{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:25:06Z","timestamp":1789676706634,"version":"4.0.1"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic>Corydalis saxicola<\/jats:italic>\n                    Bunting (CSB) is a perennial herb belonging to genus\n                    <jats:italic>Corydalis<\/jats:italic>\n                    (Papaveraceae), called \u201cYan-huang-lian\u201d in the Chinese folk. Traditionally, it is used to treat acute conjunctivitis, corneal pannus, acute abdominal pain, hemorrhoidal bleeding, haematochezia, swelling, hepatitis, cirrhosis and liver cancer based on traditional Chinese medicine (TCM) concepts.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    This review aims to summarize and analyze the pharmacokinetics, pharmacological and toxicological properties of CSB and its extracts; to highlight the relevance of modern pharmacology to traditional pharmacology; also to assess its therapeutic potential.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    CSB related literatures were searched and screened from databases including PubMed, Web of Science and CNKI. The selected literatures provided reliable source identification evidences.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In traditional medicine concepts, CSB has the effects of clearing away heat and detoxification, eliminating dampness, relieving pain, and stopping bleeding. Its modern pharmacology includes hepatoprotective, anticancer, anti-inflammatory, analgesic, antibacterial, anti-oxidative effects. Further, some pharmacological effects support its traditional uses. The CSB total alkaloids (CSBTA) are the main constituents isolated from this plant, and they exert the major of the pharmacological effects. Toxicological studies have shown that the toxicity of CSBTA is mild and reversible in rodents and beagle dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Although the present study summarizes the botany, phytochemistry, pharmacokinetics, pharmacology, toxicity, and applications of this plant, it is still necessary to systemically evaluate the chemistry, safety and parameters related to drug metabolism of the extracts or compounds from this plant before or in clinical trials in the future. Meanwhile, cancers and inflammatory-related diseases may be new research directions of this ethnomedicine.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2022.822792","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T02:16:47Z","timestamp":1644977807000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["The Traditional Uses, Phytochemistry, Pharmacokinetics, Pharmacology, Toxicity, and Applications of Corydalis saxicola Bunting: A Review"],"prefix":"10.3389","volume":"13","author":[{"given":"Yanru","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5459","DOI":"10.1002\/ptr.7181","article-title":"Molecular Updates on Berberine in Liver Diseases: Bench to Bedside","volume":"35","author":"Bansod","year":"2021","journal-title":"Phytother Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"468","DOI":"10.19378\/j.issn.1003-9783.2018.01.021","article-title":"Study on Effect and Molecular Mechanism of Corydalis Saxicola Total Alkaloids on Nonalcoholic Fatty Liver Mice","volume":"44","author":"Chen","year":"2021","journal-title":"Drug Eval. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1002\/cbdv.200890121","article-title":"DNA Topoisomerase I Inhibitory Alkaloids from Corydalis Saxicola","volume":"5","author":"Cheng","year":"","journal-title":"Chem. Biodivers"},{"key":"B4","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/pca.1067","article-title":"Simultaneous Determination of Eight Bioactive Alkaloids in Corydalis Saxicola by High-Performance Liquid Chromatography Coupled with Diode Array Detection","volume":"19","author":"Cheng","year":"","journal-title":"Phytochem. Anal."