{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:28:33Z","timestamp":1784370513910,"version":"3.55.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Potassium ion (K<jats:sup>+<\/jats:sup>) channels are pore-forming transmembrane proteins that control the transport of K<jats:sup>+<\/jats:sup> ions. Medicinal plants are widely used as complementary therapies for several disorders. Studies have shown that the modulation of K<jats:sup>+<\/jats:sup> channels is most likely involved in various pharmacological effects of medicinal plants. This review aimed to evaluate the modulatory effects of medicinal plants and their active constituents on K<jats:sup>+<\/jats:sup> channels under pathological conditions. This systematic review was prepared according to the Preferred Reporting Items for the Systematic Reviews and Meta-analyses (PRISMA) 2020 guideline. Four databases, including PubMed, Web of Science, embase, and Scopus, were searched. We identified 687 studies from these databases, from which we selected 13 <jats:italic>in vivo<\/jats:italic> studies for the review by using the Population, Intervention, Comparison, Outcomes, Study (PICOS) tool. The results of the 13 selected studies showed a modulatory effect of medicinal plants or their active constituents on ATP-sensitive potassium channels (K<jats:sub>ATP<\/jats:sub>), and small (SK<jats:sub>Ca<\/jats:sub>) and large (BK<jats:sub>Ca<\/jats:sub>) conductance calcium-activated K<jats:sup>+<\/jats:sup> channels in several pathological conditions such as nociception, brain ischemia, seizure, diabetes, gastric ulcer, myocardial ischemia-reperfusion, and hypertension via possible involvement of the nitric oxide\/cyclic GMP pathway and protein kinase. K<jats:sup>+<\/jats:sup> channels should be considered as significant therapeutic milestones in the treatment of several diseases. We believe that understanding the mechanism behind the interaction of medicinal plants with K<jats:sup>+<\/jats:sup> channels can facilitate drug development for the treatment of various K<jats:sup>+<\/jats:sup> channel-related disorders.<\/jats:p>","DOI":"10.3389\/fphar.2022.831963","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T09:42:07Z","timestamp":1645522927000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review"],"prefix":"10.3389","volume":"13","author":[{"given":"Arezoo","family":"Rajabian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Rajabian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Babaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Mirzababaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Nassiri-Asl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1515\/jbcpp-2016-0190","article-title":"Antinociceptive and Anti-inflammatory Properties of Tetracera Alnifolia Willd. 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