"Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders","volume":"43","author":"Shin","year":"2020","journal-title":"Mol. Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1091\/mbc.E12-07-0527","article-title":"Lamin A Tail Modification by SUMO1 Is Disrupted by Familial Partial Lipodystrophy-Causing Mutations","volume":"24","author":"Simon","year":"2013","journal-title":"Mol. Biol. Cel"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3390\/cells7050044","article-title":"OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A","volume":"7","author":"Simon","year":"2018","journal-title":"Cells"},{"key":"B85","doi-asserted-by":"publisher","first-page":"282041","DOI":"10.1155\/2012\/282041","article-title":"Lipophagy: Connecting Autophagy and Lipid Metabolism","volume":"2012","author":"Singh","year":"2012","journal-title":"Int. J. Cel Biol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nrm3753","article-title":"Post-translational Modifications of Intermediate Filament Proteins: Mechanisms and Functions","volume":"15","author":"Snider","year":"2014","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081884","article-title":"Structural and Mechanical Aberrations of the Nuclear Lamina in Disease","volume":"9","author":"Stiekema","year":"2020","journal-title":"Cells"},{"key":"B88","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ibror.2018.11.001","article-title":"Differential Expression of Nuclear Lamin Subtypes in the Neural Cells of the Adult Rat Cerebral Cortex","volume":"5","author":"Takamori","year":"2018","journal-title":"IBRO Rep."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1517\/14712598.2015.1052789","article-title":"Metreleptin and Generalized Lipodystrophy and Evolving Therapeutic Perspectives","volume":"15","author":"Tchang","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"key":"B90","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1080\/19491034.2016.1242542","article-title":"LMNA Missense Mutations Causing Familial Partial Lipodystrophy Do Not lead to an Accumulation of Prelamin A","volume":"7","author":"Tu","year":"2016","journal-title":"Nucleus"},{"key":"B91","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00418-011-0792-4","article-title":"Reorganization of the Nuclear Lamina and Cytoskeleton in Adipogenesis","volume":"135","author":"Verstraeten","year":"2011","journal-title":"Histochem. Cel Biol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/s0968-0004(97)01107-9","article-title":"Caspases and Caspase Inhibitors","volume":"22","author":"Villa","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"M111","DOI":"10.1074\/mcp.M111.013284","article-title":"A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles","volume":"10","author":"Wagner","year":"2011","journal-title":"Mol. Cel Proteomics"},{"key":"B94","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.bbalip.2015.12.010","article-title":"Lipid Droplets, Lipophagy, and beyond","volume":"1861","author":"Wang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2324709618786770","DOI":"10.1177\/2324709618786770","article-title":"A De Novo POLD1 Mutation Associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome in a Family with Werner Syndrome","volume":"6","author":"Wang","year":"2018","journal-title":"J. Investig. Med. High Impact Case Rep."},{"key":"B96","doi-asserted-by":"publisher","first-page":"e37427","DOI":"10.1371\/journal.pone.0037427","article-title":"Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"B97","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/0014-5793(89)81584-4","article-title":"Maturation of Nuclear Lamin A Involves a Specific Carboxy-Terminal Trimming, Which Removes the Polyisoprenylation Site from the Precursor; Implications for the Structure of the Nuclear Lamina","volume":"257","author":"Weber","year":"1989","journal-title":"FEBS Lett."},{"key":"B98","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.celrep.2013.07.024","article-title":"Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation","volume":"4","author":"Weinert","year":"2013","journal-title":"Cell Rep"},{"key":"B99","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nrc1612","article-title":"Post-prenylation-processing Enzymes as New Targets in Oncogenesis","volume":"5","author":"Winter-Vann","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"B100","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3390\/ijms22020817","article-title":"Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling","volume":"22","author":"Yan","year":"2021","journal-title":"Ijms"},{"key":"B101","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nrm.2017.76","article-title":"Cytosolic Lipolysis and Lipophagy: Two Sides of the Same coin","volume":"18","author":"Zechner","year":"2017","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.cca.2020.07.044","article-title":"Sumoylation in Liver Disease","volume":"510","author":"Zeng","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"B103","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.fct.2018.11.011","article-title":"The Functional Role of Bax\/Bak in Palmitate-Induced Lipoapoptosis","volume":"123","author":"Zhang","year":"2019","journal-title":"Food Chem. Toxicol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.820857\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T07:33:24Z","timestamp":1645774404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.820857\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":103,"alternative-id":["10.3389\/fphar.2022.820857"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.820857","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"article-number":"820857"}}