},{"key":"B5","volume-title":"Chinese Materia Medica","year":"1999"},{"key":"B6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-3-319-41334-1_2","article-title":"Berberine and its Role in Chronic Disease","volume":"928","author":"Cicero","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/NDS.S6084","article-title":"Berberine: Metabolic and Cardiovascular Effects in Preclinical and Clinical Trials","author":"Cicero","year":"2009","journal-title":"Nutr. Dietary Supplements"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e4329","DOI":"10.1002\/bmc.4329","article-title":"Comparative Pharmacokinetics of Three Alkaloids in Normal and Acute Hepatitis Rats After Oral Administration of Yanhuanglian Total Alkaloids Extract","volume":"32","author":"Dai","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/pca.1152","article-title":"Application of Microwave-Assisted Extraction Coupled with High-Speed Counter-current Chromatography for Separation and Purification of Dehydrocavidine from Corydalis Saxicola Bunting","volume":"20","author":"Deng","year":"2009","journal-title":"Phytochem. Anal."},{"key":"B10","volume-title":"Corydalis Saxicola Bunting Extractive Inhibit F-Actin Polymerization in A549 Cells and its Possible Mechanism","author":"Du","year":"2017"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.16190\/j.cnki.45-1211\/r.2020.12.002","article-title":"Inhibitory Effects of Corydalis Saxicola Bunting Total Alkaloids on M1 Macrophages Polarization","volume":"37","author":"Feng","year":"2020","journal-title":"J. Guangxi Med. Univ."},{"key":"B12","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.neulet.2017.12.004","article-title":"Dehydrocavidine Attenuates D-Galactose Induced Learning and Memory Impairment in Rats","volume":"665","author":"Fu","year":"2018","journal-title":"Neurosci. Lett."},{"key":"B13","volume-title":"Guangxi Traditional Chinese Medicine Standard 1990 Edition","year":"1992"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.7501\/j.issn.0253-2670.2014.11.005","article-title":"Study on Alkaloids from Corydalis Saxicola and Their Anti-oxidative Activities","volume":"45","author":"He","year":"2014","journal-title":"China. Tradit. Herb. Drugs"},{"key":"B15","volume-title":"Synergistic Effects and Decreasing Toxicity on the Fufang Yanzhang Capsule for Mouse Sarcoma and its Main Components Inhibiting the Proliferation of Hepatocellular Carcinoma Cells","author":"Huang","year":"2015"},{"key":"B16","first-page":"22","article-title":"Preliminary Observation on the Analgesic, Cholagogue and Cholagogue Effects of Corydalis Saxicola Total Alkaloids","volume":"4","author":"Huang","year":"1981","journal-title":"J. Zunyi Med. Univ."},{"key":"B17","first-page":"146","article-title":"Study on Main Pharmacodynamics and Acute Toxicity of Herba Corydalis Saxicolae Extract","volume":"27","author":"Huang","year":"2007","journal-title":"Chin. J. Hosp. Pharm."},{"key":"B18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1055\/s-0031-1280126","article-title":"Bioactive Isoquinoline Alkaloids from Corydalis Saxicola","volume":"78","author":"Huang","year":"2012","journal-title":"Planta Med."},{"key":"B19","volume-title":"Chinese Medicine Dictionary","author":"JiangsuNew Medical College","year":"1986"},{"key":"B20","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3969\/j.issn.1674-5671.2018.06.03","article-title":"Effect of Corydalis Saxicola Bunting Aqueous Extract on Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells and its Possible Mechanism","volume":"10","author":"Ju","year":"2018","journal-title":"Chin. J. Oncol. Prev. Treat."},{"key":"B21","doi-asserted-by":"publisher","first-page":"609119","DOI":"10.3389\/fphar.2020.609119","article-title":"Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-\u039ab and C-Fos\/NFATc1 Pathways in Rats","volume":"11","author":"Ju","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B22","first-page":"289","article-title":"Study on Active Ingredients of Corydalis Saxicola Bunting","volume":"24","author":"Ke","year":"1982","journal-title":"J. Integr. Plant Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1142\/S0192415X20500214","article-title":"Corydalis Saxicola Alkaloids Attenuate Cisplatin-Induced Neuropathic Pain by Reducing Loss of IENF and Blocking TRPV1 Activation","volume":"48","author":"Kuai","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"B24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/B978-0-12-802104-0.00009-3","article-title":"Alkaloids","volume-title":"Chapter 9 - Alkaloids\" in Pharmacognosy","author":"Kukula-Koch","year":"2017"},{"key":"B25","first-page":"173","article-title":"Tetradehydroscoulerine on Cell Proliferation and hTERT Expression of Tca8113 Cell Lines","volume":"18","author":"Lei","year":"2008","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1088\/1674-1056\/18\/10\/033","article-title":"Experimental Study on the Anti-inflammatory Activity of Yanhuanglian","volume":"18","author":"Li","year":"2009","journal-title":"Chin. J. Ethnomedicine Ethnopharmacy"},{"key":"B27","doi-asserted-by":"publisher","first-page":"104","DOI":"10.16662\/j.cnki.1674-0742.2010.01.018","article-title":"Clinical Observation on the Treatment of Viral Hepatitis with Corydalis Saxicola Bunting","volume":"29","author":"Li","year":"2010","journal-title":"China Foreign Med. Treat."