{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:33:53Z","timestamp":1792701233279,"version":"4.5.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870056 81800067"],"award-info":[{"award-number":["81870056 81800067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with a poor prognosis. Although dihydromyricetin (DHM), extracted from vine tea and other Ampelopsis species, has been proven to have anti-inflammatory and antioxidant functions, the effects of DHM on IPF remain unclear.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The effects of DHM on the differentiation, migration, proliferation, and respiratory functions of primary mouse lung fibroblasts (PMLFs) and primary human lung fibroblasts (PHLFs) were detected by western blotting, the Transwell assay, EdU staining, and the Mito Stress test. Then, the impacts of DHM on bleomycin (BLM)-induced pulmonary fibrosis were evaluated by pathological staining, western blotting, and coimmunofluorescence staining. The signaling pathway influenced by DHM was also investigated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> DHM could regulate the differentiation of fibroblasts to myofibroblasts and suppress the abnormal migration, proliferation, and respiratory functions of myofibroblasts induced by TGF-<jats:italic>\u03b2<\/jats:italic>1 or myofibroblasts from IPF patients. DHM could also alleviate pulmonary fibrosis induced by BLM. All these effects were achieved by regulating the STAT3\/p-STAT3\/GLUT1 signaling pathway.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> DHM could regulate the abnormal functions of myofibroblasts induced by TGF-<jats:italic>\u03b2<\/jats:italic>1 and myofibroblasts from IPF patients and alleviate pulmonary fibrosis induced by BLM; thus, DHM might be a candidate medicinal treatment for IPF.<\/jats:p>","DOI":"10.3389\/fphar.2022.834604","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T08:29:28Z","timestamp":1647246568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3\/p-STAT3\/GLUT1 Signaling Pathway"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1111\/febs.14577","article-title":"Glucose Transporters in Cancer - from Tumor Cells to the Tumor Microenvironment","volume":"285","author":"Ancey","year":"2018","journal-title":"FEBS J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1096\/fj.201600428R","article-title":"Profibrotic Up-Regulation of Glucose Transporter 1 by TGF-\u03b2 Involves Activation of MEK and Mammalian Target of Rapamycin Complex 2 Pathways","volume":"30","author":"Andrianifahanana","year":"2016","journal-title":"FASEB J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple Method of Estimating Severity of Pulmonary Fibrosis on a Numerical Scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J. 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