},{"key":"B28","volume-title":"The Effect of Corydalis Saxibola Bunting Total Alkaloids for Lung Cancer A549 Cell and its Possible Mechanism","author":"Li","year":"2015"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.jpba.2006.03.029","article-title":"Bioavailabilty and Pharmacokinetics of Four Active Alkaloids of Traditional Chinese Medicine Yanhuanglian in Rats Following Intravenous and Oral Administration","volume":"41","author":"Li","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"B30","first-page":"32","article-title":"Inhibition of Yanhuanglian Total Alkaloids on Cell Proliferation and Telomerase Activity of Tca8113 Cell Lines","volume":"19","author":"Li","year":"2007","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B31","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/cbdv.200890074","article-title":"Alkaloids from Corydalis Saxicola and Their Anti-hepatitis B Virus Activity","volume":"5","author":"Li","year":"2008","journal-title":"Chem. Biodivers"},{"key":"B32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.13422\/j.cnki.syfjx.2015090165","article-title":"Effect of Corydalis Saxicola Total Alkaloids on Human A549 Cell Proliferation, Apoptosis and Expressions of Caspase, Survivin","volume":"21","author":"Li","year":"2015","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B33","doi-asserted-by":"publisher","first-page":"748","DOI":"10.13220\/j.cnki.jipr.2018.10.004","article-title":"Alkaloids in the Corydalis Plants and Their Biological Activities: Research Advances","volume":"45","author":"Li","year":"","journal-title":"J. Int. Pharm. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3892\/ol.2017.7273","article-title":"Total Alkaloids of Corydalis Saxicola Bunting Inhibits Migration of A549 Cells by Suppressing Cdc42 or Vav1","volume":"15","author":"Li","year":"","journal-title":"Oncol. Lett."},{"key":"B35","first-page":"2620","article-title":"Protective Effect of Corydalis Saxicola Alkaloids(CSA) on Level of TGF-\u03921, MMP-9 in Rats with Liver Fibrosis","volume":"19","author":"Liang","year":"2008","journal-title":"Lishizhen Med. Materia Med. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jpba.2016.06.033","article-title":"Serum Metabonomics Study of the Hepatoprotective Effect of Corydalis Saxicola Bunting on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats by (1)H NMR Analysis","volume":"129","author":"Liang","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"B37","first-page":"1022","article-title":"Absorption Kinetics of Dehydrocavidine in Rats' Stomachs and Intestines","volume":"34","author":"Liu","year":"2009","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"B38","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jpba.2018.06.065","article-title":"Investigation of the Hepatoprotective Effect of Corydalis Saxicola Bunting on Carbon Tetrachloride-Induced Liver Fibrosis in Rats by 1H-NMR-Based Metabonomics and Network Pharmacology Approaches","volume":"159","author":"Liu","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3389\/fmicb.2019.01151","article-title":"Intervening Effects of Total Alkaloids of Corydalis Saxicola Bunting on Rats with Antibiotic-Induced Gut Microbiota Dysbiosis Based on 16S rRNA Gene Sequencing and Untargeted Metabolomics Analyses","volume":"10","author":"Liu","year":"","journal-title":"Front. Microbiol."},{"key":"B40","first-page":"1700","article-title":"Effects of Corydalis Saxicola Bunting on Acute Cholestasis in Rats and Expression of Related Bile Acid Transporter","volume":"34","author":"Liu","year":"","journal-title":"China J. Traditional Chin. Med. Pharm."},{"key":"B41","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.biochi.2019.04.008","article-title":"Palmatine: A Review of its Pharmacology, Toxicity and Pharmacokinetics","volume":"162","author":"Long","year":"2019","journal-title":"Biochimie"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.7501\/j.issn.0253-2670.2017.07.016","article-title":"Discrimiation of Proliferation Inhibiting Ingredients in Corydalis Saxicola on Rat Hepatic Stellate Cell-T6 Based on Composition-Activity Relationship","volume":"48","author":"Lu","year":"2017","journal-title":"Chin. Traditional Herbal Drugs"},{"key":"B43","first-page":"1976","article-title":"Studies on Quality of Corydalis Saxicola Bunting and its Preparations","volume":"29","author":"Luo","year":"2009","journal-title":"Chin. J. Pharm. Anal."},{"key":"B44","volume-title":"Chemical Constituents and Activity of Corydalis Saxicola Bunting","author":"Mao","year":"2006"},{"key":"B45","doi-asserted-by":"publisher","first-page":"43","DOI":"10.15913\/j.cnki.kjycx.2020.09.015","article-title":"Experimental Study on Antibacterial Activity of Chinese Herb Yanhuanglian In Vitro","author":"Qiu","year":"2020","journal-title":"Sci. Tech. Innovation"},{"key":"B46","volume-title":"Research of Corydalis Saxicola Bunting Total Alkaloids on Nude Mouse with Subcutaneous Transplantation Tumor and Bone Metastasis in Lung Cancer A549","author":"Sang","year":"2017"},{"key":"B47","first-page":"256","article-title":"Intestinal Transport Characteristics of Dehydrocavidine","volume":"35","author":"Shi","year":"2013","journal-title":"Chin. Traditional Patent Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"457","DOI":"10.13863\/j.issn1001-4454.2020.02.038","article-title":"The Effect of Dehydrocavidine on the Proliferation and Apoptosis of Cells MC3T3-E1 Induced by H2O2","volume":"43","author":"Shi","year":"2020","journal-title":"J. Chin. Med. Mater."},{"key":"B49","doi-asserted-by":"publisher","first-page":"113839","DOI":"10.1016\/j.ejmech.2021.113839","article-title":"Plant Isoquinoline Alkaloids: Advances in the Chemistry and Biology of Berberine","volume":"226","author":"Singh","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"B50","volume-title":"Pharmacodynamic Studies and Preclinical Safety Evaluatons of Dehydrocavidine","author":"Sun","year":"2007"},{"key":"B51","first-page":"103","article-title":"Bacteriostasis of Corydalis Saxicola Combined with Antibiotics on staphylococcus Aureus In Vitro","volume":"41","author":"Sun","year":"2020","journal-title":"J. Jinggangshan University(Natural Science)"},{"key":"B52","volume-title":"The Study of Establishing the Fingerprint Chromatogram and Revealing the Anti-hepatic Fibrosis Effect of Corydalis Saxicola Bunting Based on Serum Metabonomics","author":"Tang","year":"2017"},{"key":"B75","doi-asserted-by":"publisher","first-page":"104","DOI":"10.19378\/j.issn.1003-9783.2018.01.021","article-title":"The Chemical Constituents and Pharmacological Effects of Corydalis saxicola Bunting: A Review","volume":"29","author":"Tang","year":"2018","journal-title":"Tradit. Chinese Drug Res. Clin. Pharmacol."},{"key":"B53","first-page":"100","article-title":"Quality Assessment of Corydalis Saxicola Bunting Based on HPLC Fingerprint and Multi-Components Quantitative Determination","volume":"34","author":"Tang","year":"2019","journal-title":"China J. Traditional Chin. Med. Pharm."},{"key":"B54","first-page":"31","article-title":"Chemical Constituents of Corydalis Saxicola","volume":"5","author":"Wang","year":"2007","journal-title":"Chin. J. Nat. Medicines"},{"key":"B55","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jep.2008.02.010","article-title":"Protective Effects of Dehydrocavidine on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats","volume":"117","author":"Wang","year":"2008","journal-title":"J. Ethnopharmacol"},{"key":"B56","first-page":"7","article-title":"Inhibitory Effect of Extract from Corydalis Saxicola Bunting on HBV In Vivo","volume":"18","author":"Wang","year":"2009","journal-title":"China Pharmaceuticals"},{"key":"B57","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jep.2011.08.039","article-title":"Hepatoprotective Effects and Mechanisms of Dehydrocavidine in Rats with Carbon Tetrachloride-Induced Hepatic Fibrosis","volume":"138","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1055\/s-2007-981549","article-title":"Two New Quaternary Alkaloids and Anti-hepatitis B Virus Active Constituents from Corydalis Saxicola","volume":"73","author":"Wu","year":"2007","journal-title":"Planta Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"81","DOI":"10.14148\/j.issn.1672-0482.2015.0081","article-title":"Isolation and Structural Identification of Alkaloids from Corydalis Saxicola","volume":"31","author":"Wu","year":"2015","journal-title":"J. Nanjing Univ. Traditional Chin. Med."},{"key":"B60","first-page":"28","article-title":"MDF-based Metabolites of Aqueous Extract of Corydalis Saxicola Bunting in Rats' Plasma, Urine, Bile and Stool","volume":"32","author":"Wu","year":"2021","journal-title":"Lishizhen Med. Materia Med. Res."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2753\/csh0009-4633360181","article-title":"Comparison of TLC Between Corydalis Saxicola Bunting and Coptidis Rhizoma","volume":"36","author":"Xia","year":"2002","journal-title":"Res. Pract. Chin. Medicines"},{"key":"B62","first-page":"2052","article-title":"Pharmacodynamics of Yanhuanglian Suppository for Rats with Chronic Pelvic Inflammatory Diseases","volume":"17","author":"Xiao","year":"2019","journal-title":"Cent. South Pharm."},{"key":"B63","doi-asserted-by":"publisher","first-page":"113647","DOI":"10.1016\/j.indcrop.2021.113647","article-title":"Chemical Constituents and Antioxidative, Anti-inflammatory and Anti-proliferative Activities of Wild and Cultivated Corydalis Saxicola","volume":"169","author":"Xie","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"B64","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/md18010054","article-title":"Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species","volume":"18","author":"Xu","year":"2020","journal-title":"Mar. Drugs"},{"key":"B65","first-page":"241","article-title":"Effects of Yanhuanglian Total Alkaloids and Dehydroapocavidine on NF-Kappa B Actiity of Oral Carcinoma Cell Lines","volume":"20","author":"Xu","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B66","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13020-021-00468-5","article-title":"Corydalis Saxicola Bunting Total Alkaloids Attenuate Paclitaxel-Induced Peripheral Neuropathy through PKC\u03b5\/p38 MAPK\/TRPV1 Signaling Pathway","volume":"16","author":"Xue","year":"2021","journal-title":"Chin. Med."},{"key":"B67","first-page":"782","article-title":"Effect of Yanhuanglian and Danshen Injection on Liver Fibrosis of Chronic Hepatitis B","volume":"17","author":"Yin","year":"2001","journal-title":"J. Pract. Med."},{"key":"B74","first-page":"245","article-title":"Effects of Corydalis saxicola Bunting Total Alkaloids on Tca8113 Cell Proliferation and Apoptosis","volume":"20","author":"Yin","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1002\/ptr.6117","article-title":"Inhibitory and Inductive Effects of Corydalis Saxicola Bunting Total Alkaloids (CSBTA) on Cytochrome P450s in Rats","volume":"32","author":"Yu","year":"2018","journal-title":"Phytother Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1142\/s0192415x13500092","article-title":"Anti-hepatitis B Virus Effects of Dehydrocheilanthifoline from Corydalis Saxicola","volume":"41","author":"Zeng","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"B70","first-page":"9","article-title":"Research Progress on Alkaloids in Corydalis Saxicola Bunting","volume":"49","author":"Zhang","year":"2020","journal-title":"Technology Dev. Chem. Industry"},{"key":"B71","first-page":"5","article-title":"Study on the Application of HPLC-Diode Array Detection in Protobeberine Quaternary Alkaloids","volume":"20","author":"Zhou","year":"1989","journal-title":"Chin. Traditional Herbal Drugs"},{"key":"B72","first-page":"96","article-title":"Effects of Yanhuanglian Total Alkaloids on Bcl-2 Activity of Oral Squamous Carinoma Cell Lines","volume":"21","author":"Zhu","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B73","first-page":"11","article-title":"Experimental Study on Anti-inflammatory and Analgesic Effects of Corydalis Saxicola Rectal Suppository","volume":"28","author":"Zhuge","year":"2019","journal-title":"Chin. J. Ethnomedicine Ethnopharmacy"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.822792\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T02:17:38Z","timestamp":1644977858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.822792\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":75,"alternative-id":["10.3389\/fphar.2022.822792"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2022.822792","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]},"article-number":"822792"}}